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      • KCI등재

        익상편조직의 섬유모세포에 미치는 사이클로스포린의 영향

        이종수,이승욱,이상준,김나미,Jong Soo Lee,Seung Wook Lee,Sang Jun Lee,Na Mi Kim 대한안과학회 2012 대한안과학회지 Vol.53 No.3

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Purpose: To evaluate the response and cellular damage of cultured human pterygial cells according to the concentration and exposure time of topical cyclosporin. Methods: Human pterygial cells were exposed to a cyclosporin A concentrations of 0.1 μg/ml (0.0001%), 1 μg/ml (0.0001%), 10 μg/ml (0.001%), 100 μg/ml (0.01%), or 500 μg/ml (0.05%) for 5 or 10 minutes. An MTT-based colorimetric assay was performed to assess the metabolic activity of cellular proliferation, and a lactate dehydrogenase (LDH) leakage assay was used to determine cellular damage. The extra-cellular matrix of PIP, laminin and MMP were evaluated, and the measurement of pro-inflammatory cytokine, TNF-α and IL-1b. IL-6, IL-8 was performed using ELISA kits. Results: The pterygial cellular inhibitory effect of cyclosporin was similar to that of the control according to the concentration and exposure time (p > 0.05). Compared with the control, the level of LDH did not show a statistically significant difference between concentration and exposure time (p > 0.05). There was no significant difference of inhibitory effects by PIP, laminin, or MMP between the experimental and control groups (p > 0.05). The production of TNF-α and IL from the experimental pterygial cells due to the effect of cyclosporin was not significantly different from that of the control at a longer exposure time or stronger concentration (p > 0.05). Conclusions: The response of pterygial cells to topical cyclosporin A at concentrations less than 0.05% for less than 10 minutes of exposure time showed no prevention of pterygial recurrence. With regard to cellular damage, little effects on inhibition of PIP, laminin, MMP, IL, and TNF-α were observed compared with that of the control. J Korean Ophthalmol Soc 2012;53(3):466-472

      • KCI등재

        정상 및 원추각막에서 각막 전, 후면의 융기 및 시상면만곡도의 비교분석

        이종수,이승욱,이승민,이미현,Jong Soo Lee,Seung Wook Lee,Seung Min Lee,Mi Hyun Lee 대한안과학회 2012 대한안과학회지 Vol.53 No.10

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Purpose: To compare changes of anterior and posterior corneal elevation, and sagittal curvature according to the severity of keratoconus and to compare differences between keratoconus and normal cornea. Methods: A total of 81 eyes diagnosed with keratoconus and 20 eyes of normal subjects were evaluated with a Pentacam Scheimpflug camera. The keratoconus eyes were divided into 3 groups according to mean keratometer (K): mild (K ≤ 47.0 diopters (D)), moderate (47.0 to 52.0 D), and severe (52.0 D≥). The following parameters were obtained to evaluate the correlation of keratoconus: corneal thickness, anterior and posterior corneal elevation, and sagittal curvature. Results: Out of 81 keratoconus eyes, 56 eyes were mild, 12 eyes were moderate, and 13 eyes were severe keratoconus. The mean central corneal keratometer, anterior and posterior corneal elevation, and sagittal curvature of the keratoconus eyes were 49.7 D, 22.07 μm, 38.16 μm, 52.76 D and the values increased statistically compared to the normal eyes. Furthermore, the values increased significantly with the severity of keratoconus. ROC curve analysis showed the estimated meaningful value for anterior and posterior corneal elevation and sagittal curvature of keratoconus for diagnosis; there were no diagnostic values for corneal thickness and refractive power. Conclusions: The index of 5.5 μm for mean anterior elevation, 12.5 μm for mean posterior elevation, and 44.5 μm for mean sagittal curvature using the PentacamⓇ are useful to diagnose keratoconus. Variation of anterior and posterior elevation, and sagittal curvature measured by PentacamⓇ are useful in understanding the process of keratoconus. J Korean Ophthalmol Soc 2012;53(10):1432-1437

      • 몇종의 세균과 Saccharomyces cerevisiae에 대한 식품첨가물의 향균 특성

        이종수,오준세,김나미,금종화,이석건,Lee, Jong-Soo,Oh, Jun-Sei,Kim, Na-Mi,Keum, Jong-Hwa,Lee, Suk-Kun 배재대학교 자연과학연구소 1996 自然科學論文集 Vol.8 No.2

        현재 식품첨가물로 많이 사용되고 있는 유기산과 안정제 및 색소 등의 각종 세균과 Sacch. cerevisiae 에 대한 향균 특성을 조사하였다. 산도 조절용으로 사용되고 있는 젖산, 사과산, 호박산 및 주석산은 L. acidophilus와 Sacch. cerevisiae에 대하여 향균성이 없었으나 B. subtilis등의 세균에 대하여는 향균성이 있었고 특히 사과산은 P. aeruginosa에 대하여 강한 향균력이 있었다.(최소생육저지농도 : 0.05%). 안정제로서의 알긴산과 펙틴은 B. subtilis, E. coli, P. aeruginosa에 대하여 비교적 강한 향균성을 보였고 L. acidophilus에 대하여는 향균성이 없었다. 황색 색소(홍화엘로우)와 적색 색소(Red powder-N)는 향균성이 없었고 표백제인 $NaHSO_3$의 세균에 대한 최소생육저지농도는 0.05%, Sacch. cerevisiae에 대하여는 0.5%로 향균성이 있었다. In order to survey the safety of some food additives, antimicrobial activity of acidulants, stabilizers, antioxidants, natural coloring materials and bleaching agents against 5 strains of bacteria and Sacch. cerevisiae were investigated by dilution method and minimal inhibitory concentration(MIC) method. Malic acid as acidulants displayed the effective antimicrobial activity in vitro against P. aeruginosa and its MIC is 0.05%. Alginic acid and pectin as stabilizer also displayed strong antimicrobial activity against B. subtilis, E. coli and P. aeruginosa, and tannin(antioxidants) and $NaHSO_3$ displayed antimicrobial activity against all bacteria tested. However gums(Arabia, Xanthan, Gua) and natural coloring materials(Hongwha Yellow, Red powder-N) were not affected to growth of bacteria and Sacch. cerevisiae.

      • KCI등재

        겔형태 인공누액이 각막실질세포 및 결막상피세포에 미치는 영향

        이종수,김은희,김수진,이지은,김나미,Jong Soo Lee,Eun Hee Kim,Soo Jin Kim,Ji Eun Lee,Na Mi Kim 대한안과학회 2010 대한안과학회지 Vol.51 No.12

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Purpose: To evaluate the biological effects and cytotoxicity of gel-type artificial tears on human corneal keratocytes and conjunctival cells in vitro. Methods: Human corneal keratocytes and conjunctival epithelial cells were exposed to Soothe® and Systane® at variable concentrations. Evaluations were conducted through an MTT-based calorimetric assay to measure the metabolic activity and through a lactate dehydrogenase (LDH) assay to assess cellular damage. Apoptotic response was examined using fluorescent microscopy and flow cytometric analysis, and cellular morphologic results were evaluated with a transmission electron microscope. Results: The inhibitory effects of corneal keratocyte and conjunctival cell proliferations increased at higher concentrations and longer exposure times to Soothe® and Systane®. The LDH titers increased after Soothe® exposure, but showed no significant difference after Systane® exposure. Soothe® and Systane® treatments both produced fluorescence, representing apoptotic cells. In flow cytometry, the maximal apoptotic response was observed for both types of artificial tears, although Systane® showed less edema, as well as reduced cytoplasmic and nuclear cell degeneration compared to those of Soothe®. Conclusions: The apoptotic responses of Soothe® and Systane® are associated with inhibitory effects of human corneal keratocyte and conjunctival epithelial cell proliferations. To inhibit the cellular proliferation of human corneal keratocytes and conjunctival epithelial cells, Systane® may be less severe than Soothe® at higher concentrations and longer exposure times. J Korean Ophthalmol Soc 2010;51(12):1643-1651

      • KCI등재

        무형문화유산 Storytelling Marketing 연구 - 종로 '피맛골' 이야기를 중심으로 -

        이종수,Lee, Jong soo 국립문화재연구소 2011 문화재 Vol.44 No.1

        본 연구는 우리나라의 지역전통 문화유산 마케팅을 위하여 문화유산에 전래적 이야기를 입혀 접근하는 감성적 마케팅인 스토리텔링 마케팅 방안을 접목하기 위한 연구이다. 즉, 본 고는 지역의 전통적 문화유산인 지역전통문화유산 특성(DNA)화와 마케팅을 위하여 지역문화유산의 하나인 피맛골 음식에 이야기를 입히는 스토리텔링 적용 방안과 체험사례 개발을 통한 마케팅 방안을 제시한다. 이를 위하여 문화재의 의의와 가치 등과 지역문화유산이란 무엇이며, 문화유산과 스토리텔링의 관계, 스토리텔링 마케팅 사례 분석 및 스토리텔링 적용방안과 체험거리 소재 등을 개발하였다. 구체적으로는 지역문화유산의 사례, 성공요인과 전략, 외국의 사례 등을 제시하였다. 문화유산이란 가장 좋은 자산이라기보다 오로지 유일한 자산이기 때문에 지역의 정체성과 진정성을 담아 국내,외에 알릴 수 있는 요긴한 자산이다. 주요 대상으로 한국의 문화 DNA중 하나인 '꾼, 장이, 뱅이' 등의 사례를 토대로 피맛골 DNA를 추출, 일부 벼슬아치와 보부상(褓負商), 일반 백성인 춘보, 옥섬 이야기 등을 예시하였다. 분석의 초점과 대상은 먼저 피맛골의 시공(時空)과 인간을 소재로 그의 역사성과 이미지, 특성과 유래 등을 재조명하고, 둘째, 스토리와 체험거리로 벼슬아치, 보부상 사례와 '춘보, 옥섬' 이야기를 설정하였으며, 셋째, 스토리 공유과정으로 '뱅이집'(보부상과 춘보 국밥집) 등을 체험할 수 있는 '피마촌' 건립을 제안하였다. The article is organized as follows. The first section clarifies research questions, the purpose of the study and the methodology used when researching cultural properties & storytelling marketing of intangible cultural heritages in Korea. The Pimatgol's DNAs are liberated areas of the nation, cooked rice served in soup, a broth to chase a hangover, makgeolli, so forth. The second section deals with methods of study, the literature review consisting of previous research, the author's previous research and the theoretical background of cultural heritage's storytelling marketing. The third section presents select storytelling marketing cases about our regional cultural heritage as well as some foreign cases. The fourth section provides a few examples and cases of cultural heritage about government officials, the 'Pimatgol' peddler, the story of Chunbo and Okseom and the idea for fostering storytelling marketing. The last section concluded the study. The findings support the importance of understanding the characteristics and differences of cultural heritage & storytelling marketing because if the stories are well told, the cultural heritages will be successfully promoted.

      • KCI등재

        실사적인 3차원 물체 모델링 기법 개선

        이종수,Lee, Jong-Soo 한국정보처리학회 2003 정보처리학회논문지B Vol.10 No.2

        본 논문에서는 실사적인 3D 물체 모델링을 위해 제안된 기법들을 고찰하고, 보다 정확한 모델링을 위한 방안들을 제시하고 있다. F-행렬 추정기법의 개선과 스테레오 영상 평행화기법을 적용함으로 물체 모델링의 정확도를 높히는데 필수적임을 보여준다. In this paper, in-depth considerations are given to various techniques suggested for photographic 3D modelling and possible enhancements of the techniques are discussed. It is found that both the improvement of fundamental matrix estimation techniques and the stereo image rectification processing stage are necessary for more accurate 3D modelling.

      • 유두체가 손상된 횐쥐 암컷의 난소와 자궁 무게

        이종수,강일영,Lee, Jong-Soo,Kang, Il-Yung 대한생리학회 1967 대한생리학회지 Vol.1 No.2

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        흰쥐 암컷 29 마리를 세 무리로 나누어 한 무리에서는 유두체에 둔 전극을 거쳐 직류전류를 흘림으로써 유두체를 파괴하였으며 (유두체군), 다른 한 무리에서는 모든 조작을 유두체군에서와 마찬가지로 시행하였으나 전류는 흘리지 않았고 (수술대조군), 나머지 한 무리는 정상대조군으로 삼았다. 수술이 끝난 한 달후 세무리의 난소와 자궁을 떼어 조사하였으나 위축된 모습을 나타낸 개체는 없었으며, 유두체군, 수술대조군 및 정상대조군 사이에 난소와 자궁의 무게에 있어서 유의한 차이가 없었다. 그러므로 유두체가 여성의 성선자극 호르몬 생산에 관여한다는 증거는 찾을 수 없었다. In order to see whether the mamillary bodies participate in the control of female gonadotrophic function, 12 female rats in which the mamillary bodies were damaged by passing 0.3 ma direct cur-rent through stereotaxically implanted electrodes, 8 rats which received the same treatment except passage of current, and 9 normal rats were prepared. One month after the operation, all animals were sacrificed and their brain lesions checked histologically, their ovaries and uteri examined and weighed. The ovaries and uteri showed neither atrophic changes in any animal, nor significant differences in the weight among the 3 groups. Thus the results do not support the idea that the mamillary bo-dies are implicated in the control of female gonadotrophic function.

      • KCI등재

        β-galactosidase를 생성하는 고온성(高溫性) 세균(細菌)의 생리적(生理的) 특성(特性)에 관한 연구(硏究)

        이종수,김찬조,Lee, Jong Soo,Kim, Chan Jo 충남대학교 농업과학연구소 1982 Korean Journal of Agricultural Science Vol.9 No.1

        고온균(高溫菌)의 생리적(生理的) 특성(特性)과 내열기구(耐熱機構)에 관한 기초자료(基礎資料)를 얻고자 온천토양(溫泉土壤)에서 ${\beta}$-galactosidase를 생산(生産)하는 고온균(高溫菌)을 분리(分離)하여 동정(同定)하고, 몇가지 주요(主要)한 생리적(生理的) 특성(特性)을 검토(檢討)하였으며, 그의 균체지방산(菌體脂肪酸) 조성(組成)을 gas chromatography로 분석(分析)하여 다음과 같은 결과(結果)를 얻었다. 1. ${\beta}$-galactosidase를 생산(生産)하는 공시(供試) 균주(菌株)는 Thermus속(屬)으로 동정(同定)되었다. 2. 분리선정(分離選定)한 균주(菌株)의 최적(最適) 생육온도(生育溫度)는 $65^{\circ}C$이었고, $37^{\circ}C$에서 생육(生育)하지 않는 절대(絶對) 고온균(高溫菌)이었으며 최적(最適) pH는 6.5내외(內外)이었다. 3. NaCl에 대(對)한 내성(耐性)은 NaCl 1% 이상(以上)에서 생육(生育)하지 못했다. 4. 공시균주(供試菌株)의 항생물질(抗生物質) 내성(耐性)은 Penicillin G는 $10{\mu}g/m{\ell}$, Chloramphenicol은 $0.5{\mu}g/m{\ell}$이었다. 5. Vitamin 요구성(要求性)은 Ca-pantothenate와 pyridoxine-HCl을 절대적(絶對的) 생육인자(生育因子)로 요구(要求)하였고 niacin을 자극적(刺戟的) 생육인자(生育因子)로 요구(要求)하였다. 6. 공시균주(供試菌株)는 최대(最大) 흡수파장(吸收波長)이 420nm 부근(附近)의 색소(色素)를 생성(生成)하였고 그의 생성능(生成能)은 약(弱)하였다. 7. 공시균주(供試菌株)의 균체 지방산(脂肪酸) 조성(組成)은 palmitic acid 60.20%, lauric acid 11.80%, myristic acid 7.56%, behenic acid 4.25%, capric acid 1.77%, stearic acid 2.13%, arachidic acid 1.53%이었다. This experiment was carried out to elucidate the thermotolerant properties of a thermophilic bacterium which was isolated from soils of the hot springs area and selected for the ${\beta}$-galactosidase production. This bacterium was identified as a strain belong to the genus Thermus. Biochemical and physiological characteristics of this strain were studied, including the investigation of the fatty acid composition of its neutral fats. The results obtained were summarized as follows. 1. Optimal temperature and pH for growth of this strain were $65^{\circ}C$ and pH 6.5 respectively, and it was found to be an absolute thermophilic bacterium which could not grow at the temperature below $43^{\circ}C$. 2. No growth was obtained in the medium which contained more than 1.0% of sodium chloride. 3. The tolerable concentration of antibiotics were 10mg of penicillin G per ml of medium and 0.5mg of chloramphenicol per ml respectively. 4. This strain had auxotrophilic requirements for calcium-pantothenate and pyridoxin-HCl as an essential factor and for niacin as a stimulative factor. 5. Yellow pigment was released into the liquid culture of this strain, which showed maximum absorption at 420 nm. 6. Fatty acid composition of neutral fats of the strain was palmitic acid, 60.20%; lauric acid, 11.80%; myristic acid, 7.56%; behenic acid, 4.25%; capric acid, 1.77%; stearic acid, 2.13%; arachidic acid, 1.53%; and others unidentified, 10.7%.

      • KCI등재

        송아지 혈청 농도가 인체의 각막상피세포에 미치는 영향

        이종수,김은희,김수진,Jong Soo Lee,MD,PhD,Eun Hee Kim,MD,Su Jin Kim,MD 대한안과학회 2011 대한안과학회지 Vol.52 No.7

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Purpose: To investigate the biologic effects of topical calf serum on corneal epithelial cells in vitro. Methods: The effects of calf serum on the corneal epithelial cells were evaluated using the MTT (3-[4,5-Dimethylthiazol- 2-yl]-2,5-diphenyltetrazolium bromide) assay, and the concentration of IL-1α, TGF-β1 and MMP-9 in the cells was measured. Cell damage was determined using lactate dehydrogenase (LDH), and cellular morphologies were examined by transmission electromicroscopy. Results: Metabolic activity of the corneal epithelial cells decreased at higher concentrations and longer exposure durations. IL-1α, TGF-β1 and MMP-9 titers were lower in calf serum-treated cells than in the control. LDH and cellular damage to the corneal epithelial cells, such as chromatin margination and cytoplasmic organelle swelling, were prominent in cells treated with 30% calf serum. Conclusions: Cellular metabolic activity was higher and cellular toxicity was lower in cells treated with 10% calf serum compared to those treated with the 20% and 30% concentrations. Furthermore, inflammatory cytokines were sufficiently inhibited in cells treated with the 10% solution. These results indicate that 10% calf serum could be used clinically. J Korean Ophthalmol Soc 2011;52(7):852-858

      • KCI등재후보

        시민의 사법참여에 관한 헌법적 검토 : anhand von Einfu¨hrungsmo¨glichkeiten des Jurysystems oder der Scho¨ffengerichtsbarkei

        이종수 법과사회이론학회(구 법과사회이론연구회) 2003 법과 사회 Vol.25 No.-

        Es handelt sich in diesem Aufsatz um eine Mo¨glichkeit der Einfu¨hrung des anglo-amerikanishen Jurysysterms oder der deutschen Scho¨ffengerichtsbarkeit. In diesen La¨ndern haben sich diese Institutionen traditionell herausgebildet, hauptsa¨chlich um die rechtsprechende Gewalt zu kontrollieren. In Korea gibt es noch keine solche Institution. Dementsprechend hat die koreanishce Justiz an der Vertrauenskrise gelitten. Sie wird nach wie vor kein vertrauen der bu¨rger gewinnen ko¨nnen, solange sie keine Justizreform erfolgreich durchfu¨hren kann. Ich gehe davon aus, dass die Einfu¨hrung des Jurysystems oder der Scho¨ffengerichtsbarkeit zur Verwirklichung der Bu¨rgerbeteiligung an der Justiz nicht durch eine Verfassungsa¨nderung, sondern lediglich durch Gesetzesa¨nderungen mo¨glich ist.

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