Primary Angioplasty for Symptomatic Atherosclerotic Middle Cerebral Artery Stenosis

장윤혁,황승균,권오기 대한뇌혈관외과학회 2014 Journal of Cerebrovascular and Endovascular Neuros Vol.16 No.3

Objective : The objective of this study is to evaluate the clinical and angiographicoutcomes after primary balloon angioplasty in patients withsymptomatic middle cerebral artery (MCA, M1 segment) stenosis refractoryto medical therapy. Materials and Methods : Eleven patients with intracranial stenosis weretreated with primary balloon angioplasty. All patients had MCA stenosiswith recurrent transient ischemic attack (TIA). The indication for balloonangioplasty was patients with significant MCA stenosis: 1) age older than18 years with recurrent or progressive TIA or infarction despite optimalmedical therapy, including anti-coagulation, dual anti-platelet, and anti-lipidmedication; 2) previous ischemic events or asymptomatic severe stenosis(more than 50%) with poor collateral cerebral circulation, or diminishedcerebral perfusion on single photon emission computed tomography beforeand after administration of the intravenous dosage of acetazolamide. Results : The median age of patients was 53 years (range 44-79). Thetechnical success rate was 100%. Mean pretreatment stenosis degree was83.63 ± 9.53% and 29.1 ± 15.4% before and after angioplasty, respectively. Procedural-related complications occurred in four of 11 patients (36%),but none of the patients had permanent neurological deficit. All patientswere available for an average follow-up period of 19.4 ± 5.1 months. One patient had a stroke in the territory of angioplasty at two monthsafter angioplasty. The stroke free survival rate at 30 days and 12 monthswas 100% and 91%, respectively. Restenosis over 50% was observed inthree of 11 patients (27%); all were asymptomatic. Conclusion : Intracranial angioplasty for symptomatic MCA stenosis refractoryto medical therapy can be a treatment option to reduce the riskof further TIA or stroke.

Case of Rickettsia typhi-induced Brain Abscess Mimicking Brain Tumor

장윤혁,문장섭,Jin-Sun Jun,Tae-joon Kim,Kyung-Il Park,Soon-Tae Lee,Keun-Hwa Jung,이상건,주건 질병관리본부 2018 Osong Public Health and Research Persptectives Vol.9 No.3

Murine typhus is one of the most prevalent rickettsial infections in the world, caused by the bacterial genus Rickettsia. Though the disease manifests a relatively benign clinical course with fever, rash, and headache being the 3 classic symptoms, neurological complications may arise in patients that could become permanent. In this case study, a patient with a brain abscess caused by R typhi infection is described. Based upon the recent reemergence of arthropod-borne disease, the findings in this case are significant; R typhi can cause a brain abscess that mimics a brain tumor, which delays the diagnosis and appropriate management of the disease. Murine typhus should always be considered when performing the differential diagnosis of brain abscesses in South Korea.

Effect of Ginseng Powder Addition on Physicochemical Properties of Wheat Bread and Cookies

장윤혁,Perry K. W. Ng 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.4

This study evaluated quality properties of hard wheat-ginseng bread (10% ginseng powder, GP) and soft wheat-ginseng cookies (10% GP), and changes in ginsenosides (G) in bread and cookies upon baking. Bread loaf volume decreased when GP was added to hard wheat flour (HWF)bread formulations. Widths of cookies baked from soft wheat flour (SWF)-GP were significantly smaller than those of cookies baked from SWF. Individual G (Rb1, Rc,Rd, Rg2, and Rg3) were fractionated and identified by reversed-phase (RP)-HPLC from GP, ground bread crust,and ground bread crumb of samples baked from HWF and HWF-GP, and ground cookie samples baked from SWF and SWF-GP. Rg2 (0.17 and 0.06 mg/100 mg GP) was found in the bread crust and bread crumb of samples baked from HWF-GP, respectively, whereas Rg3 (0.07 mg/100mg GP) was present only in the bread crust. Rg2 and Rg3were not present in cookie samples baked from SWF-GP.

Influence of Nanopowdered Peanut Sprouts in Collagen-induced Arthritic Mice

장윤혁,김동휘,곽해수 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.6

Effects of powdered and nanopowdered peanutsprouts on prevention and treatment of rheumatoid arthritisin DBA/IJ mice immunized with type II collagen wereinvestigated. After induction of arthritis, mice were dividedinto groups of (1) no immunization (normal), (2) collageninducedarthritis (CIA), (3) collagen-induced arthritistreated with methotrexate (0.3 mg/kg of body weight)(MTX), (4) collagen-induced arthritis treated with powderedpeanut sprouts (0.2mg/day) (PPS), and 5) collagen-inducedarthritis treated with nanopowdered peanut sprouts (0.2 mg/day) (NPPS). Feeding methotrexate, powdered, or nanopowderedpeanut sprouts to arthritic mice significantly(p<0.05) decreased TNF-α, IL-1β, and IL-6 levels,compared to controls. Serum IgG1 levels for MTX, PPS,and NPPS group mice were 4,980.48, 6,178.44, and5,776.21 pg/mL, respectively. All values were significantly(p<0.05) lower than for CIA group mice (8,290 pg/mL). Histological scores and spleen indices of NPPS group micewere significantly (p<0.05) lower than for PPS group mice.

Steady and Dynamic Shear Rheological Properties of Extrusion Modified Fenugreek Gum Solutions

장윤혁,Steve W. Cui 한국식품과학회 2011 Food Science and Biotechnology Vol.20 No.6

This study investigated the rheological properties of extrusion modified fenugreek gum solutions (0.5, 1.0,1.5, and 2.0%, w/v) under steady and dynamic shear conditions. Fenugreek gum was extruded in a twin-screw extruder without an exit die to minimize a decrease in molecular weight of fenugreek gum during extrusion process. Both of the steady and dynamic shear rheological tests revealed that extrusion process did not substantially influence the steady and dynamic shear properties of the gum. The power law model was applied to describe the flow behavior of the extruded gum solutions. The extrusion modified fenugreek gum solutions exhibited a shearthinning flow behavior at 25ºC, and the values of consistency index (K) and apparent viscosity (η_a,_100) increased with an increase in the gum concentration. The magnitudes of storage modulus (G') and loss modulus (G'') for the extrusion modified fenugreek gum solutions increased with increasing frequency (ω) and with increasing gum concentration.

Rituximab Treatment for Idiopathic Hypertrophic Pachymeningitis

장윤혁,이순태,정근화,주건,이상건 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.2

Background and Purpose Hypertrophic pachymeningitis (HP) is a rare disease caused by autoimmunity in the meninx that causes various neurologic symptoms, including headache, seizures, weakness, paresthesia, and cranial nerve palsies. Although the first-line therapy for HP is steroids, many HP cases are refractory to steroids or recur when the steroids are ta¬pered. Here we report three HP cases that were successfully treated with rituximab (RTX). Methods From an institutional cohort recruited from April 2012 to July 2016, three HP cases that were identified to be steroid-refractory were treated with RTX (four weekly doses of 375 mg/m2). Clinical improvement was assessed by the number of relapses of any neurologic symptom and the largest dural thickness in MRI. Results All three patients were recurrence-free of neurologic symptoms and exhibited promi¬nent decreases in the dural thickness after RTX treatment. No adverse events were observed in the patients. Conclusions We suggest RTX as a second-line therapy for steroid-refractory HP. Further studies are warranted to confirm this observation in a larger population and to consider RTX as a first-line therapy.

이상(李箱) 수필에 나타나는 병원 체험: 생명정치적 시선과 식민지의 신체들

장윤혁,김춘식 동악어문학회 2023 동악어문학 Vol.90 No.-

본 논문은 이상(李箱, 1910~1937)의 수필 작품 「추등잡필」, 「병상이후」 등에 나타나는 병원 체험을 근대성과의 연관 속에서 분석하는 글이다. 지금까지 질병은 이상의 삶과 작품세계를 이해하는 중대한 키워드로 고려되어 왔다. 하지만 이 시기의 질병들이 서양의학의 지식에 의해 규명되고, 방사선 촬영 등의 기술적 조건에 의해 ‘진단(診斷)’되는 것이었다는 점에 보다 집중해야 할 필요가 있다. 결핵으로 대표되는 새로운 언어들은 인간의 신체가 방출하는 징후를 인식하는 방식을 근대적인 패러다임에 맞추어 재구성한다. 그런데 이러한 의학적 진단과 처방이 타자에 의해 이루어지기 때문에, 식민지의 환자는 그 자신의 신체를 둘러싼 정치적 힘으로부터 소외될 위험에 노출된다.「추등잡필」에서 이상은 그 자신이 형무소의 수감자들을 타자화하고 구경했던 일에 대한 부끄러움을 기록하고, 나아가 그 자신이 병원에 입원했을 때 구경거리가 되었던 체험의 불쾌감을 언급한다, 이로부터 근대의학 및 병원이 환자의 신체를 인간적으로 대해야 한다는 입장을 내비친다. 「병상이후」에서 이러한 문제의식은, 질병과 소외라는 이중의 곤경 속에서 환자 자신이 어떤 삶을 희망할 수 있는가에 대한 고민으로 발전한다. 여기서는 이상의 수필 작품에 나타나는 근대적인 병원 체험을 살펴보고, 이를 통해 생명정치적 비판, 그리고 환자들이 꿈꿀 수 있는 삶에 대한 모색이 어떻게 나타나는지 분석하려 했다.

에너지 경제 및 기후변화 : 국내 자원화시설에서 발생되는 음폐수의 발생 및 처리현황 조사 연구

장윤혁,배재근 한국폐기물자원순환학회(구 한국폐기물학회) 2008 한국폐기물자원순환학회 추계학술발표논문집 Vol.2008 No.-

음식물류폐기물공공자원화시설의운영실태조사를통한처리공정별효율적인운영방안검토

장윤혁,박준석,김정대,배재근 유기성자원학회 2010 유기물자원화 Vol.18 No.1

At present, 265 national food waste recycling facilities have been operated by public facilities95 and private facilities 160. it has continuously installed a food waste treatment facility from1997. The government set up and implemented guidelines and inspection standards for theinstallation and operation of the facilities. However, unclear detailed examination items, designsand process standards for the installation procedures of the facilities are causing problems due tothe unskilled operation management system, decrease in efficiency and defects of a facility.This study conducted mail and site surveys on 95 public food waste recycling facilities that itsuggest the ways to operate facilities which minimize problems. At the result of investigation, apre-treatment facility was not installed 2 systems(2 inputting facilities) and hopper covers andfood was overloaded. also the transportation amount was excessive.� In case of a main treatmentfacility, the secondary environmental pollution was caused by inexperienced operation and theefficiency of the facility was reduced due to excessive input of food. also the operationmanagement standards of the facilities were inappropriate. The odor and food waste leachatetreatment facility is investigated as� problems that are unskilled operation, lack of regularinspection and inappropriate capacity of the treatment facility .Based on the problems found through the investigation, it suggested some ways of efficientoperation. this study might contribute to minimize mistakes and defects and� improve theefficiency of install and operation course of food waste recycling facilities through finding. 현재전국에는255개의음식물류폐기물자원화시설이공공시설(95개소) 및민간시설(160개소)에의하여운영되고있으며, 이들시설들은97년도부터지속적으로설치되고있다. 정부에서는설치및운영에관한지침과설치검사기준등을정하여시행하고있으나, 시설설치절차에따른세부적인검토사항, 설계, 공정기준등이명확하지않아운영관리체계미흡, 처리효율저하, 시설하자등이문제점이발생되고있다. 따라서, 본연구에서는이들문제점을최소화하기위한시설운영방안을제시하기위해음식물공공자원화시설95개소를대상으로설문및현장방문조사를실시하였다. 조사결과전처리시설에서는2계열및호퍼덮개미설치, 음식물과적및이송물량과다, 주처리시설은운전미숙으로인한2차환경오염발생, 과다음식물투입으로시설효율저하, 시설운영상부적합한운전관리기준등이문제점으로조사되었다. 악취및음폐수(음식물류폐기물처리과정중발생폐수) 처리시설에서는운영미숙, 주기적인점검부족, 처리시설용량부적절등이문제점으로조사되었다.이와같이조사되어진문제점을근거로하여효율적인운영방안을제시하였으며, 향후음식물류폐기물자원화시설을설치및운영하는데있어처리효율제고, 시행착오및하자를최소화할수있을것으로판단된다.

[에너지 경제 / 기후변화] 국내 자원화시설에서 발생되는 음폐수의 발생 및 처리현황 조사 연구

장윤혁,배재근 한국폐기물자원순환학회 2008 한국폐기물자원순환학회 학술대회 Vol.2008 No.1