도인승기탕에 의한 당뇨병성 혈관장애 개선효과

이윤정,김언국,김혜윰,윤정주,이소민,이용표,이건목,강대길,이호섭,Lee, Yun Jung,Kim, Eon Kuk,Kim, Hye Yoom,Yoon, Jung Joo,Lee, So Min,Lee, Yong-Pyo,Lee, Geon Mok,Kang, Dae Gill,Lee, Ho Sub 대한한의학방제학회 2013 大韓韓醫學方劑學會誌 Vol.21 No.1

Objectives : Diabetes mellitus is the leading cause for vascular complications such as atherosclerosis. The present study is to investigate whether Doinseunggi-tang (DST) improves diabetic vascular dysfunction in type II diabetes. Methods : The db/db mice were treated with high fat/high cholesterol diet and DST (200 mg/kg/day) for 8 weeks. Results : DST significantly lowered blood glucose and systolic blood pressure. In addition, DST also markedly decreased total plasma cholesterol, triglyceride, and LDL-cholesterol, whereas increased the HDL-cholesterol. Vascular relaxation of aortic rings by acetylcholine or SNP was ameliorated by DST in a dose-dependent manner. Damage of vascular intima and hypertrophic of media was improved by DST. Immunohistological study revealed that DST attenuated the increase of ICAM-1, VCAM-1, and ET-1 expression in thoracic aorta. Conclusions : Taken together, DST suppressed hyperglycemia and diabetic vascular dysfunction in type II db/db mice. The present data suggests that Doinseunggi-tang may be prevent a development of diabetic atherosclerosis.

고지혈증 동물모델에서 홍삼과 천마 혼합투여에 의한 혈관 염증 개선연구

이윤정,김혜윰,윤정주,이소민,고정현,이호섭,최경민,강대길,Lee, Yun-Jung,Kim, Hye-Yoom,Yoon, Jung-Joo,Lee, So-Min,Kho, Joung-Hyun,Lee, Ho-Sub,Choi, Kyung-Min,Kang, Dae-Gill 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.1

Objectives : This experimental study was designed to investigate the inhibitory effects of combination with Korean red ginseng and Gastrodia rhizoma on vascular dysfunction in high-fat/cholesterol diet-induced hyperlipidemia. Methods : Sprague-Dawley rats were fed with 7.5% cocoa butter and 1.25% cholesterol for 10 weeks, with Panax ginseng (PG), and mixtures of Panax ginseng and Gastrodia rhizoma (PGM), respectively. Results : Chronic treatment with PG and PGM significantly decreased body weight. The aortic expression of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin were markedly increased in hyperlipidemia rats. Interestingly, PGM significantly decreased cell adhesion molecules expression. However, there was no significant decrease in PG group. In addition, PG and PGM group inhibited high-fat/cholesterol diet-induced cytokine such as monocyte chemoattractant protein (MCP-1) mRNA expression. Furthermore, PG and PGM group significantly decreased c-reactive protein protein (CRP) level. Especially, PGM significantly accentuated the decrease of MCP-1 mRNA expression and CRP level. Conclusions : the present study provides an evidence that combination with Panax ginseng and Gastrodia rhizoma enhances anti-vascular protective effects through suppression of vascular inflammation in hyperlipidemic rats.

건강가정지원센터의 교육사업 담당 건강가정사의 직무와 역량에 관한 연구

이윤정,Lee, Yoon-Jung 한국가족자원경영학회 2008 가족자원경영과 정책 Vol.12 No.4

The aims of this article were to examine the basic law, contents and concept of educational program for healthy family and provide the jobs and competency of healthy family supporter for educational work. The research objects were 53 healthy family supporters for educational work inclusive of full-time and part-time position. They was analyzed through the survey. The process of research consisted of two parts. One was to suggest their jobs and requirements, the other were to offer their core competency and area for improvement. First, the jobs of healthy family supporters for educational work were the planning and valuation of program. The requirements for the performance of their duties are having a bachelor's degree or a master's degree, career for 1-3years, and a certificate of qualification of healthy family supporters, social worker and family counselor. Second, their competencies were the understanding of education for family life, management for healthy family support center, planning and valuation of educational program, a theory of counsel, community networking, ability of documentation, sociality, communication skill, the ability of solving the problem, the adaptation of various environments, receptiveness, positiveness and so on.

위눈꺼풀 성형술 후 눈꺼풀계측치의 변화

이윤정,강일봉,김준현,Yoon Jung Lee,Il Bong Kang,Joon Hyun Kim 대한안과학회 2007 대한안과학회지 Vol.48 No.3

Purpose: To evaluate the morphological changes in the external eyes after upper blepharoplasty. Methods: Twenty-six eyes of 13 patients undergoing upper blepharoplasty from May 2002 to May 2003 were selected. All surgeries were performed by one surgeon. MRD1, MRD2, interpalpebral fissure height, and levator function test were each measured twice, and the averages were calculated. Likewise, significant changes were checked before and after the operation. The subjects were divided into two groups. For group A (n=12), a double line suture was stitched at the levator aponeurosis, which was directly superior to the tarsal plate. In group B (n=14) the suture was stitched at a levator aponeurosis 3 mm superior to tarsal plate. The delta levator function (postoperative mean levator function minus preoperative mean levator function) measurements were calculated and compared between the two groups. Results: The MRD1 was 2.04±0.75 (mean±SD) before the operation, and 2.0±0.81 after the operation. MRD2 was 5.23±0.75 before the operation, 5.35±0.54 after operation. Interpalpebral fissure height was 7.27±0.38 before the operation and 7.35±0.63 after the operation. There were no statistically significant factors before and after the operation in MRD1, MRD2 and interpalpebral fissure height. The levator function was 14.04±1.80 before versus 16.19±1.58 after. This increase was statistically significant (p<0.01, Wilcoxon signed ranks test). The delta levator function was 1.58±0.90 for group A and 1.96±1.36 for group B. Conclusions: After upper blepharoplasty, the measurement of levator function increased significantly.

비중격만곡증 환자의 눈물주머니코안연결술의 임상예후

이윤정,문상원,조희윤,정진혁,Yoon Jung Lee,M,D,Sang-Won Moon,M,D,Hee Yoon Cho,M,D,Jin-Hyeok Jeong,M,D 대한안과학회 2008 대한안과학회지 Vol.49 No.5

Purpose: Septal deviation has few subjective symptoms. However, a difficulty remains in doing DCR (dacryocystorhinostomy) in these patients. We investigate the clinical course of DCR in patients with a septal deviation. Methods: Acquired nasolacrimal duct-obstructed patients who had undergone DCR with septal deviation from 2003 to 2006 in our hospital were retrospectively analyzed. We measured the septal distance using paranasal computed tomography taken preoperatively and compared the sex and age of patients, the kinds of operations, outcome of surgery, and ocular and nasal complications in our analysis. Results: Twenty-two eyes of 22 patients with a mean age of 55.3 years (range 29~74) were analyzed (4 males, 18 females). Mean septal distance was 4.84 mm (range 2.18~6.99 mm). Nineteen eyes had endonasal DCR, and three had external DCR. Two had DCR combined with septoplasty. Three had septoplasty as a secondary operation, Nasal complication was synechiae in 9 eyes. DCR success was seen in 15 eyes, and DCR failure in 7 eyes. Septal distance was not correlated with DCR success but was correlated with nasal complication (Mann-Whitney test, p=0.003) Conclusions: In the case of DCR with septal deviation, the surgical technique used will need to minimize the mucosal injury and ensure appropriate nasal correction to prevent future complications.

사체를 이용한 아래눈꺼풀지방의 해부학적 연구

이윤정,강일봉,신선영,백두진,Yoon Jung Lee,M,D,Il Bong Kang,M,D,Sun Young Shin,M,D,Doo Jin Paik,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.7

Purpose: This study investigated the anatomy of infraorbital fat and the relationship between surrounding structures and infraorbital fat. Methods: Forty-one orbits from adult Korean cadavers were dissected. Among them 20 orbits were male and 21 orbits were female. The cadavers were perfused and embalmed in formalin solution. The skin and orbicularis oculi muscle were dissected to expose the arrangement and compartments of infraorbital fat. A punctal probe was used to find a deeper fat compartment lying under the another compartment. The width of each compartment and the distances from the inferior orbital rim and from the lower lid margin to the topmost point of each compartment were measured using a digital caliper. The distance from the top of the medial compartment and lower lid margin to the first appearance of the inferior oblique muscle, located between the medial and the central fat compartments, were measured, respectively. Results: The width of the medial compartment was 11.49±2.54 mm, the central compartment was 21.78±5.69 mm, and the lateral compartment was 17.94±4.99 mm. The distance from the inferior orbital rim to the medial compartment was 8.13±2.72 mm, to the central compartment was 9.91±3.44 mm, to the lateral compartment was 9.58±3.76 mm. The distance from the lower lid margin to the medial compartment was 5.55±1.22 mm, to the central compartment was 7.09±3.22 mm, and to the lateral compartment was 5.41±3.07 mm. The distance from the inferior oblique muscle to the medial compartment was 9.09±2.63 mm, and to the lower lid margin was 13.60±2.27 mm. Conclusions: Our study evaluates the normal anatomy of the infraorbital fat compartments in Korean patients and suggests a useful index for lower blepharoplasty and lower orbital surgery.

당김줄을 이용한 소아 열상 환부의 쉽고 빠른 발사 방법

이윤정,이경석,김준식,김남균,Lee, Yoon-Jung,Lee, Kyung-Suk,Kim, Jun-Sik,Kim, Nam-Gyun 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.2

Purpose: Except for continuous suture in skin layer, stitching out in facial laceration, we have to hold each knots up and cut the knots by No. 11 blade or small scissors. However, we often have difficulty in stitching out the knots on children who do not cooperate well. Therefore we introduce an easy and fast stitch out method of pediatric lacerations. Methods: From January to May 2009, we studied 15 pediatric patients (mean age 5.6 years old) who had facial laceration on face or underwent any surgery on operation room. For easy stitch out, we left the one string of the first knot long enough to extend at the opposite end of laceration site. And then the extended string was fixed to skin using Steri-strip. Next we do simple interrupted suture including the extended traction nylon string inside the knot. Through this method, we can stitch out all knots simply by lifting up the traction nylon needless to hold the each knot one by one. Results: Until stitching out, the traction nylon was just right position and there was no normal tissue injury during stitch out all knots. Patients were satisfied with the short stitch out time. Conclusion: By using the traction nylon on pediatric laceration suture, we can stitch out all the knots with no normal tissue injury in less time.

코눈물관막힘으로 오진된 누낭 편평세포암 1예

이윤정(Yoon-Jung Lee),강성민(Sung Min Kang),태경(Kyung Tae) 대한검안학회 2006 Annals of optometry and contact lens Vol.5 No.1

목적: 누낭에 발생한 종양은 드물며 만성누낭염 및 유루를 주소로 내원한 환자에서 누낭종양의 가능성을 배제하기란 쉽지 않다. 누낭에 발생한 편평상피세포 암종이 단순코눈물관폐쇄로 오진되어 누낭비강문합술을 시행받은 경우를 문헌고찰과 함께 보고하는 바이다. 대상과 방법: 56세 남자가 우안의 눈물흘림을 주소로 개인 병원에서 코경유 누낭비강문합술 및 실리콘관삽입술을 시행받고 3주 후 이유를 알 수 없는 누낭염 및 봉와직염이 발생하였다. 항생제 치료 및 실리콘관 제거에도 불구하고 큰 호전이 없었으며 부비동 수술을 위해 본원으로 의뢰되어 실시한 비점막 동결절편 조직검사에서 편평상피세포암으로 진단되었고 부비동 전산화단층촬영에서 비루관의 확장된 소견과 사골동 및 상악동으로 침윤된 소견이 발견되었다. 본원 이비인후과에서 안와내용제거 술 및 누낭, 골성 및 점막 코눈물관, 상악골, 사골동절제술, 전두동개창술을 포함한 근치절제술을 시행받고 방사선 치료를 병행하였다. 결과: 근치절제술 12개월이 경과한 현재 전산화단층촬영 및 임상검사 소견에서 재발이나 원격 전이 소견은 보이지 않고 정기적인 경과 관찰 중에 있다. Purpose: The incidence of lacrimal sac tumor is rare and it is not easy to rule out the possibility of lacrimal sac tumor in patients with symptom of chronic dacryocystitis and epiphora. We report the case in which the patient with lacrimal sac squamous cell carcinoma was misdiagnosed as simple nasolacrimal duct obstruction and underwent endonasal dacryocystorhinostomy. Methods: A 56-year-old male was underwent endonasal dacryocystorhinostomy with silicone tube insertion in private clinic and presented with dacryocystitis and orbital cellulitis of unknown cause on postoperative 3rd week. After systemic antibiotic therapy and removal of silicone tube, then he was transferred to our hospital, nasal mucosa biopsy was resulted in squamous cell carcinoma and paranasal sinus CT showed that infiltration of tumor into ethmoidal and maxillary sinus. Our otolaryngology department did radical excision including orbital exenteration, removal of lacrimal sac, nasolacrimal duct, etc. Then radiotherapy was added. Results: The patient has been under regular follow-up for 12 month after operation and until recently there has been no evidence of distant metastasis and local recurrence in view of imaging study and clinical examination.

청소년 여성 한부모의 스트레스가 학업지속에 미치는 영향: 아동 양육비 및 돌봄 지원 한부모가족 정책의 조절효과 검증

이윤정 ( Yoon Jung Lee ) 대한가정학회 2017 Human Ecology Research(HER) Vol.55 No.4

The Korean government implemented better support for adolescent single-parent families by expanding the coverage of the Single-parent Family Support Act in 2010. In order to understand the effect, this study verified the moderating effect of the single-parent family policy`s support for child rearing in the context of adolescent female single-parent`s stress levels and education sustainability. This study utilized part of the National Youth Policy Institute`s `Research on the Actual Condition of the Adolescent Pregnancy, Birth and Rearing Children`. Participants of the study were 248 adolescent single-parents aged 24 and below. The findings and discussion of this study are as follows. First, the stress level of adolescent female single-parent in continuing studies was lower than those for discontinued studies. Students who discontinued their education in the middle of studies showed an increase in life stress level relative to age because they had a low level of education and had discontinued studies before pregnancy. Second, the public nanny service has been verified as an element to increase the continuation of education by controlling the level of stress. It is advisable to fortify and expand the scope of support for childcare services in the form of a study assistant or child education assistant. Last, adolescent single-parent childcare subsidies have been verified as a direct factor that raised the meaningful level of education continuity potential to a meaningful standard that can be seen as a more effective method than general policy support for single-parent families.

단일공법 복강경하 난소낭종절제술과 고식적 방법과의 비교

이윤정 ( Yoon Jung Lee ),김명주 ( Myung Joo Kim ),성석주 ( Seok Ju Seong ),김인현 ( In Hyun Kim ),김미라 ( Mi La Kim ),송태종 ( Taejong Song ),윤보성 ( Bo Sung Yoon ),정용욱 ( Yong Wook Jung ),주원덕 ( Won Duk Joo ),전혜선 ( Hye S 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.5

목적 양성 난소낭종절제술에서 단일공과 고식적 복강경수술의 결과를 비교하여 단일공수술의 유용성과 안전성을 알아보고자 하였다. 연구방법2010년 1월부터 2011년 7월까지 단일공 복강경하 양성 난소낭종절제술을 받은 28명을 진단명에 따라 3군(자궁내막종, 성숙기형종, 그외)으로 분류하여 각 1:2비율로 고식적 복강경하 난소낭종절제술 받은 56명을 선정하여, 후향적인 의무기록 분석을 시행하였다. 결과환자의 나이, 체질량지수, 기존의 복강내 수술 여부나 낭종의 양측성 및 낭종의 평균 크기는 두 군 간 유의한 차이가 없었다. 유착박리술여부, 동시에 시행한 수술 여부, 실혈량, 수술시간, 수술 전후 혈색소 수치변화, 추가 진통제 사용 여부, 재원기간의 수술 결과에 있어서 양군 간 유의한 차이가 없었다. 그러나 낭종 종류별 분석결과, 자궁내막증에서 실혈량의 중위값은 단일공군 30 mL (범위, 30-200 mL), 고식적 복강경군 100 mL (범위, 30-450 mL)로 유의한 차이를 보였고( P = 0.017) 수술시간 또한 고식적 복강경 군의 중위값 60분(범위, 40-85분)으로 단일공군의 40분(범위, 30-100분)보다 유의하게 길었다( P = 0.004). 성숙기형종에서는 수술시간, 실혈량은 두 군 간 유의한 차이가 없었으나 수술 후 혈색소 수치감소 중위값은 단일공군에서 2.3 g/dL (범위, 2.0-3.1 g/dL)로 고식적 복강경수술을 받은 군인 1.4 g/dL 범위, 0.1-1.8 g/dL)보다 의미 있게 컸다( P = 0.002). 결론 배꼽 절개를 통한 단일공 복강경수술은 양성 난소낭종절제술에 있어 안전하고 유용하며, 기존의 고식적 복강경하 수술의 대안이 될 수 있다. Objective This study was conducted to compare the surgical outcomes between single-port access (SPA) and conventional laparoscopic ovarian cystectomy. Methods This retrospective, matched case-control study was performed in 84 cases, who underwent SPA laparoscopic ovarian cystectomy (cases: 28) by a single surgeon and conventional laparoscopic ovarian cystectomy (control: 56) by another surgeon who had similar surgical skill at our hospital between January 2010 and July 2011. Results All procedures were performed successfully in both groups without conversion to explo-laparotomy. There was no significant difference in demographic characteristics including size of ovarian cysts, estimated blood loss (EBL), operation time, hemoglobin change, postoperative hospital stay and number of patients needed extra anti-infl ammatory drugs between two groups. Analysis according to the type of cysts, median EBL (30 mL vs. 100 mL, P = 0.017) was higher in conventional group and operation time (40 minutes vs. 60 minutes, P = 0.004) was also longer in conventional group in case of endometrioma. The EBL, median operation time and postoperative hospital days were similar in both group, but median hemoglobin change was less in conventional group (2.3 g/dL vs. 1.4 g/dL, P = 0.002) in mature cystic teratoma patients. There were no signifi cant difference of surgical outcomes in others group. Conclusion SPA laparoscopic ovarian cystectomy using conventional laparoscopic instruments is feasible, effective and reliable technique, which can substitute conventional laparoscopy.