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화장품 소재 개발에 관한 누리장나무 (Clerodendrum trichotomum) 에탄올추출물의 생리활성
전홍신 ( Hong-shin Jeon ),최정윤 ( Choi Jeong Yun ),이인철 ( In-chul Lee ) 대한미용학회(구 대한미용과학회) 2017 대한미용학회지 Vol.13 No.3
The purpose of this study was to determine the potential of Clerodendrum trichotomum as a natural material for cosmetics by investigating the cytotoxicity and bioactivity of the ethanol extracts. The yield rate and phenol contents of ethanol extracts of Clerodendrum trichotomum were 3.85% and 53.266 mg/g, respectively. The electron donating ability was measured as 80.2% at 1000 μg/mL, suggesting that antioxidative activity increases as the density is increases. The inhibition rate at high density was similar with that of ascorbic acid, a control material. For the density of P. acnes, E. coli, S. epidermidis, and S. aureus, the longest ones were S. aureus (12 mm) in 1 mg/mL, S. epidermidis (15 mm) in 5 mg/mL, P. acnes and S. epidermidis (both 15 mm) in 10 mg/mL, and S. epidermidis (15 mm) in 20 mg/mL, respectively. The measurement of scavenging activity for the ABTS radical showed 97.264%, a value similar with those for Ascorbic acid and MTT assay measured by the survival rate of macrophage Raw 267.4 showed that the ethanol extracts of Clerodendrum trichotomum has no toxicity. The expression of iNOS decreased with the density over 100 μg/mL and the inhibiting effect for COX-2 was observed with the density over 300 μg/mL. These results showed that the ethanol extracts of Clerodendrum trichotomum has high potential as a raw material of natural cosmetics and this study is expected to provide fundamental date for the application.
미세먼지 자극에 의한 저온숙성 선인장 열매 추출물의 생리활성 연구
조항의(Hang-Eui Cho),강정욱(Jung-Wook Kang),최순호(Soon-Ho Choi),차영권(Young-Kwon Cha),유단희(Dan-Hee Yoo),김소은(So-Eun Kim),김효민(Hyo-Min Kim),최호민(Ho-Min Choi),조미래(Mi-Rae Jo),김지영(Jee-Yong Kim),이인철(In-Chul Lee) 한국인체미용예술학회 2020 한국인체미용예술학회지 Vol.21 No.1
Air pollutants can trigger various disorders in humans and induce skin aging effects, related cell death, and inflammation. This study demonstrated the effects of low temperature-fermented Opuntia Ficus-Indica Fruit extracts (LTOE) treated total suspended particles (TSP). LTOE induced the expression of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-8 without cytotoxicity. To investigate the anti-aging effect, LTOE inhibited the production of matrix metalloproteinase (MMP)-1 (collagenase) more than Opuntia Ficus-Indica Fruit extracts (OE) in TSP-treated Normal human fibroblast cells. This study reports the significant improvement of anti-inflammation and decrease of MMP-1 related to the LTOE, which will be helpful in processing cosmetic ingredients.
정신지체 및 자폐스펙트럼장애에서 다양한 치료방법의 사용실태
김경민(Kyung Min Kim),이인철(In Chul Choi),이석범(Seok Bum Lee),이경규(Kyung Kyu Lee),백기청(Ki Chung Paik),이정엽(Jeong Yeob Lee),임명호(Myung Ho Lim) 대한소아청소년정신의학회 2014 소아청소년정신의학 Vol.25 No.2
Objectives:The purpose of this study was to investigate the use of various treatment modalities including pharmacotherapy, education-behavior therapy, and complementary alternative treatment for children with mental retardation (MR) or autism spectrum disorder (ASD) in Korea. Methods:The sample consisted of 50 parents who have children with MR (N=28) or ASD (N=22), 38 boys, 12 girls ; mean age 14.06 (4.14) years old. A questionnaire was composed of the experienced modality, duration, cost, satisfaction etc. Results:According to the results, 56.0%, 100.0%, and 36.0% of children with MR or ASD have experienced pharmacological treatment, educational-behavioral therapy and complementary alternative medicine (CAM), respectively. Children who experienced education-behavioral therapy and CAM experienced 3.52 kinds of education-behavioral therapy and 2.78 kinds of CAM, respectively. Monthly cost of pharmacological treatment was lowest among three modality categories. Regarding treatment satisfaction by parental report, the lowest score was recorded fir CAM. Conclusion:Parents who have a child with MR or ASD are trying many treatment modalities and feeling the burden of their treatment.