붕소를 함유하지 않는 E-glass fiber의 제조 및 특성에 대한 연구

이지선,임태영,이요셉,이미재,황종희,김진호,현승균,Lee, Ji-Sun,Lim, Tae-Young,Lee, Yo-Sep,Lee, Mi-Jai,Hwang, Jonghee,Kim, Jin-Ho,Hyun, Soong-Keun 한국결정성장학회 2013 韓國結晶成長學會誌 Vol.23 No.1

E-glass 섬유는 항공기, 자동차, 레져기구의 복합재료 보강용으로 가장 널리 사용되는 유리섬유이다. 그러나 최근 E-glass 섬유의 원재료비 상승, 환경문제 및 화학적 저항성과 기계적 특성을 향상시키기 위해 산화붕소 함량을 8 %에서 0(제로)까지 감소시키는(소위 'Boron free E-glass'라고 불리는) 연구가 진행되고 있다. 본 연구에서는 'BF(Boron free E-glass)' 조성의 벌크유리와 섬유유리를 제조하고, 열적특성 및 광학적특성을 평가하였다. 5~10 %의 서로 다른 알루미나 함량을 갖는 배치를 $1550^{\circ}C$에서 2시간 용융하여 'BF(Boron free E-glass)'가 얻어졌고, 81~86 %의 높은 가시광투과율, $4.2{\sim}4.9{\times}10^{-6}/^{\circ}C$의 낮은 열팽창계수, $907{\sim}928^{\circ}C$의 연화점을 갖는 투명하고 맑은 유리가 얻어졌다. 'BF' 섬유 시편에 대한 화학적내구성 시험에 있어서는 알루미나 함량이 높아질수록 더 좋은 침식저항성을 나타냄을 확인할 수 있었다. E-glass fiber is the most widely used glass fiber for reinforced composite materials of aircrafts, automobiles and leisure equipments. But recently researches are being progressed to reduce boric oxide from 8 % to 0 (zero), as is called 'Boron free E-glass', because of increasing material cost, environmental problem, and improving chemical resistance and mechanical properties of E-glass fiber. In this study, we fabricated the bulk glass and fiber glass of 'Boron free E-glass (BF) compositions', and characterized thermal properties and optical properties. 'Boron free E-glass (BF)' was obtained by the melting of mixed batch materials at $1550^{\circ}C$ for 2 hrs with different $Al_2O_3$ compositions 5~10 %. We obtained transparent clear glass with high visible light transmittance value of 81~86 %, and low thermal expansion coefficient of $4.2{\sim}4.9{\times}10^{-6}/^{\circ}C$ and softening point of $907{\sim}928^{\circ}C$. For the chemical resistance test of 'BF' fiber samples, we identified that the higher alumina contents gives the better corrosion resistance of glass fiber.

신생아기에 새로운 CPS1 유전자 돌연변이가 확인되고, 간세포이식 시행 받은 Carbamoyl phosphatase synthetase 1 deficiency 1례

이지선,양아람,김진섭,박형두,이상훈,이석구,조성윤,진동규,Lee, Jisun,Yang, Aram,Kim, Jinsup,Park, Hyung-Doo,Lee, Sanghoon,Lee, Suk-Koo,Cho, Sung Yoon,Jin, Dong-Kyu 대한유전성대사질환학회 2017 대한유전성대사질환학회지 Vol.17 No.1

Carbamoyl phosphate synthetase 1 (CPS1) 결핍은 요소회로 이상 질환 중 하나로 상염색체 열성으로 유전되며 2q35 염색체에 존재하는 CPS1 유전자 변이로 발생된다. CPS1의 완전한 결핍을 가진 경우 신생아 시기에 빠르게 진행하는 고암모니아혈증으로 발현한다. 신생아 시기의 심한 고암모니아혈증은 즉각적인 치료를 받지 않을 시 심각한 뇌 손상, 혼수, 사망에 이르기에 진단 시 응급 투석과 체계적인 집중 치료가 필요하다. 본 증례는 생후 4일 째 신생아실에서 발열, 경련, 고암모니아혈증이 확인되어 생화학적, 분자유전학적 방법으로 두 개의 새로운 변이 c.1117G>C (p.Ala373 Pro)와 c.1883G>T (p.Gly628Val)가 이형접합체로 발견되고 CPS1 결핍이 진단된 신생아에서 응급 투석 및 집중치료와 함께 궁극적인 치료인 간이식 전 간세포이식술을 생후 1개월에 시행하여 반복적인 고암모니아혈증 발생을 막고 불가역적인 신경손상을 예방하여 현재 생후 6개월까지 단기간 경과관찰 결과 성장과 발달 및 신경학적 예후가 좋음을 보고하는 바이다. Carbamoyl phosphate synthetase 1 deficiency (CPS1D) is an autosomal recessive disorder of the urea cycle that causes hyperammonemia. Two forms of CPS1D are recognized: a lethal neonatal type and a less severe, delayed-onset type. Neonatal CPS1D cases often present their symptoms within the first days of life. Delayed-onset cases are predominantly adolescents or adults, and infantile delayed-onset cases are rare. Severe hyperammonemia in the neonatal period leads to serious brain damage, coma, and death if not treated promptly. Therefore, early diagnosis and acute treatment are crucial. Despite the improvement of treatments, including continuous hemodialysis, ammonia-lowering agents, and a low-protein diet, the overall outcome of severe forms of hyperammonemia often remains disappointing. As the liver is the only organ in which ammonia is converted into urea, liver transplantation has been considered as an elegant and radical alternative therapy to classical dietary and medical therapies. However, liver transplantation has many disadvantages, such as a considerable risk for technical complications and perioperative metabolic derangement, especially in neonates. Additionally, there is a lack of suitable donor organs in most countries. According to recent studies, liver cell transplantation is a therapeutic option and serves as a bridge to liver transplantation. Here, we report a Korean CPS1D patient with novel mutations in CPS1 who was treated by liver cell transplantation after being diagnosed in the neonatal period and showed a good neurodevelopmental outcome at the last follow-up at six months of age.

섬유화 온도 변화에 따른 E-glass fiber의 물리적 특성

이지선,이미재,임태영,이영진,전대우,현승균,김진호,Lee, Ji-Sun,Lee, MiJai,Lim, Tae-Young,Lee, Youngjin,Jeon, Dae-Woo,Hyun, Soong-Keun,Kim, Jin-Ho 한국재료학회 2017 한국재료학회지 Vol.27 No.1

E (Electric) -glass fibers are the most widely used glass fibers, taking up 90 % of the long glass fiber market. However, very few papers have appeared on the physical characteristics of E-glass fibers and how they depend on the fiberizing temperature of fiber spinning. Glass fiber was fabricated via continuous spinning process using bulk E-glass. In order to fabricate the E-glass specimen, raw materials were put into a Pt crucible and melted at $1550^{\circ}C$ for 2hrs; mixture was then annealed at $621{\pm}10^{\circ}C$ for 2hrs. The transmittance and adaptable temperature for spinning of the bulk marble glass were characterized using a UV-visible spectrometer and a viscometer. Continuous spinning was carried out using direct melting spinning equipment as a function of the fiberizing temperature in the range of $1175{\sim}1250^{\circ}C$, while the winder speed was fixed at 500 rpm. Subsequently we investigated the physical properties of the E-glass fiber. The average diameter of the synthesized glass fiber was measured by optical microscope. The mechanical properties of the fiber were confirmed using a UTM (universal materials testing machine); the maximum tensile strength was measured and found to be $1843{\pm}449MPa$ at $1225^{\circ}C$.

ZnO가 포함된 BaO-GeO₂-La₂O₃ 계 광학 유리 특성

이지선,임태영,황종희,이영진,전대우,김선욱,라용호,김진호,Lee, Ji-Sun,Lim, Tae-Young,Hwang, Jonghee,Lee, Youngjin,Jeon, Dae-Woo,Kim, Sun-Woog,Ra, Yong-Ho,Kim, Jin-Ho 한국결정성장학회 2019 韓國結晶成長學會誌 Vol.29 No.5

$3{\sim}5{\mu}m$ 범위의 중적외선에서 75 % 이상의 투과율을 갖는 $BaO-GeO_2-La_2O_3-ZnO$ 계 유리를 제조 및 특성을 평가하였다. Flow button test를 통해 유리 용융이 가능한 조성을 선택 후, ZnO를 10 mol%, 20 mol% 각각 첨가하여 $1350^{\circ}C$에서 1시간 동안 용융하여 $BaO-GeO_2-La_2O_3-ZnO$ 계 유리를 제조하였다. 이 중에서 ZnO를 20 mol% 포함하는 16 mol% BaO-56 mol% $GeO_2-8mol%$ $La_2O_3-20mol%$ ZnO 계 유리 전이 온도 $660^{\circ}C$ 이하, 굴절률 1.70 이상, Knoop 경도 530 이상 값을 가지는 것을 확인하였다. 따라서, ZnO를 20 mol% 포함하는 $BaO-GeO_2-La_2O_3-ZnO$ 계 유리는 저온에서 양호한 용융 상태와 우수한 광학적 특성을 확인하였고 특수 광학용 재료 분야에 충분히 활용이 가능하리라 판단되었다. The glass of $BaO-GeO_2-La_2O_3-ZnO$ system with a transmittance of more than 75 % at mid-wave infrared (MWIR) region in the range of $3{\mu}m$ to $5{\mu}m$ is manufactured and its property is evaluated. After selecting construction that can melt glass through flow button test, $BaO-GeO_2-La_2O_3$ system where 10 mol%, 20 mol% of ZnO were added respectively were melted at $1350^{\circ}C$ for 1 hour and $BaO-GeO_2-La_2O_3$ system of glass was manufactured. Among them, with 20 mol% of ZnO, 16 mol% BaO-56 mol% $GeO_2-8mol%$ $La_2O_3-16mol%$ ZnO system of glass was found to has less than $660^{\circ}C$ of glass transition temperature, more than 1.70 of refractive index, and more than 530 of knoop hardness. Therefore, it is concluded that glass of $BaO-GeO_2-La_2O_3-ZnO$ system of glass with 20 mol% ZnO has good melting conditions at low temperatures and excellent optical properties, thus, can be utilized for special optical materials field.

사업용 화물자동차의 교통사고 예방체계 강화방안 연구

이지선,정승주,허진수,이창섭,Lee, Ji-Seon,Jeong, Seung-Ju,Heo, Jin-Su,Lee, Chang-Seop 대한교통학회 2016 교통 기술과 정책 Vol.13 No.3

LBL법에 의해 TiO₂막이 코팅된 광촉매 글라스 비드 제조

이지선,채유진,이미재,김세기,황종희,임태영,현승균,김진호,Lee, Ji-Sun,Chae, Yoo-Jin,Lee, Mi-Jai,Kim, Sei-Ki,Hwang, Jong-Hee,Lim, Tae-Young,Hyun, Soong-Keun,Kim, Jin-Ho 한국재료학회 2012 한국재료학회지 Vol.22 No.7

$TiO_2$ thin films consisting of positively charged poly(diallyldimethylammonium chloride)(PDDA) and negatively charged titanium(IV) bis(ammonium lactato) dihydroxide(TALH) were successfully fabricated on glass beads by a layer-by-layer(LBL) self-assembly method. The glass beads used here showed a positive charge in an acid range and negative charge in an alkaline range. The glass beads coated with the coating sequence of(PDDA/TALH)n showed a change in the surface morphology as a function of the number of bilayers. When the number of bilayers(n) of the(PDDA/TALH) thin film was 20, Ti element was observed on the surface of the coated glass beads. The thin films coated onto the glass beads had a main peak of the (101) crystal face and were highly crystallized with XRD diffraction peaks of anatase-type $TiO_2$ according to an XRD analysis. In addition, the $TiO_2$ thin films showed photocatalytic properties such that they could decompose a methyl orange solution under illumination with UV light. As the number of bilayers of the(PDDA/TALH) thin film increased, the photocatalytic property of the $TiO_2$-coated glass beads increased with the increase in the thin film thickness. The surface morphologies and optical properties of glass beads coated with $TiO_2$ thin films with different coating numbers were measured by field emission scanning electron microscopy(FE-SEM), X-ray diffraction(XRD) and by UV-Vis spectrophotometry(UV-vis).

슬래그 재활용 원료를 이용한 유리섬유 제조 및 특성

이지선,김선욱,라용호,임태영,이영진,전대우,김진호,Lee, Ji-Sun,Kim, Sun-Woog,Ra, Yong-Ho,Lim, Tae-Young,Lee, Youngjin,Jeon, Dae-Woo,Kim, Jin-Ho 한국재료학회 2018 한국재료학회지 Vol.28 No.12

In this study, glass fibers are fabricated via a continuous spinning process using manganese slag, steel slag, and silica stone. To fabricate the glass fibers, raw materials are put into an alumina crucible, melted at $1550^{\circ}C$ for 2 hrs, and then annealed at $600^{\circ}C$ for 2 hrs. We obtain a black colored glass. We identify the non-crystalline nature of the glass using an XRD(x-ray diffractometer) graph. An adaptable temperature for spinning of the bulk marble glass is characterized using a high temperature viscometer. Spinning is carried out using direct melting spinning equipment as a function of the fiberizing temperature in the range of $1109^{\circ}C$ to $1166^{\circ}C$, while the winder speed is in the range of 100rpm to 250rpm. We investigate the various properties of glass fibers. The average diameters of the glass fibers are measured by optical microscope and FE-SEM. The average diameter of the glass fibers is $73{\mu}m$ at 100rpm, $65{\mu}m$ at 150rpm, $55{\mu}m$ at 200rpm, and $45{\mu}m$ at 250rpm. The mechanical properties of the fibers are confirmed using a UTM(Universal materials testing machine). The average tensile strength of the glass fibers is 21MPa at 100rpm, 31MPa at 150rpm, 34MPa at 200rpm, and 45MPa at 250rpm.

이달의 당뇨식단

이지선,Lee, Ji-Seon 사단법인 한국당뇨협회 2007 당뇨 Vol.206 No.-

한국인의 항결핵제에 의한 간독성 위험인자 예측

이지선,김현아,조은,이옥상,임성실,Lee, Ji-Sun,Kim, Hyun-Ah,Cho, Eun,Lee, Ok-Sang,Lim, Sung-Cil 대한약학회 2011 약학회지 Vol.55 No.4

Standard combination chemotherapy including isoniazid, rifampin, pyrazinamide, and ethambutol is very effective against tuberculosis. But, these medicines can cause hepatotoxicity which is the main reason for treatment interruption or change in drug regimen. In order to identify risk factors associated with hepatotoxcity in Koreans and assess elevated baseline LFTs' contributions to hepatotoxicity, a retrospective case control study was performed. The medical records of 277 patients who diagnosed with tuberculosis at a community hospital from January 1st, 2007 to June 30th, 2010 were reviewed. Patients were categorized into 3 groups (non toxic group, patients without increase in LFT levels; mild to moderate hepatotoxic group and severe hepatotoxic group). And the correlation between risk factors and hepatotoxicity was analyzed by using SPSS program. The overall incidence of hepatotoxicity was 18% and 8.7% of patients developed severe toxicity. Patients in the severe toxic group had the longest treatment period among the three groups. In 75% of severe toxic group, hepatotoxicity occurred within 18.3 days after starting medication. Hypoalbuminemia (serum albumin <3 g/dl) was a significant risk factor for development of severe toxicity. Elevated baseline transaminase (except ALT), total bilirubin, and preexisting hepatitis were also risk factors which were more than twice as likely to increase risk of severe hepatotoxicity (p>0.05). In conclusion, hypoalbuminemia (serum albumin level <3 g/dl) was a significant risk factor for anti-tuberculosis druginduced severe toxicity. Therefore, before starting antituberculosis chemotherapy, serum albumin level should be assessed at baseline. In high-risk patients (hypoalbuminemia, elevated LFTs) for hepatotoxicty, liver function should be closely monitored up to at least 21 days after taking medication.

지르코니아 함량에 따른 내알칼리 유리섬유의 특성

이지선,임태영,이미재,황종희,김진호,현승균,Lee, Ji-Sun,Lim, Tae-Young,Lee, Mi-Jai,Hwang, Jonghee,Kim, Jin-Ho,Hyun, Soong-Keun 한국결정성장학회 2015 한국결정성장학회지 Vol.25 No.6

기존의 내알칼리 유리섬유는 복합재료의 보강섬유로 가장 널리 사용되고 있는 일반적인 E-glass fiber보다 우수한 내화학 특성을 갖고 있으나 용융유리의 점도가 너무 높아 섬유화가 어려운 문제점을 가지고 있다. 본 연구에서는 지르코니아 함량이 상용 제품에 비해 낮은 범위에서 지르코니아 함량별로 내알칼리유리섬유를 제조하고 이들의 특성을 E-glass 섬유와 비교하였다. 지르코니아의 함량을 0.5~16 wt%까지 변화시키면서 제조한 각각의 배치원료를 $1600^{\circ}C$에서 2시간 용융하여 투명하고 맑은 유리를 얻을 수 있었다. 이들 유리는 약 90 %의 높은 가시광 투과율을 나타내었고, 열적특성에서 $703{\sim}887^{\circ}C$의 연화점을 나타내었으며, 지르코니아의 함량이 증가함에 따라 연화점이 상승하는 경향을 나타내었다. 지르코니아 함량이 4 wt%인 조성을 E-glass 조성과 비교한 결과, 연화점에서는 $-94^{\circ}C$의 차이를, 고온점도에 있어서는 log3 온도가 $+68^{\circ}C$, log5 온도가 $-13^{\circ}C$의 차이를 나타내었다. 내알칼리 유리섬유를 알칼리용액에 48시간 및 72시간 침적 후 SEM을 통해 섬유의 내침식성이 양호함을 확인할 수 있었고, 인장강도도 일반 E-glass 섬유에 비해 48시간에서 1.7배와 72시간에서 2.2배의 높은 값을 나타냄을 알 수 있었다. 결론적으로 이러한 내알칼리 유리섬유는 쉬운 제조조건과 낮은 지르코니아 함량에도 불구하고 좋은 특성 때문에 일반적인 내알칼리 유리섬유로서 널리 사용될 수 있을 것으로 판단되었다. Commercial AR(Alkali Resistant)-glass fiber has a good chemical resistant property, but also has a problem of difficulty in fiberizing process because of high viscosity in melted glass compare with E-glass fiber which is the most widely used for reinforced fiber of composite materials. In this study, we fabricated AR-glass fiber with low zirconia contents compare with commercial AR-glass fiber relatively, and measured properties against E-glass fiber. We obtained transparent clear glass with zirconia contents of 0.5~16 wt% by melting at $1600^{\circ}C$ for 2 hours. These AR-glass samples had high visible transmittance of 89~90 %, softening temperature of $703{\sim}887^{\circ}C$. And softening temperatures of them were increased according to the increasing zirconia contents. Compare with E-glass, AR-glass contains 4 wt% zirconia has different value of $-94^{\circ}C$ in softening temperature, $+68^{\circ}C$ at Log3 temperature and $-13^{\circ}C$ at Log5 temperature in viscosity. We could verify good alkali resistant property of the AR-glass fiber with SEM after dipping in alkali solution for 48~72 hours, and also high tensile strength, 1.7 times compare with E-glass fiber at 48 hours and 2.2 times at 72 hours. We conclude that this AR-glass fiber can be widely used as general alkali resistant glass fiber because of easy manufacturing condition and good properties even though it has low zirconia contents.