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간경변증의 간주사상 판독에 있어서의 평점제적용에 관한 임상적 연구
장고창 대한핵의학회 1970 핵의학 분자영상 Vol.4 No.2
저자는 1967년 3월부터 1970년 2월까지 방사선의학연구소에서 임상상, 검사실소견 및 생검소견으로 확진된 210예의 간경변증환자에 대하여 교질방사성금과 주사기를 이용한 색채간주사를 실시하고 여기에 임의로 설정한 평점기준을 적용하여 평점이 0인 A군(정상), 05∼3.0인 B군(경증), 3.5∼5.5인 C군(중등증) 및 6.0이상인 D군(중증)으로 구분하고 간질환의 진단 및 경중을 판독함과 동시에 간섭취율반감시간과 각종 생화학적간기능검사성적과의 상호관계를 비교검토하여 다음과 같은 결론을 얻었다. 1) 간경변증에서 색채간주사가 정상으로 나타난 빈도는 6.7±2.56%이었다. 2) 간경변증에서의 교질방사성금의 간섭취율반감시간은 간주사상에서의 평점이 증가됨에 따라 통계학적으로 유의한 연장을 나타냈다. 3) 간경변증에 있어서 생화학적간기능검사성적중 간주사상의 평점증가와 통계학적으로 유의한 상관관계가 있었던 것은 혈청 albumin치, 혈청 globulin치, A/G 비 및 BSP 저류시험성적이었으며 평점의 증가에 따라 그 치가 증가하는 경향을 보인 것은 alkaline phosphatase 활성도이었다. 4) Thymol turbidity test, cholesterol의 total치와 ester치, transaminase 활성도(SGOT, SGPT) 및 bilirubin (direct와 indirect)치와는 상관관계가 전혀 없었다. 5) 간경변증에서의 비해상율은 38.6%로서 간주사상의 평점의 증가와 더불어 그 율도 증가하는 경향을 보였고 간주사상이 정상으로 나타난 수를 제외한 주사상에 변화가 있는 군에서의 그것은 41.3%이었다. 6) 이상의 성적으로 보아 간경변증에 대한 색채간주사상판독에 이 평점제를 이용함으로써 간경변증의 진단과 경중판단에 큰 도움이 되리라고 생각한다. Although the radioisotope liver scan has primarily been of use in the detection of the intra-hepatic space occupying lesions, there has been an increasing awareness of its use in evaluation of liver function. In this study, the degree of hepatomegaly, changes in shape and mottling radiodensity on each lobe and splenic visualization in the liver scans done with colloidal radiogold were numerically expressed as scores under the arbitrary standard in 210 patients with liver cirrhosis. The clinical value of this scoring system was studied with special regards to the correlation between the radiogold hepatic uptake half time and conventional liver function tests. Following were the results; 1) The normal scan appeared in 6.7% of 210 patients with liver cirrhosis. 2) The colloidal radiogold hepatic uptake half time was abnormally and progressively prolonged in parallel to severity of hepatocellular dysfunction. The mean hepatic uptake half time in cirrhosis showing normal scan was 2.76±0.73 minutes. 3) The scoring system was well correlsted with the albumin and globumin levels, A/G ratio and BSP retention. There was some correlstive tendency in alkaline phosphatase activity. 4) There was no correlation with the thymol turbidity test, cholesterol levels, transaminase activities and bilirubin levels. 5) The spleen was visualized in 38.6% of total patitens with liver cirrhosis. Excluding normal scals in liver cirrhosis, the spleen was visualized in 41.3%. 6) The scoring system appears to cinfirm the clinical diagnosis and to give a reliable estimate of the degree of hepatocellular dysfunction in patients with liver cirrhosis.
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膠質形放射性金의 肝査走像을 利用한 肝硬燮症評價에 관한 臨床的硏究
張高昌 漢陽大學校 1977 論文集 Vol.11 No.-
Colored liver scan using colloidal radiogold which was scored by an arbitrary standard with a simple method was compared with physical signs, the conventional liver function test and radiogold hepatic uptake half time in 116 cases of liver cirrhosis who had been admitted to the Hanyang University Hospital. Numberically expressed scores were based on th edegrees of the changes in the hepatic size, shape, the distribution of hepatic mottled radio-activity and the splenic visualization on liver scan obtained by Picker scanner 500 with honeycomb collimator after the injection of 200μCi of radiogold to the patient. Scored liver scans were classified into 4 groups, The results obtained are as follow: 1. of 116 cases, The sex ratio between male and female was about 2 to 1, and about 70% of the cases ranged from the 3rd decade to the 6th in age. 2. The normal scan was 6.9% (8 cases), and minimally changed pattern was 50%(58 cases). 3. In the scoring system and the liver function test, the following results were obtained : the amount of serum albumin, alkaline phosphatase, and B. S. P. were directly proportional to the progressing of the disease, but the amount of serum globulin and hepatic uptake half time were inversely proportional. 4. The spleen visualization was 39.6% (46 cases) and the highest rate was 88.8%, which was seen in D-group. 5. Concerning physical signs, the more the score increased, the ratio of palpable liver decreased and palpable spleen increased. 6. The scoring system expects to help confirm the clinical diagnosis and to give reliable evaluation of the hepatocelluler dysfunction.
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各種甲狀腺疾患에서의 Kit 法에 依한 ^(125)I T₄檢査 (第4報) : Report 4
張高昌 최신의학사 1974 最新醫學 Vol.17 No.4
The serum thyroxine levels were determined by competitive pretein binding analysis using Tetrasorb 1251 Kit in 1.102 cases with various thyroidal states and the reproducibility of T 4 test was studied in 103 cases. Followings were the results: 1. The mean values of T-4 test were 9.1±2.8 ug/dl in 776 euthyroid cases, 19.41±4.41ug/dl in 297 hyperthyroid cases and 3.6±2.4ug/dl in 29 hypothyroid cases. 2. The diagnostic compatibilities of T-4 test were 90.3% in 776 euthyroid cases, 89.9% in 297 hyperthyroid cases and 84.1% in 29 hypothyroid cases. The diagnostic compatibility of the overall cases was 89.7%. 3. The reproducibility of T-4 test was studied with 103 samplings (103 cases). The difference of -averaged absolute values were 0.84ug/dl in 73 euthyroid cases, 0.47uiug/dl in 27 hyperthyroid cases and 1.1ug/dl in 3 hypothyroid cases. The average difference of absolute value in the overall cases was 0.751ug/dl. 4. It is again conformed that the T-4 test has a higher diagnostic accuracy than those of the conventional methods in various thyroid diseases.
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