신장을 침범한 후복막강 악성섬유성조직구종

이준녕(Jun Nyung Lee),예석준(Seok Jun Ye),김재수(Jae Soo Kim),유은상(Eun Sang Yoo),권태균(Tae Gyun Kwon) 대한비뇨기종양학회 2007 대한비뇨기종양학회지 Vol.5 No.2

화생방 통합 위해인자 탐지장비 개발 및 사용성 평가

이준녕(Lee, Joonnyong),박주옥(Park, Ju Ok),박정호(Park, Jeong Ho),양승만(Yang, Seungman),주윤하(Joo, Yoon-ha),신상도(Shin, Sang Do) 한국방재학회 2017 한국방재학회논문집 Vol.17 No.3

본 연구에서는 특수재난 대응 통합 위해인자 탐지 장비를 고안하고, 제작하여 그 사용성을 평가하였다. 본 연구에서 개발된 장비는 화학 가스 탐지 및 분석, 방사선 탐지 및 분석, 생물학 위해 인자 탐지로 구성이 되었다. 화학 가스 탐지의 결과를 상황 위험도를 나타내는 acute exposure guideline levels (AEGLs)로 변환하여 제시하고 방사선 탐지의 결과는 노출량과 누적량만이 아니라 10mSv를 기준으로 최대 활동 시간으로 제시한다. 최종 사용성 평가에서 개발된 시제품은 탐지 분석 결과에 대한추가적인 정보를 제공하여 사용자가 결과 해석을 쉽게 할 수 있도록 한 특징이 잘 나타났다. 시제품은 여러 장비의 통합으로크기가 크고 운반의 용이성은 떨어졌지만, 전반적 사용성 및 버튼 조작의 편리성, 화면 구성 및 결과 제시 방식에 대한 사용자 만족도는 높은 것으로 나타났다. In this study, we developed a unified chemical, biological, radiological, and nuclear (CBRN) threat analyzer and performed user evaluation of the device. The proposed device is composed of sub-systems capable of analyzing common toxic industrial chemical(TIC) gases, gamma rays, and common non-gaseous biological agents. The threats are analyzed and presented in a user-friendly form; the results of gas analysis are presented in the form of acute exposure guideline levels (AEGLs), the results of radiation analysis are presented in the form of maximum exposure time, and the results of biological agents analyses are presented as present or absent. In the user evaluation, the developed device is compared against commercial devices. Due to the extra analyses on the CBRN threats in addition to chemical gas concentration and radiation levels, the subjects were better able to comprehend the degree of danger as compared to the commercial devices. The proposed device was also rated as bulky and less portable as compared to the commercial devies, but was rated higher in terms of ease of use and information display

거세저항성 전립선암 치료제 개발 동향

김지원(Jiwon Kim),이준녕(Jun Nyung Lee),하윤석(Yun-Sok Ha),권태균(Tae Gyun Kwon),이상규(Sangkyu Lee) 대한약학회 2020 약학회지 Vol.64 No.4

Prostate cancer is one of the most common male cancer. It tends to be known as “mild cancer” due to its high five-year survival rate. However, some patients develop castration-resistant prostate cancer (CRPC) during androgen deprivation therapy (ADT) treatment, with high metastasis and poor prognosis. In addition to conventional ADT treatments, specific treatments are implemented for CRPC. There are four second-generation anti-androgen drugs, taxane chemotherapy, and immunotherapy using vaccines and monoclonal antibodies. This review paper outlines the mechanism of prostate cancer leading to CRPC and reviews the standard treatment of CRPC. It also summarized the trends of anticancer drugs under clinical trials to obtain CRPC as an additional indication.

Clinical Characteristics of Ureteral Duplication in Children

Min-Ji Park,Hee Sun Baek,Hae Min Jang,이준녕,Sung Kwang Chung,Shin Young Jeong,So Mi Lee,Min Hyun Cho 대한소아신장학회 2019 Childhood kidney diseases Vol.23 No.2

Purpose: Ureteral duplication is a relatively common congenital urinary tract abnormality that can be associated with various clinical problems such as vesicoureteral reflux (VUR), hydronephrosis, and ectopic ureters. The purpose of this study was to analyze the clinical characteristics of pediatric patients with recently diagnosed ureteral duplication and to identify any differences from those described in previous reports. Methods: We retrospectively reviewed the clinical characteristics and course of pediatric patients who were diagnosed with ureteral duplication between January 2008 and June 2017. Results: A total of 32 pediatric patients were diagnosed with ureteral duplication during the study period. The male to female ratio was 1:2.2. Twenty-seven patients (84.4%) were first diagnosed with ureteral duplication at less than 3 months of age, and 26 (81.3%) were first diagnosed by prenatal ultrasonography. Four of the 32 patients were diagnosed with bilateral ureteral duplication, for a total of 36 occurrences of ureteral duplication. In 17 occurrences of complete ureteral duplication (47.2%), other urinary tract anomalies were also found; namely, ureterocele (7), VUR (11), and ectopic ureter (5). However, none of the patients with incomplete ureteral duplication had ureterocele or VUR. Conclusions: With the advent of routine prenatal ultrasound, ureteral duplication is being diagnosed earlier than was previously possible, enabling timely treatment of the various accompanying urinary tract anomalies. Multicenter studies are needed to establish guidelines for standardized evaluation and treatment of ureteral duplication.

Impact of Multiple Prostate Biopsies: Risk of Perioperative Complications and Biochemical Recurrence After Radical Prostatectomy

Kyong Min Park(박경민),Jae-Wook Chung(정재욱),Jun-Koo Kang(강준구),Teak Jun Shin(신택준),Se Yun Kwon(권세윤),Hyun Chan Jang(장현찬),Yun-Sok Ha(하윤석),Seock Hwan Choi(최석환),Wonho Jung(정원호),Jun Nyung Lee(이준녕),Byung Hoon Kim 대한비뇨기종양학회 2020 대한비뇨기종양학회지 Vol.18 No.1

Purpose: The aim of this study was to analyze the perioperative complications and oncological outcomes of radical prostatectomy (RP) in patients who underwent multiple prostate biopsies. Materials and Methods: A total of 1,112 patients who underwent RP between January 2009 and April 2016 at 4 different centers were included in this study. We divided these patients into 2 groups: patients who underwent only 1st biopsy, and those who underwent 2nd or more repeated biopsies. The association between the number of prior biopsies and perioperative complications and biochemical recurrence (BCR) was analyzed. Results: Of 1,112 patients, 1,046 patients (94.1%) underwent only 1st biopsy, and 66 (5.9%) underwent 2nd or more repeated biopsies. There were no significant differences in preoperative prostate-specific antigen levels, operation times, blood loss volumes, or hospital stay durations (all p>0.05). Patients who underwent multiple prostate biopsies presented with a localized tumor significantly more often (p<0.05). The Gleason score and rate of positive surgical margins were significantly lower in patients with multiple biopsies (all p<0.05). The Cox proportional hazards model analysis indicated that there was no association between the number of prior prostate biopsies and BCR (p>0.05). Kaplan-Meier curve analysis indicated that BCR-free survival rates between the 2 groups were similar (p>0.05). Conclusions: Multiple prostate biopsies are not associated with an increased risk of perioperative complications, adverse pathological outcomes, or higher rates of BCR in patients who have undergone RP.

The Effects of Oviductal Components on the Motility and Transport in vitro of Mouse Sperms in a Capillary Tube

Lee, Joon-Yeong 全北大學校 師範大學 1976 사대논문집 Vol.2 No.-

배란시기의 수란관 구성물이 배양중인 정자의 운동능과 이동능에 미치는 영향을 보기 위해 본인 등 (1976)에 의해 개발된 미세관 배양장치에서 배양하여 조사한 결과 아래와 같은 결과를 얻었다. 1. 수관란 구성물(minced oviduct)은 정자의 운동능을 배양 4시간에 45.97%(대조군 34.66%), 배양 8시간에 34.16%로 (대조군은 27.69%) 증진시켰다. 2. 수란관 구성물은 배양 4시간에는 정자의 이동능을 매우 증진시켰고(대조군의 약 4배), 배양 8시간에는 3.33%(대조군은 2.75%)로 증진시켰다. 본 실험의 결과로 보아 수란관 내에 분비된 어떤 물질이 수란관 내에서의 정자의 운동능과 이동능을 촉진하는 것으로 사료된다.

Effects of two Methylxanthines on the Oocytes Maturation and Ovulation in the Immature Mouse

Yoon, Yong-Dal,Lee, Joon-Yeong 全北大學校 師範大學 1976 사대논문집 Vol.2 No.-

Cycle AMP의 분해효소인 cAMP phosphodiesterase의 저해제로 알려진 theophylline과 caffeine은 일상생활에서 청량음료 및 차(茶)종류를 통해 매일 섭취 되어지고 있다. 이 두 물질은 또한 antimeiotic effects를 나타내며, 일종의 mutagen으로 많이 연구되어 왔다. 이러한 물질들이 여성 생식기관에 미치는 영향을 찾아 내기 위하여 실험한 결과 다음과 같다. 1) 단순한 chemically defined media인 modified Krebs-Ringer bicarbonate solution으로도 충분히 난소내 난자의 성숙을 유도할 수 있었다. 2) Theophylline은 난소내 난자와 직접 배양된 난자의 성숙을 억제하여 dictyate 시기에 난자를 머물게 하는 반면 caffeine은 난자의 핵막붕괴 시기에는 영향을 주지 않고 난자의 성숙만을 억제하는 효과를 나타냈다. 3) 난자의 성숙을 억제하는 효과는 caffeine보다 theophylline이 더 효과적이며 theophylline은 난자의 핵막이 붕괴된 후의 시기에는 영향이 없어 두 methylxanthine이 난자의 성숙을 억제하는 시기가 다르게 나타내고 있었다. 4) 난자내의 glycogen의 함량은 theophylline에 의해 현저히 감소되며 cAMP나 caffeine은 glycogen의 함량에 영향을 주지 않는다. 5) Theophylline과 caffeine은 생식소자극 홀몬에 의해 유도된 난자의 배란을 현저히 억제하는 효과를 나타내었다. 위의 실험결과로 보아 이들 두 methylxanthine들은 난소내 난자, 또는 난자내의 phosphodiesterase를 억제하여 cAMP의 양을 높임으로서 난자의 성숙을 억제하고, 특히 theophylline은 난자내 glycogen의 함량을 감소시켜 energy 대사의 균형을 파괴하여, theophylline과 caffeine은 난자의 성숙시기에 억제를 나타냄으로서 배란된 난자의 수를 감소시키는 것으로 추정되며, 이들이 포함된 음료수를 일상 마시는 것이 여성의 생식능력에 영향을 미칠 것으로 사료되어 주의를 요한다.