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집먼지 진드기 항원으로 아토피 피부염을 유발한 NC/Nga 생쥐에 미치는 $\gamma$-PGA의 효과
장순남,김금란,문미영,강상모,Jang, Soon-Nam,Kim, Kum-Lan,Yun, Mi-Young,Kang, Sang-Mo 한국미생물·생명공학회 2010 한국미생물·생명공학회지 Vol.38 No.1
$\gamma$-PGA는 우리 전통 콩 발효식품인 청국장의 끈적끈적한 점액성 성분의 하나로, 매우 다양한 기능을 가지고 있는 천연물질이다. 이러한 $\gamma$-PGA의 아토피발진 억제 효과를 알아보고자 NC/Nga 생쥐를 사용하여 in vivo 실험을 하였다. BMAC로 유도된 NC/Nga 아토피 피부발진 생쥐에 분자량 300 kDa인 $\gamma$-PGA(PGA-HM)와 이를 저분자화 시킨 저분자 $\gamma$-PGA(PGA-LM)을 경구 투여한 결과 PGA-LM 투여군에서 clinical skin severity score가 유의성 있게 감소하였다. 혈청 IgE 수준은 PGA-LM이 대조군에 비하여 유의적으로 감소하였고, 혈청 IgG1 수준은 대조군에 비하여 감소하였으나 두 군 모두 유의성이 없었다. $CD4^+CD25^+foxp3^+$ Treg 세포가 유도되는 것을 확인하기 위하여, PGA-HM와 PGA-LM를 투여한 NC/Nga 아토피 피부발진 생쥐의 등 부위에서 mRNA를 분리히여 real-time PCR로 foxp3 mRNA 유전자 발현량을 측정한 결과는 대조군에 비하여 PGA-LM 투여군이 약 2배 이상 증가를 나타내었다. 또한 등피부 조직의 조직검사에서도 epidermis의 두께, 비만세포 침윤, 그리고 $CCR3^+$ 세포수 등이 대조군에 비하여 현저히 억제됨을 관찰할 수 있었다. 이상의 결과로 PGA-HM보다 PGA-LM이 BMAC로 아토피 피부염이 유발된 NC/Nga 생쥐에 $CD4^+CD25^+foxp3^+$ Treg 세포를 활성화하여 IgE 및 염증 사이토카인의 생산 및 $CCR3^+$ 호산구의 활성화가 억제되어 아토피조절 효과를 나타내는 것으로 사료되었다. As one of the mucous components of Cheonggukjang, traditional fermented soybean paste, $\gamma$-PGA is a natural substance with diverse functions. In this paper, an in-vivo experiment has been performed using NC/Nga mice in order to find out the efficacy of $\gamma$-PGA in human atopic dermatitis. The NC/Nga mice with BMAC-induced atopic dermatitis were administered $\gamma$-PGA (PGA-HM) with 300 kDa and low-molecular $\gamma$-PGA (PGA-LM), respectively. As a result, a significant decrease in clinical skin severity score was detected in the group that was administered PGA-LM. In terms of serum IgE levels, a significant decline was observed in PGA-LM, compared to the control group. The serum IgG1 levels also decreased more in PGA-LM than in the control group. However, no significant difference was observed in both groups. To witness the induction of $CD4^+CD25^+foxp3^+$ Treg cells, mRNA was sampled from the back of PGA-HM- and PGA-LM-administered NC/Nga mice with atopic dermatitis. In terms of the production amount of foxp3 mRNA, which was measured in real-time PCR, the group that was administered PGA-LM was twice as high as the control group. According to a biopsy on the skin on the backs of the mice, the experimental group was also far lower than the control group in terms of epidermis thickness, mast cell infiltration and the number of $CCR3^+$ cells. Therefore, it has been confirmed that the atopic dermatitis symptoms decreased more in the PGA-LM-administered NC/Nga mice than the PGA-HM-administered group by facilitating $CD4^+CD25^+foxp3^+$ Treg cells and suppressing the activity of eosinophils and production of IgE and pro-inflammatory cytokines.
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식품 및 환경, 기타 NC/Nga 생쥐에서 분리한 T 세포에서 foxp3+ 세포 활성화에 대한 PGA-LM의 효과
장순남 ( Soon Nam Jang ),김금란 ( Kum Lan Kim ),강상모 ( Sang Mo Kang ) 한국미생물생명공학회 2009 한국미생물·생명공학회지 Vol.37 No.2
Poly-γ-glutamic acid (γ-PGA) was mixed natural flora of Bacillus subtilis, contaminated from cooked soybeans. Also, it was performed to find out the antiallergic activity by using NC/Nga mice, in vitro. The γ-PGA (PGA-HM: PGA-high molecular weight), Molecular weight 300 kDa, was decomposed and made PGA-LM (PGA-low molecular weight) which has molecular weight below 30 kDa by sonication. Therefore, it was same result between PGA-HM and PGA-LM, and reported PGA-LM as basic result. We found that PGA-LM contains antiallergic efficacy that inhibit B cells and Th2 cells activation from isolated CD4+T cells in NC/Nga atopic dermatitis model mice, and not show a cytotoxicity in the hFCs. To investigate the effects of these PGA-LM in vitro, isolation of splenic B cell and CD4+T cells in atopic dermatitis mice were used. To elucidate the role of PGA-LM in anti-CD40+ interleukin-4 (IL-4)-mediated B-cell activation, showed that the capacity of B cells to expression IL-1β, IL-6, and TNF-α mRNA down-regulated, and IL-10 mRNA up-regulation by PGA-LM treatment, but it had no effect on TGF-β expression. In addition to CD4+IFN-γ+ and CD4+CD25+foxp3+, the functions of PGA-LM in the development of the CD4+CD25+foxp3+ and CD4+IFN-γ+cells, the phenotype and functions of PGA-LM induced CD4+CD25+foxp3+, and CD4+IFN-γ+cells in CD4+T cells. These results suggested that PGA-LM could change cytokine production and generate CD4+CD25+foxp3+Tregs in NC/Nga mice, and may be effective for immunotherapy in patients with AD.
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콜라겐과 식초의 복합식이가 여성의 목 피부 개선에 미치는 효과
백하나 ( Ha Na Baek ),장순남 ( Soon Nam Jang ),강상모 ( Sang Mo Kang ) 한국미용학회 2012 한국미용학회지 Vol.18 No.1
This study aims to examine an effect of multiple dose of collagen and vinegar on the improvement of woman`s neck skin. Skin roughness, skin color, melanin and erythema level were measured to comprehend the change of neck skin, so the multiple dose effects of collagen and vinegar were compared and analyzed. In the analysis of neck skin roughness & skin color average variation by increase %, the collagen+vinegar group showed variation of skin roughness with 19.7% (p=0.989), skin color with 4.6% (p=0.672) more than collagen group and vinegar group so it showed the effects of neck skin roughness and skin color changes. In the analysis of the variation of neck melanin levels, though it was not significant but the collagen+vinegar group showed 1.3fold more decreased (p=0.950) in the central neck point part than variation of decreased melanin levels of collagen group (p=0.950). In the analysis of the variation of neck erythema levels, the collagen+vinegar group showed 1.5fold more decreased (p=0.968) in the central neck point part than variation of decreased melanin levels of collagen group.
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김금란 ( Kum Lan Kim ),이유미 ( You Mi Lee ),장순남 ( Soon Nam Jang ),이재남 ( Jae Nam Lee ),최태부 ( Tae Boo Choe ) 한국미용학회 2010 한국미용학회지 Vol.16 No.3
The purpose of this study was to examine the relationship between the facial treatment methods (cleansing, exfoliation, massage, pack/mask, use of cosmetics) and skin conditions of face(pores, pigmentation, wrinkles, skin color, erythema). First of all, facial treatment index was constructed by using a questionnaire that surveyed facial treatment methods of participants. Skin conditions of face were measured by using ROBO SKIN ANALYZER (CS50). The data were collected and measured from 345 female. In order to identify actual conditions of facial treatment, facial treatment index was analyzed. Facial treatment index of participants was cleansing (15.96), use of cosmetics (14.42), manual technique (12.08), exfoliation (11.36), pack/mask (8.54). The participants were divided according to facial treatment style. Facial treatment index of special treatment group (70.96) was higher than self treatment group (58.99). It was investigated the relationship facial treatment index and skin condition of face according to facial treatment group. Special treatment group showed significantly greater improvement in wrinkles. It was discussed various relations between facial treatment index and skin condition of face. The differences of facial treatment index according to skin condition of face were analyzed. Results showed that participants didn`t use facial treatment method suitable to one`s facial skin condition.
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