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Ciprofloxacin , HK - 3140 , Norfloxacin , Ofloxacin 에 대한 Escherichia coli 저항균주의 특성
이연희,김경순,편희은,박원봉,박명환,김완주 ( Yeon Hee Lee,Kyung Soon Kim,Hee En Pyun,Woon Boong Park,Myung Hwan Park,Wan Joo Kim ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.2
Resistant strains of Escherichia coli were obtained against ciprofloxacin, ofloxacin, norfloxacin and HK-3140. Each resistant strain showed cross-resistance to other quinolones and peniciline-G. To find out the resistant mechanism, lipid and outer membrane proteins of the cells were separated and analyzed with gas chromatography and SDS denaturing gel electrophoresis. Lipid profiles from sensitive and resistant cells showed no big differences while outer membrane protein profiles showed a large variation. Sensitive cells showed better uptake of quinolone than resistant cells suggesting that the resistance against quinolone was resulted from the change in permeability through the outer membrane proteins.
개방성 안구손상 환자의 시력 예후 인자와 안외상점수의 예측도
이연희,곽주영,이성복,Yeon Hee Lee,MD,Joo Young Kwag,MD,Sung Bok Lee,MD,PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.6
Purpose: To determine the prognostic factors of visual outcome in open globe injury and to assess the possibility of an ocular trauma score (OTS) model of predictive value in open globe injuries in Koreans. Methods: The medical records of 242 patients with open globe injury from 2000 to 2010 were retrospectively reviewed. Prognostic factors of visual outcome, positive predictive rate, and negative predictive rate were surveyed. Results: In the multivariate analysis, old age, relative afferent pupillary defect, impaired initial visual acuity and retinal detachment were the worst predictive factors of vision survival. In OTS categories 1 and 2, worse final visual acuity was acquired, and positive predictive rate and negative predictive rate for assessment of final visual acuity less than 0.02 were 70.1% and 89.8%, respectively. Conclusions: The prognostic factors of open globe injury associated with impaired final visual acuity were old age, relative afferent pupillary defect, worse initial visual acuity, retinal detachment and OTS categories 1 and 2. The OTS may have prognostic value in open globe injuries in Korean patients. However, identified prognostic factors of the present study did not entirely coincide with those of other Koreans or previous studies. Therefore, additional studies on the modified open globe injury as a prognostic model in Korean patients are needed. J Korean Ophthalmol Soc 2012;53(6):825-832
섬모체망막동맥폐쇄가 첫 임상 증후로 나타난 안매독 환자 1예
이연희,남기엽,김정열,Yeon Hee Lee,Kiyup Nam,Jung Yeul Kim 대한안과학회 2011 대한안과학회지 Vol.52 No.10
Purpose: To report a case of a neurosyphilis patient with cilioretinal artery occlusion as the first manifestation. Case summary: A 58-year old man presented with a visual impairment which developed 5 days earlier in his right eye. During initial evaluation, the visual acuity in the right eye was 0.02. On fundus examination, a whitening adjacent to the macula was observed and fluorescein angiography showed filling delay and late leakage of the cilioretinal arteries. The patient was diagnosed with cilioretinal artery occlusion. Two weeks after his initial visit, visual acuity in the patient’s right eye improved to 0.7 and retinal whitening was decreased on fundus examination. Three months later, a visual decrease in the right eye reoccurred and the visual acuity was 0.01. Anterior chamber cell reaction with hypopyon was observed on slit lamp examination and vitreal opacity was noted during fundus examination. Among the numerous tests performed in order to determine the cause of uveitis, RPR antibody and treponemal antibody were found positive. The patient was diagnosed with neurosyphylis and 2 weeks after intravenous administration of penicillin, visual acuity improved to 0.7 and anterior chamber cell reaction as well as vitreal opacity decreased. Conclusions: The authors reported a case of cilioretinal artery occlusion suspected secondary to neurosyphilis. J Korean Ophthalmol Soc 2011;52(10):1254-1258
제 1형 신경섬유종증 환자에서 발생한 절반-망막중심정맥폐쇄
이연희,김경남,신경섭,김정열,Yeon Hee Lee,MD,Kyoung Nam Kim,MD,Kyoung Sup Shin,MD,Jung Yeul Kim,MD 대한안과학회 2010 대한안과학회지 Vol.51 No.1
Purpose: We report on a case of hemi-central retinal vein occlusion (Hemi-CRVO) which occurred in a patient with Type 1 neurofibromatosis. Case summary: A 31-year-old woman presented with a chief complaint of a one-month history of decreased visual acuity in the left eye. The patient had Type 1 neurofibromatosis but had no other systemic diseases. The best corrected visual acuity (BCVA) was 0.8 in the right eye and 0.05 in the left eye. Multiple Lisch nodules were present in the irises of both eyes on slit lamp examination. Fundus examination revealed a hemi-central retinal artery occlusion in the left eye. Optical coherence tomograms showed that the central macular thickness was 192 microns in the right eye and 732 microns in the left eye. There was cystoid macular edema in the left eye. A fluorescein angiogram showed delayed filling in the superior branch retinal vein of the left eye. There was an extensive area of non-perfusion of the retinal capillary in the corresponding area, including the perifoveal area. Blood tests for hyper-coagulability, autoimmune disorders, connective tissue disorders and other tests for the brain and carotid artery and coronary artery disease showed no abnormal findings. The clinical course was monitored following an intravitreal injection of bevacizumab (AvastinⓇ). Eight months later, the BCVA had improved to 0.2. Conclusions: Although it is rare, hemi-CRVO occurring in younger patients who have no underlying diseases could be related to neurofibromatosis. J Korean Ophthalmol Soc 2010;51(1):150-154
이연희,왕선진,황정민,Yeon-Hee Lee,Seon Jin Wang,Jeong-Min Hwang 대한안과학회 2008 대한안과학회지 Vol.49 No.8
Purpose: We report a patient with strabismus associated with thyroid ophthalmopathy whose condition changed remarkably for 6 years of a natural course. Case summary: A 69-year-old woman with Graves' disease presented with diplopia in April 1999. On examination, she showed left hypotropia of 50 prism diopters (Δ) accompanied by supraduction limitation and lid lag in the left eye. She was diagnosed with strabismus associated with thyroid ophthalmopathy and was observed without any intervention. In October 2000, her left hypotropia decreased to 16Δ, and esotropia of 14Δ developed. Both eyes showed limitation of supraduction, and the left eye showed limitation of abduction. In December 2003, the esotropia increased to 35Δ, and the direction of vertical strabismus changed to 40Δ of right hypotropia. Supraduction limitation of the right eye and abduction restriction of both eyes increased, and infraduction limitation of the left eye developed. In April 2005, esotropia increased to 75Δ, and the amount of right hypotropia was 35Δ. The abduction limitation of both eyes increased. Conclusion: The natural course of strabismus associated with thyroid ophthalmopathy can show continuous and remarkable changes. J Korean Ophthalmol Soc 49(8):1350-1355, 2008
이연희,황정민,오세열,Yeon Hee Lee,M,D,Jeong Min Hwang,M,D,Sei Yeul Oh,M,D 대한안과학회 2006 대한안과학회지 Vol.47 No.12
Purpose: This study investigated the natural course of strabismus associated with thyroid ophthalmopathy. Methods: A retrospective review was performed on the medical records of 31 patients with strabismus associated with thyroid ophthalmopathy who had been followed up for more than 6 months and had not received surgery. For the purpose of this study, a significant change of deviation angle was defined as more than 10 prism diopters in the primary position. Results: Forty-two percent of patients showed a significant change in deviation angle during the observation period of 23.8±17.7 months. The direction of the change was vertical in 32%, horizontal in 3%, and vertical and horizontal in 6% of patients. A significant change of deviation angle developed in 30% of patients within 6 months from the initial ophthalmologic examination, in 24% between 6 and 12 months, and in 13% of patients between 12 and 18 months from the initial examination. Conclusions: Although the deviation angle of strabismus associated with thyroid ophthalmopathy tended to stabilize with time, it nonetheless was susceptible to change even 12 months after the initial ophthalmologic examination. In addition, a vertical change in the deviation angle was more frequent than a horizontal change
이연희,김정열,남기엽,Yeon-Hee Lee,MD,Jung Yeul Kim,MD,Ki Yup Nam,MD 대한안과학회 2011 대한안과학회지 Vol.52 No.7
Purpose: To report a case of bilateral optic neuropathy related with idiopathic hypertropic pachymeningitis. Case summary: A 66-year old woman presented with acute visual loss that developed 6 days previously in the right eye and 3 days prior in the left eye. During the initial evaluation, her visual acuity was light perception in the right eye and counting fingers at 30 cm in the left eye. A relative afferent papillary defect (RAPD) was noted in the patient’s right eye. On brain MRI, the duramater was thickened and enhanced by contrast. The erythrocyte Sedimentation Rate (ESR) and C-reactive protein (CRP) level were increased and myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) as positive. Other neurological and medical abnormalities were not found. Under the suspicion of bilateral optic neuropathy due to idiopathic hypertrophic pachymeningitis, the patient was treated with methylprednisolone pulse therapy. Two days after the treatment, the visual acuity was hand movements at 20 cm in the right eye and 0.6 in the left eye. Three months after the treatment, the visual acuity was counting fingers at 20 cm in the right eye, and 0.7 in the left eye. The right eye showed optic disc pallor and diffuse retinal nerve fiber layer (RNFL) defect. The left eye showed a suspicious RNFL defect, and was otherwise normal. Conclusions: The authors report a rare case of optic neuropathy related with idiopathic hypertrophic pachymeningitis. Idiopathic hypertrophic pachymeningitis should be considered as one of the various causes of optic neuropathy. J Korean Ophthalmol Soc 2011;52(7):893-896
양방 항암치료와 병행하여 산삼약침과 봉약침 치료를 받은 전립선암 환자들의 PSA 수치 변화 관찰 보고
이연희,김채원,이광호,Lee, Yeon-Hee,Kim, Chae-Won,Lee, Kwang-Ho 대한약침학회 2011 Journal of pharmacopuncture Vol.14 No.4
Objectives: The purpose of this report is to find out how Mountain Ginseng Pharmacopuncture(MGP) and Sweet Bee Venom(SBV) treatments are effective on prostate cancer patients by monitoring Prostate specific antigen(PSA) values. Methods: We treated two prostate cancer patients with MGP and SBV from October 2008 to April 2011. One patient had localized prostate cancer, the other was in the terminal stage of prostate cancer with lung and bone metastasis and both had been receiving western anticancer therapy. We had monitored the changes of PSA value. Results: In case 1, MGP and SBV treatments seemed to be helpful in preventing the recurrence of localized prostate cancer. In case 2, PSA value was decreased by MGP treatment. Conclusions: It is conceivable that MGP and SBV are effective treatments for patients with prostate cancer.
찰스 테일러 윤리사상의현대 한국 사회 적용 가능성 탐색
이연희 ( Lee Yeon-hee ) 한국윤리학회 2016 倫理硏究 Vol.111 No.1
본고의 주된 목적은 크게 두 가지다. 하나는 (1) 찰스 테일러(Charles Taylor, 1931~) 윤리사상의 배경과 핵심 내용을 간략하게 정리하여 소개함으로써 그것이 서구 현대인의 실존적 위기에 일정한 대안을 제시하고 있음을 보여주는 것이며, 다른 하나는 (2) 시론적인 수준에서 그의 사상이 서구 개인들뿐만 아니라 현대 한국인의 윤리적 삶에도 도움이 될 수 있음을 밝히는 것이다. 구체적으로 여기서 말하는 `테일러 윤리사상`은 캐나다의 철학자 `찰스 테일러의 인간 본성에 관한 이해와 그에 기초한 도덕적 이상`을 뜻한다. 테일러는 근대 문화의 주요한 속성을 내포한 근대 윤리학은 행위자로서 인간의 본성을 제대로 파악하지 못한 채, 현실과 크게 괴리된 도덕적 이상을 내세워왔다고 진단한다. 즉 그는 우리가 현실 삶에서 겪게 되는 실제적 혹은 도덕적 곤란과 위기 속에서 해답을 찾을 수 있게끔 돕는 `실천학으로서 윤리학`이 재정립되어야 함을 암시한다. 테일러에 따르면, 근대 문화에는 `정신-신체`의 분리, `행위자-세계`의 분리, `개인-공동체`의 분리 등 주요한 세 가지 분리가 있다. 그리고 이것에 기초한 근대 윤리학자들의 이론과 사상은 오늘날 서구 개인들이 실존적 위기를 겪게 한 주범이다. 이에 따라 그는 근대 윤리학의 한계를 극복하기 위한 일종의 처방으로서, 특정한 분리의 양식을 `통합`하고자 애쓴다. 요컨대, 그는 `정신-행위자-개인`과 `신체-세계-공동체` 간의 변증법적인 통합체로서 인간 행위자의 이해와 그에 따른 도덕적 이상을 그리고 있다. 30여년의 시간 동안 일관된 관점에서 확립된 테일러의 윤리사상은 서구 사회의 근대성(modernity) 확립에 대한 비판적 검토와 철학적 반성, 그리고 그 오류를 극복하려는 노력의 총체라는 점에서 서양 윤리학사에서 중요한 의미를 가질 수 있다. 또한 그렇기 때문에 테일러의 사상은 오늘날 우리 사회에서도 지속적으로 연구될 가치가 있다. 테일러가 강조하는 `통합체로서의 인간 행위자`가 비단 서구 현대인만을 가리키는 것은 아니기 때문이다. 즉, 그의 윤리사상이 서구 개인들의 실존적 위기를 극복하는 데 설득력을 가진다는 점을 받아들인다면, 실제로 그것은 오늘날 우리 한국인이 바람직한 삶을 향유하는 데에 도움이 될 수 있다. 그러므로 테일러의 메시지를 제대로 더 검토하고, 우리식으로 재해석하여 받아들일 필요가 있다. The aim of this paper is for two things: (1) One thing is to explore ethical thought in a Canadian philosopher, Charles Taylor(1931~) and to disclose its significance in terms of a reconstruction of ethics as practical philosophy. (2) Another thing is to suggest that Taylor`s ethical thought is of help to ethical lives of contemporary Koreans as well as West modern individuals. Exactly, `the ethical thought of Taylor` means the conception of human nature of Taylor and (based on the conception) the moral ideal of him. Taylor makes a diagnosis that modern ethics involved modernity does not rightly understand human nature as a live agent, so that it proposes excessively abstractive moral ideals. In other words, he implicates that we need to establish again ethics as practical philosophy, which can help us find an answer in the practical or moral crisis experienced in real life. According to him, there are three main separations in modern culture that are `mind-body` separation, `agent-world` separation, `individual-community` separation. Made based on these, modern ethical theories and views are a main cause of existential crisis of modern people. For this reason, Taylor tries to synthesize certain separation mode implicit in the Western modern society. In short, Taylor is drawing the conception of human agent as the dialectical synthesis between `mind-agent-individual` and `body-world-community`, in accordance with it, the moral ideal. In this context, Taylor`s effort is a kind of prescription for overcome limits of modern ethics or modern culture. Taylor`s ethical thought, which has been constructed under a consistent point of view for more than 30 years, is a critical appraisal of modernity of the western society, a philosophical reflection on it, and an effort to overcome its errors. In this sense, his thought can have important meaning in Western History of ethics. And also, it is worth to be continuously studied in our Korean society today. Because human agent, as Taylor emphasized, only don`t mean to the western modern individuals. Therefore, if we could agree that Taylor`s thought will contribute to overcome an existential crisis of modern Westerns, we would also accept that it will help to Korean`s ethical life in the same manner. And this being so, we need to review more properly Taylor`s message, and reinterpret it in our way.
치주인대 기원의 섬유아 세포에 압축력을 가한 경우 Interleukin-6 및 Interleukin-8의 발현 변화에 관한 연구
이연희(Yeon-Hee Lee),김성곤(Seong-Gon Kim),남동석(Dong-Seok Nahm) 대한구강악안면외과학회 2006 대한구강악안면외과학회지 Vol.32 No.5
The fibroblast in the periodontal ligaments received various stress. Among them, compression and tension are quite important and they are related to the remodeling of tooth and alveolar bone. We studied the change of expression of interleukin-6 (IL-6) and interleukin-8 (IL-8) in the fibroblasts of the periodontal ligaments by real-time RT-PCR and ELISA. In results, the relative activity of IL-6 mRNA in 2 hours after was 1.54±0.08 and 1.00±0.05 in control and test, respectively (P<0.05). Its 12 hours after was 1.23±0.06 and 2.78±0.14 in control and test, respectively (P<0.05). The relative activity of IL-8 mRNA in 2 hours after was 1.00±0.05 and 0.24±0.01 in control and test, respectively (P<0.05). Its 12 hours after was 1.23±0.06 and 0.63±0.03 in control and test, respectively (P<0.05). The concentration of IL-6 was 1.02±0.16 ng/ml, 0.90±0.14 ng/ml, and 1.32±0.12 ng/ml (P<0.05) in control, 2, and 12 hours after, respectively. The concentration of IL-8 was 2.26±0.17 ng/ml, 1.70±0.26 ng/ml (P<0.05), and 0.84±0.47 ng/ml (P<0.05) in control, 2, and 12 hours after, respectively. In conclusion, the expression of IL-6 was significantly increased after the application of the static compressive force, but IL-8 was significantly decreased. Considering their known function, their expression is quite important in tooth and bone resorption.