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이욱빈,임재영 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.72 No.5
We report the structural, morphological, optical, and ultraviolet (UV) photoresponse properties of Al-doped ZnO (AZO) thin films prepared on silicon substrates with different Al doping concentrations by using the sol-gel spin-coating method. An analysis of the X-ray diffraction patterns of the AZO thin films revealed that the average grain size decreased and the c-axis lattice constant increased with Al content. The field-emission scanning electron microscopy images showed that with Al doping, the grain size decreased, but the film density increased with increasing Al doping concentration from 0% to 3%. These results indicate that the surface area of the film increased with increasing Al doping. The absorbance spectra revealed that the UV absorbance of the AZO thin films increased with increasing Al doping concentration and that the absorption onset shifted towards lower energies. The photoluminescence spectra revealed that with increasing Al doping, the intensity of the visible emission greatly decreased and the visible emission peak shifted forward lower energy (a red shift). The UV sensor based on the AZO thin films exhibited a higher responsivity than that based on the undoped ZnO thin film. Therefore, this study provides a facile method for improving the photoresponsivity of UV sensors.
Integrin CD11b negatively regulates Mincle-induced signaling via the Lyn–SIRPα–SHP1 complex
Quanri Zhang,이욱빈,강지선,김락균,김영준 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
During mycobacteria infection, anti-inflammatory responses allow the host to avoid tissue damage caused by overactivation of the immune system; however, little is known about the negative modulators that specifically control mycobacteria-induced immune responses. Here we demonstrate that integrin CD11b is a critical negative regulator of mycobacteria cord factor-induced macrophage-inducible C-type lectin (Mincle) signaling. CD11b deficiency resulted in hyperinflammation following mycobacterial infection. Activation of Mincle by mycobacterial components turns on not only the Syk signaling pathway but also CD11b signaling and induces formation of a Mincle–CD11b signaling complex. The activated CD11b recruits Lyn, SIRPα and SHP1, which dephosphorylate Syk to inhibit Mincle-mediated inflammation. Furthermore, the Lyn activator MLR1023 effectively suppressed Mincle signaling, indicating the possibility of Lyn-mediated control of inflammatory responses. These results describe a new role for CD11b in fine-tuning the immune response against mycobacterium infection.
OASL1 Traps Viral RNAs in Stress Granules to Promote Antiviral Responses
강지선,황윤상,김락균,이수정,이욱빈,Jeongsil Kim-Ha,김영준 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.3
Oligoadenylate synthetase (OAS) protein family is the major interferon (IFN)-stimulated genes responsible for the activation of RNase L pathway upon viral infection. OAS-like (OASL) is also required for inhibition of viral growth in human cells, but the loss of one of its mouse homolog, OASL1, causes a severe defect in termination of type I interferon production. To further investigate the antiviral activity of OASL1, we examined its subcellular localization and regulatory roles in IFN production in the early and late stages of viral infection. We found OASL1, but not OASL2, formed stress granules trapping viral RNAs and promoted efficient RLR signaling in early stages of infection. Stress granule formation was dependent on RNA binding activity of OASL1. But in the late stages of infection, OASL1 interacted with IRF7 transcripts to inhibit translation resulting in down regulation of IFN production. These results implicate that OASL1 plays context dependent functions in the antiviral response for the clearance and resolution of viral infections.
박선희,남기웅,김영규,김병구,박영빈,이욱빈,문지연,김동완,김민철,전우성,전민현,송한정,한기호,손근용,이우경,임재영 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.67 No.7
We investigated the structural and the optical properties of ZnO thin films formed on Corning glass by the oxidation of Zn thin films, which were deposited by using thermal evaporation and were then oxidized at 300 − 600 C. The grain size of the ZnO thin films increased and the grains became more densely packed with increasing oxidation temperature. In the photoluminescence (PL) spectra of the ZnO thin films, the intensity of the near-band-edge peak increased with increasing temperature to 500 C, but decreased gradually with further increases in the temperature. The transmittances of the ZnO thin films formed by oxidation at 400 and 500 C were higher than 85% in the visible-light region. Finally, the Urbach energy decreased significantly and the optical band gap exhibited a blue shift with increasing oxidation temperature from 300 to 400 C.
Genome-Wide Profiling of In Vivo LPS-Responsive Genes in Splenic Myeloid Cells
이명섭,김영준,김병일,이선민,조우철,이욱빈,강지선,최원영,류재면 한국분자세포생물학회 2013 Molecules and cells Vol.35 No.6
Lipopolysaccharide (LPS), the major causative agent of bacterial sepsis, has been used by many laboratories in genome-wide expression profiling of the LPS response. However, these studies have predominantly used in vitro cultured macrophages (Macs), which may not accurately reflect the LPS response of these innate immune cells in vivo. To overcome this limitation and to identify inflammatory genes in vivo, we have profiled genome-wide expression patterns in non-lymphoid, splenic myeloid cells extracted directly from LPS-treated mice. Genes encoding factors known to be involved in mediating or regulating inflammatory processes, such as cytokines and chemokines, as well as many genes whose immunological functions are not well known, were strongly induced by LPS after 3 h or 8 h of treatment. Most of the highly LPS-responsive genes that we randomly selected from the microarray data were independently confirmed by quantitative RT-PCR, implying that our microarray data are quite reliable. When our in vivo data were compared to previously reported microarray data for in vitro LPS-treated Macs, a significant proportion (~20%) of the in vivo LPS-res-ponsive genes defined in this study were specific to cells exposed to LPS in vivo, but a larger proportion of them (~60%) were influenced by LPS in both in vitro and in vivo settings. This result indicates that our in vivo LPS-responsive gene set includes not only previously identi-fied in vitro LPS-responsive genes but also novel LPS-responsive genes. Both types of genes would be a valua-ble resource in the future for understanding inflammatory responses in vivo.
김민수,남기웅,김동완,김하은,강해리,이욱빈,최현광,김양수,임재영 대한금속·재료학회 2015 대한금속·재료학회지 Vol.53 No.2
ZnO nanorods were hydrothermally grown on R-plane sapphire substrates coated with an as-grown ZnO seed layer and with ZnO seed layers annealed at different temperatures. The effects of the seed-layer annealing temperature on the structural and optical properties of the ZnO nanorods were investigated using scanning electron microscopy, X-ray diffraction, and photoluminescence. ZnO nanorods and nanosheets grew on the as-prepared seed layer. Only ZnO nanorods grew on the ZnO seed layer annealed above 700 ℃. The structural and optical properties of the ZnO nanorods were significantly enhanced when the seed layers were annealed at 700 ℃. A cubic equation was used to establish the non-linear exciton radiative lifetime of the free exciton emission peak. Varshni’s empirical equation fitting parameters were α = 4 × 10‒3 eV/K, β = 1 × 104 K, and Eg(0) = 3.335 eV; the activation energy was ~94.6 meV.