화야산(경기도 가평군)의 거미상

김주필(Joo Pil Kim),최한석(Han Seak Choi),이형민(Hyung Min Lee),이형진(Hyung Jeen Lee),이태후(Tae Hoo Lee),심주영(Ju Young Sim),조윤규(Yoon Kyu Jo),조원규(Won Kyu Jo),이준이(Joon Lee Lee) 한국거미연구소 2018 한국거미 Vol.34 No.2

2018년 10월 13일부터 14일까지 경기도 가평군 소재 화야산을 주야로 한국거미연구회 회원 13명(김주필, 최한석, 이형민, 이형진, 심주영, 이태후, 조윤규, 조원규, 이준이, 이현동, 윤혜원, 이광섭, 김형주)이 채집한 결과 18과 41속 48종이 채집되어 이에 보고 발표하는 바이다. From October 13 to 14 in 2018. Koran Arachnological Study members investigated the Spiders in the whole area Gyeonggi-do Gapyeong-gun, and reported 18 Families 41 Genus 48 Species of spiders. The collected spiders are placed (stored) in the Joo-Pil Spider museum.

검단산(경기도 하남시)의 거미상

김주필(Joo Pil Kim),최한석(Han Seak Choi),이형민(Hyung Min Lee),이형진(Hyung Jeen Lee),이태후(Tae Hoo Lee),심주영(Ju Young Sim),조윤규(Yoon Kyu Jo),조원규(Won Kyu Jo),이준이(Joon Lee Lee) 한국거미연구소 2018 한국거미 Vol.34 No.2

2018년 10월 2일부터 3일까지 경기도 하남시 소재 검단산을 주야로 한국거미연구회 회원 13명(김주필, 최한석, 이형민, 이형진, 심주영, 이태후, 조윤규, 조원규, 이준이, 이현동, 윤혜원, 이광섭, 김형주)이 채집한 결과 22과 43속 56종이 채집되어 이에 보고 발표하는 바이다. From October 2 to 3 in 2018. Koran Arachnological Study members investigated the Spiders in the whole area Gyeonggi-do Hanam-si, and reported 22 Families, 43 Genus 56 Species of spiders. The collected spiders are placed (stored) in the Joo-Pil Spider museum.

The Effects of Herbal Acupuncture on Immuno-regulatory Action of the Hypothalamus in Rats

이태후,박히준,임사비나,Lee Tae-Hoo,Park Hi-Joon,Lim Sabina 경락경혈학회 2003 Korean Journal of Acupuncture Vol.20 No.2

목적 : 본 연구는 염증유발 내독소인 LPS 자극을 통한 면역 스트레스에 대한 약침의 치료효과와 기전을 알아보기 위해 설계되었다. LPS를 통한 염증반응은 다양한 기전을 통해 이루어지는 데 특히, 산화질소(NO)를 생성하는 효소인 iNOS의 활성은 시상하부에서 NO의 생성을 촉진함으로써 염증반응을 발현시키는 중요한 역할을 하는데 약침이 LPS로 인해 활성화된 iNOS의 발현에 어떠한 영향을 미치는지 알아보고자 하였다. 실험방법 : 흰쥐에 LPS를 투여하고 2시간 경과한 후 약침 (소염방, 대한약침학회)을 경혈 (합곡, 족삼리)에 좌,우 각각 0.2cc 씩 피하 투여하고 RT-PCR 방법을 통하여 면역활성에 중요한 역할을 하는 시상하부에서의 iNOS의 mRNA 발현을 알아 보았다. 실험결과 : LPS 투여로 인하여 증가하였던 iNOS mRNA가 약침치료를 통해 현저하게 감소하였다. 그러나 비경혈점 (미추부위 임의혈)에 약침을 투여한 군 경혈점에 생리식염수를 투여한 군에서는 iNOS mRNA 가 감소하지 않았다. 이는 약침이 LPS를 투여한 흰쥐의 시상하부에서 iNOS의 mRNA 발현에 조절작용을 가지고 있는 것을 보여주는 결과로 약침이 면역활성에 중요한 역할을 하는 NO의 생성을 억제함으로써 면역 스트레스에 치료효과를 나타내는 것으로 보여진다. 결론 : 본 연구는 약침치료가 면역반응의 중추기관인 시상하부에서 면역반응의 중요한 조절인자인 NO의 생성을 조절하는 기전을 통해 그 치료효과를 나타내는 것을 밝혔고 더 나아가 약침에 대한 현대과학적 연구에 중요한 발판을 마련했다는 점에서 그 의의를 가지고 있다고 사료된다.

탈모 환자의 적외선 체열 진단상 안면부 체열 특성

이태후(Tae-Hoo Yi),문정배(Jung-Bae Moon),안경애(Kyung-Eh An),이혜정(Hye-Jung Lee) 대한한의학회 2006 대한한의학회지 Vol.27 No.2

탈모증 환자의 한의학적 임상 유형에 대한 연구

이태후,문정배,정지행,임강현,김희택,Lee, Tae-Hoo,Moon, Jung-Bae,Jeong, Jee- Haeng,Leem, Kang-Hyun,Kim, Hee-Taek 대한한방안이비인후피부과학회 2009 한방안이비인후피부과학회지 Vol.22 No.3

Objectives : This study was planed to evaluate clinical status of the alopecia patients who had visited Korean medicine clinic. And the result from this study would provide a standard in Korean medical diagnostic and classification method of alopecia. Methods : Clinical records of 183 patients with alopecia seen from January 2004 to April 2005 at Korean medical clinic was examined. They were classified into 4 different types according to chief complains besides alopecia by 2 Korean medical doctors. Results and conclusions : We made clinical analysis of patients of alopecia from January 2004 to April 2005. Among the alopecia patients who visit Korean medical clinic, people age between 20 and 30 had high ratio. The duration from the recognition of initial hair loss to the time of the first visit to the Korean medical clinic was less than 12 months in 20.8%(38/138), and less than 60 months in 72.2% (132/183). The condition of alopecia was more worse than other alopecia patients who visit the west medical clinic. Also the ratio with increased temperature of face or scalp is chief complaint except alopecia in alopecia patients was high in men and the ratio with dysfunction of digestive system or chronic weakness was high in women. Among the incidence of alopecia, the androgenic alopecia was most in number; 43.7%(80/183) and the sex distribution showed 83 men and 100 women.

탈모 환자의 적외선 체열 진단상 안면부 체열 특성

이태후,문정배,안경애,이혜정,Yi, Tae-Hoo,Moon, Jung-Bae,An, Kyung-Eh,Lee, Hye-Jung 대한한방체열의학회 2006 대한한방체열의학회지 Vol.5 No.1

Objectives: To examine any potential relationships between the types of alopecia and the facial heat distribution in patients with alopecia Methods: 183 patients with alopecia participated in this study to provide facial heat distribution measured by the Infrared Thermography Scanner (ITS, Nec San-ei Instruments Ltd, Japan). The thermography scan was used in a light-and heat-protected room after 20 minutes’of resting period. 1.5m of distance maintained between the patients and ITS. Results: Specificity in the type of facial heat distribution was found as follow. 1. Types of facial heat distribution can be classified as T-type and diffused patterns. 2. There was a significant difference in the pattern of facial heat distribution among different types of alopecia (p=0.002): facial heat distribution appeared T-type in Androgenic Alopecia, Alopecia Areata, and Telogen Effluvium (71.3%, 85.7%, 70.4%), whereas diffused pattern was dominant in Seborrheic Alopecia(55.6%). 3. There was a significant difference in the pattern of facialheat distribution between men and women (p<0.001): While the T-type and diffused type were equally appeared in men (50.6%: 49.4%), T-type was dominant in women (88.0% vs. 12.0%). Conclusions: We conclude that the pattern of facial heat distribution differs depends on the types of alopecia and gender. These differences may provide useful information for the diagnosis and clinical therapy for this population.

한의원에 내원한 탈모증 환자 80명의 임상적 고찰

이승민 ( Seung Min Lee ),이태후 ( Tae Hoo Yi ),금동호 ( Dong Ho Keum ) 한방재활의학과학회 2005 한방재활의학과학회지 Vol.15 No.2

Objectives : This study was planned to evaluate clinical status of the alopecia patients who had visited oriental medicine clinic. Methods : 80 patients with alopecia, who had visited oriental medicine clinic from January 2004 to August 2004, were examined. Results & Conclusions : 1. The kinds and incidences of Alopecia : androgenetic alopecia 57.5%(46/80), alopecia areata 20.0%(16/80), telogen effluvium 16.3%(13/80), seborrheic alopecia 6.3%(5/80). 2. In distribution of sex, the rate of male to female was 1:1 and most patients belonged to 20-30 year old group. 3. The most common onset of age was adolescence(63.8%) and the most common duration of hair loss was 1 to 3 years. 4. Among the 30 male androgenetic alopecia patients, Hamilton`s type 4 was most common and among the 16 female androgenetic alopecia patients, Ludwig`s type Ⅱand Ⅲ were most common. 5. Family history of baldness in Androgenetic alpoecia and alopecia areata were 56.5% and 25.0%, respectively. 6. Self-conscious causes of hair loss : stress(48.8%), irregular eating habits (21.3%), and lack of sleep (20.0%). 7. Associated diseases with alopecia patients : chronic neck pain(58.8%), temporomandibular disorders(55.0%) and seborrheic dermatitis (20.0%). 8. Associated symptoms with alopecia Patients : stress(78.8%), sleep disorders(68.8%), irregular eating habits(55.0%), Hot flush (43.8%), Stool disorders (43.8%), cold hands and feet(37.5%) and menstruation disorders(31.3%). 9. The most common scalp type was oily scalp(70.0%) and the symptoms of scalp were iching, dandruff, pain, inflammation. 10. Bian zheng(辨證) of alopecia patients : xue-re-feng-zau(血熱風燥) (25.0%), gan-shen-bu-zu(肝腎不足) (23.8%), shi-re-shang-zheng (濕熱上蒸) (16.3%), xue-re-sheng-feng(血熱生風) (13.8%), xue-xu-feng-zau(血虛風燥) (13.8%), yu-xue-zu-luo(瘀血阻絡) (7.5%)

만형자 추출물의 모발성장 촉진 효과

신헌섭 ( Heon Sub Shin ),이강진 ( Kang Jin Lee ),이태후 ( Tae Hoo Yi ) 한국두피ᆞ모발미용학회 2009 대한미용학회지 Vol.5 No.1

The hair cycle is divided 3 phases into anagen, catagen and telogen. Hair loss is the result of premature catagen caused by apoptotic signal. The process of apoptosis is controlled through the activation of many factors, such as inflammatory cytokines, p53, Bax and Bcl-2 family gene. Vitex rotundifolia has been used frequently as an indigenous medicine for curing headaches, colds, migraine, eye-pain, asthma, chronic bronchitis, and gastrointestinal infections. Recent studies have shown that the extracts from Vitex rotundifolia contain iridoids, flavonoids, and compounds with biochemical properties. In this study, C57BL/6 mice were treated topically on the depilated dorsal skin with Vitex rotundifolia extract dissolved in 70% EtOH. Moreover, treatment of Vitex rotundifolia extract onto hair cells induced more 20% growth of proliferation compared only control treated group. Also, the ratio of follicle number of anagen phase/total was increased. This result explains that Vitex rotundifolia extract has effect on prolong of anagen phase, so Vitex rotundifolia might be a potential new therapeutic source for the hair growth promotion.

피부로 침투된 양자점 나노입자의 분포와 전자현미경 분석 시 발견되는 오스뮴산 결합물과의 구분

최기주,박상용,이정민,신헌섭,양정은,이돈길,이태후,Choi, Ki-Ju,Park, Sang-Yong,Lee, Jeong-Min,Shin, Heon-Sub,Yang, Jung-Eun,Lee, Don-Gil,Mavonov, Garfurjon T.,Yi, Tae-Hoo 한국현미경학회 2012 Applied microscopy Vol.42 No.1

나노입자의 가능성은 의생물학 분야의 연구자들에 의해 열띤 토론이 되어지고 있다. 우리는 일종의 추적자인 양자점(quantum dots)을 이용하여 피부로 침투된 나노입자의 분포를 전자현미경으로 확인하는 과정에서 나타나는 문제점과 이를 해결하기 위한 방법을 제안해 보고자 하였다. 나노입자는 피부의 각질층과 모공을 통한 일부 피지세포 내부까지 침투되는 것을 확인하였다. 이 과정에서 오스뮴산이 세포 내 지방산과의 결합에 의해 나노입자 형태의 축적물이 생성되는 것을 확인할 수 있었고, 이것은 의도한 나노입자(양자점)의 분포를 확인하는데 간섭을 주는 요인이 되는 문제점을 발견하였다. 이를 해결하기 위해, 양자점과 오스뮴산을 달리 처리하는 방법을 통하여 각각의 사진에서 나타나는 나노입자의 진위 여부를 비교하므로 의도한 나노입자의 정확한 분포를 확인할 수 있었다. 이러한 결과는 의생물 분야에서 생체내 나노입자의 분포를 확인하기 위한 연구 시 오차를 감소시키고, 보다 정확한 분석을 제공할 수 있을 것으로 기대해 본다. The possibility of nanoparticles (NPs) in biotechnology had been discussed by biomedical investigators. Here we report to suggest a solution and problems when using electron microscopy to determine the distribution of quantum dots (QDs) nanoparticles that penetrate skin. The results of this study showed that NPs were able to penetrate stratum corneum (SC) and sebocyte via hair follicle. However, we have found artifacts such as nanoparticles that are produced from combination of free fatty acid and osmium tetroxide during specimen preparation. It is usually difficult to identify NPs. Therefore, we tried to resolve these problems by comparing the cross-correlation image pattern that are derived from the images of sample that had been processed differently. This method can contribute to more accurate interpretation and minimal errors during the analysis using quantum dot as tracer.

밀몽화 추출물의 멜라닌 생합성 억제 효과 및 항산화 활성 효과

박상용 ( Sang Yong Park ),이강진 ( Kang Jin Lee ),이태후 ( Tae Hoo Yi ) 한국두피ᆞ모발미용학회 2009 대한미용학회지 Vol.5 No.1

본 연구에서는 밀몽화(Buddleja officinalis) 추출물의 항산화 효과와 멜라닌 합성 저해 효능을 평가하였다. 건조된 밀몽화의 70% Ethanol 추출물에 대하여 용매별로 분획을 실시하였고, Ethyl acetate, Butanol 및 H2O 분획에 대하여 항산화 활성 및 Tyrosinase 활성 저해능을 조사 하였다. 밀몽화 70% ethanol 추출물과, Ethyl acetate 분획층은 50% 이상의 DPPH 라디칼 제거능을 보여주었다. 특히, Ethyl acetate 분획층의 경우 Tyrosinase의 활성을 70% ethanol 추출물이나 다른 분획층 보다 효과적으로 억제하였다. 또한, 세포 내에서 세포 생존율에는 변화를 주지 않으며 멜라닌의 합성을 40% 이상 저해하였다. 이러한 밀몽화 추출물의 항산화 활성과 멜라닌 합성 저해 효능은 밀몽화 추출물이 유력한 미백 물질을 함유하고 있다는 것을 예상할 수 있게 한다. 그리고 더 나아가 밀몽화 추출물을 이용한 미백 기능성 화장품 및 식품 개발에 응용할 수 있을 것으로 예상된다. Melanin synthesis is related to the presence of tyrosinase. Therefore, tyrosinase inhibitors are useful skin-whitening agent. In this study Buddleia officinalis (B.O.) extract was used for searching the anti-oxidative and skin whitening effects. As a result, B.O. extracts showed over 50% of free radical scavenging activity on DPPH at a concentration of 100 μg/mL compare to control. B.O. extracts showed 44% inhibitory effect on tyrosinase activity in the mushroom tyrosinase of 100 μg/mL. And EA fraction inhibited more than 70% of tyrosinase activity at the same concentration. Also, B.O. extracts showed effectiveness in inhibiting L-DOPA auto-oxidation. Melanin biosynthesis was estimated from B16 mouse melanoma cell, which treated with 10 nM of α-MSH and with or without B.O. extracts. B.O. extracts inhibited (>40%) melanin synthesis at 100 μg/mL, but it did not affect on cell viability. This indicated B.O. extracts inhibited tyrosinase activity and melanin biosynthesis.