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장순남,류주열,이춘식,박종포,염충섭 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
Innovative technical process for electric energy storage, Liquid Air Energy Storage system (LAES) is mature technologies based on the gas liquefaction process. In spite of many advantages such as high energy density, no geographical constraints, low investment costs and long useful life, the system has not yet widely commercialized due to low round trip efficiency (RTE) in range 50~60% of standalone process. To improve RTE and acquire high yield of liquid air, various configurations of LAES process have been considered. In this research, dual refri-gerants cycle (R-600a and methanol) for air liquefaction and thermal oil circulation for power generation via liquid air gasification have been applied to improve cycle performance significantly. Relevant process and techniques will be introduced.
집먼지 진드기 항원으로 아토피 피부염을 유발한 NC/Nga 생쥐에 미치는 $\gamma$-PGA의 효과
장순남,김금란,문미영,강상모,Jang, Soon-Nam,Kim, Kum-Lan,Yun, Mi-Young,Kang, Sang-Mo 한국미생물·생명공학회 2010 한국미생물·생명공학회지 Vol.38 No.1
$\gamma$-PGA는 우리 전통 콩 발효식품인 청국장의 끈적끈적한 점액성 성분의 하나로, 매우 다양한 기능을 가지고 있는 천연물질이다. 이러한 $\gamma$-PGA의 아토피발진 억제 효과를 알아보고자 NC/Nga 생쥐를 사용하여 in vivo 실험을 하였다. BMAC로 유도된 NC/Nga 아토피 피부발진 생쥐에 분자량 300 kDa인 $\gamma$-PGA(PGA-HM)와 이를 저분자화 시킨 저분자 $\gamma$-PGA(PGA-LM)을 경구 투여한 결과 PGA-LM 투여군에서 clinical skin severity score가 유의성 있게 감소하였다. 혈청 IgE 수준은 PGA-LM이 대조군에 비하여 유의적으로 감소하였고, 혈청 IgG1 수준은 대조군에 비하여 감소하였으나 두 군 모두 유의성이 없었다. $CD4^+CD25^+foxp3^+$ Treg 세포가 유도되는 것을 확인하기 위하여, PGA-HM와 PGA-LM를 투여한 NC/Nga 아토피 피부발진 생쥐의 등 부위에서 mRNA를 분리히여 real-time PCR로 foxp3 mRNA 유전자 발현량을 측정한 결과는 대조군에 비하여 PGA-LM 투여군이 약 2배 이상 증가를 나타내었다. 또한 등피부 조직의 조직검사에서도 epidermis의 두께, 비만세포 침윤, 그리고 $CCR3^+$ 세포수 등이 대조군에 비하여 현저히 억제됨을 관찰할 수 있었다. 이상의 결과로 PGA-HM보다 PGA-LM이 BMAC로 아토피 피부염이 유발된 NC/Nga 생쥐에 $CD4^+CD25^+foxp3^+$ Treg 세포를 활성화하여 IgE 및 염증 사이토카인의 생산 및 $CCR3^+$ 호산구의 활성화가 억제되어 아토피조절 효과를 나타내는 것으로 사료되었다. As one of the mucous components of Cheonggukjang, traditional fermented soybean paste, $\gamma$-PGA is a natural substance with diverse functions. In this paper, an in-vivo experiment has been performed using NC/Nga mice in order to find out the efficacy of $\gamma$-PGA in human atopic dermatitis. The NC/Nga mice with BMAC-induced atopic dermatitis were administered $\gamma$-PGA (PGA-HM) with 300 kDa and low-molecular $\gamma$-PGA (PGA-LM), respectively. As a result, a significant decrease in clinical skin severity score was detected in the group that was administered PGA-LM. In terms of serum IgE levels, a significant decline was observed in PGA-LM, compared to the control group. The serum IgG1 levels also decreased more in PGA-LM than in the control group. However, no significant difference was observed in both groups. To witness the induction of $CD4^+CD25^+foxp3^+$ Treg cells, mRNA was sampled from the back of PGA-HM- and PGA-LM-administered NC/Nga mice with atopic dermatitis. In terms of the production amount of foxp3 mRNA, which was measured in real-time PCR, the group that was administered PGA-LM was twice as high as the control group. According to a biopsy on the skin on the backs of the mice, the experimental group was also far lower than the control group in terms of epidermis thickness, mast cell infiltration and the number of $CCR3^+$ cells. Therefore, it has been confirmed that the atopic dermatitis symptoms decreased more in the PGA-LM-administered NC/Nga mice than the PGA-HM-administered group by facilitating $CD4^+CD25^+foxp3^+$ Treg cells and suppressing the activity of eosinophils and production of IgE and pro-inflammatory cytokines.
장순남,최준홍 대한금속재료학회(대한금속학회) 1999 대한금속·재료학회지 Vol.37 No.10
The dynamic behavior of a tungsten heavy alloy (WHA) have been studied using an exploding bridgewire (EBW) detonator to load stress pulse onto the alloy plate. The particle velocity at the rear free surface of WHA was measured with varying the specimen thickness by a velocity interferometer system for any reflector (VISAR). Simple experimental technique has been introduced herein to obtain the Hugoniot elastic limit and spall strength of metals. The peak pressure generated by the EBW detonator has been exponentially decayed with increasing the sample thickness. The fracture behavior of WHA caused by the tensile stress pulse is similar to that due to the Charpy impact test.