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이풍렬(Poong Lyul Rhee),이종철(Jong Chul Rhee),최규완(Kyoo Wan Choi),김은주(Eun Joo Kim),박창영(Chang Young Park),손정일(Jong Chul Rhee),전우규(Woo Kyu Cheon),김병익(Byeong Ik Kim),정을순(Eul Sun Jung),전성국(Seong Gook Cheon),박기호 대한내과학회 1999 대한내과학회지 Vol.57 No.1
N/A To estimate bowel patterns in the Korean, we surveyed routine check-up subjects about their bowel habits, using self-reported questionnaire. Methods : We analyzed 2939 subjects (male 1430, female 1509; age range 25 - 65 years) who had visited health promotion center for routine check-up. Subjects were given a validated self-report questionnaire, which measured the defecation frequency; stool consistency; self-report of constipation; straining to defecate; and levels of laxative use. Results : Of the whole subjects 96.4% had defecation frequency between three per week and three per day. The prevalence of two or less bowel movements per week (4.1% compared to 0.6%), straining to defecate (20.8% compared to 13.0%) and hard stool (18.0% compared to 9.3%) was higher in women than men (p<0.01). The prevalence of self-reported constipation was higher in women than men (9.0% compared to 2.9%, p<0.01). Women were more likely to use laxatives than men (5.5% compared to 0.6%, p<0.01). Conclusions : Defecation frequency in most of routine check-up subjects is between three per week to three per day. Bowel dysfunction is a greater problem in women.
중증 궤양성 대장염에서 Cyclooxygenase-2의 발현
이풍렬 ( Poong Lyul Rhee ),김재준 ( Jae J. Kim ),고광철 ( Kwang Cheol Koh ),백승운 ( Seung Woon Paik ),이종철 ( Jong Chul Rhee ),최규완 ( Kyoo Wan Choi ),오영륜 ( Young Lyun Oh ),김경희 ( Kyung Hee Kim ),김영호 ( Young Ho Kim ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 궤양성 대장염 환자의 대장 점막에서는 정상점막에서 거의 발현되지 않는 cyclooxyegnase-2(COX-2)의 발현이 관찰된다. 궤양성 대장염으로 COX-2의 발현이 가지는 의의는 잘 알려져 있지 않은데 COX-2가 염증 매개체의 생성을 통하여 대장염을 악화시키거나 반대로 대장점막의 증식을 촉진시키고 아포토시스를 억제하여 점막병변의 치유에 도움을 줄 가능성을 모두 생각할 수 있다. 최근 대장염 동물 모델에서 COX-2를 선택적으로 억제하면
기니피그 위점막이 카테콜아민 유발 위운동에 미치는 영향
이풍렬(Rhee, Poong-Lyul),김기환(Kim, Ki-Whan),이상진(Lee, Sang-Jin) 대한생리학회 1989 대한생리학회지 Vol.23 No.2
The effects of noradrenaline on the contractile and electrical activities were investigated using the circular muscle strips with intact mucosa prepared from the antrum and fundus of guinea-pig stomach. Electrical responses of circular muscle cells were recorded using glass capillary microelectrodes filled with 3 M KCI. All experiments were performed in tris-buffered Tyrode solution which was aerated with 100% O<sub>2</sub> and kept at 35℃. The results obtained were as follows: 1) The spontaneous contractions recorded from the antral and fundic circular muscle strips with intact mucosa were suppressed dose-dependently by the application of noradrenaline, whereas those recorded from the mucosa-free strips were potentiated in a dose-dependent manner. 2) The inhibitory influences on the contractile activities in the normal intact strips were developed via both α-adrenoceptors and β-adrenoceptors, while the excitatory influences in the mucosa-free strips resulted from the strong excitatory effect via α-adrenoceptors and the weak inhibitory effect via β-adrenoceptors. 3) Noradrenaline produced hyperpolarization of membrane potential, and increased the amplitude and the maximum rate of rise of slow waves in the mucosa-free strips of antral and fundic circular muscle. 4) Apamin blocked the appearance of the component of initial suppression of spontaneous phasic contractions observed in the mucosa-free strips of antral circular muscle after the application of noradrenaline. 5) The inhibitory influences on the contractile activities in the normal strips with intact mucosa remained unaffected even in the strip with separate mucosa, in which mucosa and muscle layer were mechanically disconnected . From the above results, following conclusions could be made. (1) There are no regional differences between the effects of noradrenaline on the antral circular muscle and those on the fundic circular muscle. (2) Excitatory responses to noradrenaline observed in the mucosa-free strip result from the dominant α-excitatory and tile weak β-inhibitory action of noradrenaline. (3) Inhibitory responses to noradrenaline in the normal strips with intact mucosa develop via both α-inhibitory and β-inhibitory actions.