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이병완,김진화,고승현,이병완,김난희,이상열,김현진,문민경,박석오,최경묵 대한당뇨병학회 2017 Diabetes and Metabolism Journal Vol.41 No.5
The Korean Diabetes Association (KDA) has regularly updated its Clinical Practice Guidelines. In 2017, the KDA published a position statement on the use of antihyperglycemic agents for patients with type 2 diabetes mellitus (T2DM). Growing evidence from new multinational clinical trials using novel and traditional insulin analogues has also been accumulated. Following global trends, many results of clinical trials, especially concerning the clinical efficacy and safety of insulin therapy, have been published about Korean patients with T2DM. After a systematic search of recent evidence, the KDA updated and modified its clinical practice recommendations regarding the initiation, choice, and intensification of insulin and created an insulin treatment algorithm for the first time to guide physicians caring for adult Korean patients with T2DM.
이병완,고재현,박재훈,신동명,황윤회 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.68 No.7
The temperature dependences of the acoustic properties and the dielectric relaxation times of polydimethylsiloxane were investigated by using high-resolution Brillouin and broadband dielectric spectroscopies. The longitudinal sound velocity showed a large increase upon approaching the glass transition temperature while the acoustic absorption coefficient exhibited a maximum at 263 K. Comparison of these results with previous ultrasonic data revealed a substantial frequency dispersion of the acoustic properties of this silicone-based elastomer. The relaxation times derived from the acoustic absorption peaks were consistent with the temperature dependence of the dielectric relaxation time of the structural process, indicating a strong coupling between the acoustic waves and the segmental motions of the main chains.
이병완,고재현,임준호,고영호,김광주 한국정보디스플레이학회 2014 Journal of information display Vol.15 No.4
The polyethylene terephthalate (PET) substrate is one of the key materials comprising optical films, which are essential componentsin various optical devices, such as displays. The elastic properties of oriented PET were investigated via Brillouinlight scattering spectroscopy. The high-frequency longitudinal and transverse sound velocities in the hypersonic region weredetermined using a special right-angle scattering geometry, where the information of the refractive index was not included inthe calculation. When the propagation direction of the acoustic modes was changed in the plane with respect to the stretchingdirections, the longitudinal and transverse sound velocities exhibited periodic modulations, clearly revealing the acousticanisotropy of the film arising from the stretching condition.
이병완,김규리,이용호,강은석,차봉수,이현철 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.6
Purpose: The objective of this study was to investigate clinical and laboratory parameters that could predict which patients could maintain adequate glycemic control after switching from initial insulin therapy to oral hypoglycemic agents (OHAs) among patients with type 2 diabetes (T2D). Materials and Methods: We recruited 275 patients with T2D who had been registered in 3 cohorts of initiated insulin therapy and followed up for 33 months. The participants were divided into 2 groups according to whether they switched from insulin to OHAs (Group I) or not (Group II), and Group I was further classified into 2 sub-groups: maintenance on OHAs (Group IA) or resumption of insulin (Group IB). Results: Of 275 patients with insulin initiation, 63% switched to OHAs (Group I) and 37% continued insulin (Group II). Of these, 44% were in Group IA and 19% in Group IB. The lowest tertile of baseline postprandial C-peptide-to-glucose ratio (PCGR), higher insulin dose at switching to OHAs, and higher HbA1c level at 6 months after switching to OHAs were all associated with OHA failure(Group IB; p=0.001, 0.046, and 0.014, respectively). The lowest tertile of PCGR was associated with ultimate use of insulin (Group IB and Group II; p=0.029). Conclusion: Higher baseline level of PCGR and lower HbA1c levels at 6 months after switching to OHAs may be strong predictors for the successful maintenance of OHAs after switching from insulin therapy in Korean patients with T2D.