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Cognitive Improvement Effect of Resplex Alpha A in the Scopolamine-induced Mouse Model
장봉근,권영선,박선영,이건우,강혜연,김점용 셀메드 세포교정의약학회 2023 셀메드 (CellMed) Vol.13 No.14
Administration of Scopolamine can be considered a psychopharmacological model of Alzheimer's disease (AD). We made an animal model of Alzheimer's disease (AD) by administering Scopolamine to Blab/c mice. In this study, we investigated the effects of Resplex Alpha on memory impairment and cognitive function in mice in a mouse animal model of Scopolamine-induced memory impairment. Through Y-mazed and passive avoidance behavioral assays, we observed that Resplex Alpha recovered Scopolamine-induced short-term memory and cognitive functions. The results of our study imply that Resplex Alpha may be beneficial in the prevention of Alzheimer's disease (AD).
나한나,장봉근,최원문,Kwang Yul Kim 한국기상학회 2011 Asia-Pacific Journal of Atmospheric Sciences Vol.47 No.3
Typhoon Morakot (2009) produced 2855 mm of rain and was the deadliest typhoon to impact Taiwan with 619 deaths and 76missing persons, including a landslide that wiped out an entire village. While Morakot did not exceed the heaviest 24-h rain record,the combination of heavy rain and long duration that led to the record accumulation is attributed to the southwest summer monsoon influence on the typhoon. Thus, a special combination of factors was involved in the Morakot disaster: (i) Strong southwesterly monsoon winds; (ii) Convergence between the typhoon circulation and monsoon flow to form an east-west oriented convective band over the Taiwan Strait that was quasi-stationary and long-lasting; (iii) A typhoon in a specific location relative to the Central Mountain Range and moving slowly; and (iv) Steep topography that provided rapid lifting of the moist air stream. The contributions of each of these four factors in leading to the Morakot disaster are reviewed primarily based on new research presented at the International Conference on Typhoon Morakot (2009). Historical data sets, new Doppler radar observations, and numerical modeling have advanced the understanding of the special conditions of monsoon-influenced typhoons such as Morakot. This research is also leading to modifications of existing and development of new forecasting tools. Gaps in scientific understanding, limits to the predictability, and requirements for advanced forecast guidance tools are described that are challenges to improved warnings of these extreme precipitation and flooding events in monsoon-influenced typhoons.
진영호,신현주,안혜정,장봉근,박나현,홍종기 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.10
Anthocyanins (ACs) and flavonoids were isolated from three different berry species (blueberry, black chokeberry, and cranberry) via high-speed counter-current chromatography (HSCCC). A total of 19 ACs and 9 flavonoids in three berry extracts were characterized using LC-ESI-MS/MS. The MS/MS spectra of ACs and flavonoids produced a commonly abundant [M-gluc]+ ion due to the easy cleavage of the glycosidic ether bond, which is directly reflected the structural information of the aglycon moiety and linked glucose. Among the identified 19 ACs, the major compounds were identified as glycosylated ACs linked with 3-O-galactose, 3-O-glucose, 3-O-arabinoside, and 3-O-xylose. Three ACs and four flavonoids were the first time observed in three berry extracts. Particularly for the black chokeberry extract, the total amounts of ACs were 10-fold higher than other two berry extracts. LC-MS/MS combined with HSCCC will be alternative technique for identifying new ACs and for the quality evaluation of ACs in colored fruits.