광변색성 안경렌즈의 임상적 유용성 및 효과 평가

임상현,조문식,김준순.Sang-Hyun Lim. M.D.. Moon-Sik. Cho. M.D.. Joon-Soon. Kim. M.D. 대한안과학회 2005 대한안과학회지 Vol.46 No.9

Purpose: To evaluate stability and effects of photochromic lenses in light-sensitive patients. Methods: Analyzing 65 patients, this research employed a standardized survey, fundus examination, and slit-lamp biomicroscopy to evaluate the changes in photophobia, tears, asthenopia, and the deterioration of outdoor visual acuity after wearing photochromic lenses for one month. Measurement of visual acuity was performed outdoors at noon on a bright day using Dr. Hahn’s standard test chart for 3 m. Results: Photochromic lenses, considerably decreased photophobia, tears, and asthenopia. The “normal” visual acuity of 38 patients was established without photochromic lenses. Re-examination after the lenses had been worn for a specified period of time showed that 29 subjects could discern at least one line higher than their “normal” acuity. Conclusions: Photochromic lenses reduced photophobia and the disabling effect of bright light such that comfort was increased. Not only did the lenses improve vision, they also enhanced the overall quality of vision.

보크트-고야나기-하라다 증후군 환자 1예에서 치유 경과에 따른 다국소망막전위도 변화

임상현,박수은,박태관,온영훈,Sang Hyun Lim,Su-Eun Park,Tae Kwann Park,Young Hoon Ohn 대한안과학회 2006 대한안과학회지 Vol.47 No.3

Purpose: To assess the changes of retinal function together with recovery progress in a patient with Vogt-Koyanaki-Harada syndrome using a multifocal electroretinogram (mfERG). Methods: The retinal changes of a 32-year-old woman diagnosed with Vogt-Koyanaki-Harada syndrome have been investigated and compared for different times such as before treatment and 3 and 6 months after treatment using a fluorescein angiogram, electroretinogram (ERG) and mfERG. Results: As time passed, the patient`s visual acuity was recovered, the serous retinal detachment in the posterior pole was restored, and the phenomenon of late subretinal leakage disappeared on fluorescein angiogram, while aggregation and atrophy of the retinal pigment epithelium were detected. The early-stage responses of the retina decreased on ERG; however, it has gradually recovered and was determined to be normal after 6 months. Responses measured on the mfERG have increased during the 6 months after surgery compared to the pre-treatment, but there was still a partial lack of response. Conclusions: In this case, the abnormal condition of retinal function existed continuously on the mfERG, even when the serous retinal detachment in the posterior pole was recovered. In this regard, a long-term systematic investigation and subsequent mfERG treatment have been thought to be necessary for patients with this disease.

오갈피나무 속(屬) 식물의 항당뇨 및 혈당강하 효과

임상현(Sang Hyun Lim),박유화(Yu Hwa Park),권창주(Chang Ju Kwon),함헌주(Hun Ju Ham),정햇님(Haet Nim Jeong),김경희(Kyung Hee Kim),안영섭(Young Sup Ahn) 한국식품영양과학회 2010 한국식품영양과학회지 Vol.39 No.12

오갈피나무 속의 가시오갈피(Eleutherococcus senticosu), 섬오갈피나무(Eleutherococcus gracilistylus), 오가나무(Eleutherococcus sieboldianus), 오갈피나무(Eleutherococcus sessiliflorus)의 잎 부위를 이용하여 α-glucosidase와 α-amylase 활성 저해 효과를 통한 혈당강하 효과를 평가하였다. α-Glucosidase 활성 저해 효과를 비교한 결과 섬오갈피 잎 추출물이 acarbose 대비 약 43.38%의 활성 저해 효과를 나타내었고, 가시오갈피 잎 추출물이 41.24%의 저해효과를 보였다. α-Amylase 활성 저해 효과를 측정한 결과 acarbose가 10 ㎎/mL의 농도에서 73.25%의 활성 저해 효과를 보였으며, 가시오갈피 잎 추출물이 acarbose 대비 91.90%의 높은 활성 저해 효과를 나타내었다. 또한 streptozotocin(STZ)으로 당뇨를 유도한 모델에 2주간 오갈피나무 속 식물 추출물을 섭취시킨 후 혈당과 지질 개선 효과를 탐색한 결과 STZ 투여로 인하여 모든 당뇨 유발군은 정상군에 비하여 혈당 수준이 유의적으로 증가하였다. 당뇨 유발 대조군(C)과 대비하여 시료 투여군인 가시오갈피(T1), 섬오갈피나무(T2), 오가나무(T3), 오갈피나무(T4)군 모두 혈당이 크게 감소하였다. 혈중 지질 농도 변화 실험 중 총 콜레스테롤의 함량은 정상군에 비하여 당뇨 유발 대조군은 증가하는 경향을 나타내는 반면 약물 투여군인 가시오갈피(T1), 오가나무(T3), 오갈피나무(T4)군에서는 대조군에 비하여 유의적으로 감소하였다. HDL-cholesterol은 오가나무군에서 대조군에 비하여 55.61% 가장 크게 유의적으로 증가하였다. LDLcholesterol의 경우 정상군과 대조군과의 큰 차이가 관찰되지 않았으나 섬오갈피나무, 오가나무에서는 유의적으로 증가하였고, 가시오갈피와 오갈피나무 투여군에서는 대조군에 비하여 유의적으로 감소하였다. 혈중 중성지방의 경우 또한 총 콜레스테롤과 유사하게 대조군의 경우 혈중 농도가 증가하였다. 약물 투여군인 오가나무군은 60.16%, 오갈피군은 60.80%, 가시오갈피군은 50.16% 대조군 대비 유의적으로 감소하였다. 적출한 간 내의 중성지방의 농도를 측정한 결과 대조군의 경우 정상군에 비교하여 유의적인 증가를 보였으며, 가시오갈피군, 섬오갈피나무군은 각각 대조군 대비 유의적으로 감소하였다. 이상의 결과들에서 오갈피나무 속 추출물들은 혈당강하 및 당뇨대사 이상으로 인한 지질대사의 개선에 효과적인 것으로 나타났다. Hypoglycemic effect through activity inhibition of α-glucosidase and α-amylase was evaluated using leaves of Eleutherococcus senticosu, Eleutherococcus gracilistylus, Eleutherococcus sieboldianus and Eleutherococcus sessiliflorus which belong to Acanthopanax sessiliflorus genus. As a result of measuring α-glucosidase activity inhibition, extract of Eleutherococcus gracilistylus showed around 43.38% of activity inhibition compared with acarbose and extract of Eleutherococcus senticosu showed 41.24% inhibitory effect. As a result of measuring α-amylase activity inhibition, acarbose showed 73.25% of activity inhibition in 10 mg/mL concentration, and the extract of Eleutherococcus senticosu leaves showed 91.90% higher activity inhibition compared with acarbose. Also, after subjects in a model were induced diabetes with streptozotocin (STZ) intake plant extract from Acanthopanax sessiliflorus for 2 weeks, effect of improving blood glucose level and fat was examined. In all groups with specimen, Eleutherococcus senticosu (T1), Eleutherococcus gracilistylus (T2), Eleutherococcus sieboldianus (T3) and Eleutherococcus sessiliflorus (T4), blood glucose level was significantly decreased compared with that in control group (C). In an experiment of examining changes in fat concentration in blood, total cholesterol content increased in a control group compared with a normal, while in T1, T3 and T4, it decreased significantly compared with the control group. As for HDL-cholesterol, it significantly increased in all diabetes induced groups compared with the normal group, and in T3, it increased the most significantly by 55.61% compared with the control group. In case of LDL-cholesterol, specific difference between the normal group and the control group was not found; however, significant increase was detected in T2 and T3, whereas in T1 and T4, it decreased significantly compared with the control group. As for triglyceride, its concentration increased in the control group like total cholesterol. It decreased 60.16% in T3, 60.80% in T4 and 50.16% in T1 compared with the control group. As a result of measuring the concentration of triglyceride in extracted liver, the control group showed significant increase compared with the normal group, whereas T1 and T2 showed significant decrease compared with the normal group. The above results show that extracts from Acanthopanax sessiliflorus genus are effective for hypoglycemic and improving fat metabolism due to diabetes.

비타민나무(Seabuckthorn, Hippophae rhamnoides L)의 생육특성 및 산지간 생육비교

임상현(Sang Hyun Lim),정햇님(Haet Nim Jeong),박유화(Yu Hwa Park),김희연(Hee Yeon Kim),김경희(Kyung Hee Kim) 한국원예학회 2009 한국원예학회 학술발표요지 Vol.2009 No.5

통계적 분석을 이용한 고도정수처리 공정에서의 최적 오존 주입량 및 잔류 오존 주입량 예측 기법 연구

임상현 ( Sang Hyun Lim ),이임섭 ( Im Seop Lee ),구자용 ( Ja Yong Koo ) 한국물환경학회(구 한국수질보전학회) 2015 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2015 No.-

고구마뿌리혹선충(Meloidogyne incognita)에 대한 국내 자생식물의 살선충 활성

임상현(Lim Sang-Hyun),주영철(Yong Ze Zhu),김미성(Mi-Sung Kim),이유선(Yu-Sun Lee),손정식(Jeong-Sik Son),박동식(Dong-Sik Son),허장현(Jang-Hyun Hur),김희연(Hee-Yeon Kim),최해진(Hae-Jin Choi),김경희(Kyung-Hee Kim),김성문(Songmun Kim) 한국농약과학회 2004 농약과학회지 Vol.8 No.4

Large economic losses have been reported by root-knot nematide, Meloidogyne incognita, in Korea. However, fewy environmentally-friendly nematicide alternatives for the control of M. incognita have been developed. This study was conducted of Korean native plants to screen nematicidal activity which could be used by organic farmers. Methanol extracts (1,000 ㎎ L?¹) from fifty-three Korean native plants were applied to 24-well tissue culture testplates containing 1 × 10² M incognita and the nematicidal activities were determined, Nematicidal activities of the methanol extracts in common purslain (Portulaca oleraceae L.) and water mouse-ear-chickweed (Stellaria aquatica Scop.) were 60.0% and 40.6%, respectively, compared with that of control, however, those of other forty-one plants were less than 30%. Our results suggest that the methanol extracts of common purslain and water mouse-ear-chickweed contain nematicidal active compounds.

모바일 상거래에 대한 IT인력의 혁신저항

임상현(Sang Hyun Lim),이충권(Choong Kwon Lee),차경진(Kyung Jin Cha),서종원(Jongwon Seo) 한국전자거래학회 2015 한국전자거래학회지 Vol.20 No.1

본 연구는 기술에 대한 이해와 경험의 정도가 높은 IT종사자들이 모바일 상거래와 같은 혁신에 대한 저항에 있어서 비IT 종사자과 비교하여 어떤 차이가 있는지를 살펴보고자 하였다. 모바일 상거래에 대한 인식을 대상으로 하였다. 총 317명의 설문결과는 IT인력이 모바일 상거래에 저항하는 요인으로는 지각된 위험, 적합성, 복잡성이 확인되었으며, 비IT인력의 경우 상대적 이점, 적합성, 복잡성이 주요 요인이었다. 그리고 모바일 상거래의 두 집단 모두의 결과에서 혁신저항이 클수록 사용의도가 낮게 나타났다. This study investigates the differences between IT workers, who possess a high understanding of technology, and non-IT workers in the resistance to accepting an innovative service like mobile commerce. From a total of 317 survey respondents, the results of the study revealed that perceived risk, compatability, and complexity were the significant factors for resistance to mobile commerce for IT workers, while relative advantage, compatibility, and complexity were the factors of resistance for non-IT workers. Higher innovation resistance was shown to result in lower intention of use for both groups of mobile commerce users.

심포지엄 및 학술연구(學術硏究) 발표요지(發表要旨) : 제2분야: 잡초 생리생태 및 기타 ; 강원북부지역의 단풍잎돼지풀 발생 실태와 방제 방안

임상현 ( Sang Hyun Lim ),김경희 ( Kyung Hee Kim ),최해진 ( Hae Jin Choi ),김희연 ( Hee Yeon Kim ),김미성 ( Mi Sung Kim ),이유선 ( Yu Sun Lee ),박동식 ( Dong Sik Park ),김성문 ( Song Mun Kim ) 한국잡초학회 2004 한국잡초학회 별책(학술대회 초록집) Vol.24 No.2

장소성을 바탕으로 한 플래시 몹의 공간적 구현에 관한 연구

임상현(Lim, Sang-Hyun),김개천(Kim, Kai-Chun) 한국실내디자인학회 2013 한국실내디자인학회논문집 Vol.22 No.6

Space in the past had characteristics of place which are required for specific behavior to be done as we recognized it easily. However, for space in modern times, the purpose, forms and behavior space has, have changed as tools comprising the space have changed. ‘Virtual space’ which has been a conversation topic recently is unspecific and changeable space whose forms and geological location are not defined clearly. In addition, behaviors caused by this virtual space in combination with real space are taking place. The nature of Flash Mob which is one of the typical behaviors which take place starting from virtual space to be connected with real space, is that it is intangible game culture whose forms and behaviors are not fixed, and it is not limited to a specific place. Besides, Flash Mob is characteristic of representing game culture in modern society, and its nature can be summarized as temporariness, non-placeness, anonymity, double-sidedness and so forth. Since events generally take place in every place when man is involved in space, it’s possible to generally think events derived from interpersonal relationships between man and man. We are to study spatial characteristics of Flash Mob by analyzing features and cases of the Flash Mob by means of them.

돌단풍 잎 용매추출물의 생리활성

임상현(Sang-Hyun Lim),김희연(Hee-Yeon Kim),박민희(Min Hee Park),박유화(Yu Hwa Park),함헌주(Hun Ju Ham),이기연(Ki Yun Lee),김경희(Kyung-Hee Kim),박동식(Dong Sik Park),김성문(Songmun Kim) 한국식품영양과학회 2010 한국식품영양과학회지 Vol.39 No.12

돌단풍 잎의 항산화, 항염, 항당뇨, 항비만 활성을 탐색하고자 강원도 양구에서 자생하고 있는 돌단풍의 잎을 채집하여 에탄올과 증류수로 각각 추출하였다. 항산화 활성은 DPPH 라디칼 소거반응, 총 폴리페놀 함량 및 총 플라보노이드 함량을 측정하여 검정하였다. 돌단풍 잎의 에탄올과 물 추출물의 DPPH 라디칼 소거능 IC50값은 각각 549.86과 62.14 ㎍/mL이었고, 총 폴리페놀 함량은 에탄올 추출물이 307.63 ㎎/g으로 물 추출물의 총 폴리페놀 함량인 86.96 ㎎/g보다 높게 나타났으나 총 플라보노이드 함량은 에탄올과 물 추출물 각각 118.98과 110.16 ㎎/g으로 비슷한 함량을 나타냈다. 항염 활성은 RAW264.7 세포에 LPS와 돌단풍 잎 추출물을 동시에 10 ㎎/mL 처리하여 NO 생성량을 측정하였으나 효과는 없었다. 항당뇨 활성은 α-glucosidase와 α-amylase 저해활성을 측정하였으며, 돌단풍 에탄올과 물 추출물의 α-glucosidase IC50값은 각각 5.62와 425.63 ㎍/mL이었고, α-amylase IC50값은 각각 4,623.87과 10,000 ㎍/mL 이상으로 돌단풍 에탄올 추출물의 항당뇨 활성은 매우 뛰어났다. 항비만 활성 탐색은 pancreatic lipase의 활성저해를 측정하였으며, 그 결과 돌단풍 잎의 에탄올과 물 추출물의 IC50값은 모두 10,000 ㎍/mL 이상으로 항비만 활성은 없는 것으로 나타났다. 이러한 결과 돌단풍 잎 추출물의 항산화, 항당뇨의 기능성활용 가공식품 및 건강기능식품으로의 개발이 기대된다. In this study, the bioactivities of ethanol (EEAR) and water extract (WEAR) from the leaf of Aceriphyllum rossii were investigated. In the anti-oxidative activity, IC50 of DPPH radical scavenging activity was respectively 549.86 and 62.14 ㎍/mL by EEAR and WEAR. Anti-inflammatory activity of EEAR and WEAR has been evaluated on inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) release by the macrophage RAW 264.7 cells. EEAR and WEAR inhibited inflammatory by 5.58 and 16.85% in 10 ㎎/mL, respectively. In the anti-diabetic activity, IC50 of α-glucosidase inhibitory activity was 5.62 and 425.63 μg/mL by EEAR and WEAR. IC50 of α-amylase inhibitory activity of EEAR and WEAR was 4,623.87 and over 10,000 ㎍/mL, respectively. In the anti-obesity, all lipase inhibitory activity (IC50) of EEAR and WEAR was up 10,000 ㎍/mL. Finally, EEAR and WEAR exhibited anti-oxidative and anti-diabetic activity. It suggests that Aceriphyllum rossii could be potentially used as a resource of bioactive materials for health functional foods.