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        • KCI등재SCOPUS

          Bladder Pain Syndrome Treated with Triple Therapy with Gabapentin, Amitriptyline, and a Nonsteroidal Anti-Inflammatory Drug

          이지완,한동엽,정희종 대한배뇨장애요실금학회 2010 International Neurourology Journal Vol.14 No.4

          Purpose: Bladder pain syndrome is a chronic disease that manifests as bladder pain, frequency, nocturia, and urgency. Gabapentin, amitriptyline, and nonsteroidal anti-inflammatory drugs are efficacious treatments for bladder pain syndrome. Here, we assessed the effect of triple therapy with these drugs in women with bladder pain syndrome. Methods: Between May 2007 and May 2010, we conducted a prospective nonrandomized study on 74 patients with bladder pain syndrome. Of these patients, 38 (11 men and 27 women; mean age, 55.9 years; range, 25 to 77 years; mean follow-up, 12.6 months) were administered the interstitial cystitis (IC) symptom scales (O'Leary-Sant Symptom Index) and visual analog scale (VAS) 1, 3, and 6 months after treatment to assess the efficacy of triple therapy. Results: The pretreatment O'Leary-Sant IC symptom score was 11.7, and the post-treatment scores were 4.4, 3.8, and 4.0 at 1, 3, and 6 months, respectively; the pretreatment problem index score was 10.5, and the post-treatment scores were 3.7, 2.7, and 2.9 at 1, 3, and 6 months, respectively. The pretreatment VAS score was 6.7, and the post-treatment scores were 1.8, 1.5, and 1.7 at 1, 3, and 6 months, respectively. The O'Leary-Sant IC symptom index and problem index and VAS scores improved considerably 1 month after treatment (P<0.05). However, the results at 1, 3, and 6 months after treatment were not significantly different (P>0.05). Conclusions: Triple therapy was sufficiently effective in patients with bladder pain syndrome and caused no significant adverse effects. However, large-scale studies should be performed to verify our findings. Purpose: Bladder pain syndrome is a chronic disease that manifests as bladder pain, frequency, nocturia, and urgency. Gabapentin, amitriptyline, and nonsteroidal anti-inflammatory drugs are efficacious treatments for bladder pain syndrome. Here, we assessed the effect of triple therapy with these drugs in women with bladder pain syndrome. Methods: Between May 2007 and May 2010, we conducted a prospective nonrandomized study on 74 patients with bladder pain syndrome. Of these patients, 38 (11 men and 27 women; mean age, 55.9 years; range, 25 to 77 years; mean follow-up, 12.6 months) were administered the interstitial cystitis (IC) symptom scales (O'Leary-Sant Symptom Index) and visual analog scale (VAS) 1, 3, and 6 months after treatment to assess the efficacy of triple therapy. Results: The pretreatment O'Leary-Sant IC symptom score was 11.7, and the post-treatment scores were 4.4, 3.8, and 4.0 at 1, 3, and 6 months, respectively; the pretreatment problem index score was 10.5, and the post-treatment scores were 3.7, 2.7, and 2.9 at 1, 3, and 6 months, respectively. The pretreatment VAS score was 6.7, and the post-treatment scores were 1.8, 1.5, and 1.7 at 1, 3, and 6 months, respectively. The O'Leary-Sant IC symptom index and problem index and VAS scores improved considerably 1 month after treatment (P<0.05). However, the results at 1, 3, and 6 months after treatment were not significantly different (P>0.05). Conclusions: Triple therapy was sufficiently effective in patients with bladder pain syndrome and caused no significant adverse effects. However, large-scale studies should be performed to verify our findings.

        • KCI등재

          SWAT을 이용한 미래기후변화에 따른 금강유역의 지하수위 거동 평가

          이지완,정충길,김다래,김성준,Lee,,Ji,Wan,Jung,,Chung,Gil,Kim,,Da,Rae,Kim,,Seong,Joon 한국수자원학회 2018 한국수자원학회논문집 Vol.51 No.3

          본 연구에서는 금강유역($9,645.5km^2$)을 대상으로 SWAT (Soil and Water Assessment Tool)을 이용하여 HadGEM3-RA RCP 4.5와 8.5 기후 변화 시나리오에 따른 미래 기간(2020s: 2010~2039, 2050s: 2040~2069, 2080s: 2070~2099 )의 지하수위 변화를 평가하였다. 이를 위해 SWAT 모형의 검 보정은 11년(2005~2015)동안의 유역내 2개 댐지점(대청댐, 용담댐)의 일별 유입량 및 저수량, 5개 관정지점(JSJS, OCCS, BEMR, CASS, BYBY)의 일단위 지하수위 관측자료, 3년 5개월(2012년 8월~2015년 12월) 동안의 3개 보지점(세종보, 공주보, 백제보)의 일별 유입량 및 저수량 자료를 이용하였다. 2개 댐의 유입량 및 저수량 검보정 결과, Nash-Sutcliffe 모델효율(NSE)은 각각 0.57~0.67, 0.87~0.94, 결정계수($R^2$)는 각각 0.69~0.73, 0.63~0.73의 범위를 보였으며, 3개 보의 유입량 및 저수량의 NSE는 각각 0.68~0.70, 0.94~0.99, $R^2$는 각각 0.83~0.86, 0.48~0.61로 검보정 되었다. 5개 지점의 지하수위에 대한 $R^2$는 0.53~0.61이었다. 유역 전체의 미래 기온은 기준년도(1976~2005) 대비 2080s RCP 8.5 시나리오에서 최고 $4.3^{\circ}C$ 상승하고 강수량은 6.9% 증가하였으며, 미래 지하수위는 5개 지하수위 관측지점 중 금강 상류 3개 지점(JSJS, OCCS, BEMR)에서 각각 -13.0 cm, -5.0 cm, -9.0 cm 감소하였고, 금강 하류 2개 지점(CASS, BYBY)에서는 각각 +3.0 cm, +1.0 증가하였다. 미래 지하수위는 유역 내 강수량의 계절별 공간적 편차에 따른 지하수 충전량의 차이에 기인한 것으로 판단된다. The purpose of this study is to evaluate the groundwater level behavior of Geum river basin ($9,645.5km^2$) under future climate change scenario projection periods (2020s: 2010~2039, 2050s: 2040~2069, 2080s: 2070~2099) using SWAT (Soil and Water Assessment Tool). Before future evaluation, the SWAT was calibrated and validated using 11 years (2005~2015) daily multi-purpose dam inflow at 2 locations (DCD, YDD), ground water level data at 5 locations (JSJS, OCCS, BEMR, CASS, BYBY), and three years (2012~2015) daily multi-function weir inflow at 3 locations (SJW, GJW, BJW). For the two dam inflow and dam storage, the Nash-Sutcliffe efficiency (NSE) was 0.57~0.67 and 0.87~0.94, and the coefficient of determination ($R^2$) was 0.69~0.73 and 0.63~0.73 respectively. For the three weir inflow and storage, the NSE was 0.68~0.70 and 0.94~0.99, and the $R^2$ was 0.83~0.86 and 0.48~0.61 respectively. The average $R^2$ for groundwater level was from 0.53 to 0.61. Under the future temperature increase of $4.3^{\circ}C$ and precipitation increase of 6.9% in 2080s (2070~2099) based on the historical periods (1976~2005) from HadGEM3-RA RCP 8.5 scenario, the future groundwater level shows decrease of -13.0 cm, -5.0 cm, -9.0 cm at 3 upstream locations (JSJS, OCCS, BEMR) and increase of +3.0 cm, +1.0 cm at 2 downstream locations (CASS, BYBY) respectively. The future groundwater level was directly affected by the groundwater recharge by the future seasonal spatial variation of rainfall in the watershed.

        • KCI등재

          금강유역 2014~2016년 기상학적 가뭄과 농업가뭄간의 상관성 평가

          이지완,김경호,김세훈,우소영,김성준 한국습지학회 2019 한국습지학회지 Vol.21 No.5

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          The purpose of this study is to analyze the relationship between SPI (Standardized Precipitation Index) meteorological drought and RDI (Reservoir Drought Index) agricultural drought for Geum river basin. Drought Indices was calculated by collecting data of precipitation and agricultural reservoir water storage rate from 2014 to 2016. To evaluated the correlation between meteorological and agricultural drought, the Pearson correlation and the Receiver Operation Characteristic (ROC) analysis were conducted to evaluate the correlation between meteorological and agricultural droughts. The SPI-6 and RDI showed the highest relationship with Pearson coefficient 0.606 and ROC hit rates 0.722 respectively, and the spatial occurrence patterns of drought using overlapped SPI-6 and RDI, the big differences between the 2 indices were occurred in the upstream areas of Miho stream and Nonsan stream from August to October 2015. The analysis using reservoirs specifications for areas where reservoir droughts occurred was conducted, and the areas showing severe drought of RDI were the reservoir areas having relatively small value of basin magnifying power (BMP). This means that a reservoir has the reaction capability for agricultural drought mainly depending on the reservoir BMP. 본 논문의 목적은 금강유역을 대상으로 Standardized Precipitation Index (SPI) 기상학적 가뭄지수, 농업용 저수지 가뭄지수(Reservoir Drought Index, RDI)간의 관계를 통해 기상학적 가뭄이 농업에 미치는 상관성을 분석하는데 있다. 2014년부터2016년까지의 강수량, 농업용 저수율 자료를 수집하여 가뭄지수를 산정하였으며, 기상학적 가뭄과 농업가뭄간의 상관성을평가하기 위해 Pearson 상관계수와 Receiver Operation Characteristic (ROC) 분석을 실시하였다. 상관분석결과 SPI-6와RDI의 Pearson 및 ROC 적중룰이 각각 0.606, 0.722으로 가장 높게 분석되었고 가뭄의 공간적 발생패턴을 분석하기 위해공간분포된 SPI-6와 RDI를 중첩한 결과 2015년 8월부터 2015년 10월의 심한 가뭄 발생 시 미호천 상류 유역과 논산천 유역에서 중복적으로 가뭄의 심도의 차이가 발생하는 것을 확인하였다. 저수지 가뭄이 발생한 지역에 대한 저수지의 제원을 이용하여 분석을 수행한 결과, RDI 가뭄이 크게 나타난 지역은 유역배율이 작은 저수지들이 많이 모여 있는 지역일수록 극심한 가뭄을 겪는 것으로 분석되어, 유역배율에 따라 저수지의 농업가뭄 대응능력에 차이가 있음을 확인하였다.

        • KCI등재

          KOMPSAT-2 위성영상과 현장 측정자료를 통한 식생지수와 수확량의 상관관계 분석

          이지완,박근애,조형경,이규호,나상일,박종화,김성준 한국농공학회 2011 한국농공학회논문집 Vol.53 No.3

          This study refers to the derivation of simple crop yield prediction equation by using KOMPSAT-2 derived vegetation index. For a 1.25 ha small farm area located in the middle part of South Korea, the KOMPSAT-2 panchromatic and multi-spectral images of 31th August 2008, 17th November 2008, and 10th September 2009 were used. The field spectral reflectance during growing period for the 6 crops (rice, potato, corn, red pepper, garlic, and bean) were measured using ground spectroradiometer and the yield was investigated. Among the 6 vegetation indices (VI), the NDVI and ARVI between measured and image derived showed high relationship with the coefficient of determination of 0.85 and 0.95 respectively. Using the 3 years field data, the NDVI and ARVI regression curves were derived, and the yields were tried to compare with the maximum VIs value.

        • KCI등재

          보육료지원 확대의 여성 노동공급 효과 분석

          이지완 한국사회복지정책학회 2020 사회복지정책 Vol.47 No.2

          This study aims to analyze the effect of childcare subsidy which expanded to all classes on the labor supply of mothers in 2013. Furthermore, it intends to examine if the policy affects differently according to women's educational level and the age of the child. Considering that the expansion of childcare subsidy only affects the household with a child under five years old, the analysis employs the methodology of difference in difference that identifies the causal effect of policies. It compares the before and after the policy change, 2010-2011 and 2013-2015 respectively. The analysis model includes basic model, educational level model, and young and younger child model. For analysis, the 13, 14, 16, 17, and 18 waves of Korean Labor and Income Panel Survey were employed. The main findings of the study are summarized as follows. First, as a result of the basic model, the childcare subsidy expansion from 2012 to 2013 significantly increased the propensity of women's labor market participation. It is in line with previous research which confirmed that the childcare subsidy universalization has a positive effect on the mother's labor supply (Lee, 2016; Yoon and Kim, 2017; Kim, 2018). Second, as a result of the educational level model, the size of the labor supply effect is larger for mothers with low educational level. Highly educated women are more likely to have elevated expectations for the quality of childcare institution, thus bearing increased opportunity cost for paid work (Yoon, 2010). Besides, their child-rearing is more difficult to be replaced by a childcare institution (Lee, 2015). Third, as a result of a young and younger child model, mothers of a younger child under 2 years-old has a slightly higher probability of being employed than a young child aged 3-5. These findings have the following implications. This study confirms that the childcare subsidy has a positive role in increasing the labor supply of mothers with a young child. It implies that the expansion of universal childcare contributes to the de-familiarization of childcare in Korea by enabling women to reconcile the paid work and childminding. Besides, this study found that the effect of childcare subsidy expansion differs depending on mothers' socio-economic features. The labor supply effect was higher among women in low socioeconomic status, implying that the childcare subsidies further lessen the childcare burden of mothers with low educational level. 본 연구는 2013 년 전계층으로 확대된 정부의 보육료 지원이 영유아 자녀를 둔 여성의 노동공급에 미치는 영향을 실증적으로 분석하는 것을 목적으로 한다. 보육료 지원 확대가 영유아 가구에게만 영향을 미치는 점을 고려하여 정책의 인과적 효과를 파악할 수 있는 이중차이 분석법(Difference in Difference)을 활용하였다. 정책 확대 이전 시기는 2010-2011년, 이후 시기는2013-2015년으로 설정하여 비교하였고, 연구를 위해 한국노동패널조사 13, 14, 16, 17, 18차자료를 활용하였다. 나아가 본 연구는 정책의 효과가 여성의 학력과 아동의 연령에 따라 상이하게 나타났는지 살펴보고자 하였다. 이를 위해 분석 모형은 총 세 가지로 기본모형, 학력모형, 영⋅유아 모형으로 나누어 집단별로 정책효과를 분석하였다. 분석 결과, 기본모형의 분석 결과 보육료지원 확대는 영유아 모의 노동시장 참여율을 유의미하게 증가시켰다. 학력모형 분석 결과, 보육료 지원 확대로 인한 정책효과가 저학력 집단에서 더크게 나타났다. 영유아 모형에서는 영아 모(母)집단에서 유아 모(母) 집단보다 정책효과가 보다클 것으로 예상했으나 이는 학력모형에 비해 작은 차이였다. 이러한 결과를 통해 보육료 지원 정책이 양육부담으로 인해 노동시장에 참여하기 어려운 모의 노동공급을 증가시키는 데 긍정적인역할을 하고 있다는 것을 확인하였다. 보편적 보육의 확대가 2차 소득자, 즉 여성의 노동공급을증가시키며, 영유아 돌봄의 부담을 점차 탈가족화(de-familization)하는 데 기여하고 있는 것이다. 특히 보육료 지원은 저학력 여성의 노동참가율을 증가시키는 데 더 큰 정책효과가 있어 보육료지원이 양육에 대한 시간적, 금전적 부담을 보다 크게 느끼는 저학력 여성이 경제활동에 참여할 수있도록 보육 부담을 줄여주는 역할을 하고 있음을 확인하였다. 이에 따라 보육에 대한 부담을 보다 완화하고 영유아 모(母)의 경제활동을 지원할 수 있는 정책적 노력을 제언하였다.

        • KCI등재

          Xylooligosaccharide 의 랫트에 대한 아급성경구독성

          이지완,이창승,윤세왕,양창근,이운택,류보경,강부현,박윤제 한국식품위생안전성학회 2000 한국식품위생안전성학회지 Vol.15 No.2

          The subacute toxicity of xylooligosaccharide (XO) was evaluated in SD rats. Groups of 60 male and 60 female rats were orally administered with 0, 333, 1000 or 3000 mg/kg of XO for 13 weeks. The changes of body weight, food and water consumption were investigated for 17 weeks, while heamatological values and histopathological findings were investigated at the end of the 13 weeks and 17 weeks including 4 weeks of recovery periods. No death and toxic effects were observed during the test periods. There were statistically significant changes in several parameters, but these change had no direct relationship to dosage. Clinical changes were general occurrence and no specific toxicity was related to XO. Gross necropsy and histopathology revealed that no target organs were found in the treated mouse with XO. According to the results, no-observed effect level of XO is estimated to be above 3000 mg/kg.

        • KCI등재

          Xylooligosaccharide 의 복귀돌연변이시험

          이지완,이창승,윤세왕,오화균,양창근,이운택,류보경,강부현,박윤제 한국식품위생안전성학회 1999 한국식품위생안전성학회지 Vol.14 No.3

          To evaluate the bacterial reverse mutation of xylooligosaccharide(XO)s the in vitro Ames test using Salmonella typhimurium (TA98, TA100, TA1535, TA1537) and Escherichia coli (WP2 uvrA) was performed. XO was negative in Ames test with Salmonella typhimurium and Escherichia coli with and without rat liver microsomal enzyme (S-9 fraction). According to the results, XO does not cause bacterial reverse mutation.

        • KCI등재

          Xylooligosaccharide 의 랫트에 대한 급성 경구독성

          이지완,이창승,윤세왕,오화균,양창근,박윤재,이운택,류보경,강부현 한국식품위생안전성학회 1999 한국식품위생안전성학회지 Vol.14 No.3

          The acute toxicity of xylooligosaccharide(XO) was evaluated in SD rats. Groups of 15 male and 15 female rats were orally administered XO (0, 5000 or 10000 ㎎/㎏). The changes of body weight and clinical signs were investigated for 14 days after treatments. No death and toxic effects were observed for 14 days. Soft stool and diarrhea appeared right after treatment for over dose and non-digestive feature of XO but these clinical signs disappeared on the next day. No significant changes in body weight and abnormal gross findings were observed in relation to XO. According to the results, XO has no special toxic effects and LD50 values of XO are above 10000 ㎎/㎏ in male and female rats.

        • KCI등재

          KOMPSAT-2 위성영상과 현장 측정자료를 통한 식생지수와 수확량의 상관관계 분석

          이지완,박근애,조형경,이규호,나상일,박종화,김성준,Lee,,Ji-Wan,Park,,Geun-Ae,Joh,,Hyung-Kyung,Lee,,Kyo-Ho,Na,,Sang-Il,Park,,Jong-Hwa,Kim,,Seong-Joon 한국농공학회 2011 한국농공학회논문집 Vol.53 No.3

          This study refers to the derivation of simple crop yield prediction equation by using KOMPSAT-2 derived vegetation index. For a 1.25 ha small farm area located in the middle part of South Korea, the KOMPSAT-2 panchromatic and multi-spectral images of 31th August 2008, 17th November 2008, and 10th September 2009 were used. The field spectral reflectance during growing period for the 6 crops (rice, potato, corn, red pepper, garlic, and bean) were measured using ground spectroradiometer and the yield was investigated. Among the 6 vegetation indices (VI), the NDVI and ARVI between measured and image derived showed high relationship with the coefficient of determination of 0.85 and 0.95 respectively. Using the 3 years field data, the NDVI and ARVI regression curves were derived, and the yields were tried to compare with the maximum VIs value.

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