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Acarbose가 백서 소장 점막의 자당 분해효소 활성도와 이의 mRNA에 미치는 영향
임선희(Seon Hee Lim),임창영(Chang Young Lim),정현채(Hyun Chae Jung),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.3
N/A Background/Aims: The a-glucosidase inhibitors, acarbose and miglitol have been successfully used to control postprandial hyperglycemia in diabetics. They probably work by slowing down carbohydrate digestion and absorption, but the nature of their effect on the enzymes and the level of specific action have not been studied. This animal experiment is aimed to evaluate the effects of acarbose on intestinal disaccharidase activity and to explore the gene expression of the intestinal sucrase after intake of acarbose. Methods: Fifty normal adult rats were given acarbose orally in doses of 20 mg/ kg for 5 days and then sacrificed at the first(Group A), fourth(Group B), seventh (Group C), and 14th day(Group D) after withdrawal of acarbose. Intestines of 50 rats were obtained and divided into 3 equal length. Mucosal homogenates were prepared for measurement of specific activities of disaccharidases. Total RNA was extracted for determination of the amount of sucrase mRNA by Northern and slot hybridization. Results: The specific activities of sucrase were significantly reduced in mucosal homogenates of proximal segment of small intestines in Groups A, B, and C as compared witb those in control group(p0.05). But there were no changes in rniddle and distal segments in Groups A, B, and C. And decreased specific activities of sucrase in proximal segment in Groups A, B, and C were completely recovered in Group D. The amount of sucrase mRNA was correlated with the specific activities of sucrase in the proximal segment of small intestine in groups A, B, and C(r=0.67, p-- 0.05). Conclusions: Acarbose reversibly inhibits sucrase activities only in the proximal segment of small intestine. Genetic regulation determining inhibition of a-glucosidase by acarbose is considered to occur at the transcription level. (Korean J Gastroenterol 1995;27:300 - 308)
대학생의 성인애착이 대인관계문제에 미치는 영향: 내면화된 수치심과 거부민감성의 매개효과
임선희(Lim, Seon-Hee), 김경미(Kim, Kyoung-Mi) 한국교육치료학회 2022 교육치료연구 Vol.14 No.3
본 연구는 대학생의 성인애착이 대인관계 문제에 미치는 영향을 알아보고, 성인애착과 대인관계문제와의 관계에서 내면화된 수치심과 거부민감성의 이중매개효과를 검증하였다. 이를 위해 전국의 대학생 529명을 대상으로 성인애착, 대인관계문제, 내면화된 수치심, 거부민감성 척도를 실시하였다. 순차매개효과를 검증하기 위해 기술통계 및 상관분석, SPSS Macro 부트스트래핑(bootstrapping) 방법을 적용하였다. 연구결과, 첫째, 대학생의 애착불안과 애착회피가 높을수록 대인관계 문제가 높았다. 둘째, 성인애착과 대인관계 문제의 관계에서 내면화된 수치심과 거부민감성이 각각 부분매개효과를 보였다. 셋째, 성인애착은 내면화된 수치심과 거부민감성의 순차매개 경로를 거쳐서 대인관계 문제에 영향을 미치는 것으로 나타났다. 결과를 바탕으로 대인관계 문제에 영향을 미치는 변인으로 성인애착, 내면화된 수치심 및 거부민감성을 확인하였고, 대인관계문제를 호소하는 대학생에게 효과적으로 개입할 수 있는 치료적 방향의 기초를 강구하였다는데 의의가 있다. This study aims to explore the relationship between adult attachment and interpersonal problems among college students, and to confirm whether such relationship is sequentially mediated by internalized shame and rejection sensitivity. For this study, 529 participants were surveyed online forms. ECR, KIIP-SC, ISS, and PSQ were used for the measurement. For the collected data, SPSS was used for descriptive statistics, correlation analysis, and bootstrapping was performed using PROCESS Macro. The result of this study is as follows. First, attachment anxiety and attachment avoidance predicted interpersonal problems significantly. Second, internalized shame partially mediated the relationship between adult attachment and interpersonal problems. Third, rejection sensitivity partially mediated the relationship between adult attachment and interpersonal problems. Lastly, adult attachment indirectly influences interpersonal problems through the sequential mediation effect of internalized shame and rejection sensitivity. Based on these results, the limitation and suggestion of the study are discussed.
궤양성 대장염 환자의 대장 점막에 발현된 Chemokine 유전자의 발현 양상 - 합성 RNA를 이용한 정량적 역전사 PCR법의 응용
임창영(Chang Young Lim),임선희(Seon Hee Lim),정현채(Hyun Chae Jung),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.4
N/A Background/Aims: Chemokines play an important role in the recruitment of neutrophil and mono- cyte. Recently, the implication of the cytokines in the ulcerative colitis is increasingly emphasized. The purpose of this study was to explore the profile of the chemokine gene expression in the colonic mucosa in patients with ulcerative colitis, and to quantify cytokine mRNA by way of quantitative reverse transcriptional PCR using synthetic standard RNA. Methods: Total tissue RNA was extracted from colonic biopsies of normal controls(NC, n=10) and patients with ulcerative colitis (n=8) [from active(Uca, n=8) and normal looking mucosa(Ucnlm, n=7) areas]. The chemokines for study were interleukin-8(IL-8), monocyte chemotactic & activating factor(MCAF), and additionally granulocyte macrophage colony stimulating factor(GM-CSF). Detection and quantification of chemokine gene expression were performed by quantitative reverse transcriptional PCR. Results: IL-8 mRNA was detected in 6 from 8 Uca, 3 from 7 Ucnlm, and 3 from 10 NC. MCAF mRNA was detected in 7 from 8 Uca, 3 from 7 Ucnlm, and 1 from 10 NC. GM-CSF mRNA was detected in 1 from 8 Uca, and none from 10 NC. IL-8 and MCAF mRNA expression was increased in the Uca compared to normal controls, and their mRNA expression level was higher in Uca compared to normal controls. Conclusions: These findings sugge.t that the chemokines such as IL-8 and MCAF may play an important role in the pathogenesis of ulcerative colitis. Further studies are demanded to reach a conclusion on whetber highly expressed IL-8 and MCAF in normal looking mucosa of ulcerative colitis could be involved in pathogenesis of UC. (Korean J Gastroenterol 1995;27:394 - 402)
임병철(Byung Chul Lim),고재중(Jae Jung Ko),안경주(Kyung Ju Ahn),이규현(Gyu Hyun Lee),박용주(Yong Ju Park),임선희(Seon Hee Lim),김나영(Na Young Kim),이계희(Kye Heui Lee) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.6
N/A Background/Aims: The parenteral transmission routes of HCV infection such as transfusion or drug abuse are well known, but there are no known risk factors in about half of HCV infections. In these group we considered the probability that the transmission is done by sexual or non-sexual contacts between family embers and studied anti-HCV antibody positive rate among each family members of patients with chronic C liver disease to understand the route of HCV transmission. Methods: One hundred and ten family members of 31 chronically HCV-infected patients who admitted to Kangnam General Hospital were tested for anti-HCV antibody by secon<l generation enzyrne immunoassay. Among 31 index patients, 4 were hepatocellular carcinoma, 10 were liver cirrhosis, and 17 were chronic hepatitis patients. In all patients the degree of liver injury was ascertained by clinical findings, ultrasonography and/or biopsy. Results: Overall out of 110 family members of 31 chronically HCV-infected patients, 3(2.7%) members were positive fc>r anti-HCV antibody, indicating a higher but not significant anti-HCV antibody rate than that of general population(0.93%). But the positive rate of anti-HCV antibody among spouses of index patients was 11.1%(3 of 27), which was significantly different than that of general population or those of other family member groups(p<0.01). The positive rate of anti-HCV antibody among spouses of patients with hepatocellular carcinoma, liver cirrhosis and chronic hepatitis was 25%, 0% and 13.3%, respectively. Conclusions: These results suggest that sexual contact plays a more important role in HCV infection than household contact among family members and more systematized and prospective studies are required to clarify the transmission route of HCV infection. (Korean J Gastroenterol 1996; 28:824-831)
박정진(Jeong Jin Park),임선희(Seon Hee Lim),김봉룡(Bong Ryong Kim),김형완(Hyoung Wan Kim),김준완(Joon Wan Kim),김태형(Tae Hyong Kim),장유현(Yoo hyun Jang),이계희(Kyu Heui Lee),양대현(Dae Hyun Yang) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.1
Idiopathic portal hypertension (IPH) is a rare disease characterized by overt splenomegaly and portal hypertension in the absence of cirrhosis or vascular obstruction. The most common cause of death in IPH patients is known to be variceal bleeding, which is usually treated with surgical method. Recently, interventional radiologic methods such as transjugular intrahepatic portocaval shunt, ballon-occluded retrograde transvenous obliteration, or partial splenic embolization (PSE), have been tried to control portal hypertension. A 24-year-old man presented with repeated gastrointestinal bleeding due to rupture of esophageal varices, but his liver function tests were completely normal and any possible etiologies of his portal hypertension couldn’t be demonstrated. He was diagnosed as IPH by laparoscopic liver biopsy after PSE, which could control portal hypertension as well. For twelve months after PSE, he hasn’t experienced bleeding again. We report the case of PSE to control portal hypertension in a patient with IPH who presented with variceal bleeding. (Korean J Gastroenterol 2001;38:48-52)
소장 선암으로 오인되었던 Peutz-Jeghers 증후군
양대현 ( Dae Hyun Yang ),김나영 ( Na Young Kim ),임병철 ( Byung Chul Lim ),박용주 ( Yong Ju Park ),이계희 ( Kye Heui Lee ),이규현 ( Gyu Hyun Lee ),임선희 ( Seon Hee Lim ),최신은 ( Shin Eun Choi ),안경주 ( Kyung Ju Ahn ) 대한소화기학회 1997 대한소화기학회지 Vol.30 No.6
Peutz-Jeghers syndrome is an autosomal-dominant hereditary disorder manifested by a combina- tion of mucocutaneous pigmentations and gastrointestinal polyposis. Although the polyps are believed to he benign in nature, recently it has been realized that patients with this syndrome are subject to increasing risk for the developement of malignant neoplasm during long term follow-up. When investigating the neoplastic changes within Peutz-Jeghers polyps, pseudoinvasion-epithelial misplacement, should be carefully ruled out. In this report, we present a case of a 16-year old female who was operated or for intussusception caused by Peutz-Jeghers polyp in the small intestine, which showed pseudoinvasion-epithelial misplacement, initially misdiagnosed as adeho-carcinoma. To find out any possibility of the development of malignant neoplasm, the entire gastrointestinal tract from esophagus to rectum was searched via endoscopy and intraoperative enteroscopy, and all of the polyps were removed. (Korean J Gastroenterol 1997; 30:820 - 825)