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Chitosan 에 의한 Mutans streptococci 의 증식억제 및 saliva - coated hydroxyapatite beads 에의 부착 억제효과
이정환,김환규,장기완 대한구강보건학회 1998 大韓口腔保健學會誌 Vol.22 No.4
Chitosan, a chitin derivative by N-deacetylation, stimulates the ordered regeneration of oral soft tissues, prevents the har㎖ful action of organic acid, and exhibits bactericidal action against several pathogens. In this study, we examined the effects of chitosan on the growth and adsorption to saliva-coated hydroxyapatite beads of mutans streptococci in vitro. The strains of mutans streptocci were S. mutans KCTC 3065 S. cricetus KCTC 3292, S. rattus KCTC 3294, and S. sobrinus SL-1 KCTC 3308 strain. We found that chitosan of sublethal concentrations had inhibitory effects on growth and adherence to saliva-coated hydroxyapatite beads of mutans streptococci. The results obtained were as follows. 1. The inhibitory effects of chitosan on the growth of S. murans KCTC 3065 strain were 28%, 31%, 52% at the concentrations of 100㎍/㎖, 500㎍/㎖, and 1000㎍/㎖ of chitosan, respectively. 2. The rate of growth inhibition was 20-28% by chitosan alone, and 42-58% by chitosan with the 3 kinds of sugars supplemented as the substrates. The growth patterns in S. rattus KCTC 3294 strain was differed from that of S. mutans KCTC 3065. The rate of growth inhibition in S. mutans KCTC 3065 strain was 28% when chitosan was supplemented. 3. The effects of with and without chitosan for the adherences to saliva-coated hydroxyapatite were evaluated when the sucrose, glucose, and sorbitol were supplemented as the substrates. The reduction of adsorption to saliva-coated hydroxyapatite beads in S. mutans KCTC 3065 strain was ranged from 47 to 58% when sugar was supplemented.