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      • SCOPUSKCI등재

        HPLC를 이용한 인삼, 홍삼, 산양산삼 및 홍산삼의 성분 비교 분석

        이장호,권기록,차배천,Lee, Jang-Ho,Kwon, Ki-Rok,Cha, Bae-Chun 대한약침학회 2008 Journal of pharmacopuncture Vol.11 No.2

        Objectives The aim of this experiment is to provide an differentiation of ginseng, red ginseng, cultivated wild ginseng(CWG), and red wild ginseng(RWG) through component analysis using HPLC(High Performance Liquid Chromatography, hereafter HPLC). Methods Comparative analyses of ginsenoside $Rg_3$, ginsenoside $Rh_2$, and ginsenosides $Rb_1$ and $Rg_1$ of various ginsengs were conducted using HPLC. Results 1. CWG was relatively heat-resistant and showed slow change in color during the process of steaming and drying, compared to cultivated ginseng. 2. Ginsenoside $Rg_3$ was not detected in cultivated ginseng and CWG, whereas it was high in red ginseng and RWG. Ginsenoside $Rg_3$ was more generated in red ginseng than in RWG. 3. Ginsenoside $Rh_2$ appreared during steaming and drying of cultivated ginseng, whereas it was more increased during steaming and drying of CWG. 4. Ginsenoside $Rg_1$ content was more increased during steaming and drying of cultivated ginseng, whereas it was more decreased during steaming and drying of CWG. 5. Ginsenoside $Rb_1$ content was increased about 500% during steaming and drying of cultivated ginseng, whereas it was increased about 30% during steaming and drying of CWG, indicating that ginsenoside $Rb_1$ was more generated in red ginseng than in RWG. 6. Ginsenoside $Rg_3$ content was higher, whereas ginsenoside $Rg_1$ content was lower in 11th RWG than in 9th RWG, indicating that ginsenoside $Rg_3$ content was increased and $Rg_1$ content was decreased as steaming and drying continued to proceed. Ginsenoside $Rh_2$ and $Rb_1$ contents began to be increased, followed by decreased after 9th steaming and drying process. Conclusions Above experiment data can be an important indicator for the dentification of ginseng, red ginseng, CWG, and RWG. And the following studies will be need for making good product using CWG.

      • KCI등재
      • CONDUIT을 이용한 헬리콥터 조종성에 대한 비행제어법칙 설계 및 최적화

        이장호,김응태,이석천,유혁,Lee, Jangho,Kim, Eung-Tai,Lee, Sugchon,Ryu, Hyeok 항공우주시스템공학회 2012 항공우주시스템공학회지 Vol.6 No.2

        The evaluation of simulation models against ADS-33 quantitative rotorcraft handling qualities metrics has, in the past, been a time consuming effort, involving many individual analyses in both the time and frequency domains. Manual tuning of control system parameters to meet handling qualities and performance specifications has been cumbersome and complicated. Performing rigorous trade-off studies for numerous variations in the control system is too time consuming to be practicable. With the complex interaction of time- and frequency based specifications for the closed- and broken-loop responses, it is difficult to know if the design makes the most effective use of the available control power. The Control Designer's Unified Interface (CONDUIT) software makes possible rapid optimization and trade-offs of design configurations against handling qualities specifications.

      • KCI등재

        임상검체에서 분리된 병원성 사상균의 분자생물학적 분석

        이장호,권계철,구선회,Lee, Jang Ho,Kwon, Kye Chul,Koo, Sun Hoe 대한임상검사과학회 2020 대한임상검사과학회지(KJCLS) Vol.52 No.3

        임상 검체에서 분리된 65개의 사상형 진균을 대상으로 연구하였다. 이 균주들은 형태학적으로 동정이 불가능한 진균, 형태학적으로 유사하여 동정이 까다로운 균주, 종(species) 수준의 동정이 요구되는 균종들이다. PCR과 염기서열분석은 ITS. DiD2, 그리고 β-tubulin 유전자를 표적 부위로 하였고, 증폭된 염기서열은 상동성 분석을 위하여 GenBank 데이터베이스의 알고리즘을 이용하여 분석하였다. 형태학적으로 속 수준의 동정이 가능한 진균은 61.5%이었고, 65주의 염기서열분석으로 62 균주는 속과 종의 동정이 가능하였다. 형태학적 검사와 염기서열분석의 결과, 속과 종이 불일치한 경우 14주(21.5%)이었고, 형태학적으로 동정이 불가능하였던 사례는 11 균주이었다. B. dermatitidis, T. marneffei, 그리고 G. argillacea 등은 염기서열분석으로 국내에서 처음으로 확인하였다. Aspergillus와 같이 흔히 분리되고 성장이 빠른 진균들의 경우에는 형태학적인 검사가 보고시간과 비용 면에서는 매우 유용한 방법이다. 분자유전학적인 검사 방법은 비용과 임상적 중요성 등을 고려하여야 하지만 분자유전학적 검사를 병행하여 신속하고 정확한 결과를 제공할 수 있다. Sixty-five molds isolated from clinical specimens were included in this study. All the isolates were molds that could be identified morphologically, strains that are difficult to identify because of morphological similarities, and strains that require species-level identification. PCR and direct sequencing were performed to target the internal transcribed spacer (ITS) region, the D1/D2 region, and the β-tubulin gene. Comparative sequence analysis using the GenBank database was performed using the basic local alignment search tool (BLAST) algorithm. The fungi identified morphologically to the genus level were 67%. Sequencing analysis was performed on 62 genera and species level of the 65 strains. Discrepancies were 14 (21.5%) of the 65 strains between the results of phenotypic and molecular identification. B. dermatitidis, T. marneffei, and G. argillacea were identified for the first time in Korea using the DNA sequencing method. Morphological identification is a very useful method in terms of the reporting time and costs in cases of frequently isolated and rapid growth, such as Aspergillus. When molecular methods are employed, the cost and clinical significance should be considered. On the other hand, the molecular identification of molds can provide fast and accurate results.

      • 95인승급 터보프롭 중형항공기 꼬리날개 사이징

        이장호,강영신,배효길,이해창,Lee, Jangho,Kang, Youngsin,Bae, Hyogil,Lee, Hae-Chang 항공우주시스템공학회 2013 항공우주시스템공학회지 Vol.7 No.3

        Tail wing is important to designing of civil aircrafts, because it is responsible for aircraft stability and control. Tail wing has a role in aircraft control and makes aircraft fly stably without any pilot control input. Also, designing of tail wing determine trim drag force in whole aircraft. Center of gravity(CG) of aircraft travels with various effects as placement of passenger's seats, location of cargo bay, etc. In designing horizontal tail volume, aircraft CG travel has to be considered to have margin so that it should be sized to provide adequate stability and control for the airplane's entire CG range throughout the flight envelope. Finally, it is essential to have sufficient elevator control to perform stall at forward CG for all flaps down configurations. Such stalls establish the FAR stall speed which airplane take-off and landing performance. This paper deals with the process for tail wing design regarding the aircraft CG travel and results for 95-seat type turboprop aircraft.

      • KCI등재

        보리두갈래진딧물 [Schizaphis graminum (Rondani)]의 온도발육과 발육모형

        이장호,김태흥,김지수,황창연,이상계,Lee, Jang-Ho,Kim, Tae-Heung,Kim, Ji-Soo,Hwangn, Chang-Yeon,Lee, Sang-Guei 한국응용곤충학회 2007 한국응용곤충학회지 Vol.46 No.2

        보리두갈래진딧물 [Schizaphis graminum (Rondani)] 의 발육실험은 $15-32.5^{\circ}C$, 상대습도 $65{\pm}5%$, 광주기 16L:8D 조건에서 조사하였다. 진딧물의 발육 중 약충 사충률은 $15^{\circ}C$에서 $32.5^{\circ}C$까지 조사했을 때, 어린약충기간의 사충률이 대부분을 차지하였고, 온도가 높아지면서 사충률이 점차적으로 감소하였다. 그러나 $30^{\circ}C$부터 다시 증가하여, $32.5^{\circ}C$에서 다른 온도보다 사충률이 높게 나타났다. 진딧물의 전체 약충 발육기간을 보면 $30^{\circ}C$에서 4.9 일로 가장 짧았고 $15^{\circ}C$에서 13.8 일로 가장 길었다. $15^{\circ}C$에서 $30^{\circ}C$까지 온도가 증가함에 따라 발육기간이 짧아지는 경향을 보이지만, $32.5^{\circ}C$부터 다시 발육기간이 6.4 일로 길어졌고, $35^{\circ}C$에서는 모든 약충이 죽어서 발육기간에 포함하지 않았다. 발육영점온도는 $6.8^{\circ}C$이었고, 유효 적산온도는 105.9일도였다. 온도별 발육율은 Sharpe and DeMichele 의 모델을 변형시켜 Schoolfield 등이 제시한 온도별 발육모형에 잘 부합되어 보리두갈래 진딧물의 발육모형을 적용하는데 적합한 것으로 생각한다. 생리적 연령에 따른 발육완성시기를 Weibull function을 이용했을 때 온도별 발육시기의 누적발육률을 비교적 잘 설명하였다. The development of Schizaphis graminum (Rondani) was studied at various constant temperatures ranging from 15 to $32.5^{\circ}C$, with $65{\pm}5%$ RH, and a photoperiod of 16L:8D. Mortality of the $1_{st}-2_{nd}\;and\;the\;3_{rd}-4_{th}$ stage nymphs were similar at most temperature ranges while at high temperature of $32.5^{\circ}C$, more $3_{rd}-4_{th}$ stage individuals died. The total developmental time ranged from 13.8 days at $15^{\circ}C$ to 4.9 days at $30.0^{\circ}C$ suggesting that the higher the temperature, the faster the development. However, at higher end temperature of $32.5^{\circ}C$ the development took 6.4 days. The lower developmental threshold temperature and effective accumulative temperatures for the total immature stage were $6.8^{\circ}C$ and 105.9 day-degrees, respectively and the nonlinear shape of temperature related development was well described by the modified Sharpe and DeMichele model. The normalized cumulative frequency distributions of developmental period for each life stage were fitted to the three-parameter Weibull function. The attendance of shortened developmental times was apparent with $1_{st}-2_{nd}\;nymph,\;3_{rd}-4_{th}$ nymph, and total nymph stages in descending order. The coefficient of determination $r^2$ ranged between 0.80 and 0.87.

      • Stateflow를 이용한 소형제트기 Flight Director의 비행모드 구현

        이장호,김성필,성기정,김웅태,Lee, Jangho,Kim, Sungpil,Sung, Kijeong,Kim, Eungtai 항공우주시스템공학회 2007 항공우주시스템공학회지 Vol.1 No.2

        Flight modes of automatic flight control system for light general aviation flight deck. Garmin G1000, were realized using Stateflow. In developing aircraft, it is difficult to verify the operational flight program in particular branch statement because developer can not see any visual logical steam. So, Stateflow has been used to visualize logical stream, transition from one flight mode to another flight mode. The performance was approved by applying flight mode transition conditions of G1000 to proposed transition system that is composed of states, switches, events, data and transition conditions. DURMI-II was used as 6-DOF simulation model.

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