http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
투명세포육종의 세침흡인 세포학적 소견 - 1예 보고 -
임성철,정유경,김동출,이윤경,신은택,Lim, Sung-Chul,Chung, You-Kyung,Kim, Dong-Chool,Lee, Yoon-Kyung,Shin, Eun-Taik 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.2
Clear ceil sarcoma(CCS) is an uncommon soft tissue sarcoma that occurs in tendons and aponeuroses, usually of the lower extremities and is believed to be of neural crest origin that have a capability to produce melanin. These tumors commonly metastasize and have a very poor prognosis. The fine needle aspiration cytologic finding of CCS is not well documented. We recently experienced a case of CCS. The patient was a 54-year-old male with painful swelling of the right inguinal area. Fine needle aspiration cytology revealed polygonal or fusiform tumor cells with clear or granular cytoplasm and vesicular nuclei containing one or two nucleoli. Immunohistochemical staining for S-100 protein and HMB-45 revealed strong positivity and variable developing stages of premelanosomes were observed by electron microscopy in the excised specimen.
3개 침제조회사 침구(鍼具)에 대한 침감지표 비교 - 이중 맹검 무작위 배정법 -
임성철,서정철,김경운,서보명,김성웅,이세연,정태영,한상원,이현,Lim, Seong-chul,Seo, Jung-chul,Kim, Kyung-un,Seo, Bo-myung,Kim, Sung-woong,Lee, Se-youn,Jung, Tae-young,Han, Sang-won,Lee, Hyun 대한침구의학회 2004 대한침구의학회지 Vol.21 No.6
Objective : This study was designed to compare acupuncture sensation index among three different acupuncture devices. Methods : A, B and C acupuncture devices were inserted into Quchi(LI 11) of the subjects. After 5 minutes the subjects completed a questionnaire rating the intensity of 21 kinds of acupuncture sensation; hurting, penetrating, sharp, aching, intense, spreading, radiating, tingling, pricking, stinging, pulling, heavy, dull, numb, electric, shocking, hot, burning, cool, pulsing, and throbbing. We compared subjective evaluations of acupuncture sensation among the groups. Results : The acupuncture sensation index when administrated among three different acupuncture devices(A, B and C) was not significantly different. The acupuncture sensation of B acupuncture devices showed significant difference than A or C in Spreading, Dull, Numb item. But, the other items of acupuncture sensation were not significantly different among three acupuncture devices. Conclusions : We found that acupuncture sensation index when administrated among three different acupuncture devices. Further study is needed to know different acupuncture sensation among acupuncture devices.
전자교반에 의한 Al 합금의 초정입자 미세화에 관한 연구
임성철,윤의박 ( Sung Chul Lim,Eui Pak Yoon ) 한국주조공학회 1996 한국주조공학회지 Vol.16 No.5
N/A The change of microstructure of Al-7wt%Si alloy was examined by using a induction motor of 3-phases and 2-poles in semi-solid electromagnectically stirring process. The size and degree of sphericity of primary solid particles were observed by means of change of cooling rate. At a certain cooling rate, the size of primary solid particles increased and the sphericity became perfect, as the fraction of solid increased. The average size of primary solid particles was 43㎛ when the fraction of solid was 0.3 and at 600℃, input voltage 140V, cooling rate 2.5℃/s. It was shown that the size of primary solid particles was proportional to local solidification time.
전자교반시 미세화제첨가에 따른 Al-7wt%Si 합금의 미세조직변화
임성철,윤의박 ( Sung Chul Lim,Eui Pak Yoon ) 한국주조공학회 1996 한국주조공학회지 Vol.16 No.5
N/A To gain a semi-solid alloy the electromagnetic stirring by an induction motor of 3 phase and 2-poles was used. And it was also observed that the change of primary particle size, distribution and degree of sphericity by addition of a refiner, Al5Ti1B. The effect of refiner on the distribution and dimensions of primary particles prior to that electromagnetic refining on those was examined. In case of electromagnetic stirring with the refiner Al5Ti1B, the average size of primary solid particles increased as the fraction of solid increased. However it decreased as the amount of Al5Ti1B addition increased to 0.5% and then it was increased again as the addition amount of Al5Ti1B increased above 1.0%. The average size of primary solid particles was 31㎛ in case of melt temperature 600℃ when the fraction of solid was 0.3, input voltage 140V, cooling rate 2.5℃/s, and 0.5% Al5Ti1B. To use the electromagnetic stirring with the addition of a refiner was able to obtain more small primary solid particles than to use the electromagnetic stirring only.
전자교반시 Al-7wt%Si 합금의 초정입자에 미치는 유동의 영향
임성철,윤의박 ( Sung Chul Lim,Eui Pak Yoon ) 한국주조공학회 1996 한국주조공학회지 Vol.16 No.6
N/A In this study, to gain the semi-solid alloy we employed the electromagnetic rotation by a induction motor of 3-phases and 2-poles for Al-7wt%Si alloy and observed the size of primary solid particle, distribution state of primary solid particle, the degree of sphericity, and fraction of primary solid for the evaluation of its results. The size of primary solid particle increases from 98㎛ to 118㎛ as solid fraction increases from 0.2 to 0.5. The degree of sphericity increased as the solid fraction increased. Solid particles obtained from the microstructures of isothermally held sample were coarsened and the degree of sphericity was enhanced as isothermal holding time increased. However, when the sample was stirred for more than 40min, solid particles merged together and liquid phase was entrapped within the cluster of solid particles. The size of primary solid particle was not changed significantly with the variation of input voltages by 160V over which solid particles began to merge together to be a large cluster of about 170㎛ at 180V. The standard deviation and the degree of sphericity were not changed significantly with the variation of input voltage.
Estradiol valerate와 Letrozole에 의해 유발되는 다낭성난소증후군의 난소변화 비교
임성철 ( Sung Chul Lim ),정문진 ( Moon Jin Jeong ),김세은 ( Se Eun Kim ),김승현 ( Seung Hyun Kim ),김삼철 ( Sam Cheol Kim ),서승용 ( Seung Yong Seo ),김탁 ( Tak Kim ),강성수 ( Seong Soo Kang ),배춘식 ( Chun Sik Bae ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.6
목적: 다낭성난소증후군(polycystic ovary syndrome, PCOS)을 estradiol valerate (EV)와 letrozole (LE)로 유발할 수 있는데 인간의 다낭성난소증후군과 가장 유사한 질환동물 모델이 무엇인가를 알아보고자 하였다. 연구방법: EV와 LE를 각각 랫드에 처리하여 PCOS를 유발시킨 후 희생시켜 난소를 적출하였다. 난소를 조직학적으로 관찰하여 다낭성 난소 변화 유발유무, 난소의 크기, 난포낭의 크기 및 수를 측정하고 난포 및 간질세포의 황체화 등을 비교 관찰하였다. 결과: LE처리군은 EV처리군에 비하여 난소의 크기 및 난포낭의 수가 유의하게 증가하고 난포막세포의 황체화가 뚜렷하여 인간의 PCOS와 더유사한 소견을 보였다. 결론: 랫드에서 LE처리에 의한 PCOS는 PCOS질환유발 동물 모델로 더 적합한 것으로 평가된다. Objective: To compare ovarian morphology of the estradiol valerate (EV)-and the letrozole (LE)-induced polycystic ovary syndrome (PCOS) in rat models. Methods: EV were injected (IM) to 10 Sprague-Dawley rats and LE were administered (PO) to the other 10 Sprague-Dawley rats for 21 days. Sixty days after single injection of EV and 21 days after LE administration, the animals were sacrifi ced and the ovaries were sectioned, measured and analyzed histopathologically. Results: LE-treated group showed larger ovary bearing more abundant cystic follicles with luteinized theca cells. These fi ndings were more similar to human PCOS ovarian morphology. Conclusion: LE-induced PCOS model is recommended to conduct PCOS-related animal experiments.
중학교 2학년 과학영재들의 자유탐구 활동에서 나타난 과학적 추론 능력 분석
임성철 ( Sung Chul Lim ),김진화 ( Jin Hwa Kim ),정진우 ( Jin Woo Jeong ) 경북대학교 과학교육연구소 2013 科學敎育硏究誌 Vol.37 No.2
이 연구의 목적은 자유탐구 활동에서 나타난 중학교 2학년 과학 영재 학생들의 과학적 추론 능력을 알아보는 것이다. 과학영재들이 과학자가 지식을 얻는 과정과 유사한 자유탐구 활동을 실시할 때어떠한 과학적 추론과정을 거쳐 탐구하고 있으며 과학적 추론 능력이 어느 정도인지를 확인하고 분석하는 것은, 학생 지도에 있어서 교육적 시사점을 줄 수 있다. 이를 위하여 정선희 등(2011)이 번역한 Dolan과 Grady(2010)의 CSRI Matrix를 이용하여 추론 복잡성을 분석하였으며, 추론 복잡성이 높을수록 과학자가 지식을 얻는 과학적 추론 과정과 비슷하다. 연구 결과, 자유탐구의 과정별로 추론 복잡성 단계는 다양하게 분포하였다. 특히 의문 생성 과정과 연구 의문과 자료 연결 과정은 5개 팀이 모두 비교적 높은 추론 복잡성 단계를 나타낸 반면, 예비가설 생성과정·변인 선택·실험의 한계나 결점 고려 등은 비교적 낮은 단계를 나타내었다. 그리고 의사소통 및 연구 결과 방어는 가장 다양한 추론 복잡성단계 분포를 나타내었다. The purpose of this study was to analyze the scientific reasoning ability during open-inquiry activities of science-gifted 2nd middle school students. Open-inquiry activity is similar to process of scientists` science knowledge generation. Identifying and analyzing the scientific reasoning process and the scientific reasoning ability during open-inquiry activities of science-gifted students, will be able to provide implications for future research. CSRI Matrix(Dolan & Grady, 2010) was used to analyze the complexity of the scientific reasoning ability. The higher degree of complexity of the scientific reasoning is similar to process of scientists` science knowledge generation. The results showed that each process of the open-inquiry activities were distributed by various steps of complexity of the scientific reasoning. Particularly, ‘The generating questions’ and ‘Connecting data to the research question’ were ‘most complex`` step in all teams. On the other side, ‘Posing preliminary hypotheses’, ‘Selecting dependent and independent variables’, ‘Considering the limitations or flaws of their experiments’ were low steps in most teams. And ‘Communicating and defending findings’ was distributed by most various steps of complexity of the scientific reasoning.
Sung-Chul Lim(임성철),Cheol Hee Choi(최철희),Song Iy Han(한송이) 한국생명과학회 2009 생명과학회지 Vol.19 No.12
항암제 내성을 획득한 암세포는 많은 경우 다양한 세포 독성 물질에 대해 교차 내성을 나타낸다. 그러나 온열 치료가 내성 획득 종양에 적용 될 때의 종양 세포의 사멸 효과는 알려져 있지 않다. 본 연구는 시스플라틴에 내성을 갖는 위암 세포 주, SNU601/Cis2이 열충격에 반응하는 민감도와 세포 사멸 방식을 조사함으로써 약물 내성 종양의 온열 치료 효과를 예측하고자 하였다. 정상 위암 세포 주 SNU601/WT은 열충격에 매우 민감하게 반응하며 apoptosis로 사멸하지만, 내성 위암 세포 주 SNU601/Cis2는 미열충격에 내성을 나타내었으며 고열충격에 노출되자 necrosis로 사멸하였다. 또한 SNU601/Cis2에서 necrosis의 발생은 열충격에 의한 JNK1/2의 활성화와 HSP27의 발현저하 현상과 관련되어 있었다. Necrosis의 유도는 세포막 파괴에 의해 세포 내부 물질의 방출로 인한 주변 조직의 염증반응을 수반하는데, 이러한 염증 반응은 암의 성장을 촉진하고 암의 성상을 심화시키는 것으로 보고되고 있다. 이러한 관점에서, 온열 치료가 약물 치료와 병행 될 경우에는 교차 내성과 necrosis로 인한 역효과를 방지하기 위하여, 그 적용이 주의 깊게 이루어져야 할 것으로 판단된다. Carcinoma cells that had acquired resistance to a chemotherapeutic drug often show cross-resistance to various other cytotoxic drugs. In the present study, we explored the effect of heat shock in cisplatin-resistant gastric cancer cells SNU601/Cis2 to figure out the efficacy of hyperthermia in drug-resistant carcinoma. While SNU601/WT cells showed a high-sensitivity response to heat shock by dying through apoptosis, SNU601/Cis2 cells were considerably resistant to mild heat shock, but died by necrosis upon treatment with harsh heat shock. The occurrence of necrosis in SNU601/Cis2 cells was linked to the suppression of both JNK1/2 activation and HSP27 induction in response to heat shock. Since necrosis is closely associated with tumor malignancy and poor prognosis through inflammatory responses, our result suggests that hyperthermic treatment should be carefully applied when it is combined with chemotherapy.