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      • 이선주의 졸업 작품 「Shape of water (부제 : 사랑의 모양)」 해설

        이선주 동덕여자대학교 미래전략융합대학원 2024 국내석사

        RANK : 247679

        본 소논문은 「Shape of water (부제 : 사랑의 모양)」 라는 주제를 토대로 만들어진 4곡의 졸업 작품을 해설한 것이다. 영화 “Shape of water”는 서로 다른 두 종의 생명체가 만나 사랑하는 방식을 물이라는 매개체를 통하여 그려낸 작품이다. 모든 사람들이 끔찍하다고 말하는 괴생명체를 보고 연민을 느끼며 사랑에 빠지는 주인공의 모습을 보면서, 과연 나는 나와 다른 타인을 어떠한 시각으로 바라보고 있으며 어떠한 태도로 접근해야 좋을지에 대해 깊이 생각해보게 되었다. 특히 인상 깊었던 장면들을 이 영화의 전개에 따라 음악으로 표현하였다. 1) 다른 행성에서 : 온 몸이 비늘로 덮인, 물고기도 인간도 아닌 끔찍하게 생긴 괴생명체를 보고 첫 눈에 이끌리는 인간여자. 이 둘은 한 공간에 있음에도 마치 다른 행성에 있는 듯한 착각을 불러일으킨다. 낯선 생명체를 마주했을 때, 두려움과 거부감이 아닌 호기심과 동질감으로 대하는 주인공의 태도가 인상 깊었고 그 느낌을 곡으로 표현해보았다. 2) 사랑이라는 마음이 무얼까 떠올렸을 때 : 영화의 주인공은 농아이다. 장애인이기 때문에 차별받고 소외됐던 자신의 모습을 물고기 형상을 한 괴생명체에게 투영시키며 친절을 베푼다. 주인공이 괴생명체에게 느끼는 감정이 단순히 연민과 동질감을 넘어 사랑이라는 것을 보여주는 장면들에서 나는 사랑의 진정한 의미는 무엇일까 다시 한번 생각해보게 되었다. 3) 사랑하면 누구나 다 : 현실적으로 말이 안 되고 기괴하리만치 아름답게 느껴지는 동화 같은 스토리지만 충분히 공감 할 수 있는 사랑 이야기였다. 사랑하면 누구나 동일하게 느낄 수 있는 감정을 개인적인 생각으로 표현한 곡이다. 4) F I N A L : 이 영화에는 말 못하는 농아, 흑인여성, 동성애자와 같은 소수자들에 대한 차별의 이야기를 다루는 장면들이 많이 나온다. 종을 넘어선 두 부류의 사랑이라는 설정도, 그리고 그 사랑을 응원하는 모든 사람들이 상대적으로 주류의 기준에서 벗어난 ‘아웃사이더’ 라는 점도 마음에 들었다. 그리고 그런 사회적 약자에 대비되는 캐릭터, 말하자면 악역이 등장하는데 이 인물은 자기주장이 강하고 소수자들에게 차별적 발언을 서슴없이 내뱉는 고집이 센 전형적인 60년대 남성주의 마초 캐릭터이다. 그가 세상을 판단하는 방식이 철저하게 선입견에 의해 지배되고 있었다는 것을 죽기 바로 직전에 가서야 깨닫는 장면을 보고 그는 단순히 특권을 누리는 가해자가 아닌 나약한 인간이었음을 느꼈고 그 느낌을 곡으로 표현하였다.

      • Hydrophilicity of non-fatty acid moiety: significant determinant affecting antibacterial activity of lauric acid esters

        이선주 서울대학교 대학원 2016 국내석사

        RANK : 247631

        What affects to the antibacterial activities of lauric acid esters was investigated. Based on the results of antibacterial activity test evaluating minimum inhibitory concentration and minimum bactericidal concentration, sesamol laurate was found to have no effect on either Gram positive bacteria or Gram negative bacteria. On the other hand, erythorbyl laurate had antibacterial activity to Gram positive bacteria. To investigate why the antibacterial activities are shown differently between sesamol laurate and erythorbyl laurate, monolaurin, sucrose monolaurate, isoamyl laurate, and methyl laurate, erythorbyl laurate, and sesamol laurate were chosen based on hydrophilicity of non-fatty acid moiety. Minimum inhibitory concentration was assessed by broth micro-dilution method against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, and Salmonella Typhimurium. Monolaurin, erythorbyl laurate, and sucrose monolaurate showed antibacterial activities against Gram positive bacteria. On the other hand, isoamyl laurate, methyl laurate, and sesamol laurate had no inhibitory effect on both Gram positive and Gram negative bacteria even treated up to 1.0 mM. The mechanism of monolaurin, erythorbyl laurate, and sucrose monolaurate was investigated by measuring the released cell constituents at 260 nm using spectrophotometer and the lipid compositional changes using gas chromatography (GC). 260 nm absorbing materials of Staphylococcus aureus treated with monolaurin, erythorbyl laurate, and sucrose monolaurate were increased for 2 h, and membrane lipid composition was also changed. Octanol/water partition coefficient was calculated by atom/fragment contribution method. The partition coefficients indicating lipophilicity were 7.175, 5.284, and 5.717 for isoamyl laurate, methyl laurate, and sesamol laurate, respectively, whereas monolaurin, erythorbyl laurate, and sucrose monolaurate showed 3.670, -0.6858, and -4.122, respectively. The hydrophilic-lipophilic balance values of isoamyl laurate, methyl laurate, and sesamol laurate were 1.800, 3.700, and 4.835, respectively, while monolaurin, erythorbyl laurate, and sucrose monolaurate had the higher HLB value of 7.025, 15.25, and 16.09, respectively. These results suggested that lauric acid esters should retain proper hydrophilicity based on the log P value of lower than 4, and the HLB value of higher than 7 to incorporate into bacterial cell membrane as antibacterial agents.

      • Built Environment and Health among Urban Residents : Spatial Analysis of Community Health Surveillance Data

        이선주 서울대학교 대학원 2018 국내박사

        RANK : 247631

        Background A neighborhood environment is comprised of a physical environment and a socioeconomic environment and influences human health in a range of ways. Within a physical environment, all the human-made surroundings are referred to as built environment (BE), and it substantially influences the health of people living in an urban setting, more so in cities with higher population density. Interests and intervention from the public health perspective on health and wellness in the BE as a remedy against communicable diseases diminished after the 19th century but began to resurface in recent years to get to the bottom of noninfectious disorders relating to physical activities. Unfortunately, most studies conducted in this area focused on increasing quantity of physical activities of the general population and the scope of dialogue needs to be much expanded to deal with various health issues and effect on a vulnerable population. In South Korea, the demographic convergence in the Seoul Metropolitan Area is on the extremely high side, making it one of the most densely populated regions in the world. Accordingly, a multilateral evaluation in public health on its BE is very important. Especially, to overcome the numerous problems materialized due to the rapid expansion of cities in the past few decades, it is imperative to deliberate urban renewal programs regarding public health. However, the previous studies verified individual environmental factors, that was evaluated in Western cities, in connection with physical activities, and most of them were in the field of urban planning. A continuous health surveillance system is indispensable to determine and evaluate health effects of BE, and it is important to first determine whether the regional data from public health surveillance system are compatible with this study. Furthermore, applying spatial analysis and geographic information system will facilitate determining the relationship between urban planning components and its public health impact in a more extensive geographical region. Objectives The purpose of this study is to explore the urban built environmental factors that affect public health through spatial analysis using regional public health surveillance data, determine correlation among those factors and present basis stemming from the public health perspective for healthy urban renewal. This study aimed to evaluate the effect of urban BE on healthy activities and health results. Applying three aspects, density, distance, and accessibility, for measuring BE out of the available 5, the following analyses were performed: Analysis 1: Correlation between accessibility to public transport and walking practices in adults Analysis 2: Correlation between fast food outlet density and prevalence of obesity in adults Analysis 3: Correlation between distance to a major roads and allergic diseases in children Methods Information on individual health behaviors and diseases prevalence was collected from public health surveillance data, more specifically, the Community Health Survey data (2011-2014, 92,357 subjects) for adults of 19 years of age or higher and the Seoul Atopy-Friendly School Survey data (2010, 24,040 subjects) for children. The built environmental factors influencing them were analyzed using a geographic information system, which required very precise location information. To achieve this, the participants of the Seoul Atopy-Friendly School Survey were geocoded on their home addresses. Those of the Community Health Survey were geocoded on regional representative location based on their type of residence (detached house, apartment) and geographically censored information of their home address at the community level (424 dongs in 2014). Of the many elements to the BE, accessibility to public transport by a community, density of top 5 fast food outlets (McDonald's, Lotteria, Burger King, KFC, Popeyes) by county, distance to major roads from residential address were used in analyses 1, 2 and 3. As for the impact of BE, walking duration (minutes) per week, obesity as defined by BMI of 25kg/m2, and prevalence of allergic and atopic diseases (atopic eczema, asthma, allergic rhinitis) were determined in each analysis. Results Accessibility to public transport and weekly walking duration had a nonlinear relationship, where the walking duration for those who lived between 1.0 to 1.5km from a subway station increased by 28.5 minutes (95% CI=16.7 - 40.2) but for those who lived 1.5km or farther away from a subway station decreased by 1.9 minutes (-19.9 – 16.1). The density of fast food outlets, when adjusted with personal and regional factors, had an insignificant correlation with obesity in a county-level (male: Odds ratio=1.01, 95% CI=0.97 – 1.05; female: 1.04, 0.99 – 1.09). Because the density of fast food restaurants closely correlated with regional socioeconomic level, when the effect was determined after adjusting the financial independence of the region, there was some discrepancy between the regional socioeconomic level and gender, but overall it had an insignificant correlation with obesity. The odds of atopic eczema were higher for children living on less than 4 floors and 150m, 150-300m, and 300-500m away from a major street than those living over 500m away, respectively by 1.15 (1.01 – 1.32), 1.17 (1.03 – 1.34) and 1.16 (1.01 – 1.34) times; and the odds of atopic dermatitis increased by 1.08 (1.01 – 1.15) times if the road density increased by 13,120m2 within 300m of place of residence. For the children living on the tenth floor and higher, the prevalence of asthma and allergic rhinitis was higher for those living closer to major roads, but its effect was not consistent. Discussions In this study, the effect of urban BE measure regarding accessibility, density, and distance on walking practice and health results such as obesity and atopic eczema were analyzed by applying spatial analysis on public health monitoring data. Based on the results of analyses, the following implications were drawn: (1) the recently diminishing amount of physical activities exercised by urban residents could be significantly improved through increased neighborhood walkability, and one of the methods for improvement may increase adjusting accessibility to public transport from the place of residence; (2) because obesity of urban residents is affected by neighborhood diet environment, additional intervention from the public health discipline must be considered simultaneously; and (3) higher proximity to roads indicate higher air pollution in the neighborhood and it may trigger other health issues such as allergic reaction and atopic eczema especially for those with restricted activity perimeter, e.g., children. To sum up, adjusting access in BE will increase physical activity level, and thereby, effectively reduce noninfectious disorders such as obesity, but it may also increase the prevalence of noninfectious disorders in a certain population with vulnerability. Therefore, to improve the health issues in our cities, we must first adequately test various urban planning concepts formulated in Western urban environments and need better awareness and proactive intervention from the public health perspective.

      • 일시적 수영운동과 걷기운동이 건강한 성인의 혈압과 동맥경직도에 미치는 영향

        이선주 성균관대학교 과학기술대학원 2011 국내석사

        RANK : 247631

        유산소 운동이 동맥의 기능을 개선시킨다. 유산소 운동 중 대표적인 수영운동이 동맥경직도에 미치는 영향에 대한 정보는 거의 없다. 본 연구의 목적은 일시적 수영운동과 걷기운동이 건강한 성인의 혈압과 동맥경직도에 미치는 영향에 대해 알아보고자 하였다. 연구 방법은 건강한 성인 남녀 26명을 대상으로 수영그룹(14명), 걷기그룹(12명)으로 무선으로 배정하였다. 각각 처치된 운동에 참여 한 후 20분과 40분에 혈압과 동맥경직도를 측정하였다 본 연구에서도 일시적인 수영운동과 걷기운동이 혈압과 동맥경직도에 미치는 영향을 살펴 본 결과, 걷기 운동은 혈압과 파형증가지수, 경동맥-대퇴동맥 맥파전파속도를 유의하게 감소시킨 반면, 수영운동은 걷기 운동에 비해 혈압 감소 효과가 떨어지는 것으로 나타났다. 또한 운동 후 20분에 혈압이 증가한 사람들의 비율이 걷기 운동에 비해 수영운동에서 더 높았다. 동맥경직도 변화에서도 걷기 운동 후에 경동맥-대퇴동맥 맥파전파속도가 지속적으로 감소되는 경향을 보인 반면, 수영 운동 후 20분에는 경동맥-대퇴동맥 맥파전파속도가 증가하는 것으로 나타났다. 또한, 파형증가 지수에서도 운동 후 20분에 수영운동이 걷기 운동에 비해 더 많이 증가하는 경향을 보였다. 이러한 수영운동 후 동맥경직도의 증가는 수축기 혈압의 증가와 밀접한 관련이 있는 것으로 나타났다. Although aerobic exercise improves arterial function, there is little information on the effects of swimming exercise on arterial stiffness. The purpose of this study was to compare the acute effects of swimming and walking on arterial stiffness in young subjects. Twenty-six healthy subjects (age 21±2 yrs and body mass index 22±2kg/m2)were randomized to either an acute bout of swimming exercise(n=14, 1,500m for male and 1,200m for female at 60∼70% of heart rate reserve) or walking exercise(n=12, 30-minute at same intensity with swimming). Carotid-femoral pulse wave velocity and aortic augmentation index, as indices of aortic stiffness, were measured using applanation tonometry. All variables were measured at baseline, 20 and 40 minutes after each exercise. Walking exercise significantly decreased systolic and diastolic blood pressure (p<0.05), but there was no significant changes following the swimming exercise. Augmentation index at 75bpm was significantly increased following the swimming exercise 20 minutes post exercise (-8.5±11.3 to -3.7±10.7%, p<0.05), but did not significantly changes following the walking exercise. Carotid-femoral pulse wave velocity was increased after swimming exercise (6.75±0.89 to 6.98±0.66m/s) and decreased after walking exercise (6.28±0.61 to 6.12±0.57m/s) at 20 minutes post exercise, but changes were not statistically significant. These findings suggest that there are different blood pressure and arterial stiffness changes after acute swimming and walking exercise. Further studies are needed to clarify the effects of long term swimming exercise on arterial stiffness.

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