자궁경부암 환자에서 sentinel lymph node 탐색을 위해 isosulfan blue dye 사용시 발생한 급성 과민반응 1예

임채춘,남궁성은 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.2

Sentinel lymph node를 찾기 위한 시각적 표식자로 Isosulfan blue dye의 이용이 malignant lymphama, breast cancer, thyroid cancer, head and neck surgery 및 산부인과 영역에서는 cervical cancer, vulvar cancer 수술시 많이 이용될 것으로 기대된다. 비교적 안전하며, 인체에 무해한 것으로 알려진 isosulfan blue dye가 투여 후 20분 이내에는 급성 과민반응이 일어날 수 있음을 문헌을 통해, 그리고 실제로 경험한 바 이를 보고하는 바이다. The sentinel lymph node is defined as the first node of a regional lymphatic basin that receives the lymphatic drainage from a tumor, thus representing an elective site of lymph node metastasis. According to the sentinel lymph node hypothesis, histologically negative sentinel lymph nodes can guarantee the histological negativity of the remaining regional lymph nodes. These assumptions suggest that the sentinel node can be a suitable marker of regional lymph node status. Thus sentinel node biopsy may be a reasonable alternative to unnecessary pelvic lymph nodes dissection and a suitable method for limited control of early stage cervical cancer. To improve the sentinel node detection in surgical procedures, we investigated lymphatic mapping of sentinel lymph nodes with isosulfan blue day (lymphazur 1%) and technetium-99m colloid albumin. We have made it a rule to inject 5 ml of isosulfan blue dye in the peritumoral area of cervix. It is reported that isosulfan blue dye has been safe and easily used in the detection of sentinel lymph node in melanoma, breast cancer and vulvar cancer. We experienced a case of anaphylactic reactions to isosulfan blue dye in cervical cancer patient, so we report it with a brief review of literature.

포스타 : 임신주수에 따른 Mullerian Inbiting Substance의 혈중농도 변화

임채춘,조현희,김미란,권동진,김은중,김진홍,이진우,김장흡 대한산부인과학회 2001 대한산부인과학회 학술대회 Vol.87 No.-

부인종양확 : 난소에 전이된 원발성 간암 1예

임채춘,김성주,박영한,강정배,박성택,박성호,김홍배,장봉림 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

Hepatocellular carcinoma (HCC) spreads via the hematogenous route, the lymphatic route, or by direct invasion into adjacent argans. The common extrahepatic metastatic sites of HCC are the lungs, peritoneum, adrenal glands, and heart, and there are rare reports of nasal cavity, orbital cavity, skin, external auditory canals, and pharynx. The ovary is a rare site of metastasis for HCC, which was first reported in 1983. Metastasis of hepatocellular carcinoma to the ovary is notably rare. Although advance in imaging technology has allowed for earlier detection of disease, hepatocellular carcinoma is usually asymptomatic and discovered at an advanced stage with metastasis. The most common sites of metastasis include lung, peritoneum, adrenal gland, and bone, but rarely, the nasal cavity, orbit, gallbladder, and ovary can be metastatic sites. We experienced a case of metastatic hepatocellular carcinoma of the ovary in a living patient. An exploratory laparotomy was performed, and a soft, ovoid cystic mass was identified in the right ovary. Right salphingo-oophorectomy was performed. The pathological features showed metastasis of HCC with clear resection margins. Although metastasis of HCC to the ovary is very rare, it should be suspected in a female patient with a lower abdominal mass and an elevated serum AFP and CA125 levels in the absence of other demonstrable metastases. Recently we experienced a case of HCC metastasis to the ovary, so we report this case with reviewing of other literature.

포스타 : 일반 부인과학 ; 폐경후 여성에서 골밀도 예측을 위한 골대사 표지물질의 병행검사의 의의

임채춘,정기욱,김미란,류순원,권동진,김장흡,임용택,김진홍,이진우 대한산부인과학회 1999 대한산부인과학회 학술대회 Vol.84 No.-

포스타 : 일반 부인과학 ; 반복제왕절개 수술시 근막상절개(Suprafascial incision) 방법의 수술후 효과

임채춘,송희영,황지영,유진희,류순원,김진홍,김수평 대한산부인과학회 1998 대한산부인과학회 학술대회 Vol.82 No.-

일반연제 발표 : 부인종양 ; 자궁경부암 유전적 감수성 인자로서 GST 효소 유전자 검사의 의의

임채춘,김용욱,김태웅,유기성,김진우,이준모,남궁성은 대한산부인과학회 2001 대한산부인과학회 학술대회 Vol.87 No.-

Sentinel Node Biopsy as an Indicator for Pelvic Nodes Dissection in Early Stage Cervical Cancer

임채춘,Jong-SupPark,Seog-NyeonBae,Sung-EunNamkoong 대한의학회 2002 Journal of Korean medical science Vol.17 No.4

암 수술시 Sentinel Lymph Node의 임상적 유용성

임채춘,황성진,박종섭,남궁성은 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.6

목적 : 이 연구의 목적은 외음부 암 환자의 수술시 sentinel lymph node를 탐색하고 동결절편의 조직병리학적 결과를 통해 수술을 최소화 할 수 있는지에 대한 임상적 적용가능성을 평가하는 데 있다. 연구 대상 및 방법 : 2001년 3월부터 2002년 1월까지 가톨릭대학교 강남성모병원에서 외음부 암 확진 후 근치적 외음부 절제술 및 일측 또는 양측 서혜 대퇴부 임파절 절제술을 시행한 4명의 환자를 대상으로 하였으며, 수술전 technetium-99 m colloid albumin의 주입과 수술중 isosulfan blue dye를 주사한 후 sentinel lymph node를 찾아낸 뒤 이를 임상병리과에 보내고 그 동결생검 결과를 얻는다. 결과 : 4명의 환자에서 총 10개의 sentinel lymph node와 110개의 non-sentinel lymph node를 얻었다. 동결생검 결과 10개의 sentinel lymph node는 모두 음성 (benign)이었고 sentinel lymph node가 음성일 때 영구 조직검사 결과가 양성 (malignant)으로 나온 경우는 없었다. 결론 : 외음부 암 환자에서 sentinel lymph node를 찾아 이를 제거한 후, 동결절편의 조직병리학적 결과가 음성 (benign)일 경우에는 더 이상의 광범위한 서혜 대퇴부 임파 절제술을 피함으로써, 수술 후 합병증을 최소화하고 삶의 질을 향상시키는 데 임상적 유용성이 있을 것으로 생각된다. Objective : The purpose of this study is to evaluate the validity of sentinel lymph node detection and the possibility of clinical application in treatment of vulvar cancer patients. Patients and Methods : From March 2001 to January 2002, four patients with vulvar cancer were eligible for this study. All the patients were preoperative technetium-99 m colloid albumin and intraoperative isosulfan blue dye injection intradermally at the junction of tumor mass and normal skin. Superficial lymphatic channels and groin lymph node dissections were made to detect sentinel lymph node and then complete inguinofemoral lymph nodes dissection was performed. All the sentinel lymph nodes were sent to pathologic department for frozen biopsy. Results : Ten sentinel lymph nodes were identified in one-hundred and ten groin lymph nodes. All the ten sentinel lymph nodes showed benign. There was no case that non-sentinel lymph nodes were positive in the presence of negative sentinel lymph nodes by frozen biopsy (negative predictive value was 100%). Conclusion : Sentinel lymph nodes detection by combination use of technetium-99 m colloid albumin and isosulfan blue dye injection was simple and accurate in our preliminary study. To reduce postoperative morbidity, lymphedema and to minimize extensive inguinofemoral lymph nodes dissection, sentinel lymph node frozen biopsy may be a reasonable alternatives and a suitable method for limited control of vulvar cancer. This preliminary study showed the possibility of clinical application of sentinel lymph node detection in vulvar cancer surgery.

Prognostic Value of HPV DNA Typing in Sentinel Lymph Node and Primary Lesion of Cervical Cancer

임채춘,박종섭,남궁성은 대한산부인과학회 2002 대한산부인과학회 학술대회 Vol.88 No.-

부인종양학 : 자궁경부의 신경내분비암종 1예 (초)

김지현,임채춘,박영한,장봉림,강정배 대한산부인과학회 2010 대한산부인과학회 학술대회 Vol.96 No.-