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      • SCOPUSKCI등재

        한국 남성 불임환자에서 Y 염색체상의 AZF Gene에 대한 분석 및 DAZ Gene의 발현 양상

        이호준,이형송,송견지,변혜경,서주태,김종현,이유식,Lee, Ho-Joon,Lee, Hyoung-Song,Song, Gyun-Jee,Byun, Hye-Kyung,Seo, Ju-Tae,Kim, Jong-Hyun,Lee, You-Sik 대한생식의학회 1997 Clinical and Experimental Reproductive Medicine Vol.24 No.1

        Cytogenetic observations of loss of the distal portion of the Y chromosome long arm were found to be associated with disrupted spermatogenesis. The existence of a gene involved in the regulation of spermatogenesis, the azoospermia factor (AZF), was postulated. In this study, we screened the AZF region including DAZ and DAZH genes and observed the expression pattern of DAZ and DAZH transcript in infertile men with azoospermia and oligospermia by using a sequence-tagged site (STS)-based PCR method. PCR primers were synthesized for 11 STSs that span Yq interval 6, SRY, DAZ, and DAZH, functional DAZ homologue on chromosome 3. Microdeletions were detected in 4/32 (12.5%) azoospermic men and 1/11 (9%) severe oligospermic men. Only 2 of 5 patients had microdeletions of Yq that contained the DAZ gene, whereas the other 3 patients had deletions extending from intervals 5L-6F proximal to the DAZ gene on Yq. Testis biopsies of the azoospermic patients revealed a variety from Sertoli cell-only syndrome to testicular maturation arrest. Of 4 men with clinical data available, average testis size was R: 13.8 cc, L: 13.8 cc, serum T was $4.0{\pm}1.25$ ng/ml, LH was $3.63{\pm}1.90$ mIU/ml, and FSH was $8.85{\pm}5.13$ mIU/ml. These values did not differ significantly from the remainder of the patients tested. We could not observed the DAZ transcript in 2 patients, who have no mature spermatozoa. In 11.6% of patients microdeletions of the AZF could be detected. These deletions in the AZF region seem to be involved causing spermatogenic failure. But the frequency of microdeletions proximal to DAZ suggests that DAZ is not the only gene associated with spermatogenic failure.

      • KCI등재

        샘플링 광섬유 Bragg 격자를 이용한 광섬유 내의 유도 Brillouin 산란 억제

        이호준,Lee, Ho-Joon 한국광학회 2005 한국광학회지 Vol.16 No.6

        I have investigated a scheme for suppressing stimulated Brillouin scattering in optical fibers. The scheme makes use of a sampled Bragg grating fabricated within the fiber used for transmitting intense Q-switched pulses. The grating is designed such that the spectrum of the Stokes pulse generated through stimulated Brillouin scattering falls entirely within its stop band. I show numerically that the number of sampled fiber Bragg gratings in 1 m is applied directly to suppressing stimulated Brillouin scattering rather than the coupling coefficient. This prevents the build up of the backward-propagating Stokes wave and mitigates the deleterious effects of stimulated Brillouin scattering. The simulation shows that 15 ns pulses with 1 kW peak power can be transmitted though a 1 m-long fiber with little energy loss using this scheme. 본 논문에서는 광섬유 내에서 유도 브릴루앙 산란을 억제하는 방법에 대하여 연구하였다. 광섬유 내에 샘플링 브라그 격자를 사용함에 의하여 강한 Q-스위치 펄스를 전송할 수 있도록 하였다. 격자는 유도 블릴루앙 산란으로 생성되는 스토크 펄스의 스펙트럼이 모두 브라그 격자의 반사 대역에 오도록 설계된다. 1 m 내에 샘플링 광섬유 브라그 격자의 수가 결합계수 보다 유도 브릴루앙 산란의 억제에 직접적인 영향을 미친다는 것을 보였다. 이것은 후방 스토크 파의 발생을 억제하며 유도 브릴루앙 산란의 악 영향을 감소시킨다. 본 연구 방법을 통하여 1 kW 최대 파우어를 갖는 15 ns 펄스가 작은 에너지 손실을 발생시키며 전송될 수 있다는 것을 시뮬레이션을 통해 보였다.

      • KCI등재

        고해상도 레이더용 다중산란점 발생장치의 설계 및 제작

        이호준,김윤진,윤승구,정해창,공덕규,이재웅,변영진,Lee, Ho-Joon,Kim, Youn-Jin,Yoon, Seung-Gu,Jeong, Hae-Chang,Kong, Deok-Kyu,Yi, Jae-Woong,Byun, Young-Jin 한국군사과학기술학회 2016 한국군사과학기술학회지 Vol.19 No.5

        We designed the multiple scattering points generation system to simulate an actual situation of target signal for high range resolution radar system. This provides replicating the target signals and controlling the status of target signals for radar system. This is composed transmit antenna and multi target generator. Transmit antenna is waveguide array antenna and multi target generator has signal distribution module and control & power module. Multi target generator is able to provide the high isolation and variable output power. Moreover, in order to monitor all output signals of the multi target generator, the flows of signals are programed in control & power module. The performance is demonstrated using experimented results of high range resolution radar.

      • KCI등재

        다엽제한기 소조사면의 6 MV 광자선 출력선량계수

        이호준,최태진,오영기,전경수,이용희,김진희,김옥배,오세안,김성규,예지원,Lee, Ho Joon,Choi, Tae-Jin,Oh, Young Kee,Jeun, Kyung Soo,Lee, Yong Hee,Kim, Jin Hee,Kim, Ok Bae,Oh, Se An,Kim, Sung Kyu,Ye, Ji Woon 한국의학물리학회 2014 의학물리 Vol.25 No.1

        종양부위의 입체적이고 선택적인 치료가 가능해 임상표적부피(clinical target vlume, CTV)에 높은 선량으로 집중조사하고 부작용을 현저히 줄이는 세기조절방사선치료는 치료예후를 향상시키고 있다. 방사선세기조절 치료는 MLC의 개방면적과 개방시간으로 조사면내 플루언스를 조정하므로 소형조사면의 선량이 누적되어 원하는 선량이 조사하게 된다. 따라서 소형조사면과 계층형 조사면의 출력선량계수의 정확성은 곧 Portal MU 결정에 정확성을 더할 수 있고, 종양에 조사되는 선량의 정확성을 향상할 수 있으므로, 이 연구는 Clinac Ex (Varian) $3{\times}3cm^2$에서 $0.5{\times}0.5cm^2$까지 조사면을 선정하였고 방사선은 6 MVX선의 소형조사면의 출력선량계수를 평가하였다. 조사면은 다엽제한기를 $40{\times}40cm^2$로 개방하고 Collimator jaw를 이용한 것과 Collimator를 $10{\times}10cm^2$로 고정하고 다엽제한기에 의한 조사면으로 구분하여 출력선량계수가 결정되었다. 검출기는 유효체적이 $0.01cm^3$이고 내경 2 mm인 CC01 (Scanditronix-Wellope)이온전리함과 SFD 다이오드 검출기(0.6 mmØ, $500{\mu}m$ 두께, Scanditronix-Wellope)와 다이아몬드 검출기(T60003, PTW)와 X-Omat film을 사용하였다. 결과는 다엽제한기 조사면의 출력선량계수는 $3{\times}3cm^2$에서 $0.899{\pm}0.0106$, $2{\times}2cm^2$에서 $0.855{\pm}0.0106$, $1{\times}1cm^2$에서 $0.764{\pm}0.0082$, $0.5{\times}0.5cm^2$에서 $0.602{\pm}0.0399$를 얻었다. Jaw를 $10{\times}10cm^2$로 고정하고 다엽제한기의 조사면의 출력계수는 MLC를 $40{\times}40cm^2$에 jaw에 의한 소형조사면의 것보다 최대 3.8% 높게 나타남을 확인하였다. 따라서 세기조절방사선치료 TPS에는 collimator jaw 보다 다엽제한기 조사면 크기의 출력선량계수가 설정되는 것이 중요함을 의미한다. The IMRT is proper implement to get high dose deliver to tumor as its shape and selective approach in radiation therapy. Since the IMRT is performed as modulated the radiation fluence by the MLC created the open shapes and its irradiation time, the dose of segment of radiation field effects on the cumulated portal dose. The accurate output factor of small and step shape of segment is important to improve the determination of deliver tumor dose as it is directly proportional to dose. This experiment performed with the 6 MV photon beam of Clinac Ex(Varian) from $3{\times}3cm^2$ to $0.5{\times}0.5cm^2$ small field size for collimator jaw in MLC free and/or for MLC open field in fixed collimator jaw $10{\times}10cm^2$ using the CC01 ion chamber, SFD diode, diamond detector and X-Omat film dosimetry. As results of normalized to the reference field of $10{\times}10cm^2$ of MLC, the output factor of $3{\times}3cm^2$ showed $0.899{\pm}0.0106$, $0.855{\pm}0.0106$ for $2{\times}2cm^2$, $0.764{\pm}0.0082$ for $1{\times}1cm^2$ and $0.602{\pm}0.0399$ for $0.5{\times}0.5cm^2$. The output factor of MLC open field has shown a maximum 3.8% higher than that of the collimator jaw open field.

      • SCOPUSKCI등재

        동결보존에 의한 인간배아의 생존률과 임신에 관한 연구

        이호준,이승재,노성일,백혜란,김문규,Lee, Ho-Joon,Lee, Seung-Jae,Roh, Sung-Il,Paik, Hye-Ran,Kim, Moon-Kyoo 대한생식의학회 1990 Clinical and Experimental Reproductive Medicine Vol.17 No.2

        This study was done to verify factors affecting viability after cryopreservation and pregnancy rate after frozen-thawed embryo transfer into uterus. Embryos were cryopreserved slow freezing and slow thawing and used DMSO as cryoprotectant. The results were to follows. 1. Viability of frozen-thawed embryos were 75.5% (94/105), which compared with viability of embryos according to cell stage, $2{\sim}5$ cell was 68.4% and $6{\sim}16$ cell 80.4% were significant differences (p<0.05). 2. No significant difference in duration of cryopreservation on effects affecting pregnancy rate was observed. 3. Number of embryo transfered into uterus was significant differences (p<0.05). 4. Four pregnancies resulted following replacement of 35 frozen-thawed.

      • SCOPUSKCI등재

        체외배양 생쥐정소세포에서 합성에스트로겐이 P450 등위효소의 발현에 미치는 영향

        이호준,김묘경,고덕성,김길수,강희규,김동훈,Lee, Ho-Joon,Kim, Myo-Kyung,Ko, Duck-Sung,Kim, Kil-Soo,Kang, Hee-Kyoo,Kim, Dong-Hoon 대한생식의학회 2001 Clinical and Experimental Reproductive Medicine Vol.28 No.2

        Objective: To know the effects of xenoestrogen on spermatogenesis, we investigated the expression of cytochrome P450s enzymes (CYPscc, $CYP_{17{\alpha}}$, CYP19) and $3{\beta}$-HSD genes involved in steroidogenesis. Methods: Mouse testicular cells were prepared from 15-day-old ICR mice which had only pre-meiotic germ cells by enzyme digestion using collagenase and trypsin. Testicular cells were cultured in DMEM supplemented with FSH (0.1 IU/ml) and 10% FBS or medium with estrogen ($E_2$), bisphenol-A (BPA), octylphenol (OP; $10^{-9},\;10^{-7},\;10^{-6},\;10^{-5},\;10^{-4}M$, respectively) and aroclor 1254 (A1254) known as PCBs for 48 hours. The gene expression of cytochrome P450 enzymes were examined by semi-quantitive RT-PCR. The production of estrogen and testosterone was examined by RIA. Results: As results, expression of CYPscc mRNA was not significantly decreased, but $3{\beta}$-HSD and $CYP_{17{\alpha}}$. mRNA were significantly dose-dependent decreased. And production of testosterone and estrogen were not different except BPA and OP group ($10^{-5}M$). Conclusion: BPA, OP and A1254 might inhibit steroidogenesis by decreasing CYPscc, $3{\beta}$-HSD and $CYP_{17{\alpha}}$. mRNA expression in the mouse testis. These results suggest that BPA, OP and PCBs like as an endocrine disruptors inhibit the productions of steroidogenic enzymes and decrease the production of T and E by negative feedback mechanism. Therefore, these might disrupt steroidogenesis in Leydig cells of testis and would disturb testicular function and subsequently impair spermatogenesis.

      • KCI등재
      • SCOPUSKCI등재

        체외수정시술시 미세조작술에 의한 수정률 향상과 임신에 관한 연구

        이호준,최규완,전종영,박종민,권혁찬,김문규,Lee, Ho-Joon,Choi, Kyoo-Wan,Jun, Jong-Yung,Park, Jong-Min,Kwon, Hyuck-Chan,Kim, Moon-Kyoo 대한생식의학회 1990 Clinical and Experimental Reproductive Medicine Vol.17 No.1

        The purpose of this study is to improve fertilization rate in IVF-ET program of patients with male infertility used micromanipulation technique, partial zona dissection (PZD) or micro-insemination by sperm transfer (MIST). The results were as follows 1. The fertilization rate of non-micromanipulated oocytes and micromanipulated (PZD) oocytes were 12.5% (n=2) and 42.2% (n=19), respectively, and showed significant differences between two groups (p<0.05). 2. The fertilization rate of micromanipulated (MIST) oocytes was 30% (n=27). 3. The damage rate of Group 1 (PZD) and Group 2 (MIST) were 15.7% (3/19) and 29.6% (8/27), respectively. 4. One pregnancy resulted following replacement of micromanipulated (MIST) embryos in 4 patients.

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