Acral Persistent Papular Mucinosis 2예

이미우(Mi Woo Lee),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.2

We describe two cases of acral persistent papular mucinosis. The characteristic findings include discrete papules on the extensor surfaces of the hands and wrists, mucous deposits within the dermis, persistence or slow progression for several years. APPM may be considered as the disease entity in the same spectrum with lichen myxedematosus. (Korean J Dermatol 2000;38(2):236~239)

과립세포종의 임상 및 병리조직학적 연구

이미우(Mi Woo Lee),최지호(Ji Ho Choi),성경제(Gyung Je Sung),문기찬(Gee Chan Moon),고재경(Jae Gyung Ko) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.8

Background: Granular cell tumor is a rare neoplasm with characteristic histopathologic morphology. There were no comprehensive studies about the features of granular cell tumor in Korea. Objective: Our purpose was to find the clinical, pathological and immunohistochemical features of granular cell tumor. Methods: The sixteen patients with granular ce11 tumor seen at our institution over a 10-year period were retrieved. Clinical records and pathology slides of the patients were reviewed retrospectively. Results and Conclusion: 1. Granular cell tumor is rare, with a frequency of 0.006% of all surgical specimen. 2. Skin and subcutaneous tissues are the most predilection sites, and esophagus or gastric walls are the second common sites. 3. There are no multifocal cases and only one case of malignant granular cell tumor. 4. Granular cell lesions from many different sites share similar light microscopic features. 5. The Schwann cell origin of the tumor is demonstrated by reactivity with S-100 protein.

유방외 Paget병의 임상적 연구

이미우(Mi Woo Lee),최지호(Ji Ho Choi),성경제(Gyung Je Sung),문기찬(Gee Chan Moon),고재경(Jae Gyung Ko) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.8

Background: Extramammary Paget's disease (EMPD) is a rare skin neoplasm usually observed in apocrine-bearing regions. There were no comprehensive studies about the clinical features of EMPD in Korea. Objeetive: Our purpose was to study in detail the clinical findings of EMPD. Methods: The fifteen patients with EMPD at our institution over ten years were retrieved. Clinical records and pathology slides of the patients were reviewed retrospectively. Results: l. EMPD was seen more frequently in men than women (14:1 male:female ratio). 2. The most predilection site was penoscrotal area. 3. Thirteen percent of patients (2/15) with the disease had an associated underlying malignancy. 4. Twenty-two percent (2/9) of patients with wide excision had local recurrence during the follow-up period. Conclusion: EMPD in Korea may be characterized by male predominance and penoscrotal location. The incidence of concomitant malignancy may be lower than that in Caucasian. However, a search for internal malignancy and regular follow-up is still warranted.

만성 신부전 환자의 후천성 천공성 피부증에 대한 연구

이미우(Mi Woo Lee),최지호(Ji Ho Choi),성경제(Gyung Je Sung),문기찬(Gee Chan Moon),고재경(Jae Gyung Ko) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.9

Background: Acquired perforating dermatosis (APD) is a skin disorder occurring in patients with diabetes mellitus and/or chronic renal failure requiring dialysis. Objective : The purpose of this study was to clarify the clinical and histhopathological features of APD. Method: Twelve patients with APD who had biopsies done at Asan Medical Center were retrieved for this study. Clinical data and histopathologic specimens were reviewed. Results and Conclusion: 1. Sex ratio was 3:1 (9 male: 3 female) and mean age of onset was 52.1 years. 2. All patients had pruritic umbilicated papules with central keratotic plugs. The most predilection site was trunk. 3. Nine patients had an associated underlying non-insulin dependent diabetes mellitus 4. Skin lesions had developed on pre-dialysis in three patients, and after mean duration of 3.3 years on dialysis in remaining nine. 5. Histopathological examinations revealed the features of perforating folliculitis, Kyrle's disease or reactive perforating collagenosis. But we did not find any specimen resembling elastosis perforans serpiginosa. 6. It makes sense to designate the diseases as acquired perforating dermatosis rather than as one of the separate perforating diseases.

HMB - 45 염색에 음성을 보인 저색소성 세포성 청색모반 1 예

이미우(Mi Woo Lee),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.2

Blue nevus is a benign pigmented lesion of dermal melanocytes with a number of histologic and clinical variants. We report a variant of cellular blue nevus that is minimally pigmented. Immunohistochemistry showed the case to be strongly positive with S-100 protein, but negative with Ki-67 and HMB-45 antibody. There is a potential for hypopigmented cellular blue nevus to be confused with other benign nevus, such as intradermal nevus, Spitz nevus, and deep penetrating nevus and malignant melanoma.

켈로이드성 변화를 보인 결절성 근막염 1 예

이미우(Mi Woo Lee),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh),강숙경(Sook Kyoung Kang),배지영(Jee Young Bae) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.2

Nodular fasciitis is a reactive myofibroblastic proliferative lesion and is frequently misdiagnosed as a sarcoma. Histopathologically, nodular fasciitis can be grouped into three subtypes based on their relation with the fascia: subcutaneous, fascial, intramuscular. The subcutaneous type is the most common type. Its histological appearance is quite variable, with lesions ranging from highly cellular pseudosarcomatous to myxoid proliferations, to hyalinized tumefactions with keloid-like strands of collagen. Herein we report a case of subcutaneous nodular fasciitis showing keloid-like, hylainized, and thickened collagenous change.

한국인에서의 악성 흑생종에 대한 임상 및 병리 조직학적 연구 - 대한피부과학회 피부병리연구분과위원회 공동연구 -

이미우 ( Mi-Woo Lee ),고재경 ( Jai-Kyoung Koh ),권경술 ( Kyung-Sool Kwon ),김낙인 ( Nack-In Kim ),김상원 ( Sang-Won Kim ),김수남 ( Soo-Nam Kim ),김방순 ( Bang-Soon Kim ),김유찬 ( You-Chan Kim ),김종민 ( Jong-Min Kim ),명기범 ( Ki- 대한피부과학회 2003 대한피부과학회지 Vol.41 No.1

Backgorund ; Malignant melanoma in Korean has been increasing as in other countries, but there is no nationwide survey of malignant melanoma in Korea. Objective : The aim of this study was to document the clinical and histopathological features of cutaneo

한국인에서의 피부 림프종의 임상 및 병리조직학적 연구 - 대한피부과학회 피부병리연구분과위원회 공동연구 -

이미우 ( Mi-Woo Lee ),고재경 ( Jai-Kyoung Koh ),권경술 ( Kyung-Sool Kwon ),김낙인 ( Nack-In Kim ),김상원 ( Sang-Won Kim ),김수남 ( Soo-Nam Kim ),김방순 ( Bang-Soon Kim ),김유찬 ( You-Chan Kim ),김종민 ( Jong-Min Kim ),명기범 ( Ki- 대한피부과학회 2003 대한피부과학회지 Vol.41 No.1

Background: The relative frequency and clinicopathologic characteristics of lymphomas vary according to geography and race. Data on the features of cutaneous lymphoma in Korea are limited. Objective . The aim of this study was to document the relative occ

결절성 근막염 , 16 예의 고찰

이미우(Mi Woo Lee),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.1

Background: Nodular fasciitis is a reactive fibroblastic or myofibroblastic proliferative lesion that clinically and histologically can be misdiagnosed as a sarcoma. It is not familiar with dermatologist. Objective: We performed the study to review the clinical and histological characteristics of nodular fasciitis. Method: We reviewed the clinical and histopathological findings in sixteen patients with nodular fasciitis who visited Asan Medical Center during 10 years from 1989 to 1999. Results: l. Of the 16 patients, male to female sex ratio was 6:10. The mean age of onset was 29.9 years. 2. The mean duration of symptom was 4.5 months and in five patients the duration was less than one week. 3. Most frequently the upper extremity was involved, followed by the cheek. The maximum diameters of the most lesions were less than 3cm. 4. Histopathologically, nine cases showed subcutaneous type, five cases showed intramuscular type, and one case was suspected as an intradermal type. 5. Thirteen lesions were totally excised, and two lesions were only partially excised. There was no recurrence after the mean follow-up period of 27 months in thirteen patients. Conclusion:Nodular fasciitis is a benign disease, treated by simple or wide excision. Therefore, in those instances of apparent recurrence, reevaluation of the initial tissue specimen and the clinical course is needed for a correct diagnosis. (Korean J Dermatol 2001;39(1): 1~6)

피부 이식편 대 숙주반응의 임상 및 병리학적 연구

이미우(Mi Woo Lee),장성은(Sung Eun Jang),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh),김원(Won Kim),한영숙(Young Sook Han) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.3

Background: Graft-versus-host disease (GVHD) frequently produces cutaneous and systemic complications in patients receiving allogenic bone marrow transplantation. Familiarity with these reactions and their treatment is important to dermatologists involved in the care of bone marrow transplant recipients. Objective: Our purpose was to find the clinical and histopathological features of cutaneous graft versus host reaction (GVHR). Methods: We retrospectively reviewed patients who had undergone cutaneous GVHR after allogenic bone marrow transplantation in our institute over ten years. Results and Conclusion: 1. We found GVHD in 40% patients with allogenic bone marrow transplantation. 2. There was cutaneous GVHR in 86.5%, liver GVHR in 44.2% and gastrointestinal systems involvement in 34.6% of all GVHD patients. 3. Acute cutaneous GVHR presented as a generalized maculopapular exanthem and chronic cutaneous GVHR appeared as generalized maculopapular eruptions or lichenoid lesions. 4. Histopathologically, in 65.4%(17/26) of acute GVHR showed characteristic changes such as basal cell degeneration, dyskeratotic cells in epidermis, spongiosis, subepidermal cleft, and inflammatory cell infiltration and in 78.3% of chronic GVHR revealed acute GVHR-like or lichenoid change. 5. Treatment of moderate to severe GVHD consisted of high-dose corticosteroids and cyclosporine. There were 23.1% mortality due to sepsis in GVHD patients. (Korean J Dermatol 2001; 39(3): 267-273)