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활성산소종 형성을 통한 협죽도 잎 에탄올 추출물의 Caki-1 인체 신세포암 Apoptosis 유발
장자원,김성윤,최영현,황원덕 대한암예방학회 2011 Journal of cancer prevention Vol.16 No.2
Nerium indicum, an India-Pakistan-originated shrub belonging to the oleander family, is reported to possess many pharmacological activities including stimulation of cardiac muscle, anti-diabetes,anti-angiogenesis and neuroprotection activities. However, the cellular and molecular mechanisms of apoptosis induction by N. indicum extract in human cancer cells are poorly understood. In the present study, it was investigated the biochemical mechanisms of the pro-apoptotic effects by ethanol extract of N. indicum leaf (ENIL) in Caki-1 human renal carcinoma cells. It was found that ENIL could inhibit the cell proliferation of Caki-1 cells in a concentration- and time-dependent manner, which was associated with the induction of apoptosis as determined using DAPI staining and flow cytometric analysis. The induction of apoptotic cell death by ENIL was connected with a loss of mitochondrial membrane potential (MMP), proteolytic activation of caspase-3 and -9, and degradation of poly (ADP-ribose) polymerase (PARP) in Caki-1 cells. However, ENIL did not significantly affect the activity of caspase-8 and the levels of the inhibitor of apoptosis protein (IAP) family members. In addition, following exposure to ENIL,the production of reactive oxygen species (ROS) were increased, and inhibition of ROS generation by ROS scavenger, N-acetylcysteine (NAC), attenuated ENIL-induced apoptosis. Taken together, these findings suggest that ENIL may be a potential chemotherapeutic agent for use in control of Caki-1 human renal carcinoma cells and further studies will be needed for identification of active compounds that confer the anti-cancer activity of ENIL. (Cancer Prev Res 16, 167-179, 2011)
부자 및 천오를 포함한 한약이 간 손상 수치에 미치는 영향
장자원,김지윤,민성순,송수진,김기탁,황원덕,Jang, Ja-Won,Kim, Ji-Yun,Min, Sung-Soon,Song, Su-Jin,Kim, Ki-Tak,Hwang, Won-Duk 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.4
Objectives : Boo-ja and Cheon-o are not commonly prescribed, but are necessary for some clinical conditions, dispite the fact that some negative effects have been known to occur with these medicines. Hence, consequences for aspartate aminotransferase(AST), alanine aminotransferase(ALT) due to herbal medicines, including boo-ja and cheon-o are here reported. Methods : From January 2005 to July 2005, results were analyzed for 36 inpatients belonging to the sixth internal medicine department of Dongeui Oriental Medical Hospital who took herbal medicine, including boo-ja and cheon-o, over 20 days. The study is about the comparison and the investigation of LFT, and all results were taken upon their hospitalization and upon their departure. The standard of liver injury was used as a standard for their examinations. Results were as follows : No Change in normal limit : 28 of the 36 Increased AST. ALT from when they were hospitalized : 2 of 36 Normalized AST. ALT from when they were hospitalized with results higher than normal : 6 of 36 These results show no side-effects, therefore suggest that these herbal medicines, including boo-ja and cheon-o, do not cause adverse side-effects for patients of this kind if administered as was done in this study.
부자(附子) 및 천오(川烏)를 함유한 처방(處方)이 간기능(肝機能)에 미치는 영향(影響)(II)
송수진,장자원,황원덕,Song, Su-Jin,Jang, Ja-Won,Hwang, Won-Duk 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.2
Objectives: Boo-ja and Cheon-o are not commonly prescribed, but are necessary for some clinical conditions, dispite the fact that some negative effects have been known to occur with these medicines. Hence, consequences for aspartate aminotransferase (AST), alanine aminotransferase(ALT) due to herbal medicines, including boo-ja and cheon-o are here reported. Methods: From January 2005 to July 2005, iresults were analyzed for 40 inpatients belonging to the sixth internal medicine department of Dongeui Oriental Medical Hospital who took herbal medicine, including boo-ja and cheon-o, over 20 days. The study is about the comparison and the investigation of LFT, and all results were taken upon their hospitalization and upon their departure. The standard of liver injury was used as a standard for their examinations. Results : 1. No Change in normal limit . 34 of the 40 2. Increased AST. ALT from when they were hospitalized : 2 of 40 Normalized AST, ALT from when they were hospitalized with results higher than normal : 6 of 40 3. These results show no side-effects, therefore suggest that these herbal medicines, including boo-ja and cheon-o. do not cause adverse side-effectsfor patients of this kind if administered as was done in this study.
AIDP 환자(患者)의 한양방(韓洋方) 치료(治療) 1례(例)
김종환,박상욱,장자원,신우진,홍현우,김지윤,최인선,황원덕,Kim Jong-Hwan,Park Sang-Wook,Jang Ja-Won,Sin Woo-Jin,Hong Hyun-Woo,Kim Ji-Yun,Choi In-Sun,Hwang Won-Duek 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.4
Introduction: Guillain-Barre syndrome(GBS) is defined as a recognizable clinical entity that is characterized by rapidly evolving symmetric limb weakness, a loss of tendon reflexes, absent or mild sensory signs, and variable autonomic dysfunctions. Recently there is an opinion that Acute Inflammatory Demyelinating Polyradiculoneuropathy'(AIDP) is more effective than 'GBS' for the symptoms. These symptoms are applicable to rheumatic arthritis(痺), flaccid paralysis of limb(?) caused by wind, cold and dampness(風, 寒, 濕) from an oriental medical view point. On this, we reported one case that diagnosed as 'complex of rheumatic arthritis(痺) and flaccid paralysis of limb(?)' at our oriental medical hospital. Result: we considered these symptoms as 'complex of rheumatic arthritis(痺), flaccid paralysis of limb(?)'. In accordance with the result, we treated the patient with Chung-Sang Tong-Jung On-Ha(淸上通中溫下). We concluded that external factors such as wind, cold and dampness(風, 寒, 濕) and internal factors like vital energy's disharmony(生氣不調和) affected the patient.
숏폼 콘텐츠의 형식적, 내용적 특성이 이용자 반응에 미치는 영향 -틱톡 뉴스를 중심으로-
유경한,강지안,장자원,최지은,독몽기,왕일범 한국멀티미디어학회 2022 멀티미디어학회논문지 Vol.25 No.12
This research investigates the features of TikTok News, a newly emerging form of news content, as well as the elements of TikTok news that affect users' reactions based on the number of views, likes, and comments. The survey's findings indicate that individuals prefer hard news and anecdotally focused frameworks when it comes to content. Second, it was found that among the formal components, the source of the information—whether it was present or not—was a content aspect that affected how news was used. However, among the formal aspects, neither the image processing technique nor the caption's attribute had any effect on any of the three TikTok metrics (view count, likes, or comments). Last but not least, the relationship between content and formal components had an impact on user response. This demonstrates that despite the fact that TikTok users are substantially distinct, they generally consume news similarly.
뇌졸중환자의 정구성정색소성 빈혈에 대한 사육탕가미방의 임상적 효과
박상은,홍수현,장자원,송수진,홍상훈,서상호,Park, Sang-Eun,Hong, Su-Hyun,Jang, Ja-Won,Song, Su-Jin,Hong, Sang-Hoon,Seo, Sang-Ho 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.4
Objective : Normocytic Normochromic Anemia is one of the most common cases in clinics of all types of morphological Anemia. This study is aimed at examining significant curative effects of Sayuktanggami-bang on Cerebral vascular accident(CVA) patients with Normocytic Normochromic Anemia. Methods : For this study to examine the effects of Sayuktanggami(四六湯加味方), Patients were divided into 2 groups. Group A(experimental group) consisted of 19 cases prescribed Sayuktanggami-bang, Group B (control group) consisted of 15 cases prescribed other herbs. Before presciption, They were tested for CBC, AST, ALT, Total protein, Cholesterol, TG, HDL, BUN, Creatinine, Uric acid, Na, K, Cl while fasting, then were given the herbs over two weeks. They were checked again for changes over those two weeks. Results : In cases of group A, the statistical significance of CBC changes before and after treatment were recognizable : RBC(p<0.01), Hb(p<0.01), Hct(p<0.01). In comparing CBC changes between group A and group B which developed cerebral infarction group, a type of CVA, the significance of curative effects in group A is recognizable over group B before and after treatment : RBC(p<0.01), Hb(p<0.01), Hct(p<0.05). Cytotoxic reaction was nonexistant. Conclusion : Results of this study suggest that Sayuktanggami-bang has curative effects for CVA patients with normocytic normochromic anemia.
박상은,최인선,장자원,홍상훈,서상호,Park, Sang-Eun,Choi, In-Sun,Jang, Ja-Won,Hong, Sang-Hoon,Seo, Sang-Ho 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3
Evans syndrome, as originally described, refers to autoimmune hemolytic anemia accompanied by thrombocytopenia. The autoantibodies in Evans syndrome are directed specifically against red cells, platelets, or neutrophils and are not crossreacting. The incidence of autoimmune hemolytic anemia is estimated to be approximately 10 cases per million people. Many patients have associated disorders, such as lupus erythematosus and other autoimmune disease, chronic lymphadenopathy, or hypogammaglobulinemia. In Oriental Medicine, the approach to Evans syndrome is made in view of deficiency of blood. The ailment was treated through methods of Oriental Medicine. Acupucture and herbal medicine were administered to patients diagnosed with Evans Syndrome by ecchymosis at the lower limb after continued gingival bleeding. As a result significant improvement in RBC, Hb, Hct, and PLT were observed and complaints abated.