Deconvolution 분석을 이용한 좌우단락양 측정의 의의

이명철,조보연,고창순,오연상 대한핵의학회 1984 핵의학 분자영상 Vol.18 No.1

The purpose of this study is to investigate significance of new method for quantification of left to right cardiac shunts using deconvoution analysis as an adjunct to gamma variate analysis in patients with bad bolus injection. In the present study, quantitative radionuclide angiocardiography (QRAC) was performed with and without deconvolution analysis (DA) in 37 patients with left to right shunt and 103 control patients without shunt. The results obtained were as follows; 1) The mean value of Qp/Qs in 103 control patients was 1.10±0.12 without DA, and was 1.01±0.03 with DA. 2) Correlation(r) between oximetry and QRAC with DA was 0.87 ana correlation(r) between oximetry and QRAG without DA was 0.61. 3) The 13 patients with left to right shunt, whose Qr/Qs was greater than 3.0 by QRAC without DA, was studied by DA. Then the Qp/Qs values were measurable in these 13 patients by DA and they showed significant correlation with oximetry. (r=0.68) The results indicate that deconvolution analysis technique for quanfication of a left to right shunt provides more reliable and accurate shunt quantification, and reduces the influences of poor bolus injection.

요관 이행세포암종에 99mTc-MDP 가 섭취된 1예

이명철,조보연,고창순,안일민,손인,임상무 대한핵의학회 1982 핵의학 분자영상 Vol.16 No.1

Postoperative Thyroid-Stimulating Hormone Levels Did Not Affect Recurrence after Thyroid Lobectomy in Patients with Papillary Thyroid Cancer

이명철,김민주,최훈성,조선욱,이국행,박영주,박도준 대한내분비학회 2019 Endocrinology and metabolism Vol.34 No.2

Background: Thyroid-stimulating hormone (TSH) suppression is recommended for patients who undergo thyroidectomy for differentiated thyroid cancer (DTC). However, the impact of TSH suppression on clinical outcomes in low-risk DTC remains uncertain. Therefore, we investigated the effects of postoperative TSH levels on recurrence in patients with low-risk DTC after thyroid lobectomy. Methods: Patients (n=1,528) who underwent thyroid lobectomy for papillary thyroid carcinoma between 2000 and 2012 were included in this study. According to the mean and dominant TSH values during the entire follow-up period or 5 years, patients were divided into four groups (<0.5, 0.5 to 1.9, 2.0 to 4.4, and ≥4.5 mIU/L). Recurrence-free survival was compared among the groups. Results: During the 5.6 years of follow-up, 21 patients (1.4%) experienced recurrence. Mean TSH levels were within the recommended low-normal range (0.5 to 1.9 mIU/L) during the total follow-up period or 5 years in 38.1% or 36.0% of patients. The meanand dominant TSH values did not affect recurrence-free survival. Adjustment for other risk factors did not alter the results. Conclusion: Serum TSH levels did not affect short-term recurrence in patients with low-risk DTC after thyroid lobectomy. TSHsuppression should be conducted more selectively

머신러닝과 공통데이터모델을 활용한 국가 간암 검진 대상자의 간암 예측 모델

이명철,최경선,서혜선 한국보건사회약료경영학회 2022 한국보건사회약료경영학회지 Vol.10 No.1

BACKGROUNDS To find early liver cancer, the ministry of health and welfare has conducted surveillance targeting high-risk patients. In 2017, the incidence rate of liver cancer in surveillance was 0.9%, suggesting that a broad patient group was included in surveillance. In this study, to reduce surveillance patients, a prediction model with zero-falsenegative was developed using a machine learning. METHODS To develop the model, we used 2016 Health Insurance Review & Assessment Service-National Patients Sample utilized to the Common Data Model (CDM). This study targeted patients who did not have a severe condition of liver cancer in surveillance. The number of the target was 13,703 cases. The covariates for the model were identified by a chi-square test conducted on gender, age group, condition between a case and control group. LASSO was performed to develop the model. RESULTS Gender, age group, forty diseases were selected as a covariate. The model has an AUC of 0.745, a negative rate of 4.0%, a specificity of 4.5%, and a PPV of 11.8% with zerofalse- negative. CONCLUSION It might be possible to refine surveillance and save the budget of the National Health Insurance Service, and governments.

한국운동재활학회지 Journal of Exercise Rehabilitation 국제화 전략

이명철 한국운동재활학회 2016 한국운동재활학회 학술대회 Vol.2016 No.05

게이트 방법과 감쇠보정이 심근 관류 SPECT 의 관상동맥질환 진단 성능에 미치는 영향

이명철,이동수,정준기,소영,김경민,여정석,천기정 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.2

Purpose: Either gated myocardial perfusion SPECT or attenuation corrected SPECT can be used to improve specificity in the diagnosis of coronary artery disease. We investigated in this study whether gating or attenuation correction improved diagnostic performance of rest/stress perfusion SPECT in patients having intermediate pre-test likelihood of coronary artery disease. Materials and Methods: Sixty-eight patients underwent rest attenuation-corrected T1-20l/dipyridamole stress gated attenuation-corrected Tc-99m-MIBI SPECT using an ADAC vertex camera (M:F=29:39, aged 59±12 years, coronary artery stenosis≥70%. one vessel: 13, two vessel: 18, three vessel: 8, normal: 29). Using a five-point scale, three physicians graded the post-test likelihood of coronary artery disease for each arterial territory (1 normal, 2: possibly normal 3:equivocal, 4: possibly abnormal, 5: abnormal). Sensitivity, specificity and area under receiver-operating-characteristic curves were compared for each operator between three methods:A) non-attenuation-corrected SPECT; (B) gated SPECT added to (A); and (C) attenuation-corrected SPECT added to (B). Results: When grade 3 was used as the criteria for coronary artery disease, no differences in sensitivity and specificity were found between the three methods for each operator Areas under receiver- operating-characteristic curves for diagnosis of coronary artery disease revealed no differences between each modality (p>005). Conclusion: In patients at intermediate risk of coronary artery disease, gated SPECT and attenuation-corrected SPECT did not improve diagnostic performance.

해양 스포츠 발전을 위한 중요 쟁점 요인 분석

이명철,윤양진 釜山大學校 附設 體育科學硏究所 2014 體育科學硏究所 論文集 Vol.31 No.-

This study's purpose is analyzing the pending issue and main issue of marine sporting world. In this study, the question investigation was conducted to 50 people who had been selected from marine sports experts(research expert, association administrator, staff) population by having target sampling. First, all the research participants choose the order of priority like this; 1st, financeguarantee, 2nd, abouttheleader, 3rd, educational institution, 4th, abouttheinstitution, 5th, aboutthelawandsystem. Second, each parts of marine sports specialist choose the order of priority little bit differently; researchspecialistchoose 1st, finance guarantee, 2nd, abouttheleader, associationadministratorchoose 1st, finance guarantee, 2nd, about the institution, workerchoose 1st, about the leader, 2nd, financeguarantee. Third, for the details of top 3 of research participants order of priority is that for about the leader is 1st, treatment, 2nd, specialeducationalprogram, for about the finance guarantee is 1st, support of city executive, 2nd, support of an athletic as sociation and each events association, for about the institution is 1st, number of possession of equipment ,2nd, lack of space per number of user. 본 연구는 해양스포츠계가 안고 있는 현안 문제점과 쟁점화 되고 있는 사안 중 중요 쟁점요인을 분석하는데 목적을 두고 해양스포츠 전문가(연구전문가, 협회행정가, 종사자)를 모집단으로 설정하여 유목적적표집법을 이용하여 50명을 선정, 설문조사를 실시하였다. 자료분석은 SPSS/PC 21.0 Windows Program의 기술통계를 이용하여 해양스포츠전문가들이 선택한 중요 쟁점요인에 대한 우선순위를 분석하여 다음과 같은 결론을 얻었다. 첫째, 연구참여자 전체가 선택한 우선순위에서 1순위 재정확보, 2순위 지도자관련, 3순위 교육기관, 4순위 시설관련, 5순위 법·제도관련 등의 순으로 나타났다. 둘째, 해양스포츠 전문가의 위치에 따른 우선순위에서 연구전문가가 선택한 우선순위에서 1순위 재정확보, 2순위 지도자관련, 협회행정가는 1순위 재정확보, 2순위 시설관련, 종사자가 선택한 우선순위에서 1순위 지도자관련, 2순위 재정확보로 나타났다. 셋째, 연구참여자의 상위 3순위에 대한 세부내용으로 지도자관련 요인에 대한 세부내용 우선순위는 1순위 처우, 2순위 전문적 교육프로그램 지원, 재정지원 요인의 세부내용 우선순위는 1순위 시도행정의 지원, 2순위 체육회 및 각 종목별 협회의 지원, 시설관련 요인에 대한 세부내용 우선순위는 1순위 장비보유 수, 2순위 사용인원 대비 공간부족에 관한 순으로 나타났다.

저용량의 스테로이드 사용이 류마토이드 관절염환자의 골밀도 및 혈청 Osteocalcin에 미치는 영향

이명철,조보연,이홍규,고창순,민헌기,이명식,김성연,송영욱 대한내분비학회 1990 Endocrinology and metabolism Vol.5 No.1

Low dose glucocorticoids are effective in the management of rheumatoid arthritis, but there remains concern about their side effects, particularly osteoporosis. To examine the effect of low dose glucocorticoids on the bone mineral density and osteoblastic activity in rheumatoid arthritis, bone mineral density (NSAID) and serum osteocalcin were measured in 26 patients treated with nonsteroidal anti inflammatory drugs and 19 patients treated with glucocorticoid (prednisolone daily dose less than 10 mg) and 145 normal controls. Bone mineral densities at the femur neck and trochanter were significantly decreased in NSAID group compared with the normal controls and those at the lumbar spine, femur neck, trochanter and Ward's triangle were significantly decreased in steroid group compared with the normal controls. However the Z values of bone mineral densities were not different between the two groups at either site. Serum osteocalcin was not decreased significantly in steroid group. These findings suggest that low dose glucocorticoid treatment in rheumatoid arthritis is not assiciated with an increased risk of osteoporosis and that low dose glucocorticoid does not inhibit osteoblastic activity. (J. Kor Soc Endocrinol 5:37~44, 1990)

방사성동위원소 방출 단층촬영의 임상이용 현황

이명철,Lee, Myeong-Cheol 한국동위원소협회 1991 동위원소회보 Vol.6 No.2

국제통화기금(IMF)구제금융도입과 우리나라 금융기관 주가반응에 관한 실증적 연구

이명철,강종만,박주철,Lee, Myeong-Cheol,Gang, Jong-Man,Park, Ju-Cheol 한국재무관리학회 2001 財務管理論叢 Vol.7 No.1

본 연구에서는 IMF 구제금융도입과 관련된 일련의 사건들이 우리나라 금융기관 주가에 미친 영향을 분석하여 금융기관에 대한 시장전망의 추이를 알아보았다. IMF 구제금융도입은 궁극적으로 안정된 금융시스템을 추구한다는 (+)의 효과와 금융기관구조조정에 따른 규제와 이에 드는 비용으로 인한 (-)의 효과가 혼재되어 있다. IMF 구제금융도입과 이에 따른 제도정비에 금융기관 주가가 보인 반응을 살펴보기 위하여 IMF 긴급구제금융요청, 구제금융지원협상 타결, 금융개혁관련법안 국회통과, 외채협상타결, 기업구조조정 관련법안 국회통과 등 5개를 사건일1, 2, 3, 4, 5로 하여 사건연구방법에 의하여 분석하였는데 그 결과는 다음과 같다. 첫째, 사건일 1, 2, 3, 4에서는 누적평균초과수익률이 유의한 (-)의 반응을 보여 금융기관의 기업가치에 관한 부정적 반응이 나타났다. 그러나 사건일5(기업구조조정 관련법안 국회통과)를 계기로 누적평균초과수익률이 유의적이지는 않지만 (+)의 반응으로 반전되고 있어 금융기관에 대한 시장전망이 나아짐을 보여주었다. 둘째, 누적평균초과수익률이 일반은행과 다른 업종(증권, 종금, 보험)간에는 유의한 차이가 있었으나 다른 업종(증권, 종금, 보험)간에는 유의한 차이가 없었으며 금융기관의 누적초과수익률이 자기자본비율과 유의한 (+)의 선형관계로 나타나지 않아 IMF 충격으로 시장효율성이 저하된 것으로 나타났다. 그러나 이 또한 사건일5(기업구조조정 관련법안 국회통과)를 계기로 강력한 구조조정과정을 겪고 있는 종합금융회사를 제외하고는 누적초과수익률이 자기자본비율과 유의적이지는 않지만 (+)의 반응이 보여 시간이 경과함에 따라 IMF 충격으로 야기된 비효율적인 시장반응이 개선되고 있음이 밝혀졌다.