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Desflurane 흡입 마취 유도 시 기도 과민성에 대한 Lidocaine과 Fentanyl의 효과
최인규 ( In Gyu Choi ),최영순 ( Young Soon Choi ),민진혜 ( Jin Hye Min ),김용호 ( Yong Ho Kim ),채영근 ( Young Keun Chae ),이우경 ( Woo Kyung Lee ),이용경 ( Yong Kyung Lee ),이애리나 ( Ae Re Na Lee ),조형래 ( Hyong Rae Cho ),채홍석 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.6
Background: Inhalation induction with desflurane can cause airway irritability and sympathetic stimulation. The aim of this study was to investigate whether lidocaine and fentanyl could reduce these unwanted reactions. Methods: Seventy-five patients who had premedication with midazolam were randomly allocated to one of three groups to receive intravenous saline (S group), lidocaine 1.5 mg/kg (L group), fentanyl 1 μg/kg (F group), respectively, before tidal volume induction with desflurane in oxygen and nitrous oxide. We recorded airway irritability such as cough, apnea, laryngospasm and excitatory movement and hemodynamic changes. Results: Airway irritability was not significantly different between the groups. In F group, mean blood pressure at LOC ver and LOC BIS and heart rate at LOC ver, LOC BIS and just before intubation were lower than those of S group (P<0.05). Other results were not significantly different. Conclusions: The results of the study showed that intravenous fentanyl and lidocaine had no beneficial effects to reduce airway irritability, but intravenous fentanyl could significantly reduce hemodynamic stimulation during inhalation induction with desflurane in the patients who were premedicated with midazolam. (Korean J Anesthesiol 2009; 57: 693∼7)