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한국인 전신성홍반성루푸스 환자에서 HLA-DRB1, DQB1 대립유전자의 연관성 및 항인지질 항체와 항β<sub>2</sub> Glycoprotein I 항체에 관한 연구
이상곤,차훈석,양윤선,Lee, Sang Gon,Cha, Hoon Suk,Yang, Yoon Sun 대한면역학회 2002 Immune Network Vol.2 No.4
Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by diverse clinical manifestations and autoantibody production, which is known to be strongly influenced by genetic factors. Previous studies have revealed the associations of SLE with HLA class II alleles and antiphospholipid antibody system (anticardiolipin antibody (aCL) and anti-${\beta}_2$ glycoprotein I antibody (anti-${\beta}_2$ GPI)). Therefore, we studied the associations of HLA class II alleles with SLE and antiphospholipid antibody system. Methods: The genotyping for HLA-DRB1 and DQB1 alleles were performed in 61 SLE patients and 100 controls by the polymerase chain reaction (PCR)-sequence specific oligonucleotide probe method. ELISA tests for aCL and anti-${\beta}_2$ GPI were performed in 39 of the 61 SLE patients. The results were evaluated statistically by Chi-square test. Results: The frequencies of the HLA-$DRB1^*15$ and $DQB1^*06$ in SLE patients were significantly higher than those in controls. HLA-$DRB1^*12$ was significantly lower in SLE patients than controls. Nine of 39 patients were positive for aCL (IgG) and three were positive for aCL (IgM). One of 39 patients were positive for anti-${\beta}_2$ GPI (IgG) and none of them positive for anti-${\beta}_2$ GPI (IgM). Association of aCL with HLA class II alleles was not observed in our study. Conclusion: According to our results, it was found that HLA-$DRB1^*15$ and $DQB1^*06$ were associated with genetic susceptiblility and $DRB1^*12$ was associated with resistance to SLE in Korean population. No Association of aCL with HLA class II alleles was observed and the positive rate for anti-${\beta}_2$ GPI was very low.
도심항공 모빌리티(UAM)를 위한 틸트 덕티드 팬 형 eVTOL의 초기 사이징
이상곤,고보성,안성호,황호연,Lee, Sang Gon,Ko, Bo Sung,Ahn, Seong Ho,Hwang, Ho Yon 한국항공운항학회 2021 한국항공운항학회지 Vol.29 No.3
A large amount of time and cost is consumed due to congestions caused by an increasing number of cars which results in a lot of emissions. To overcome these problems, a new electric vertical takeoff and landing (eVTOL) aircraft is being considered. Since vertical take off and landing without a separate runway is realized and electricity is used as a power source, it could solve the saturated ground traffic congestions without emissions. In this paper, the initial sizing was performed based on the Nexus 6HX of Belltextron which is a tilt-ducted fan type. In this study, the electric propulsion system that only uses battery was implemented instead of current Nexus 6HX hybrid electric propulsion. Aerodynamic analyses were performed using OpenVSP and XFLR5. Power-to-weight ratio, wing loading, estimated weight were calculated with these analyses.
직접형 디지탈 주파수 합성기 동작 속도 향상을 위한 파이프라인형 위상누산기의 설계
이상곤,유흥균 ( Sang Gon Lee,Heung Gyoon Ryu ) 충북대학교 산업과학기술연구소 1994 산업과학기술연구 논문집 Vol.8 No.2
Abstract_Roman In this paper, we design the logic circuit of pipelined phase accumulator in DDFS(direct digital frequency synthesizer) with dynamic D F/F, and simulate it. The design methods of the adder and D F/F are described. To design and verify th
이상곤,Lee, Sang-Gon 대한수의사회 2014 대한수의사회지 Vol.50 No.2
안구표면은 자연스럽게 형성되는 세균집단의 거처로 항시 소독이 되어 있지 않은 상태로 존재한다고 봐야 한다. 예방 또는 치료를 목적으로 사용되는 적절한 항생제를 선택하려면 안구표면에 항시 산재하는 세균들에 관한 것은 물론 병원균에 효력이 있는 약품 그리고 그 약품의 부작용에 관한 사항들을 숙지해야 한다는 것은 수의사로서 자명한 사실이다. 이 글은 문헌들을 토대로 하여 개와 고양이 안구부(眼口部)에 서식하는 세균 그리고 병원균들과 그에 응용해야 할 항생물질들을 사용하는 데 조금이라도 도움이 될 수 있도록 간단히 분류 적절하게 이용할 수 있기를 바라는 마음에서 정리한 것이다.