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냉각전에 생사의 차이가 넙치육의 사후조기의 물리$\cdot$화학적변화에 미치는 영향
조영제,이호수,유승균,김태진,이남걸,최영준,CHO Yong-Je,LEE Ho-Su,YOU Seung-Geun,KIM Tae-Jin,LEE Nam-Gul,CHOI Young-Jun 한국수산과학회 1998 한국수산과학회지 Vol.31 No.4
To clarify the effect of life or death condition before cooling on the physicochemical properties of plaice, Paralichthys olivaceus muscle at the early period after death, the plaices were dipped in the refrigerated sea water ($0^{\circ}C$) either as alive or after anesthesia killing. These samples were stored at $0^{\circ}C$ sea water and the changes in rigor-mortis, ATP breakdown, content of ATP and its related compounds, breaking strength and lactate accumulation through storage were investigated. Acceleration of rigor-mortis, ATP breakdown and lactate accumulation were taster in the samples refrigerated as alive than in samples killed by anesthesia before cooling. ATP in samples refrigerated as alive showed little breakdown until 7.5 hrs but it was decomposed completely after 17.5 hrs storage. The breaking strength in muscle of plaice was 1736.2 $\pm$ 65.4 g immediately after killing. The breaking strength in samples dipped in refrigerated sea water as alive increased more rapidly and showed the maximum value over 7.5 hrs (2183.3$\pm$32.2 g), However, in case of samples killed by anesthesia before cooling, the value and time reached around the maximum breaking strength were 2126.3 $\pm$ 32.2 g and 12.5 hrs, respectively and then decreased until 30 hrs. From these results, it could be suggested that dipping in refrigerated sea water after anesthesia killing before cooling is more effective in maintaining freshness of fresh plaice muscle than refrigerating as alive.
조영일,Jong-Hyun Park,Chul-Won Lee,라원희,정종욱,Jung-Ro Lee,Kyung-Ho Ma,Seok-Young Lee,Kang-Seob Lee,Myung-Chul Lee,Yong-Jin Park 한국유전학회 2011 Genes & Genomics Vol.33 No.2
Sixteen polymorphic microsatellite (SSR) markers, developed from an SSR-enriched genomic DNA library of sesame (Sesamum indicum L.), were used to assess genetic diversity,phylogenetic relationships, and population structure among 150 sesame accessions collected from 22 countries. A total of 121 alleles were detected among the sesame accessions. The number of detected alleles varied from 2 to 18, with an average of 7.6 alleles per locus. Polymorphism information content values ranged from 0.03 to 0.79, with an average of 0.42. These values indicated an excess of heterozygous individuals at 16 loci and an excess of homozygous individuals at three loci. Of these, 32 genotype-specific alleles were identified at 11 of 16 polymorphic SSR markers. Cluster analyses were performed by accession and population, revealing a complex accession distribution pattern with mean genetic similarity coefficient of 0.45 by accession and 0.52 by population. The wide variation in genetic similarity among the accessions revealed by SSRs reflected a high level of polymorphism at the DNA level. Model-based structure analysis revealed the presence of three groups that were basically consistent with the clustering results based on genetic distance. These findings may be used to augment the sesame germplasm and to increase the effectiveness of sesame breeding.
초미세 분쇄한 감국으로부터 추출된 phenolic 화합물의 xanthine oxidase 저해 효과
조영제(Young-Je Cho),김병오(Byung-Oh Kim),박혜진(Hye-Jin Park),이은호(Eun-Ho Lee),조재범(Jae-Bum Jo),이재은(Jae-Eun Lee),임수빈(Su-Bin Lim),김예진(Ye-Jin Kim),박기태(Ki-Tae Park),최무영(Moo-Young Choi) 한국생명과학회 2017 생명과학회지 Vol.27 No.8
본 연구에서 98종의 한약재로부터 인체에 무해한 물과 ethanol을 용매로 이용한 추출물에 대하여 xanthine oxidase (XOase)의 저해에 의한 통풍억제 효과를 측정한 결과 Chrysanthemum indicum L. (83.45%), Cuscuta chinensis (60.22%), Asiasarum sieboldi F. Maekawa (51.66%), Acorus gramineus (67.8%), Aconitum pseudo-laeve var. erectum (75.23%), Thuja orientalis (47.27%), Polygonum aviculare (53.98%), Carthami semen (63.99%), Syzygium aromaticum (40.22%) 등이 비교적 높은 XOase 저해율을 나타내었다. 감국의 경우 물과 ethanol 추출물 모두에서 XOase 저해활성이 가장 높게 측정되어 시료로 선발되었다. 감국의 유효성분을 확인한 결과 단순 고형분보다 고형분에 포함된 phenolic 성분이 XOase 저해 효과에 관여함이 입증되었다. 효율적인 추출을 위한 분쇄조건은 일반분쇄보다는 초미세 분쇄한 시료에서 추출 수율이 높아짐이 확인되었다. 추출된 감국 추출물의 XOase 저해 활성은 ethanol 추출물이 물 추출물에 비해 상대적으로 높은 저해 활성을 나타내었으며, phenolics의 첨가농도가 높아지면서 XOase에 대한 저해 활성은 농도 의존적으로 증가하는 것으로 확인되었다. 따라서 초미세 분쇄 기술은 감국으로부터 XOase 저해 물질의 추출 수율 증가를 목적으로 적용할 수 있는 기술로 개발이 가능할 것으로 판단되었다. In this study, the extracted phenolic compounds from 98 species of oriental herbal medicine were examined for biological activities to be used as functional resources. In particular, the anti-gout effect by xanthine oxidase (XOase) inhibition was determined using water and ethanol as extraction solvents because of their non-toxicity in the human body. The extracts of Chrysanthemum indicum L. (83.45%), Cuscuta chinensis (60.22%), Asiasarum sieboldi F. Maekawa (51.66%), Acorus gramineus (67.8%), Aconitum pseudo-laeve var. erectum (75.23%), Thuja orientalis (47.27%), Polygonum aviculare (53.98%), Carthami semen (63.99%), and Syzygium aromaticum (40.22%) showed relatively high XOase inhibitory activity. Chrysanthemum indicum L. was selected for its high XOase inhibitory activity. The biological compounds in Chrysanthemum indicum L. were identified to contain phenolics included in extracts of solids. Ultrafine grind technology showed a higher extraction yield than normal grind and fine grind technology. Ethanol extracts showed relatively higher XOase inhibitory activity than water extracts. XOase inhibitory activity increased in a dependent manner as phenolic concentration increased. Therefore, ultra- fine grind technology was confirmed for use in increasing the extraction yield of XOase inhibitory compounds from Chrysanthemum indicum L.. Extracts from Chrysanthemum indicum L. are expected to be a useful functional resource for the prevention or treatment of gout.
신부전이 동반된 신실질의 Malakoplakia 1 예
조영일(Young Il Jo),유태석(Tae Seok Yoo),허원만(Weon Mahn Heo),유종길(Jong Kil Yoo),조화상(Hwa Sang Jo),유광하(Kwang Ha Yoo),이순일(Soon Il Lee),임형래(Hyung Rae Lim),김경수(Kyung Soo Kim),전혜정(Hae Jeong Jeon),이현순(Hyun Sun Lee) 대한내과학회 1996 대한내과학회지 Vol.51 No.6
Malakoplakia is a rare chronic granulomatous disease generally confined to the urinary bladder, but occasionally occuring in other tissue. Since the initial case of Michaelis-Gutmann in 1902, about 200 cases have been reproted. Among these cases, renal parenchymal malakoplakia accounts for only 16M. It is most common in middle-aged females with chronic urinary tract infection. The pathogenesis of malakoplakia is unclear, but defective killing and impaired digestion of phagocytosed bacteria as a result of a low GMP/AMP ratio is believed to contribute to its pathogenesis, Improperly digested bacteria be- comes mineralized, leading to the formation of the pathognomonic Michaelis-Gutmann bodies. Renal parenchymal malakoplakia is very rare, and occurs bilateral in about 50% of the cases. Although conservative medical management with an intracellularly active antibiotics, ascorbic acid and a cholinergic agonist has been recommended for unilateral renal malakoplakia, nephrectomy has been advocated as the treatment of choice. Bilateral renal malakoplakia behaves as a progressive, destructive, and fatal disease, and little is known about the satisfactory treatment for it. We experienced a case of renal parenchymal malakoplakia with renal insufficiency in a 66-year-old man. He was admitted for surgery of anal prolapse. On preoperative evaluation, azotemia, pyuria, and an enlarged right kidney were incidentally detected. A percutaneous renal biopsy was performed and the specimen showed the characteristic Michaelis Gutmann bodies, After long-term therapy with antibiotics, renal function was recovered partially, pyuria disappeared and the enlarged kidney decreased in size. Herein, we report this case with a review of the literatures.
Helicobacter pylori 감염에 의한 위염의 병리조직학적 양상 및 박멸치료 후의 호전
조영일(Young Il Jo),박형석(Hyung Seok Park),송기호(Ki Ho Song),인행환(Haeng Hwan In),윤성욱(Seong Yuk Youn),김예리(Yei Lee Kim),이재동(Jae Dong Lee),진춘조(Choon Jo Jin),윤상애(Sang Ae Yoon) 대한내과학회 1998 대한내과학회지 Vol.54 No.2
body and fundus. A signi6cant, positive correlation was noted between HP score and the score for inflammation, for activity, and for mucus depletion. After eradication of HP infection, significant improvement in activity, chronic inflammation, and mucus depletion was detected in responders with a successful HP eradication; the activity return to normal in follow-up, and chronic inflammation and mucus depletion was decreased significally in severity in responders(p<0.05%). No significant reduction in severity of gastritis and mucus depletion was detected in the non-responders with persistent HP infection following anti-HP triple therapy. Conclusion: The eradication of HP results in a rapid, significant histopathological improvement in the gastritis scores and epithelial damage in gastric mucosa.
조영천(Youngchun Jo),강해용(Haeyong Kang),이현경(Hyunkyung Lee),전진호(Jinho Jeon),이현섭(Hyeonseop Lee) 한국물리학회 2024 새물리 Vol.74 No.1
Optoelectronic properties of a phototransistor made from solution-processed amorphous InGaZn oxide (a-IGZO) were investigated. This wide bandgap metal oxide semiconductor is known for its optical transparency, yet it exhibits visible light absorption attributed to sub-gap states resulting from oxygen vacancies. The study found that depositing a thin layer of aluminum oxide (AlO<SUB>x</SUB>) on the transistor channel led to an increase of photocurrent in the visible spectrum. Additionally, surface treatment of the a-IGZO thin film with UV ozone reduced persistent photoconductivity at 450 nm. Analysis of the absorption coefficient and optical band gap indicated that the results were associated with changes in the oxygen vacancy states within the a-IGZO thin film. The ability to control photocurrent and persistent photoconductivity through the deposition of aluminum (Al) and UV ozone treatment opens up exciting possibilities for applications in photosensors and neuromorphic systems.