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이영실,김지연,김승형,김동선,Lee, Young-Sil,Kim, Jiyoun,Kim, Seung-Hyung,Kim, Dong-Seon 대한본초학회 2017 大韓本草學會誌 Vol.32 No.6
Objective : Hyperuricemia is a metabolic disease characterized by elevated blood uric acid levels, and its prevalence is rapidly increasing worldwide. Alpiniae Oxyphyllae Fructus (AO) belonging to Zingiberaceae is one of well-known traditional medicines in China and Korea, and has been used to treat intestinal disorders, urosis, diuresis, and chronic glomerulonephritis traditionally. However, the effect of AO has not been studied. In this study we investigated the anti-hyperuricemic effect of AO, and the mechanisms underlying the effect in potassium oxonate (PO)-induced hyperuricemic rats. Methods : To examine the anti-hyperuricemic effects of the AO extract, serum uric acid levels were analyzed in normal and PO-induced hyperuricemic rats. The mechanism underlying the effects of the AO extract on uric acid levels was studied through xanthine oxidase (XOD) activity test and uric acid uptake assay in vitro. The chemical finger printing of the AO extract was analyzed using HPLC-DAD. Results : The AO extract significantly reduced serum uric acid levels in normal as well as PO-induced hyperuricemic rats. It also significantly inhibited the uptake of uric acid in oocytyes and human embryonic kidney cells (HEK293) expressing urate transporter (URAT)1, but not XOD activity in vitro. The chemical finger printing analysis of the AO extract showed nootkatone as a main component. Conclusion : The AO extract exhibits anti-hyperuricemic effects, and these effect were accompanied by increasing excretion of uric acid in kidney. Therefore, the AO extract could be used for prevention or treatment of hyperuicemia and gout.
주요 외국의 의약품 위험분담제도에 대한 고찰: 계약현황과 사후관리방안을 중심으로
이영실,배승진,이보람,손경복,최현진,배은영,장수현,이태진 한국보건의료기술평가학회 2017 보건의료기술평가 Vol.5 No.1
This study was carried out to investigate the current situation of risk sharing arrangements (RSA) in other countries, mainly focusing on types of contracts and management system, in order to suggest helpful implications for Korean RSA system. United Kingdom (UK), Australia, Italy, Germany were selected considering their similarity with the Korean system and the availability of data. We searched for existing researches, guidelines, reports, and related webpages using PubMed, Google, and relat- ed websites for each country. UK’s RSA is referred to as patient access scheme (PAS). It is included in NICE’s recommendation and does not have specific criteria for application. It uses simple discount schemes more than complex schemes. PAS is evaluated alongside the NICE’s recommendation. Aus- tralian RSA consists of RSA for financial risk and the managed entry scheme (MES) for clinical uncer- tainty. There are no specific criteria in the application for RSA. But the application for MES requires high clinical needs and subsequent clinical trial. Most of contracts are financial-based schemes. Deci- sion about the renewal of contracts is based on the market situation and the newly introduced man- aged access programme (MAP) requires pharmaceutical companies to provide information about potential cancellation of reimbursement and to obtain patient’s consent. Italian RSA is referred to as managed entry agreements. It also does not include specific criteria in the application but has unique national level web-registry. Unusually, Italy uses outcome-based schemes substantially. Germany has unique mandatory rebate system. Overall, there were considerable differences between those countries we examined and Korea. But Australian MAP shed some light on the management of RSA in Korea.
이영실 한국고분자학회 2023 폴리머 Vol.47 No.3
In this study, the phase morphology of polycarbonate/poly(butylene terephthalate) (PC/PBT) blends was examined and the impact of chemical composition, molecular weight, and processing conditions on the phase morphology was determined. Through precise control of these variables, the researchers were able to create PC/PBT nano-blends with exceptional material properties and processing stability. The nano-blend showed remarkable fatigue and impact resistance, making it a strong candidate for use in mobile devices that are exposed to repeated stress and impact. The study also revealed that the PC/PBT morphology can be tailored from micro-scale to nano-scale by using the appropriate processing protocol, allowing for the desired properties to be achieved. The physical properties of the PC/PBT blends were explained in terms of their phase structures, thermodynamics, and kinematic principles.
스포츠 지도자 멘탈코칭 프로그램 개발을 위한 교육요구분석
이영실,이경화 숭실대학교 영재교육연구소 2019 Global Creative Leader Vol.9 No.2
The purpose of this study is to analyze the educational need for mental coaching program development for sports leaders. Based on the previous research, the questionnaire for the educational needs analysis was prepared. The content validity was verified by one professor of pedagogy and two coaching experts, and 150 sports leaders were surveyed. The collected data was analyzed with t-test, Borich need assessment model and the Locus for Focus Model. The findings of this study showed that sports leaders recognized almost the importance and educational necessity of five sub-factors of mental control, self-regulation, coaching leadership, coaching skill and communication. According to the Borich’s educational need analysis, the ranked order was listening, emotion control, alternative search, concentration, and anxiety control. The results of the Locus for Focus Model were derived from the six components of concentration, behavior planning, listening, feedback, empathy, and understanding of others in the HH segment. Based on the results of this study, some implications were suggested. 본 연구는 스포츠 지도자를 위한 멘탈코칭 프로그램이 필요하다는 측면에서 교육요구분석을 통하여 스포츠지도자 멘탈코칭 프로그램에 포함되어야 할 멘탈코칭의 중요도와 교육 필요도 항목의 우선 순위를 규명하는 데에 목적이 있다. 선행연구를 분석하여 요구분석 설문지를 작성한 후, 교육학 교수 1명과 코칭 전문가 2명에게 내용타당도를 검증받았으며, 스포츠지도자 150명 대상으로 조사를 실시하였다. 수집된 자료는 SPSS 22.0 프로그램을 이용하여 t-test, 우선순위를 산출하기 위하여 Borich 요구도 분석, The Locus for Focus Model의 방법으로 분석하였다. 연구결과에서 스포츠지도자들은 멘탈조절, 자기조절, 코칭리더십, 코칭스킬, 의사소통으로 구성된 다섯가지 하위요인에 대해서 거의 대부분 중요성과 교육필요성을 인식하고 있었다. Borich 요구도 분석에 의하면, 산출된 순위는 경청, 정서조절, 대안탐색, 집중력, 불안조절 순서로 나타났다. The Locus for Focus Model로 분석한 결과는 HH분면에서 집중력, 행동계획, 경청, 피드백, 공감능력, 타인이해의 여섯 개 구성요인이 도출되었다. 본 연구결과를 바탕으로 몇 가지 함의가 제안되었다.
중복장애자녀의 부모교육을 통한 임파워먼트 향상에 관한 연구-지적 및 자폐성장애와 정신장애의 중복장애를 중심으로-
이영실,강윤경 한국임상사회사업학회 2009 임상사회사업연구 Vol.6 No.2
최근 장애인의 인구는 계속적으로 증가추세이다. 특히, 여러 유형의 장애 중 지적장애, 자폐성장애의 경우 성장하는 과정 중 비장애인과 여러 가지 측면에서 격차가 많이 발생하며 때로 뜻하지 않게 일시적이거나 영구적으로 정신장애라는 중복된 장애를 겪으며 살아야한다. 따라서 이들은 평생을 통해 지속적인 보호가 필요하며, 이러한 장애인을 돌보는 부모에게는 큰 부담으로 느껴진다. 본 연구는 중복장애자녀를 둔 부모들의 부담을 덜고 중복장애자녀의 지역사회통합화를 위하여 부모들의 임파워먼트가 중요하다고 보았다. 그리하여 지역복지관을 이용한 부모교육을 통하여 임파워먼트 향상에 대한 효과성을 알고자 본 연구를 하게 되었다. 결과로는 부모교육을 통하여 중복장애자녀의 미래준비에 대해 만족을 얻었으며 모든 프로그램을 통하여 심리적 안정을 통한 가족유대감을 형성하였음으로 전체적인 만족감을 표현하였다. 또한 대상자들이 자조모임을 형성함으로 하여 교육을 받은 부모들이 임파워먼트향상을 도모하였으며 앞으로 중복장애자녀를 양육하는데 있어 방향성을 제시하는데 도움이 되었다. Recently, disabled population has been continuously increased. Especially, for the intellectual disability / autism among many kinds of disability, children who suffer from such disabilities show big differences in various areas when they are growing, compared to ordinary children. Sometimes, they have to live with multiple disabilities caused by unexpected temporary and permanent mental disorder. Therefore, they must be given continual protections during their entire life and their parents who provide cares for them would have big burden. As this study recognized reducing such burden of parents and empowerment to parents for integration into the local society as important elements, it was carried out to find effects of education of parents pro-vided by a local welfare center on increase of empowerment. In findings, participants expressed overall satisfaction about the programs because they satisfied the preparation for the future of children with multi-ple disabilities by educating parents and formed family relationship with psychological stability by partic-ipating in all the programs. Also, it is shown that participants planned to increase empowerment to edu-cated parents through forming a self supporting group and the programs helped to show direction for bringing up their children who have multiple disability.