An overview of herbal medicine for atopic dermatitis

이향숙,Lee, Hyang-Sook The Korean Medicine Society for the Herbal Formula 2009 대한한의학 방제학회지 Vol.17 No.2

목 적 : 한약 또는 한약제제의 아토피성 피부염에 대한 치료효과를 조사하고 향후 연구방향을 제시하기 위하여 고찰연구를 시행하였다. 방 법 : PubMed에 한약과 아토피성 피부염과 관련된 검색어의 조합을 넣어 포함기준에 맞는 무작위배정 대조군 임상연구만 포함하였다. 연구설계, 치료방법, 대조군, 평가지표, 결과, 부작용 관련 정보를 미리 정해놓은 자료 추출 형식에 맞추어 추출하고 방법론적 질 평가는 옥스포드 질 평가 척도와 그룹 할당 은닉(allocation concealment) 여부를 평가하였다. 연구들이 임상적 및 통계적으로 상이하여 메타분석은 이루어지지 않고 기술적 고찰만 실시하였다. 결 과 : 모두 8편의 연구가 고찰기준을 만족시켰다. 다양한 복합한약제제와 한약이 포함된 외용제가 평가되었는데 8편 가운데 5편에서 아토피성 피부염의 증상을 호전시키는 것으로 나타났다. 방법론적 질은 대체로 양호한 것으로 나타났으며 일부 효과적인 것으로 나타난 한약복합제제에서 간손상 등의 부작용도 보고되었다. 결 론 : 한약 또는 한약제제를 이용한 치료는 아토피성 피부염의 증상개선에 도움이 되는 것으로 보이나 현재 근거는 부족하다. 우리나라에서 많이 쓰이는 한약제제들 역시 엄정한 임상연구를 거쳐 그 효과를 평가하고 근거를 구축해야 할 것이다.

쥐의 뇌 시토졸 Aldehyde Dehydrogenase의 정제 및 특성에 관한 연구

이향숙,주충노,Lee, Hyang-Sook,Joo, Chung-No 생화학분자생물학회 1993 한국생화학회지 Vol.26 No.6

쥐의 뇌 시토졸 분획으로부터 aldehyde dehydrogenase(ALDH. EC 1.2.1.3)를 황산암모늄 분별침전, DEAE-Sephacel, Blue Sepharose CL-6B, 5'-AMP Sepharose 4B affinity chromatography 방법으로 분리 정제하였다. Short chain aliphatic aldehyde나 aromatic aldehyde에 대한 $K_m$값은 $10^{-3}M$ 수준이 었고 indole-3-acetaldehyde에 대 한 $K_m$값은 $10^{-4}M$ 수준이었으나, succinic semialdehyde에 대해서는 매우 낮은 $K_m$값($10^{-6}M$ 수준)을 나타내었으며 친화력도 가장 큰 것으로 보아 ${\gamma}-aminobutyrate$ 대사와 연관성이 큰 것으로 생각된다. $NAD^+$에 대한 $K_m$값($10^{-5}M$ 수준)은 $NADP^+$에 대한 $K_m$값($10^{-4}M$ 수준)의 1/10 정도이였으며 $NAD^+$가 주로 보조효소로 작용하는 것으로 생각된다. 이 효소의 disulfiram에 의한 억제현상은 disulfiram의 농도가 $10{\mu}M$일 때 효소활성이 약 15% 감소되었으나, disulfiram의 농도가 $25{\mu}M$로 증가하여도 약 30%의 효소활성은 남아있었다. 또한 이 효소는 dehydrogenase 활성외에 esterase 활성을 나타내었고 iodoacetamide, phenylmethylsulfonylfluoride, pyridoxal-5'-phosphate 등에 의해 활성 이 억제 되는 것으로 보아 cysteine, serine, lysine같은 아미노산 잔기가 효소활성 부위에서 중요한 역할을 할 것으로 생각된다. Rat brain cytosolic aldehyde dehydrogenase (ALDH, EC 1.2.1.3) was purified by ammonium sulfate precipitation, DEAF-Sephacel, Blue Sepharose CL-6B and 5'-AMP Sepharose 4B affinity chromatography. $K_m$ values of the cytosolic ALDH for short chain aliphatic aldehyde and aromatic aldehyde were $10^{-3}M$ level and that for indole-3-acetaldehyde was $10^{-4}M$ level. However, this enzyme had a very low $K_m$ value ($10^{-6}$ level) and the greatest affinity for succinic semialdehyde suggesting that the cytosolic ALDH seemed to be closely related to the metabolism of ${\gamma}-aminobutyrate$. $K_m$ of this enzyme for NAD was $10^{-5}M$ level while that for $NADP^+$ was $10^{-4}M$ level. It seemed that $NAD^+$ might be mainly used as a cofactor of this enzyme. Rat brain cytosolic ALDH was sensitive to disulfiram and the enzyme activity decreased to about 50% in the presence of $10{\mu}M$ disulfiram but 30% of the total activity of this enzyme remained even in the presence of $25{\mu}M$ disulfiram. This enzyme had esterase activity as well. It was realized that iodoacetamide, phenylmethylsulfonylfluoride, pyridoxal-5'-phosphate inhibited the enzyme activity suggesting that amino acid residues such as cys-teine, serine, lysine might participate at the active site of this enzyme.

쥐의 뇌 시토졸 Aldehyde Dehydrogenase 의 정제 및 특성에 관한 연구

이향숙,주충노 ( Hyang Sook Lee,Chung No Joo ) 생화학분자생물학회 1993 BMB Reports Vol.26 No.6

Rat brain cytosolic aldehyde dehydrogenase (ALDH, EC 1.2.1.3) was purified by ammonium sulfate precipitation, DEAF-Sephacel, Blue Sepharose CL-6B and 5`-AMP Sepharose 4B affinity chromatography. K_m values of the cytosolic ALDH for short chain aliphatic aldehyde and aromatic aldehyde were 10^(-3)M level and that for indole-3-acetaldehyde was 10^(-4)M level. However, this enzyme had a very low Km value (10^(-6) level) and the greatest affinity for succinic semialdehyde suggesting that the cytosolic ALDH seemed to be closely related to the metabolism of γ-aminobutyrate. K_m of this enzyme for NAD was 10^(-5)M level while that for NADP+ was 10^(-4) M level. It seemed that NAD+ might be mainly used as a cofactor of this enzyme. Rat brain cytosolic ALDH was sensitive to disulfiram and the enzyme activity decreased to about 50% in the presence of 10 μM disulfiram but 30% of the total activity of this enzyme remained even in the presence of 25 μM disulfiram. This enzyme had esterase activity as well. It was realized that iodoacetamide, phenylmethylsulfonylfluoride, pyridoxal-5`-phosphate inhibited the enzyme activity suggesting that amino acid residues such as cys-teine, serine, lysine might participate at the active site of this enzyme.

초산(醋酸), 질산(窒酸), 인산(燐酸)을 함유한 삼원계(三元系) 폐혼산(廢混酸)으로부터 인산(燐酸) 회수(回收)에 관한 기초 연구(硏究)

이향숙,이창훈,신준영,김주엽,안재우,Lee, Hyang-Sook,Lee, Chang-Hoon,Shin, June-Young,Kim, Ju-Yup,Ahn, Jae-Woo 한국자원리싸이클링학회 2005 자원리싸이클링 Vol.14 No.5

Recovery of phosphoric acid from waste acid mixture of acetic, nitric and phosphoric acid has been attempted by using solvent extraction method. In this work, organic phosphate was used as an extraction agent. The effect of phosphate concentration, agitation speed and time on the solvent extraction of acetic and nitric acids has been investigated. The optimum concentration of phosphate for preferential extraction of acetic and nitric acids from waste acid was found to be about 50% irrespective of agitation speed and time. Purified phophoric acid was recovered from extraction residue at 1/3 of A/O ratio and 6th stage of extraction stage, which is well consistent with the value calculated by using McCabe-Thiele diagram.

STRICTA(침 임상연구에서 중재 보고를 위한 표준) 개정판: CONSORT Statement의 확충안

이향숙 ( Hyang Sook Lee ),차수진 ( Su Jin Cha ),박히준 ( Hi Joon Park ),서정철 ( Jung Chuo Seo ),박종배 ( Jong Bae J. Park ),이혜정 ( Hye Jung Lee ) 경락경혈학회 2010 Korean Journal of Acupuncture Vol.27 No.3

Objectives and methods: The Standards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA) were published in five journals in 2001 and 2002. These guidelines, in the form of a checklist and explanations for use by authors and journal editors, were designed to improve reporting of acupuncture trials, particularly the interventions, thereby facilitating their interpretation and replication. Subsequent reviews of the application and impact of STRICTA have highlighted the value of STRICTA as well as scope for improvements and revision. To manage the revision process a collaboration between the STRICTA Group, the CONSORT Group, and the Chinese Cochrane Centre was developed in 2008. An expert panel with 47 participants was convened that provided electronic feedback on a revised draft of the checklist. At a subsequent face-to-face meeting in Freiburg, a group of 21 participants further revised the STRICTA checklist and planned dissemination. Results: The new STRICTA checklist, which is an official extension of CONSORT, includes six items and 17 sub-items. These set out reporting guidelines for the acupuncture rationale, the details of needling, the treatment regimen, other components of treatment, the practitioner background, and the control or comparator interventions. In addition, and as part of this revision process, the explanations for each item have been elaborated, and examples of good reporting for each item are provided. In addition, the word controlled in STRICTA is replaced by clinical, to indicate that STRICTA is applicable to a broad range of clinical evaluation designs, including uncontrolled outcome studies and case reports. Conclusions: It is intended that the revised STRICTA, in conjunction with both the main CONSORT Statement and extension for nonpharmacologic treatment, will raise the quality of reporting of clinical trials of acupuncture.

만성 요통 한자의 침 치료 경험: 질적 연구

이향숙 ( Hyang Sook Lee ),손행미 ( Haeng Mi Son ),김송이 ( Song Yi Kim ),송미연 ( Mi Yeon Song ),이준환 ( Jun Hwan Lee ),박히준 ( Hi Joon Park ) 경락경혈학회 2010 Korean Journal of Acupuncture Vol.27 No.2

Objective: To explore and describe chronic low back pain (cLBP) patients` experience of acupuncture treatment Methods: Eleven patients with cLBP who agreed and completed the informed consent to take part in this qualitative study were interviewed thoroughly and tape-recorded. Transcribed data were read independently by 4 researchers and analysed thematically with ground theory. Results: All participants chose acupuncture treatment for their cLBP because either they preferred, other people recommended, or felt conventional treatment being more comfortable. Most of the participants experienced improvement during acupuncture treatment and continued treatment motivated by mere expectations. Participants also expressed the specific physical responses/sensations to the effect of acupuncture; various adverse effects during the course of acupuncture treatment. Economic burden was another concern when combined with other therapies in Korean Medicine hospitals. It is considered as a specifically important to those who give acupuncture treatment to obtain a full treatment effect. Conclusions: The emotional facts that Korean patients with cLBP receiving acupuncture treatment benefited by the treatment and considering specific sensations from doctor-patient relationship were turned out to be important to have the maximum treatment effect. Findings from this study should be considered in both acupuncture research and practice.

EJB 기반의 사원 정보 관리 컴포넌트 개발에 관한 연구

이향숙(Hyang-Sook Lee),박진호(Jin-Ho Park),류성열(Sung-yul Rhew) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.1A

소프트웨어에 대한 요구사항이 증가하고 그 규모가 점차 거대, 복잡해짐에 따라 소프트웨어의 재사용성은 주목할만한 이슈로 부각되고 있으며 많은 기법이나 지침에 제안되고 있다. 특히 저 예산으로 짧은 개발 기간 동안 기존의 시스템을 버리지 않고 새로운 시스템을 구축하려는 기업들의 요구에 맞게 최근 EJB기반의 컴포넌트 개발은 재사용성을 확보할 수 있는 가장 주목 받는 방안으로 제시되고 있다. 본 논문에서는 사원정보관리 어플리케이션에 EJB를 적용해 컴포넌트로 함으로써 컴포넌트 개발시 실무적인 유용성을 검증해 본다.

공격적 유아를 위한 애착증진 집단치료놀이 프로그램 개발과 적용

이향숙 ( Hyang Sook Lee ),임지향 ( Ji Hyang Lim ),권명옥 ( Myung Ok Kwon ) 한국정서행동장애학회 2006 정서ㆍ행동장애연구 Vol.22 No.1

The purpose of this study is to develop and apply the Group Theraplay program to enhance the attachment of the infant who have some trouble with social competence in connection with child aggression, and this study is based on attachment theory which refers reduction of aggression to self esteem. The group Theraplay program is divided into the beginning, middle and closing, which are comprised of the seven steps with total twenty sessions depending on the purpose of each session. Total 143 three, four or five year old infants are the objects of this study who just have entered into preschool. Infant aggression tests for both parents and teachers have been taken for these infants. Among them, ten infants who got above the average scores in all test measures have then participated in thirty-minute group Theraplay program, twice a week for ten weeks. To verify the effects of the program, the analysis have been carried out based on the samples of aggressive behavior, task concentration, rejection of activity interference and smile/laugh from the contents of video tape recording. As an analysis result, child aggression, activity interference and rejection were reduced. In the mean time, task concentration and smile·laugh activities were enhanced. Such result was shown through the analysis of behavior change progress by each term of the group theraplay. Furthermore, through interview with the parents and teachers after applying the group theraplay, I confirmed the effects that the infants were greatly reduced in behavior problems, obtained self-confidence and behaved in consideration of other`s emotions.

종합병원 간호사의 섬망 지식, 비판적 사고 성향, 공감 역량이 섬망 간호 수행에 미치는 영향: 횡단적 서술적 조사연구

이향숙(Hyang Sook Lee),양정은(Jeong Eun Yang) 한국노인간호학회 2025 노인간호학회지 Vol.27 No.1

Purpose: This study aimed to identify factors influencing general-hospital nurses’ delirium knowledge, critical-thinking disposition, and compassion competence on delirium nursing performance. Methods: This research included 193 nurses from three shifts at three general hospitals, each with over 500 beds, in Jeolla Province. Data were collected from January 29 to February 20, 2024. The collected data were analyzed using SPSS 25.0, descriptive statistics, independent t-test, one-way ANOVA, Pearson’s correlation, and hierarchical multiple regression. Results: The factors affecting delirium-nursing performance, age (β=.40, p=.025) and compassion competence (β=.37, p<.001), explained 32.0% of the variance in the model. Conclusion: The factors influencing the performance of delirium care among general-hospital nurses were age and compassion competence. Policy support and self-coaching programs are necessary to continuously develop nurses’ compassion competence.

유아의 외현화 문제행동감소를 위한 통합치료 사례연구 -몬테소리교육과 집단치료놀이의 통합치료를 중심으로-

이향숙 ( Hyang Sook Lee ) 한국실천유아교육학회 2006 실천유아교육 Vol.11 No.-