갑상선의 저분화 "도암종"의 세침흡인 세포검사 - 1례 보고 -

이승숙,하창원,조경자,장자준,Lee, Seung-Sook,Ha, Chang-Won,Cho, Kyung-Ja,Jang, Ja-June The Korean Society for Cytopathology 1994 대한세포병리학회지 Vol.5 No.1

저자들은 접할 기회가 흔치 않은 갑상선의 저분화암종인 일명 "도암종"의 세침흡인 세포검사 1예를 경험하고 조직학적으로 확인하였기에 문헌검색과 함께 보고하는 바이다. 흡인 도말된 세포들은 비교적 깨끗한 도말배경에 중등도 이상의 높은 세포밀도를 보였으며, 세포들은 개개로 흩어지는 양상과 판상의 군집을 이루는 양상이 어우러져 관찰되었다. 때로 세포들이 소포배열을 이루는 곳도 관찰되었다. 대부분의 종양세포들은 비교적 비슷한 크기와 모양을 나타내었으나 일부의 세포들은 현저한 다형성을 보였다. 일부의 세포에서 핵에 주름을 보였으나 소수에 불과하여 이는 어떤 갑상선병변에서나 관찰할 수 있는 비특이적 변화로 간주되었다. 세포의 겹침이 별로 없이 높은 세포밀도를 보이는 점, 세포가 개개로 흩어지는 양상과 소수 다형성이 현저한 세포의 혼재 등은 본 종양을 진단하는데 도움이 되는 소견으로 생각되며, 이러한 소견을 염두에 둠으로써 수술전 진단에 도움을 줄 수 있으리라 생각된다. A case of poorly differentiated "insular" carcinoma of the thyroid is presented and discussed with references to the literature. Un fine needle aspiration cytology of our case, the aspirates were highly cellular with tumor cells appearing as dispersed isolated cells as well as in dense clusters and syncytial formations. Occasional microfollicles containing colloid were evident. Most of nuclei were fairly uniform with considerable variability and a few showed definite atypical features. Nuclear grooving was additional features. Necrotic debris was not seen. Our cytologic findings were correlated well with histology, confirming typical insular pattern of tumor cells with the presence of occasional pleomorphic cells and papillary carcinoma-like features. With much attention to cytological features of insular carcinoma, it would be possible to diagnose a preoperative suggestive diagnosis, even though not definitive.

소림프구가 주종을 이루는 림프종의 세침흡인 세포검사 -소림프구 중심병변의 감별진단-

이승숙,Lee, Seung-Sook 대한세포병리학회 2006 대한세포병리학회지 Vol.17 No.2

타액선병변의 세침흡인 세포검사

이승숙,박인애,함의근,이상국,Lee, Seung-Sook,Park, In-Ae,Ham, Eui-Keun,Lee, Sang-Kook 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.2

Fine needle aspiration cytology has become a frequently used technique for the diagnosis of lesions in the head and neck. Fine needle aspiration cytology of the salivary glands were performed on 66 patients. In 59 patients with satisfactory samples, cytologic diagnoses were as follows; there were 47 benign lesions, including pleomorphic adenoma(20), Warthin's tumor(3), benign cystic lesion(4), Inflammatory lesion(4), lymphoid lesion(3), myoepithelioma(1), unspecified benign neoplasm (5), and unclassified benign lesion(7). There were 6 cases of undetermined malignancy and 6 malignant lesions including mucoepidermoid carcinoma(3), adenoid cystic carcinoma(1), carcinoma ex pleomorphic adenoma(1), and metastatic carcinoma(1) in cytologic diagnosis. In 25 patients, the cytologic diagnosis was correlated with histologic findings. The sensitivity of the benign lesion was 96% and the specificity was 82%. There was no false-positive diagnosis. The sensitivity and the specificity of pleomorphic adenoma were 75% and 95%, respectively. Some of Warthin's tumors were confused with benign cystic lesion due to frequent cystic change of the tumor. The sensitivity and specificity of the malignant lesions were 56% and 88%, respectively. There were three false negative diagnoses. Two mucoepidermoid carcinomas were correctly diagnosed by cytology. Two of three adenoid cystic carcinomas were misdiagnosed as benign tumors.

미학적사고로 본 시간과 공간에 대한 인식연구-여백과의 관계를 중심으로-

이승숙 ( Lee Seung Sook ) 한국디자인트렌드학회 2007 한국디자인포럼 Vol.16 No.-

회화예술이 갖는 美的 意味와 哲學的 價値를 통해 時間과 空間에 대한 인식이 어떻게 변화되고 발전되어 왔는가를 알아보는 것이 본 연구의 의도이다. 동양회화의 기본원리는 對立과 呼應같은 관계성에 뿌리를 두고 있는데 이는 儒敎, 道敎, 佛敎와 같은 東洋哲學이 그 基底에 있다. 특히 여백은 동양회화의 표현기법으로 중요한 의의를 지니고 있으며, 시간과 공간의 무한한 자유를 상징하는 체계로서 자리 잡고 있다. 여백의 무한한 경계는 시각적으로 도달 할 수 없는 부분인 동시에 筆墨으로 표현 할 수 없는 영역이다. 여백은 잔잔하고 고요한 가운데 많은 뜻을 함축하고 있고 그 깊은 곳에서 배어나오는 아름다운 자태를 표현하는 것이 동양의 마음을 담은 그림이다. 동양예술은 기교의 강조 보다 여백을 지향해 왔는데 이는 시간적으로 無限이면서 공간적으로 아직 未完이기도 한 것이다. The main purpose of the thesis is to study how our conception and awareness has been changed and developed by philosophical value of esthetic meaning the Fine Art has. The basic principle of Oriental painting is based on relationships such as confrontation and harmonization, and it can be said that it is influenced by oriental religions like Taoism, Buddhism, and Confucianism. Emptiness especially has an important meaning as an essential way of expressing, symbolizing the unlimited freedom of time and space. The unlimited frontier of emptiness is an unreachable area of visual attraction, also inexpressible area of oriental painting. The emptiness implies a lot of meanings in its calmness, and it can be called an Oriental painting when the inner beauty of the painting itself is taken out by the emptiness. The Oriental Arts have not been about techniques, it have been about the emptiness. It symbolizes both the unlimited potential of time and the imperfectness of space.

거대 농흉으로 발견된 폐방선균증 1예

김덕룡 ( Duck Ryung Kim ),최윤희 ( Yoon Hee Choi ),이승환 ( Seung Whan Lee ),이종신 ( Jong Sin Lee ),김민재 ( Min Jae Kim ),이승숙 ( Seung Sook Lee ),최두환 ( Du Hwan Choe ),김철현 ( Cheol Hyeon Kim ),이재철 ( Jae Cheol Lee ) 대한결핵 및 호흡기학회 2004 Tuberculosis and Respiratory Diseases Vol.57 No.6

다문화가정 자녀의 이중언어 관련 연구 동향 분석

이승숙(Lee, Seung-Suk),권경숙(Kwon, Kyung-Sook) 한국어린이미디어학회 2018 어린이미디어연구 Vol.17 No.1

본 연구는 다문화가정 자녀의 이중언어를 주제로 한 국내 학술지 및 학위논문을 분석․고찰함으로써 현재까지의 선행연구들의 경향을 살펴보고 그 결과를 바탕으로 향후 연구의 방향성을 제시하고자 한다. 이를 위해 2006년부터 2017년 10월까지 발표된 국내 학술지 및 학위논문 중 ‘다문화가정 영유아 및 아동의 이중언어 사용, 경험 또는 이중언어 교육을 주제로 한 논문 총 89편을 선정하였다. 수집된 국내 학술지 및 학위논문의 연도별, 연구주제와 연구방법에 따른 연구 동향을 분석한 결과는 다음과 같다. 첫째, 2012년부터 최근까지 이중언어 관련 논문 수가 급격히 증가하고 있는 추세임을 알 수 있었다. 이는 2012년「다문화 학생 교육 선진화 방안」이 발표되고 이중언어 교육 강화를 추진과제로 설정하면서 다문화가정 자녀의 이중언어에 대한 관심이 확대되고 이와 관련한 연구가 크게 증가하는 것으로 보여 진다. 둘째, 연구주제는 이중언어 관련 이론 및 정책 방안 모색 연구가 가장 많았으며, 다문화가정 자녀의 이중언어 실태 조사, 인식 및 태도 등의 순으로 연구가 이루어지고 있음을 알 수 있었다. 셋째, 연구대상은 다문화가정 자녀를 대상으로 한 연구가 가장 많고 그 다음으로는 부모대상 연구가 많았으며, 특히 결혼이민자인 어머니를 대상으로 한 연구가 많이 수행되었음을 알 수 있었다. 넷째, 연구유형을 분석한 결과 질적 연구 방법을 가장 많이 사용하였으며, 면담을 통해 자료를 수집한 연구가 가장 많음을 알 수 있었다. 넷째, 자료 분석 방법으로는 질적 분석을 가장 많이 사용하는 것으로 나타났다. The purpose of this study is to identify the future direction of research on bilingual children from multicultural families. This study looked at 89 published domestic academic journals and thesis papers from 2006 to October 2017. The analyzed research topics included infant and child bilingual language usage, experience and bilingual education. These conclusions then became the foundation to predict the future direction of research, regarding bilingual children from multicultural families. First, the result of the annual research distribution analysis showed a sharp increasing trend in bilingual research from 2012 to present. In 2012, the government started a policy to strengthen bilingual education. As a result, interest and research in bilingual education of multicultural families increased from 2012. Secondly, the analysis of research themes showed that bilingual related theories and research to create new government policies had the highest percentage. Following this, the two most popular themes were the current situation of multicultural families and the relationship between bilingualism and development. Third, the analysis of research subjects showed that children and infants were the most popular research subjects. After children and infants, adults were the most popular research subjects. If we separate adults into mothers and fathers, father based papers were especially insufficient as there were only 3. Fourth, analysis of research types showed that qualitative research, collected through interviews, was the most popular. Following this, quantitative method was the most popular and within quantitative papers, difference analysis was the most popular.

원발성 갑상선 림프종의 세침흡인 세포학적 소견 - 1예 보고 -

권미선,이승숙,고재수,정진행,이교영,Kwon, Mi-Seon,Lee, Seung-Sook,Koh, Jae-Soo,Chung, Jin-Haeng,Lee, Kyo-Young 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.1

Primary malignant lymphoma of the thyroid gland is uncommon malignancies. Its fine needle aspiration cytology (FNAC) findings are rarely described in the literature. This article highlights the FNAC diagnosis of primary malignant lymphoma of the thyroid gland. A 70-year-old female presented with a rapidly enlarging thyroid mass of five months' duration. FNAC smears showed low cellularity consisting of predominantly atypical enlarged lymphoid cells admixed with a few small lymphocytes, plasma cells, and oncocytic cells. Some disrupted lymphoid cells were also present. The tumor cells infiltrated into the thyroid follicular epithelium forming lymphoepithelial lesion, The cytologic appearance showed a diffuse mixture of cell types with only a few small, mature lymphocytes and many enlaraed lymphoid cells. The enlarged lymphoid cells were atypical and pleomorphic with nuclear clefting and irregularities. Grossly, the left lobe of the thyroid was nearly replaced by a diffuse firm to soft solid mass with smooth tan fish-flesh homogeneous cut surface. Histological diagnosis was diffuse large B-cell lymphoma with areas of marginal zone B-cell lymphoma of MALT type.

분화도가 높은 간세포암종의 세침흡인 세포학적 소견 - 비종양성 병변과의 감별 -

강신광,이승숙,조경자,하화정,Khang, Shin-Kwang,Lee, Seung-Sook,Cho, Kyung-Ja,Ha, Hwa-Jeong 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.1

The fine needle aspiration biopsy(FNAB) has become a popular method to diagnose mass lesions of the liver. Although many reports have listed FNAB criteria to be used to diagnose hepatocellular carcinoma(HCC), a diagnostic dilemma still exists at the extreme ends of the spectrum, particularly for well differentiated HCC. The authors reviewed a series of FNAB specimens of the liver to distinguish well differentiated HCC from nonneoplastic liver. Fifteen cytologic features were examined in this study: high cellularity, large sheet formation, trabecular pattern, acinar pattern, dispersed pattern, irregular arrangement, increased nuclear/cytoplasmic ratio, naked nuclei, irregular chromatin, irregular nuclear contour, multinucleation, uniform macronucleoli, multiple nuclei, uniform small cytoplasm and monotony of atypia. These features were examined in a series of 76 FNAB specimens. Fifty two specimens were from patients with HCC and 24 specimens were from patients with nonneoplastic lesion or tumors other than HCC containg adequate amount of nonneoplastic hepatocytes in smear. All specimens were coded as to the presence or absence of the above cytologic features. With the use of step-wise logistic regression analysis, three features were identified as the key cytologic features predictive of HCC: irregular chromatin, monotony of atypia and absence of large sheet formation. When these criteria were used, the sensitivity diagnosing HCC by FNAB was 94.2%, specificity 100%, positive predictive value 100% and negative predictive value was 88.9%.

두피에 전이한 상피-근상피암종의 세침흡인 세포학적 소견 - 1예 보고 -

권미선,이승숙,고재수,정진행,Kwon, Mi-Seon,Lee, Seung-Sook,Koh, Jae-Soo,Chung, Jin-Haeng 대한세포병리학회 2000 대한세포병리학회지 Vol.11 No.2

Epithelial-myoepithelial carcinoma is an uncommon, low grade malignant epithelial neoplasm and metastasis is exceedingly rare. This article highlights the fine needle aspiration cytology(FNAC) of a case of metastatic epithelial-myoepithelial carcinoma of the scalp. A 51-year-old female presented with the left parietotemporal scalp mass two months after the lett parotidectomy for epithelial-myoeplthelial carcinoma. FNAC from the scalp mass showed a biphasic population of ductal epithelial and myoeplthelial origin. These epithelial aggregates were numerous and formed a distinct three dimensional architecture in the background of numerous naked nuclei. The three dimensional architectures were predominantly composed of tightly cohesive eosinophilic ductular epithelial cells which tended to aggregate, overlap, and form tubules. Clear myoepithelial cells in three dimensional tissue fragment were inapparent and a few were attached to the periphery of the fragments. A few myoepithelial cells with clear abundant vaculoated cytoplasm were found In the foamy background. The cytological diagnosis was metastatic epithelial-myoepithelial carcinoma. The histologic findings of the scalp mass were those of typical epithelial-myoepithelial carcinoma. Cytologic distinction of epithelial-myoepithleial carcinoma, pleomorphic adenoma, and adenoid. Cytologic carcinoma may be very difficult but careful attention to clinical features and cellualr details can classify these neoplasms correctly.

"Atypical Squamous Cells of Undetermined Significance"의 질적 분류와 조직 소견과의 비교

고재수,정진행,이승숙,조경자,Koh, Jae-Soo,Chung, Jin-Haeng,Lee, Seung-Sook,Cho, Kyung-Ja 대한세포병리학회 1999 대한세포병리학회지 Vol.10 No.1

To evaluate whether different qualifications of a cytologic diagnosis of "atypical squamous cells of undetermined significance(ASCUS)" predict a greater or lesser likelihood of tissue diagnosis of uterine cervix, we compared different cytologic qualifications of ASCUS with the tissue diagnosis. One hundred twenty-two consecutive Papanicolaou smears showing ASCUS in women who had undergone cervical biopsy within nearest 30 days were collected. The 122 smears were qualified as "favor reactive"(25%), "favor low grade squamous intraepithelial lesion (LSIL)"(24%), "favor squamous intraepithelial lesion(SIL)"(16%), "favor high grade squamous intraepithelial lesion(HSIL)"(16%), and "not otherwise specified"(19%). Squamous intraepithelial or invasive lesion was pathologically confirmed by cervical biopsy in 13%, of the "favor reactive", 27% in "favor LSIL", 70% in "favor SIL", 75%, in "favor HSIL", and 35% in "not otherwise specified" smears. There were significant associations between the favor reactive smear and the benign biopsy finding and between the favor SIL smear and the biopsy shewing a squamous intraepithelial or more severe lesion. Nevertheless, most of favor LSIL smears exhibit reactive process in tissue biopsy. Conclusively, qualified ASCUS stratifies women Into different risk groups for SIL. The cytopathologist should make the cytologic diagnosis of "ASCUS, favor LSIL" circumspectly.