담낭 선종은 담낭의 전암성 병변인가?

이달식,유일영,전원중,채희복,박선미,윤세진,최재운,성노현 대한소화기학회 2007 대한소화기학회 추계학술대회 Vol.2007 No.-

Peroxisome Proliferators-Activated Receptor γ2 Pro12Ala 유전자 다형성과 당뇨병성 신증과의 연관성조사

이규호,정희석,최관용,김현,이달식,강지영,전현정,오태근 대한당뇨병학회 2008 Diabetes and Metabolism Journal Vol.32 No.5

Background: Peroxisome proliferators-activated receptor γ (PPARγ) is a member of the nuclear hormone receptor superfamily of ligand-activated transcription factors and known to play a role in regulating the expression of numerous genes involved in lipid metabolism, metabolic syndrome, inflammation, and atherosclerosis. The PPARγ2 Pro12Ala polymorphism has recently been shown to be associated with diabetic nephropathy. In this study, we evaluated the relationship between PPARγ2 Pro12Ala polymorphism and type 2 diabetic nephropathy whose duration of diabetes was over 10 years. Methods: We conducted a case-control study, which enrolled 367 patients with type 2 diabetes. Genotyping of PPARγ2 Pro12Ala polymorphism was performed using polymerase chain reaction followed by digestion with Hae III restriction enzyme. Results: The genotype or allele frequencies of PPARγ2 Pro12Ala polymorphism were not significantly different in diabetic patients with or without diabetic nephropathy. The genotype frequencies in terms of diabetic retinopathy and macrovascular complications such as coronary artery disease or stroke were not different either. Interestingly, nephropathy patients with Ala/Pro genotype showed lower C-peptide levels than those of Pro/Pro genotype. Conclusion: Our results suggest that PPARγ2 Pro12Ala polymorphism is not associated with diabetic nephropathy in type 2 diabetic patients. (KOREAN DIABETES J 32:402-408, 2008) Background: Peroxisome proliferators-activated receptor γ (PPARγ) is a member of the nuclear hormone receptor superfamily of ligand-activated transcription factors and known to play a role in regulating the expression of numerous genes involved in lipid metabolism, metabolic syndrome, inflammation, and atherosclerosis. The PPARγ2 Pro12Ala polymorphism has recently been shown to be associated with diabetic nephropathy. In this study, we evaluated the relationship between PPARγ2 Pro12Ala polymorphism and type 2 diabetic nephropathy whose duration of diabetes was over 10 years. Methods: We conducted a case-control study, which enrolled 367 patients with type 2 diabetes. Genotyping of PPARγ2 Pro12Ala polymorphism was performed using polymerase chain reaction followed by digestion with Hae III restriction enzyme. Results: The genotype or allele frequencies of PPARγ2 Pro12Ala polymorphism were not significantly different in diabetic patients with or without diabetic nephropathy. The genotype frequencies in terms of diabetic retinopathy and macrovascular complications such as coronary artery disease or stroke were not different either. Interestingly, nephropathy patients with Ala/Pro genotype showed lower C-peptide levels than those of Pro/Pro genotype. Conclusion: Our results suggest that PPARγ2 Pro12Ala polymorphism is not associated with diabetic nephropathy in type 2 diabetic patients. (KOREAN DIABETES J 32:402-408, 2008)

호흡기 : 만성폐쇄성폐질환과 결핵성 파괴폐의 임상양상 비교 (초)

정희석,김현,강지영,이규호,이달식,최관용,신윤미,이기만,최강현 대한내과학회 2008 대한내과학회 추계학술대회 Vol.2008 No.-

담낭선종 혹은 선종연관 병변의 조직 병리학적 분석

이승호 ( Seung Ho Lee ),이달식 ( Dal Sik Lee ),유일영 ( Il Young You ),전원중 ( Won Joong Jeon ),박선미 ( Seon Mee Park ),윤세진 ( Sei Jin Youn ),최재운 ( Jae Woon Choi ),성노현 ( Ro Hyun Sung ) 대한소화기학회 2010 대한소화기학회지 Vol.55 No.2

목적: 담낭 선종에서 암종으로 진행 여부를 알아보기 위해 담낭 절제술을 시행한 검체에서 담낭 선종과 선종 연관병변의 조직학적 특징을 조사하였다. 대상 및 방법: 1,847예의 담낭절제술을 받은 환자에서 담낭 선종 26예, 상피내암 9예, 침윤성 선암 28예를 포함한 63예의 담낭 절제 조직을 대상으로 하였다. 한 명의 병리 의사가 선종과 선종의 바탕 위에 국소적인 악성화 혹은 선암에서 발견되는 선종 잔류조직 등 선종 연관 병변을 조사하였다. 담낭 선종은 형태학적으로 관형, 관유두형, 유두형으로 분류하고, 구성하는 표피세포에 따라 담상피, 위상피화생, 장상피화생으로 분류하였다. 양성 선종과 암성 선종에서 환자의 나이와 병변의 크기를 비교하였다. 결과: 전체 담낭 절제술에서 선종 연관병변은 1.8%에서 발견되었다. 상피내암 9예와 침윤성 암종 28예 중에서 선종 연관 병변은 각각 7예, 1예가 있었다. 선종에 동반된 암종 8예는 모두 고분화암이었고, 단일 병변이었다. 암성 선종은 양성 선종에 비하여 종양의 장경이 컸고(1.8 cm 대 0.9 cm, p=0.01), 환자들의 나이가 많았지만 통계적인 차이는 없었다(57세 대 47세, p=0.09). 선종을 구성하는 상피 세포 및 형태학적 분류에 따라 양성 선종 혹은 암성선종의 빈도는 차이가 없었다. 담낭 선종에서 악성 변화를 보인 선종은 23.5%였다. 결론: 담낭 선종은 드문 질환이나 악성화 진행은 자주 발견되었다. 암성 선종은 상피내암이 많고, 고분화암이며, 단일 병변이었다. 담낭 선종은 전암성 병변으로 담낭 선종-선암 연속은 담낭암 병인 중의 하나로 생각한다. Background/Aims: In order to determine the malignant potential of gallbladder adenoma for progression to carcinoma, we evaluated the histopathologic features of adenoma and adenoma-related lesions on cholecystectomized specimens. Methods: Among 1,847 cholecystectomized specimens, 63 specimens from 26 benign adenomas, 9 carcinomas in situ (CIS), and 28 invasive carcinomas were selected. A pathologist reviewed all specimens and selected benign adenomas, CIS in the adenoma, and adenoma residue in invasive carcinomas. Adenomas and adenoma- related lesions were classified according to morphology (tubular, tubulopapillary, and papillary) and the consisting epithelium (biliary, pyloric metaplasia, and intestinal metaplasia). The age and the size of the benign adenomas and carcinomas in the adenoma were also compared. Results: Adenoma and adenoma-related lesions were found in 34 out (1.8%) of all resected gallbladder. Among 9 CIS and 28 invasive carcinomas, adenoma-related lesions were detected in 7 and 1 case, respectively. All eight carcinomas arising in the adenoma were well-differentiated solitary tumors. The diameters of the carcinomas in the adenoma were, on average, larger than that of the benign adenomas (1.8 cm vs. 0.9 cm, p=0.01). The patients with carcinomas in the adenoma were, on average, older than those with benign adenomas, although the difference was insignificant (57 years vs. 47 years, p=0.09). The morphology and consisting epithelium did not differ between the benign adenomas and carcinomas in the adenoma. The malignant transformation occurred in 23.5% of adenomas. Conclusions: Gallbladder adenoma is a rare disease, although malignant transformation occurs frequently. Adenoma is a precancerous lesion and the adenoma-carcinoma sequence is one of the gallbladder cancer carcinogenesis. (Korean J Gastroenterol 2010;55: 119-126)

포스터 전시 발표 순서 : 호흡기 ; 만성폐쇄성폐질환과 결핵성 파괴폐의 임상양상 비교 (초)

정희석,김현,강지영,이규호,이달식,최관용,신윤미,이기만,최강현 대한내과학회 2008 대한내과학회지 Vol.75 No.1S

인슐린 결핍성 당뇨병으로 발현한 MELAS증후군 1예

정희석,강지영,김현,이규호,이달식,최관용,오태근,전현정 대한내분비학회 2008 Endocrinology and metabolism Vol.23 No.6

MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes) syndrome is characterized by stroke-like episodes before the age of 40, encephalopathy, seizures, dementia and lactic acidosis, and is caused by mutations in mitochondrial DNA. Diabetes mellitus and cardiac involvement are also frequently seen in MELAS syndrome. It is a classic mitochondrial disorder that shows a slow, chronic, progressive course, and presents with multiple organ involvement including the central nervous system, skeletal muscle, eye, cardiac muscle and gastrointestinal system. Here, we report a case of 33 year-old woman with insulin-deficient diabetes mellitus and sensorineural hearing loss experiencing repeated stroke-like episodes. MELAS syndrome with an A3243G point mutation was confirmed by mitochondrial DNA sequencing analysis. MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes) syndrome is characterized by stroke-like episodes before the age of 40, encephalopathy, seizures, dementia and lactic acidosis, and is caused by mutations in mitochondrial DNA. Diabetes mellitus and cardiac involvement are also frequently seen in MELAS syndrome. It is a classic mitochondrial disorder that shows a slow, chronic, progressive course, and presents with multiple organ involvement including the central nervous system, skeletal muscle, eye, cardiac muscle and gastrointestinal system. Here, we report a case of 33 year-old woman with insulin-deficient diabetes mellitus and sensorineural hearing loss experiencing repeated stroke-like episodes. MELAS syndrome with an A3243G point mutation was confirmed by mitochondrial DNA sequencing analysis.

금형가공용 초고속 지능형 절삭시스템 기술개발

최현진(Hyun-Jin Choi),박철휴(Chul-Hue Park),이달식(Dal-Sik Lee),고영훈(Young-Hoon Koh),이태호(Tea-Ho Lee) 한국기계가공학회 2009 한국기계가공학회 춘추계학술대회 논문집 Vol.2009 No.6

In these days, It is necessary to develop the cutting machine satisfied the needs of IT component industry according to the growth of the mold industry. This paper is the introduction of the roadmap and the component technologies in "Development of high-speed and intelligent machine tools used for cutting mold" that has developed from December 2008.

증례 : 소화기 ; 임신 중 발생한 고중성지방혈증에 의한 급성 췌장염 1예

강지영 ( Ji Young Kang ),최관용 ( Guan Yong Choi ),정희석 ( Hee Seog Jeong ),이달식 ( Dal Sic Lee ),주혜진 ( Hye Jin Joo ),배일헌 ( Il Hun Bae ),박선미 ( Seon Mee Park ) 대한내과학회 2009 대한내과학회지 Vol.77 No.1

고지혈증과 급성 췌장염이 있었던 임산부에서 임신과 비만으로 유발된 제V형 고지혈증에 의한 급성 췌장염을 경험하였기에 문헌고찰과 함께 보고한다. Hypertriglyceridemia-induced pancreatitis is a rare, but serious, complication of pregnancy. We report a case of acute pancreatitis associated with type V hyperlipoproteinemia in pregnancy. A 36-year-old primigravida was admitted at 16 weeks of gestation with severe abdominal pain. Chemical analysis showed high serum pancreatic enzymes and very high serum triglyceride. Abdominal magnetic resonance imaging (MRI) showed diffuse swelling of the pancreas and a peripancreatic fluid collection. A diagnosis of acute pancreatitis with type V hyperlipoproteinemia was made. She recovered from the acute pancreatitis with conservative management and the serum triglyceride decreased rapidly with dietary restriction of fat, insulin/glucose, fenofibrate, and omega-3. We review the management of hypertriglyceridemia-induced acute pancreatitis in pregnancy. (Korean J Med 77:104-108, 2009)

볼바를 이용한 공작기계의 3차원 공간오차 해석

이호영(Ho-Young Lee),최현진(Hyun-Jin Choi),손재환(Jae-Hwan Son),이달식(Dal-Sik Lee) 한국기계가공학회 2011 한국기계가공학회지 Vol.10 No.5

Machine tool errors have to be characterized and predicted to improve machine tool accuracy. Therefore, it is very important to assess errors in machine tools. Volumetric error analysis has been developed by many researchers. This paper presents a useful technique for analyzing the volumetric errors in machine tools using the ball bar. The volumetric error model is proposed in specific vertical machining center and the program is developed for generating NC code, acquiring the ball bar data, and analyzing the volumetric errors. The developed system assesses the volumetric errors such as positional, straightness, squareness, and back lash. Also this system analyzes the dynamic performance such as servo gain mismatch. The radial data acquired by ball bar on 3D space is used for analyzing these errors. It is convenient to test the volumetric errors on 3D space because all errors are calculated at once. The developed system has been tested using an actual vertical machining center.

머시닝센터의 성능평가를 위한 시험방법에 관한 고찰

이호영(Ho-Young Lee),박철우(Chul-Woo Park),손재환(Jae-Hwan Son),이달식(Dal-Sik Lee),이준두(Jun-Du Lee) 한국기계가공학회 2009 한국기계가공학회 춘추계학술대회 논문집 Vol.2009 No.6월

In these days, the high speed and high precision machine tools have been widely applied to manufacture a die and machine elements product in industry filed according to increasing the need of high quality products. Therefore it is very important to evaluate the performance of machining center. In this paper, the methods of the evaluation tests of the geometric accuracy and the motion accuracy for machining center are studied with Korea Standards(KS).