단백뇨 없는 Mesangial IgM Nephropathy 1예

이강휴,강경표,김원,강명재,박성광,강성귀 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.2

An 51-year-old woman presented with microscopic hematuria without protenuria for long time. Laboratory studies demonstrated the presence of red blood cells in urine, a normal serum IgM level, the absence of antinuclear antibodies, and a normal complement level. Renal biopsy revealed that some glomeruli are enlarged with endocapillary cell proliferation and a few glomeruli exhibit prominent vascular pole of the tufts and segmental increase in mesangial cell and matrix. Immunofluorescence studies demonstrated segmental granular deposits for IgM. Electron microscopy showed well-preserved foot process associated with focal effacement. Biopsy findings were consistent with IgM nephropathy. We present this case to promote understanding of the pathogenesis of IgM nephropathy. (Korean J Nephrol 2002;21(2):317-321)

조영제를 이용한 난원와 막성심방중격의 천자 전 확인

이강휴,이경석 대한심장학회 2008 Korean Circulation Journal Vol.38 No.10

Background and Objectives: Pressure monitoring and injection of contrast media after piercing the fossa ovalis are used to avoid life-threatening complications during transseptal procedures. However, when performing those maneuvers, the information provided can only be obtained after having pierced structures that may not have been the intended target. When we injected the contrast media through a Brockenbrough needle before piercing the fossa, the dye that had collected under the membranous septum tented by the transseptal equipment (tenting) was observed on the left anterior oblique (LAO) projection and this indicated the fossa ovalis. This study was performed to evaluate the usefulness and safety of tenting in order to identify the membranous septum during transseptal procedures. Subjects and Methods: Contrast injections were performed on the fossa ovalis and the septal wall surrounding it during 64 transseptal procedures. The rates of dye staining and tenting in both the muscular and membranous septums were compared. Results: No areas of the muscular septum exhibited any tenting. Various rates of dye staining of those areas were observed. However, the membrane of the fossa exhibited tenting without dye staining in all 64 cases. The sensitivity of the tenting without dye staining to identify the Fossa was 98%, and the specificity was 100%. Conclusion: Tenting without dye staining could differentiate the membranous septum from the muscular one with high diagnostic accuracy. This method could be used as a safe landmark for the fossa ovalis before piercing it during transseptal procedures. Background and Objectives: Pressure monitoring and injection of contrast media after piercing the fossa ovalis are used to avoid life-threatening complications during transseptal procedures. However, when performing those maneuvers, the information provided can only be obtained after having pierced structures that may not have been the intended target. When we injected the contrast media through a Brockenbrough needle before piercing the fossa, the dye that had collected under the membranous septum tented by the transseptal equipment (tenting) was observed on the left anterior oblique (LAO) projection and this indicated the fossa ovalis. This study was performed to evaluate the usefulness and safety of tenting in order to identify the membranous septum during transseptal procedures. Subjects and Methods: Contrast injections were performed on the fossa ovalis and the septal wall surrounding it during 64 transseptal procedures. The rates of dye staining and tenting in both the muscular and membranous septums were compared. Results: No areas of the muscular septum exhibited any tenting. Various rates of dye staining of those areas were observed. However, the membrane of the fossa exhibited tenting without dye staining in all 64 cases. The sensitivity of the tenting without dye staining to identify the Fossa was 98%, and the specificity was 100%. Conclusion: Tenting without dye staining could differentiate the membranous septum from the muscular one with high diagnostic accuracy. This method could be used as a safe landmark for the fossa ovalis before piercing it during transseptal procedures.

Periprocedural Hemoglobin Drop and Contrast-Induced Nephropathy in Percutaneous Coronary Intervention Patients

이강휴,이상록,강경표,김희정,이선화,이경석,채제건,김원호,고재기 대한심장학회 2010 Korean Circulation Journal Vol.40 No.2

Background and Objectives: The development of contrast-induced nephropathy (CIN) is associated with an increased risk of death and late cardiovascular events after percutaneous coronary intervention (PCI). The relationship between CIN and hemoglobin drop has been controversial. The aim of this study was to evaluate the clinical usefulness of periprocedural hemoglobin drop as a nontraditional risk factor for CIN. Subjects and Methods:Five-hundred thirty-seven patients who underwent PCI were divided into 2 groups: Group I (486 patients: patients who did not develop CIN) and Group II (51 patients: patients who developed CIN). All patients were administered iodixanol as contrast media during coronary angiography. CIN is defined as a rise in serum creatinine of ≥25%or ≥0.5 mg/dL above the baseline value within 48 hours after contrast administration. Results: Baseline clinical and cardiovascular risk factors were not significantly different between the two groups, except for low abdominal circumference (Group I : Group II=87.9±9.0 cm : 81.2±15.1 cm, p=0.024), body weight (Group I : Group II=63.5±10.6 kg : 59.7±9.2 kg, p=0.008), body mass index (BMI) (Group I : Group II=24.4±3.4 kg/m2 : 23.4±2.8 kg/m2, p=0.032), pre-PCI hemoglobin (Group I : Group II=13.2±2.0 g/dL : 12.3±2.0 g/dL, p=0.003),and post-PCI hemoglobin (Group I : Group II=12.4±1.9 g/dL : 11.5±1.8 g/dL, p=0.001). Multiple logistic regression analysis showed that a periprocedural drop in hemoglobin (>1 g/dL) was an independent predictor of CIN, like other known risk factors. Conclusion: A periprocedural drop in hemoglobin of more than 1 g/dL is another important independent predictor for CIN, even in patients administered the lowest nephrotoxic contrast agent, iodixanol, during PCI.

Helicobacter pylori 박멸과 장기간 Proton Pump 억제제 투여 후에 호전된 Menetrier씨 병 1예

이강휴,이나리,곽재용,임창열,이승욱 대한소화기내시경학회 2004 Clinical Endoscopy Vol.28 No.1

Menetrier's disease is a protein losing hypertrophic gastropathy characterized by hypoproteinemia, and often is associated with the development of gastric cancer. Though the cause of Menetrier's disease has been unknown, the association with Helicobacter pylori was reported. A 30- year-old man was hospitalized for the evaluation of progressive dyspepsia for 2 years, hypoproteinemia, and recently aggravated epigastric pain with weight loss. Gastroscopy revealed prominent folds and multiple variable sized polypoid eminence in the body and antrum with positive CLO test. Histological findings revealed gastritis with erosions and foveolar hyperplasia. Any other diseases causing protein losing enteropathy were excluded. After the eradication of the H. pylori and long term treatment with proton pump inhibitor, clinical, endoscopic, and biochemical resolution ensued. Thus, we suggest that H. pylori eradication should be tried in patients with Menetrier's disease before invase treatment modalities such as surgical resection. Menertrier씨 병은 저단백혈증과 동반된 hypertrophic gastropathy를 특징으로 하는 질환이며, 종종 위암의 발생과 연관되어 있다. 발병의 원인은 아직 잘 알려져 있지 않는데, 최근 일부 연구에서 Helicobacter pylori (H. pylori)와의 연관성이 보고되고 있다. 30세 남자가 2년 동안 지속적인 소화 불량과 저단백혈증, 최근 악화된 체중 감소와 상복부 통증을 주소로 입원하였다. 상부 내시경 검사에서 위 전정부와 체부에 저명한 주름과 많은 수의 다양한 용종성 점막 증식 소견을 보였고, CLO 검사는 양성이었다. 조직 검사에서 위염과 소와 증식 소견을 보였다. 환자에게 H. pylori 제균요법 및 장기간의 proton pump 억제제 투여가 시행되었고, 환자는 알부민 값의 증가와 함께 증상 개선 및 체중 증가, 내시경소견의 호전을 보였다. 저자들은 H. pylori 박멸과 장기간 proton pump 억제제 투여 후에 호전된 Menetrier씨 병 1예를 경험하였기에 국내에서 처음으로 보고하는 바이다.

겨울칠 대륙고기압 확장시 호남지방 대설특성 : 2005년 12월 21일 사례를 중심으로

이강휴,정관영,원효성,류찬수 한국기상학회 2006 한국기상학회 학술대회 논문집 Vol.2006 No.-

영상신호 증폭을 이용한 사람 상태 감시 시스템

이강휴(Kang-Hyu Lee),박두복(Du-bok Park),고한석(Han-Seok Ko) 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.6

Recently, there are many commercialized applications which exploit body signals in non-invasive manner. For instance, body signals are frequently applied in the field of surveillance such as face recognition, iris recognition, and finger print recognition. Furthermore, the health inspection by analyzing body signals becomes also a potential application since subtle body motion signals such as heart rate can intuitively show human health state. In this paper, we propose a method that estimates such subtle body motion by magnifying the signal of human skin. First, the specific region of interest(ROI) is cropped to reduce the computational complexity. Then, HSV color space conversion is conducted to extract the color information. In the converted color space, hue(H) signal is magnified based on Eulerian video magnification. Finally, subtle body motion is estimated by analyzing inflection points of the magnified hue(H) signal. Experimental results validate the proposed method can estimate the human motion (e.g. heart rate) with high accuracy.

Ssangcheon, Life of Lee Young-Choon (1903–1980)

이창섭,이강휴,이주민,윤순재 연세대학교의과대학 2024 Yonsei medical journal Vol.65 No.4

Not applicable

약물용출 스텐트를 이용한 Full Metal Jacket (≥60 mm) 시술의 단기 및 장기 성적

이선화,채제건,이강휴,이상록,이경석,김원호,고재기 대한심장학회 2008 Korean Circulation Journal Vol.38 No.2

Background and Objectives: Drug-eluting stents (DES) are effective for the maintenance of patency in patients with various complex coronary artery diseases. We investigated the efficacy of full metal jackets (FMJs,≥60 mm) using overlapping DES for very long coronary lesions. Subjects and Methods: The medical records and angiographic data of ninety-nine patients, and 100 FMJs that were implanted at Chonbuk National University Hospital since March 2003, were analyzed. Results: The mean age was 63±10 years and median follow-up period was 17.0 months. The mean lesion length was 57.7±10.8 mm, the mean number of implanted DES for FMJ was 2.2±0.5, and the mean length of the FMJ was 68.5±11.4 mm. Thirty percent of the lesions were the culprits of acute myocardial infarction and 22% were chronic total occlusive lesions. The procedural success rate was 98%. Triple antiplatelet agents were prescribed for 37.4% of the patients and the mean duration of clopidogrel use was 11.9±5.7 months. Overall major adverse cardiac events developed in 10% of patients. One patient died of probable stent thrombosis by the Academic Research Consortium definition. Follow-up coronary angiography was performed in 69% of cases. Binary restenosis was documented in 9 lesions (13.0%) and five FMJs (7.2%) were revascularized. Stent fractures were detected in four FMJs (5.8%). Conclusion: Although FMJs using DES may be regarded as a relatively safe and effective therapeutic approach for diffuse long coronary lesions, longer-term follow-up data with a larger population is needed to establish safety including special consideration for strategy of antiplatelet therapy. Background and Objectives: Drug-eluting stents (DES) are effective for the maintenance of patency in patients with various complex coronary artery diseases. We investigated the efficacy of full metal jackets (FMJs,≥60 mm) using overlapping DES for very long coronary lesions. Subjects and Methods: The medical records and angiographic data of ninety-nine patients, and 100 FMJs that were implanted at Chonbuk National University Hospital since March 2003, were analyzed. Results: The mean age was 63±10 years and median follow-up period was 17.0 months. The mean lesion length was 57.7±10.8 mm, the mean number of implanted DES for FMJ was 2.2±0.5, and the mean length of the FMJ was 68.5±11.4 mm. Thirty percent of the lesions were the culprits of acute myocardial infarction and 22% were chronic total occlusive lesions. The procedural success rate was 98%. Triple antiplatelet agents were prescribed for 37.4% of the patients and the mean duration of clopidogrel use was 11.9±5.7 months. Overall major adverse cardiac events developed in 10% of patients. One patient died of probable stent thrombosis by the Academic Research Consortium definition. Follow-up coronary angiography was performed in 69% of cases. Binary restenosis was documented in 9 lesions (13.0%) and five FMJs (7.2%) were revascularized. Stent fractures were detected in four FMJs (5.8%). Conclusion: Although FMJs using DES may be regarded as a relatively safe and effective therapeutic approach for diffuse long coronary lesions, longer-term follow-up data with a larger population is needed to establish safety including special consideration for strategy of antiplatelet therapy.

포스터 전시 발표 : 순환기, 호흡기 ; 굴곡성 기관지 내시경을 이용한 기관지결석 제거 2예

이규선,이나리,이강휴,이양덕,이홍범,이용철,이양근 대한내과학회 2002 대한내과학회 추계학술대회 Vol.63 No.-

서해상에서 발달한 중규모대류계와 지형에 관한 연구

원효성,정관영,이강휴,류찬수 한국기상학회 2006 한국기상학회 학술대회 논문집 Vol.2006 No.-