Identification and antimicrobial susceptibility of bacteria from the uterus of bitches with pyometra

이소현,조종기,신나리,김혜수,용환율,이강남,유한상,이병천,황우석,Lee, So-hyun,Cho, Jong-ki,Shin, Na-ri,Kim, Hye-soo,Yong, Hwan-yul,Yoo, Han-sang,Lee, Kang-nam,Lee, Byeong-chun,Hwang, Woo-suk The Korean Society of Veterinary Science 2000 大韓獸醫學會誌 Vol.40 No.4

본 연구는 1998년부터 1999년까지 서울대학교 수의과대학 부속동물병원에 내원한 개중 자 궁축농중으로 진단된 개의 자궁내용물로부터 균을 분리, 동정하고 항생제 감수성 검사를 실시하여 개 자궁축농증 치료를 위한 기초 자료로 사용하고자 하였다. 위 병원에 내원하여 자궁축농증으로 진단된 개는 16두였으며, 이들로부터 자궁적출술을 이용하여 자궁을 적출한 후 원인균을 분리하였고, 분리된 균에 대하여 15종의 항균제에 대하여 감수성 검사를 실시하였다. 16두의 개로부터 분리된 균은 Escherichia coli 11주, Serratia marcescens 2주, Staphylococcus aureus 및 Salmonella spp 각 l주 씩 이었다. 이들 균주들에 대하여 항균제 감수성 검사를 실시한 결과, 대부분의 균주들이 enrofloxacin, norfloxacin, chloramphenicol, nalidixic acid, gentamicin, Trimethprim-sulfamethazole, tetracycline에 대하여는 높은 감수성을 나타내었고, carbenicillin, amikacin, ampicillin, neomycin에 대하여는 중등도의 감수성을 나타내었으나, vancomycin, streptomycin, bacitracin, colistin에 대하여는 저항성을 나타내었다. This study was performed to isolate and identify bacteria from uterus with pyometra and examine their susceptibility to antimicrobial agents. Uterus of 16 bitches with pyometra were surgically removed by ovariohysteroctomy and then bacteria were isolated and identified. Also, susceptibility test to 15 antimicrobial agents was performed. Out of 16 bitches, 11 strains of Escherichia coli, 2 strains of Serratia marcescens, and 1 strain of Staphylococcus aureus and Salmonella spp. were identified. In antimicrobial susceptibility test, the majority of isolates were susceptible to enrofloxacin, norfloxacin, chloramphenicol, nalidixic acid, gentamicin, trimethprim-sulfamethazole, tetracycline, and moderately susceptible to carbenicillin, amikacin, ampicillin, neomycin, but resistant to vancomycin, streptomycin, bacitracin and colistin. In conclusion, E coli was the most common bacteria isolated from bitches with pyometra and those susceptible antimicrobial agents could be recommended to medical therapy of pyometra.

텍스트마이닝을 활용한 "잊힐 권리"의 토픽 분석

이소현,구본진,Lee, So-Hyun,Koo, Bon-Jin 한국정보관리학회 2022 정보관리학회지 Vol.39 No.2

This study examined the issues and characteristics that appeared in news and journal articles related to the 'right to be forgotten' using text mining analysis. Data for analysis were collected from 2010 to 2020 with the keyword 'right to be forgotten'. Keyword analysis and topic modeling analysis were performed on the collected data. As a result, in the last 10 years the issues about 'right to be forgotten' are not much different in news and journal articles and the approaches also are similar. However, it confirmed common issues and the partial difference between news and journal articles through comparison. Therefore in Archives and Records Management Studies, it is necessary to discuss derived in this study. In particular common issues are considered first but if there are differences in issues, it is needed to discuss them in various ways. This study is meaningful to understand the meaning and to draw issues that may arise in the future of the 'right to be forgotten'. The results of this study will contribute to be variously discussed on the 'right to be forgotten' in Archives and Records Management Studies.

텍스트마이닝을 이용한 미용성형 주요 요인에 관한 연구

이소현,손새아,김희웅,Lee, So-Hyun,Shon, Saeah,Kim, Hee-Woong 한국지식경영학회 2019 지식경영연구 Vol.19 No.4

Recently, the growth of beauty industry such as plastic surgery and beauty is continued every year in Korea. With the increased interest in appearance based on the improvement of life standard and the development of media, people's perception of cosmetic plastic surgery is changing. Now, as the service for consumer satisfaction based on their desire, the perception of plastic surgery medical service is changed to the high value-added industry with the high growth potential. Thus, this study aims to suggest the strategies for providing the medical service that could satisfy customers, by drawing the factors cognized as important when customers aim to get the cosmetic plastic surgery, and then additionally analyzing the relationships of those factors. On top of performing the topic modeling based on customers' comments data of social commerce related to cosmetic plastic surgery, this study also conducted the network analysis for visualizing the relations of each keywords. The drawn main factors were divided by applying the sub-categories of the SERVQUAL theory, and the additional characteristics of plastic surgery were shown by referring the relevant previous researches. Moreover, the interview with the cosmetic plastic surgery specialists (plastic surgeons) and customers who actually received the plastic surgery, helped the understanding of the interpretation of each factor and the actual relevant phenomenons. The significance of this study is to draw and discuss the main factors that should be observed by Korean cosmetic plastic surgery medical institutes, by mining and analyzing the opinions of customers interested in the cosmetic plastic surgery and procedure with the use of topic modeling. In other words, the quality of medical service of cosmetic plastic surgery could be improved by presenting the key factors that could be considered by the cosmetic plastic surgery medical service suppliers and also the actual strategies.

양극산화 임플란트 표면에 적용된 헤파린과 골형성단백질(rhBMP-2)이 치조골 증대에 미치는 효과: 방사선학적 평가

이소현,조재영,윤미정,전영찬,허중보,정창모,Lee, So-Hyoun,Jo, Jae-Young,Yun, Mi-Jung,Jeon, Young-Chan,Huh, Jung-Bo,Jeong, Chang-Mo 대한치과보철학회 2013 대한치과보철학회지 Vol.51 No.4

연구 목적: 본 연구는 골형성단백질의 서방출을 위해 헤파린과 골형성단백질 (rhBMP-2)을 화학적으로 고정시킨 양극산화 티타늄 임플란트가 골 결손부에서 임플란트 주변의 수직적 골증대에 미치는 효과를 방사선학적으로 평가하고자 시행되었다. 연구 재료 및 방법: Pure-Titanium을 사용하여 길이 7.0 mm, 직경 3.5 mm의 실험용 임플란트 18개를 제작하였다. 모든 임플란트를 양극산화처리 하였고, 플랫폼 하방 2.5 mm에 식립 기준선을 표시하였다. rhBMP-2가 코팅되지 않은 임플란트 집단을 대조군으로, dip and dry 방법으로 rhBMP-2를 물리적 흡착시킨 집단을 BMP군, 3,4-dihydroxyphenylalanine(DOPA)-heparin을 이식하고 rhBMP-2를 화학적으로 고정시킨 집단을 Hep-BMP군으로 설정하였다. 각군별6개씩의 임플란트를 3마리의 비글견 양측 하악에 한쪽에 3개씩 총 18개를 치조정 상방으로 2.5 mm 노출시켜 식립하였다. 식립 직후와 4주, 8주에 식립부위의 방사선학적 검사가 시행되었고, 각 시기별, 각 군별 임플란트의 근원심 변연골의 수직적 재생량에 대한 평균값과 표준편차를 얻었다. Kruskal-Wallis test와 Mann-Whitney U test를 이용하여 4주, 8주에서 대조군과 실험군들의 차이를 비교 분석하고, 유의 수준5%에서 통계적으로 검정하였다. 결과:방사선학적 관찰 결과 임플란트 근원심 변연골 재생량(평균값 ${\pm}$ 표준편차)은 4주에 대조군은 $0.09{\pm}0.22mm$, BMP군은 $1.02{\pm}0.72mm$, Hep-BMP군은 $1.29{\pm}0.51mm$ 였으며, 8주에서는 각각 $0.11{\pm}1.26mm$, $1.11{\pm}0.58mm$, $1.59{\pm}0.79mm$였다. 두 실험군 모두 4주와 8주에서 대조군과 비교 시 유의한 수직적 골증대를 나타냈으나(P<.05), Hep-BMP군과BMP군의 비교에서는 유의한 변연골 재생량 차이를 보이지 않았다(P>.05). 결론: 골형성단백질을 물리적으로 흡착시키거나 서방출 위해 헤파린을 이용하여 화학적으로 고정시킨 양극산화 임플란트 표면은 모두 골 결손부에서 임플란트 주변골의 수직적 증대에 효과적이었다. 그러나 방사선학적 관찰의 한계 내에서 골형성단백질의 이 두가지 적용방법간에는 수직적 골증대량에 유의한 차이가 없었다. Purpose: The aim of this study was to evaluate the effect of immobilization of the recombinant human bone morphogenetic protein 2 (rhBMP-2) on anodized titaum implants coated with heparin to enhance the vertical alveolar ridge augmentation in the supraalveolar peri-implant defect region. Materials and methods: 18 pure titanium implants (7.0 mm in length, 3.5 mm in diameter) were manufactured for this study. All implants were anodized and designed insertion reference line marked with laser at the apical 2.5 mm from the fixture platform. Implantation of 6 noncoated anodized implants (Control group), 6 anodized implants physically adsorbed with rhBMP-2 by dip and dry method (BMP group) and 6 anodized implants chemically immobilized 3,4-dihydroxyphenylalanine (DOPA)-heparin/ rhBMP-2 (Hep-BMP group) was performed in the both mandibular of three male adult beagle dogs using split-mouth design. Radiologic examinations were performed immediately after implant placement and 4 and 8 weeks after implant placement. The amount of mesio-distal bone augmentation was evaluated by measuring the vertical distance from the platform to the marginal bone. Statistical analysis was performed using one-way analysis of variance (SPSS version 18.0) and multiple comparison analysis of The Kruskal-Wallis test and the Mann-Whitney U test. Statistical significance was established at the 5% significant level. Results: At the 4 weeks vertical alveolar ridge augmentation of Control group, BMP group and Hep-BMP group is $0.09{\pm}0.22mm$, $1.02{\pm}0.72mm$, and $1.29{\pm}0.51mm$, At the 8 weeks $0.11{\pm}1.26mm$, $1.11{\pm}0.58mm$, $1.59{\pm}0.79mm$ according to radiographic observations. The two experimental groups showed a significantly increasing in vertical bone height compared with the control group (P<.05). However, there is no significant difference between the BMP group and Hep-BMP group (P>.05). Conclusion: The rhBMP-2 coated implants were enhanced the vertical bone growth in the supraalveolar peri-implant defect area. However, there is no significant difference between chemically and physically coating method.

반복성 구토 또는 역류증 환아에서 24시간식도 산도 측정의 의의

이소현,이창한,정기섭,Lee, So-Hyun,Lee, Chang-Han,Chung, Ki-Sup 대한소아소화기영양학회 1999 Pediatric gastroenterology, hepatology & nutrition Vol.2 No.2

목 적: 소아에서 흔히 볼 수 있는 반복적 구토 또는 게우기는 대부분 생리적 위식도 역류에 기인하지만 치료가 필요한 병적인 역류와 감별이 필요하다. 병적 역류의 진단에 이용되는 24시간 식도산도 측정의 임상적 의의와 더불어 역류지표들을 평가해 보고자 본 연구를 시행하였다. 대상 및 방법: 반복적 구토 또는 게우기를 주소로 내원한 환아들 중 glass electrode 및 GastrograpH (MIC, Switzerland)를 이용하여 24시간 식도 산도측정을 시행한 87례를 대상으로 병적 역류의 연령별 빈도를 알아보고, 생리적 및 병적 역류군의 역류 지표들의 평가와 더불어 두 군내에서의 하루중 시간대 별 역류 지수의 차이를 알아보고자 하였다. 결 과: 총 87명 중 병적 역류 환아는 32명(36.8%) 였으며, 연령별로는 6개월 미만에서 32.5%, 6개월~1세 사이 13.3%, 1~2세 사이 61.5%, 2~3세 사이 14.3%, 3세 이상에서는 66.7%에서 병적역류를 보였다. 생리적 역류군에서 총 역류지수는 1세미만에서 $3.7{\pm}2.9%$, 1세 이상에서 $1.8{\pm}1.5%$로 1세 전후에서 유의한 차이(p=0.02)를 보였으며, 하루 시간대별 1세 전후의 역류지수는 아침시간대에서만 1세 이하군이 의의 있게(p=0.04) 높았다. 역류횟수는 각각 $118{\pm}150$, $108{\pm}104$회로 1세 전후에서 유의한 차이는 없었다. 5분 이상 지속된 역류횟수는 1세 전후에서 각각 $1.7{\pm}1.9$, $0.8{\pm}1.0$회로 1세이하에서 유의하게(p=0.03) 많았으며, 가장 긴 1회 역류시간은 1세 전후에서 각각 $604{\pm}551$초, $275{\pm}296$초로 1세 이하에서 유의하게(p=0.007) 길었다. 병적 역류군에서 총역류지수는 1세 미만에서 $17.7{\pm}11.6%$, 1세 이상에서$7.7{\pm}2.9%$였고 역류횟수는 1세 전후에서 각각 $365{\pm}224$, $294{\pm}202$회였으며, 5분 이상 지속된 역류횟수는 $8.9{\pm}4.6$, $3.2{\pm}1.8$회였다. 가장 긴 1회 역류시간은 1세 전후에서 각각 $1955{\pm}2190$초, $1093{\pm}706$초였다. 생리적 및 병적 역류군 각각에서 하루 시간대 사이의 역류 지수를 비교한 결과 유의한 차이는 없었다. 결 론: 반복적 구토 또는 게우기를 주소로 내원한 환아에서 glass electrode 및 GastrograpH를 이용한 24시간 식도 산도 측정 검사상 1세 미만에서는 역류 지수 10%, 1세 이상에서는 5%를 기준으로 했을 때 병적 역류는 36.8%에서 관찰되었다. 생리적 및 병적 역류군의 시간대별 역류 지수 사이에는 유의한 차이가 없었다. 본 연구에서 병적 역류군의 역류발생빈도가 연령에 따라 차이가 크며, 특히 1~2세 사이의 환아에서 그 비율이 현저히 높았고, 또한 1세 전후의 역류지수도 현저한 차이를 보이므로, 향후 보다 많은 영유아들을 대상으로 조사 분석하여 1~2세 사이의 병적 역류의 기준 역류 지수를 5~10% 사이에서 더 세분하는 것이 필요할 것으로 생각된다. Purpose: The aim of this study was to evaluate the clinical significance of 24 hour pH monitoring in the pediatric patients with recurrent vomiting or regurgitation. Methods: We performed 24 hour pH monitoring on 87 pediatric patients with recurrent vomiting or regurgitation using GastrograpH with glass electrode. The pathologic GER was determined by the reflux index (RI). RIs>10% were considered positive in patients <1 year of age, whereas RIs of >5% were positive in other age groups. We evaluated the mean and standard deviation of the reflux parameters between physiologic and pathologic GER groups, and also compared the reflux indices of each group with respect to time zones of the day. Results: Pathologic GER was found in 32 of 87 patients (36.8%), and the age incidence included 32.5% in infants <6 months old, 13.3% in infants aged 6 months-1 year old, 61.5% in children aged 1~2 years old, 14.3% in children aged 2~3 years old and 66.7% in children >3 years old. In physiologic GER patients, the RI was $3.7{\pm}2.9%$ for the patients <1 year old (group A), and $1.8{\pm}1.5%$ for those ${\geq}1$ year old (group B) which was statistically significant between the 2 age groups (p=0.02). The number of long refluxes more than 5 minutes was significantly increased (p=0.03) in group A ($1.7{\pm}1.9$) than in group B ($0.8{\pm}1.0$). The duration of the longest reflux was significantly longer (p=0.007) in group A ($604{\pm}551$ sec) than in group B ($275{\pm}296$ sec). In pathologic GER patients, the RI was $17.7{\pm}11.6%$ for the patients <1 year old and $7.8{\pm}2.9$ for those ${\geq}1$ year old. The number of long refluxes of more than 5 minutes were $8.9{\pm}4.6$ and $3.2{\pm}1.8$, and the duration of the longest reflux were $1955{\pm}2190$ sec and $1093{\pm}706$ sec for each age group. In both physiologic and pathologic GER patients, there was no significant difference of RI among the time zones of the day. Conclusion: Pathologic GER was found in 36.8% of patients. There was significant difference of RI between those <1 year old and those ${\geq}1$ year old in physiologic GER patients. There was no significant difference of RI among the time zones of the day in both pathologic and physiologic groups. In our study, the frequency of pathplogic GER was too much higher in age group of 1~2 years old (61.5%) than in group of 6 months-1 year old (13.3%), which means that further study is needed to determine the pathologic criteria of RI (Vandenplas criteria is >5%) in the age group of 1~2 years old.

자폐 범주성 장애 아동의 실행기능 중재 연구의 동향 및 과제

이소현(SoHyun Lee),이귀남(Kwinam Lee),봉귀영(Guiyoung Bong),이해나(Haena Lee) 한국자폐학회 2023 자폐성 장애연구 Vol.23 No.2

Executive function, a cognitive ability closely related to the core deficit areas of autism spectrum disorders, necessitates a thorough understanding of every child’s profile and provision of appropriate support. This study aimed to review the latest research trends and analyze the interventions targeting the enhancement of executive function in children with autism spectrum disorders. In accordance with the criteria, a total of 29 experimental studies were selected. An overview of general characteristics and a detailed analysis of specific intervention attributes were conducted. Executive function intervention studies among children with autism spectrum disorders have been underway since 2004, mostly in the fields of psychology and psychiatry, targeting primary school-aged children with high functioning autism spectrum disorders. The most used interventions were cognitive behavioral/instructional strategies (CBIS) and exercise and movement (EXM). Notably, a high proportion of interventions were used to facilitate flexibility and inhibition subcategories of the executive function. Based on the findings, the future directions and educational implications regarding intervention aimed at enhancing executive function in children with autism spectrum disorders were discussed.

이달의 X-선 : 고열을 동반한 폐의 공동성 병변

이소현 ( Lee So Hyeon ),변은경 ( Byeon Eun Gyeong ),이혜진 ( Lee Hye Jin ),이진화 ( Lee Jin Hwa ),조영주 ( Jo Yeong Ju ),한운섭 ( Han Un Seob ),김혜영 ( Kim Hye Yeong ),박성숙 ( Park Seong Sug ),장중현 ( Jang Jung Hyeon ) 대한결핵 및 호흡기학회 2000 Tuberculosis and Respiratory Diseases Vol.49 No.5

영유아 교사 이미지 척도 개발 연구

이소현 ( Lee So-hyun ),이종호 ( Lee Jong-ho ),이은정 ( Lee Eun-jung ) 커뮤니케이션디자인학회(구 시각디자인학회) 2019 커뮤니케이션 디자인학연구 Vol.69 No.-

본 연구의 목적은 영유아 교사 이미지 척도를 개발하는 것이다. 이를 위해 선행연구 고찰, 전문가 인터뷰, 예비조사 과정을 거쳐 설문지의 최종 시안을 구성하였다. 본 조사는 서울과 경기 지역의 유치원과 어린이집에 근무하고 있는 영유아교사 230명을 대상으로 설문조사를 실시하였으며, 설문지의 응답 결과를 바탕으로 요인분석을 실시하였다. 총 3차에 걸쳐 탐색적 요인분석을 실시하였으며, 4개의 요인, 24개의 문항으로 구성된 영유아교사 이미지 척도를 개발하였다. 신뢰도 검증결과, 개발된 척도의 Cronbach α값은 .904였으며, 4개의 하위요인에 대한 Cronbach α값은 .727 ~ .815로 나타났다. 본 연구는 영유아교사 이미지 연구의 기초 자료로 사용할 수 있다는 데 의의가 있다. The purpose of this study is to develop early childhood teacher image scale. In order to achieve this objective, the final draft of the questionnaire was formed after consideration of prior research, interviewing experts, and preliminary investigation. The survey was conducted on 230 teachers working at kindergartens and daycare centers in Seoul and Gyeonggi Province, and a factor analysis was conducted based on their responses. A total of three exploratory factor analyses were conducted, and an image scale for early childhood teachers was developed consisting of four factors and 24 questions. The results of the reliability verification are as follows. The Cronbach α value for the developed scale was 0.904 and Cronbach’s alphas ranging from .727 to .815 for each of the five sub-factors. It is meaningful that this study can be used as a basis for the study of early childhood teacher image.

CNF 수용액의 전기분해를 통한 수소생산 기초 연구

이소현(So-hyeon Lee),이수안(Su-an Lee),곽미현(Mi-hyeon Kwak),황원기(Won-Ki Hwang),이권영(Kwon-Yeong Lee) 한국신재생에너지학회 2018 한국신재생에너지학회 학술대회논문집 Vol.2018 No.4

비지정 관광지 유지관리비 징수 필요성 연구: 평창군 농촌마을을 중심으로

이필순(Lee, Pil-Soon),이재우(Lee, Jae-Woo),이소현(Lee, So-Hyun),이성철(Lee, Sung-Chul) 한국관광레저학회 2021 관광레저연구 Vol.33 No.7