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임병섭,황경균,심광섭,Lim, Byung-Sup,Hwang, Kyung-Gyun,Shim, Kwang-Sup 대한치과마취과학회 2005 Journal of Dental Anesthesia and Pain Medicine Vol.5 No.2
Facial nerve paralysis following delayed complication after trauma was rare and hard to find reason After symptom of facial nerve paralysis was found, careful clinical and neuropathic investigation needed through electromyography and nerve conduction velocity. It is necessery to Hewing that functional degenaration of nerve conduction was irresible or not. It is important to determine if palsy is already present alter trauma or some later time because origin of viral infection or temperature change may possible.
가토 두개골 결손부에 이식된 ${\beta}-TCP$의 골치유 과정에서 PRP의 효과에 관한 연구
이성훈,황경균,박창주,임병섭,조정연,백승삼,심광섭,Lee, Soung-Hoon,Hwang, Kyung-Gyun,Park, Chang-Joo,Lim, Byung-Sup,Cho, Jung-Yeon,Paik, Seung-Sam,Shim, Kwang-Sup 대한악안면성형재건외과학회 2006 Maxillofacial Plastic Reconstructive Surgery Vol.28 No.5
Purpose : Platelet rich plasma (PRP) is an autologous material with many growth factors, such as BMPs, PDGF, $TGF-{\beta}_1$, $TGF-{\beta}_2$, VEGF, and IGF, facilitating bone healing process. The prominent osteoconductive activity and the biodegradable nature of beta-tricalciumphosphate (${\beta}-TCP$) for bone grafts in animal experiments have been reported. The purpose of this study was to evaluate the effect of PRP on the osteogenesis of ${\beta}-TCP$. Materials & Methods : Two artificial calvarial bone defects were made in 32 rabbits which were divided into 2 groups. In one group of 16 rabbits, autogenous bone / ${\beta}-TCP$ was grafted on each side of cranial bone defect. In the other group of 16 rabbits, mixture of ${\beta}-TCP$ and PRP / PRP alone was grafted on each side of the cranial bone defect. The animals were sacrificed at 2, 4, 8, and 12 weeks after surgery. The specimens were harvested and examined histologically and immunohistochemically by the expression of BMP2/4/7, PDGF, VEGF and $TGF-{\beta}_1$. Results : The mean volume of new bone formation was significantly higher at 4, 8, 12 weeks in autogenous graft than that in ${\beta}-TCP$. The BMP2/4 expression was significantly higher at 4 weeks in autogenous bone graft and at 4 weeks in mixture of ${\beta}-TCP$ and PRP and at 12 weeks in ${\beta}-TCP$. The expression of BMP7, PDGF, VEGF and $TGF-{\beta}_1$ showed no significant difference in autogenous, ${\beta}-TCP$, mixture of ${\beta}-TCP$ and PRP, and PRP alone during grafted bone regeneration. Conclusion : The results showed that PRP had no additional value in promoting healing process of ${\beta}-TCP$ grafts.
가토 두개골 결손부에 이식된 β-TCP의 골치유 과정에서 PRP의 효과에 관한 연구
이성훈,황경균,박창주,임병섭,조정연,백승삼,심광섭 대한악안면성형재건외과학회 2006 Maxillofacial Plastic Reconstructive Surgery Vol.28 No.5
THE EFFECT OF PRP ON THE BONE REGENERATION OF Β-TCP GRAFTED IN RABBIT CRANIAL BONE DEFECT