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Solution Structures and Molecular Interactions of Selective Melanocortin Receptor Antagonists
이철진,윤지혜,임승길,이원태 한국분자세포생물학회 2010 Molecules and cells Vol.30 No.6
The solution structures and inter-molecular interaction of the cyclic melanocortin antagonists SHU9119, JKC363,HS014, and HS024 with receptor molecules have been determined by NMR spectroscopy and molecular modeling. While SHU9119 is known as a nonselective antagonist,JKC363, HS014, and HS024 are selective for the melanocortin subtype-4 receptor (MC4R) involved in modulation of food intake. Data from NMR and molecular dynamics suggest that the conformation of the Trp9 sidechain in the three MC4R-selective antagonists is quite different from that of SHU9119. This result strongly supports the concept that the spatial orientation of the hydrophobic aromatic residue is more important for determining selectivity than the presence of a basic, ‘‘arginine-like’’ moiety responsible for biological activity. We propose that the conformation of hydrophobic residues of MCR antagonists is critical for receptor-specific selectivity.
이철진 한국엔터테인먼트산업학회 2019 한국엔터테인먼트산업학회논문지 Vol.13 No.8
One philosopher said that knowing the identity of one clump of grass on the roadside could reveal all the mysteries of the universe. If you know one, you can know two. If you know two, you can know three. If you know the form, you can know the whole. If you know the image(eidos), you can know the non-image, life, and death. But we are wandering in a dream because we don't know the one clump of grass,“One”. For a long time I have been searching for a road to know“One”. While studying of the process searching the truth, not only do we reveal logic development making One a language, but also we would like to provide the application of cultural contents applied to that One.
호텔 종사자의 지각된 조직공정성과 경력정체, 심리적 계약 간 관계 연구
이철진,천민호 관광경영학회 2015 관광경영연구 Vol.67 No.-
This study aims to analyze the structural relationship among perceived organizational justice, career plateau and psychological contract intention by hotel employees based on rapidly changing employment circumstances and rapidly growing management characteristics of hotel industry in recent years. For actual proof analysis, I have extracted 214 samples through a survey performed on employees of tourist hotels located in Seoul, and analyzed basic data and structural equation model by using SPSS 23.0 and AMOS 23.0. As a result, the following implications were drawn. First, perceived organizational justice by hotel employees was analyzed to have positive(+) effect on the career plateau; secondly, content plateau among subordinate concepts of career plateau was analyzed to have positive(+) effect on the psychological contract; third, the procedural justice was analyzed to have no meaningful effect on the career plateau. Consequently, this study found conflicting result with the existing studies which claim that hotel employees who perceive career plateau have negative effect on their attitude toward organization and job intention; this result explains the importance of job stability perceived by employees in recent management environment, and suggests that career plateau with justice could take positive role in subjective and psychological continuous relationship orientation issues that employees have against hotel company.