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- 저자 : 이근석(Lee Keun-Seog) (검색결과 4 건)
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이근석(Keun Seok Lee),이윤종(Yun Jong Lee),이원섭(Won Sup Lee),안진석(Jin Seok Ahn),이종태(Jong Tae Lee),김원석(Wen Seong Kim),허대석(Dae Seog Heo),방영주(Yung Jue Bang),박선양(Seon Yang Park),조광현(kwang Hyun Cho),김병국(Byoung Koo 대한내과학회 1996 대한내과학회지 Vol.51 No.3
N/A Objectives: Sweet`s syndrome(acute febrile neutrophilic dermetosis) is characterized by fever, neutrophilia, erythematous painful cutaneous plaques, a dense dermal infiltrate onsisting of mature neutrophils, and a rapid response to steroid therapy, This condition is clinically important because it is associated with malignancy and it should be one of the differential diagnosis in the febrile immunocompromized patients with skin lesion, In spite of its clinical importance, there was no report on the epidemiologic characteristics of Sweets syndrome in Korean patients so far because of the rarity of Sweet`s syndrome, This study was performed to investigate characteristics and clinical significance of Sweet`s syndrome in Korean patients. Methods : The authors report a case of Sweet`s syndrome associated with acute myelogenous leukemia, and review the other 23 Korean patients with Sweet's syndrome that have been published in the literature. The characteristics of malignancy-associa- ted Sweet`s syndrome are compared with those of Sweet`s syndrome without malignancy association. Results: 1) Twenty-four cases of Sweet`s syndrome were analysed. Male to female ratio was 8:16 and the mean age was 44.8± 11.7 years. In 79% of patients, fever was noticed during the episodes of Sweet's syndrome. The most frequent sites of skin lesions were the upper extremities(83%), followed by face and head(75%), the lower extremities(75%), neck(46%), and trunk (13%). 2) Associated underlying systemic disorders were present in 15(62%) of the patients. The most frequent associations were chronic inflammatory bowel disease in seven patients, hematologic neoplasia in five, and solid neoplasia in one patients. 3) Leukocyte counts(mean 13,400±8,000/mm3) were higher than 10,000/mm3 in 16(67%) of patients. Erythrocyte sedimentation rates(mean 66.8±44.4mm/ hour) were elevated in 18(82%) of patients. 4) Skin lesion improvements were observed within 2 to 5 days from the initiation of steroid therapy. 5) Malignancies were associated in 6 patients. The initial appearance of Sweet`s syndrome lesions preceded or occurred concurrently with the detection of previously unsuspected malignancy in 67%(4 of 6 patients), In malignancy associated Sweet's syndrome, relative male preponderance, older age, and higher leukocyte counts were observed compared with Sweet's syndrome which is not associated with malignancy. There were no statistical significances, however. The erythrocyte sedimentation rate was the only statistically significant parameter. Conclusion: The characteristics of Sweet`s syndrome in Korean patients were similar to the characteristics of their western counterparts. Workup for malignancy seems appropriate far newly diagnosed Sweet`s syndrome patients in case of elevated erythrocyte sedimentation rate, leukocytosis, old age, and male sex
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비-동질 안정 프로세스 기반 임베디드 시스템 소프트웨어의 신뢰성 특성에 관한 연구
한상섭(Han Sang-Seop),백영구(Baek Young-Gu),이근석(Lee Keun-Seog),전현덕(Jeon Hyun-Duck),류호중(Ryu Ho-Jung),이기서(Lee Key-Seo) 한국철도학회 2001 한국철도학회 학술발표대회논문집 Vol.- No.-
In this paper, we apply NHPP model example to s/w process in order to get to know s/w reliability, The test is constructed by a test zig of commercial product loaded real embedded sytstem s/w. It is established to s/w reliability prediction and estimation of real-time embedded system s/w. It is computed the prediction value of cumulative failures, the failure intensity, the reliability and the estimation value of MTTF, Failure Rate. To the more realization of high reliability in the real-time embedded system s/w, if the embedded system s/w is ensured to the test coverage and constructed to stable s/w process & operating system, we can improve the performance and the reliability characteristic of the real-time embedded system s/w.
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허대석,이종태,이광우,김철우,안진석,이원섭,김노경,방영주,김병국,박선양,김태유,이근석,박영이 대한내과학회 1996 대한내과학회지 Vol.50 No.5
T-cell primary leptomeningeal lymphoma is extremely rare, although secondary leptomeningeal lymphoma is relatively common. We present the case of a 49-year old man who suffered severe headache and nuchal rigidity for 10years because of T-cell primary leptomeningeal lymphoma. Diagnosis was established by morphologic and immunologic studies of cerebrospinal fluid(CSF). We tried intrathecal chemotherapy with methotrexate, hydrocortisone, and cytarabine, but without success. The leptomeningeal lymphoma responded poorly to intrathecal chemotherapy, and the patient is now under observation with anticoagulation therapy for cerebral venous thrombosis which is secondary to the leptomeningeal lymphoma. The clinical and pathological features of primary and secondary central nervous system(CNS) lymphoma are reviewed in reference to this most unusual patient.
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김지현,허대석,이세훈,이원섭,김노경,김학균,방수미,변재호,류민희,이근석,정주영,나임일,방영주 대한내과학회 2000 대한내과학회지 Vol.58 No.4
Background : The aim of this study is to determine prognostic factors of breast cancer in Korean patients who underwent curative mastectomy. Methods : Medical records of 181 patients who underwent curative mastectomy were reviewed. Relapse-free survival and overall survival were documented for each patient. Factors influencing survival were analyzed using Cox proportional hazard model. Results : Overall 5-year survival rate was 82.0%, and 8-year survival rate was 74.7%. Multivariate analysis indicated that multiple axillary lymph node involvement (≥4), postmenopausal status, and negative estrogen receptor were independent adverse prognostic factors. The adjusted relative risks of multiple axillary lymph node involvement (≥4), postmenopausal status, and negative estrogen receptor were estimated 2.60 (95% Confidence Interval (CI): 1.28-5.30), 2.64 (95% CI: 1.46-4.79), and 2.27 (95% CI: 1.19-4.35), respectively. Conclusion : Multiple axillary lymph node involvement (≥4), postmenopausal status, and negativstrogen receptor were independent adverse prognostic factors in Korean breast cancer patients after curative mastectomy.(Korean J Med 58:446-452, 2000)$quot;
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