아토피 피부염 환자에 대한 임상적 연구

윤화정(Hwa-Jung Yun),고우신(Woo-Shin Ko) 대한한의학회 2001 대한한의학회지 Vol.22 No.2

곽향정기산가미방(藿香正氣散加味方) 투여 및 소장정격(小腸正格) 시술을 이용한 편평사마귀의 치료 효과

윤정민,신상호,윤화정,고우신,Yun, Jeong-Min,Shin, Sang-Ho,Yoon, Hwa-Jung,Ko, Woo-Shin 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.1

Objective : The purpose of this study was to investigate the effects of Combination therapy with Gwakhyangjeonggisangamibang and Sojangjeonggyeok on patients with verucca plana. Methods : Sixty-five patients(male 19, female 46) with verruca plana were treated with Gwakhyangjeonggisangamibang and Sojangjeonggyeok for at least 3 months. After treatment, a clearance rate was divided into 4 scales such as; complete clearance / partial clearance-good / partial clearance-poor / no change. Statistical analysis was performed by using Independent-sample t-test. Results : Mean age of patients was 30.3 and mean period of disease duration was 64.6 months. Fifty-eight patients(73.8%) showed complete clearance, nine(13.8%) partial clearance-good, and eight(12.3%) partial clearance-poor. Complete clearance group(CC group) was statistically younger than failure group and disease duration of CC group was shorter than failure group. Although treatment period of failure group was statistically longer than CC group and dosage(貼) of herbal medicine of failure group was more than CC group, failure group showed partial clearance. Conclusion : This data demonstrates that combination therapy with Gwakhyangjeonggisangamibang and Sojangjeonggyeok could be an effective and safe treatment for the verucca plana.

사마귀 클리닉 내원환자에 대한 통계적 고찰

윤정민,신상호,윤화정,고우신,Yun, Jeong-Min,Shin, Sang-Ho,Yoon, Hwa-Jung,Ko, Woo-Shin 대한한방안이비인후피부과학회 2009 한방안이비인후피부과학회지 Vol.22 No.2

Objective : The purpose of this study is to investigate the characteristics of patients with warts. Methods : We conducted statistics study on 100 patients, who had visited to Wart Clinic, from September 2008 to February 2009. Results : The results were as follows. 1. The wart was found more often from female(64%) than from male(36%). The age distributions of patients showed highest in 21-30 years, followed by 31-40 years, and 11-20 years. 2. The distributions of duration of warts showed highest in 1-5 years, followed by 6-10 years, and over 10 years. 3. The most common warts were Verruca plana(48%), Verruca vulgaris(25%), Verruca vulgaris with Palmoplantar wart(14%), Verruca plana with Verruca vulgaris(9%). 4. The Verruca vulgaris was found mostly in the hand, whereas the Verruca plana was seen mostly in the face. 5. Laser therapy was the most common previous treatment, followed by cryotherapy, immunotherapy in order. 6. The distributions of duration of treatment showed highest in 1-4 weeks, followed by 5-8 weeks, 9-12 weeks in order. 7. After treatment, 43 cases(43%) showed complete clearance, and 29 cases(29%) showed partial clearnace. Conclusion : We analyzed the characteristics of patients with warts. Further studies would be needed to develop the better treatment on warts.

스테로이드 치료후 리바운드 현상이 발생한 한포진 치험 1례

신상호,윤정민,허정은,고우신,윤화정,Shin, Sang-Ho,Yun, Jeong-Min,Heo, Jeong-Eun,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3

Objectives : The purpose of this study is to know the effect of Korean medical treatment on pompholyx including steroid rebound phenomenon. Methods : We experienced one case of pompholyx treated with herbal medicine, pharmacupuncture and acupuncture. To evaluate the results of this treatment, we categorized symptoms into four items which are vesicles, itching, erythema and erosions. Results & Conclusions : After treatment we observed the improvement. Based on this experience, it is considered that the Korean medicine can be applied to the treatment of pompholyx.

냉동치료 경험이 있는 손과 발의 난치성 사마귀에 대한 한방치료의 효과

신상호,윤정민,허정은,고우신,윤화정,Shin, Sang-Ho,Yun, Jeong-Min,Heo, Jeong-Eun,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.2

Objective : The purpose of this study is to know the efficacy of Korean medical treatment for recalcitrant hand and foot warts with an experience of cryotherapy. Methods : Twenty-two patients(male 12, female 10) with recalcitrant warts visited Amar Korean Medicine Clinic and were treated with herbal medicine, herbal acupuncture, acupuncture, moxibustion and bloodletting for at least 3 months. After treatment, a clearance rate was divided into 4 scales such as; complete clearance / partial clearance-good / partial clearance-poor / no change. Results : Mean age of patients was 23.4 years and mean period of disease was 43.6 months. Mean duration of treatment was 3.0 months and mean dosage(貼) of herbal medicine was 89.1. Nineteen patients(86.4%) showed complete clearance, one(4.5%) partial clearance-good, and two(9.1%) partial clearance-poor. Conclusion : This data demonstrates that Korean medical treatment could be an effective treatment for recalcitrant warts.

패혈증 쇼크에서 단삼 추출물의 억제 효과와 그 기전에 관한 연구

신상호,윤정민,고우신,윤화정,Shin, Sang-Ho,Yun, Jeong-Min,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.3

Objectives : This study was performed to investigate the protective effects and mechanisms of Salvia miltiorrhizae Radix extract (SME) on endotoxin shock.Methods : We used two models; LPS-induced sepsis model for in vivo model, and murine peritoneal macrophages responses for in vitro. SME was administrated orally to mice. After 1 hr, LPS was injected intraperitoneally. Survival rate was checked each time per 12 hr for 5 days. Mice were sacrificed 3 hr after LPS injection, then blood samples and organs were harvested. Cytokines secretion was measured by ELISA. Organs tissues were observed with microscope. Murine peritoneal macrophages were cultured for 1 hr either in a medium alone or in a medium that contained SME, as indicated. Then, the cells were treated with LPS for 24 hr. mRNA levels of cytokines were measured by real-time RT-PCR. Cytokine levels in the supernatants were measured by ELISA. The amount of nitrite was measured by using the Griess method to evaluate NO production. The cell lysates were analysed by Western blotting using antibodies for iNOS and β-actin was used as an internal control to monitor equal protein loading.Results : SME improverd the survival rate of mice model. SME inhibited the secretion of inflammatory cytokines and organs damages on Endotoxin Shock model. SME suppressed cytokine expression, cytokine secretion,NO production, iNOS expression in LPS-induced murine peritoneal macrophages.Conclusions : The results suggest that SME has protective effects on endotoxin shock through suppression of inflammatory cytokines, organ damages, NO production and so on.

Anti-allergic Effect of Gyokejsamu1tang-gagam(?桂四物湯-加減) in the RBL-2H3 Mast Cells

총배빈,신우진,류지효,김성희,윤화정,김원일,Tsung, Pei-Yun,Shin, Woo-Jin,Lyu, Ji-Hyo,Kim, Seong-Hui,Yoon, Hwa-Jung,Kim, Won-Il The Society of Korean Medicine Ophthalmology 2008 한방안이비인후피부과학회지 Vol.21 No.3

비만세포의 한 종류인 rat basophilic leukemia (RBL-2H3) 세포를 이용하여 교계사물탕-가감의 항알레르기 효과를 확인하고자 하였다. Phorbol 12-myristate 13-acetate (PMA)와 calcium ionophore A23187을 이용하여 RBL-2H3 세포를 자극한 후 세포의 탈과립 정도를 $\beta$-hexosaminidase assay로 확인한 결과, 전 처리한 교계사물탕-가감의 농도 의존적으로 탈과립을 억제하였다. Pro-inflammatory cytokines인 tumor necrosis factor (TNF)-alpha와 interleukin(IL)-4의 분비량을 enzyme-linked immunosorbent assay (ELISA)로 확인한 결과 교계사물탕-가감의 농도 의존적으로 감소하였으며, 이들 cytokines와 염증 반응에 주요한 인자인 cyclooxygenase (COX)-2 의 mRNA 발현 정도 역시 교계사물탕-가감에 의해 감소함을 확인할 수 있었다. 이러한 실험 결과로 보아 교계사물탕-가감은 알레르기 관련 질환의 치료에 응용될 수 있을 것으로 사료된다.

비내시경을 활용한 알레르기 비염에 대한 한의학적 변증 지표의 관찰자간, 관찰자내 신뢰도 연구

김규석,윤영희,박정수,김남권,김경준,김희택,홍승욱,장보형,윤화정,최인화,고성규,Kim, Kyu-Seok,Yun, Young-Hee,Park, Jeong-Su,Kim, Nam-Kwen,Kim, Kyung-Jun,Kim, Hee-Taek,Hong, Seung-Ug,Jang, Bo-Hyeong,Yoon, Hwa-Jung,Choi, In-Hwa,Ko, Seong- 대한한방안이비인후피부과학회 2013 한방안이비인후피부과학회지 Vol.26 No.2

Objectives : We performed a pilot study to investigate inter- and intra-rater reliability of pattern identification using nasal endoscopy for allergic rhinitis(AR). Methods : Eight experts of ophthalmology, otolaryngology and dermatology of Korean medicine evaluated 20 nasal endoscopy photograph cases of AR patients with pattern identification index using nasal endoscopy for AR including the nasal membrane color(pale / hyperemia), nasal membrane humidity(dryness / dampness), rhinorrhea(watery / yellow), and membrane edema (atrophic / edematous) on nasal endoscopy. Results : Intra-rater agreement(%) and Kappa coefficient was generally from 'moderate' to 'good'(% agreement: 73.13-90% / Kappa coefficient: 0.547-0.748). Inter-rater agreement(%) and Kappa coefficient was also from 'moderate' to 'good' (% agreement: 65-85% / Kappa: 0.475-0.778) except 'humidity(dryness / dampness)' item (% agreement: 55.98% / Kappa: 0.340). In findings of subgroup analysis according to affiliation of raters, Inter-rater agreement(%) and Kappa coefficient of raters in same affiliation was higher than inter-rater agreement(%) and Kappa coefficient of raters in different affiliation except 'dryness / dampness' item. Conclusions : It is necessary to improve objectivity and reproducibility of pattern identification using nasal endoscopy for allergic rhinitis(AR) through the development of detail-oriented criteria and enhanced training of clinicians with development of standard operating procedures(SOPs).

아토피 피부염 환자의 한의학적 유형분류에 대한 임상적 연구

윤화정,고우신 동의대학교 한의학연구소 2001 동의한의연구 Vol.5 No.-

목적 : 아토피 피부염의 진단에 있어 가장 중요한 것은 임상적인 증상이며, 상태의 평가와 치료효과에 대한 기준의 연구가 계속 시도되고 있다. 이에 우리는 한의학적인 진단 기준의 확립을 위해 이 연구를 시도하였다. 방법 : 2000년 3월부터 2000년 9월까지 6개월간 동의대학교 부속한방병원 한방 피부과에 내원한 아토피 피부염 환자 50명을 대상으로 하였다. 결론 : 1. 아토피 피부염 환자를 濕熱型과 血虛風燥型으로 한의학적인 임상유형으로 분류하였다. 2. 아토피 피부염 환자를 변증 유형별로 분석해보니 초진시에는 濕熱型이 많았으며 치료를 해나감에 따라 급성기 증상이 작아지고 血虛風燥型이 많아졌다. 3. 환자 50명 중 남녀비율로 볼 때 17명 대 33명으로 여자 환자가 약 2배 가량 많았으며, 시기별로 분류하면 제3기 즉 성인기 환자가 반 이상을 차지하였다. 4. 유아기 환자들은 범위가 넓지 않고 병변 상태는 중등도이며, 사춘기 및 성인기로 갈수록 부위는 미만성으로 몸 전체에 퍼져있으며 상태 또한 중증이 많이 나나타났다. 5. 부위 및 병변별 점수와 호전도를 분석한 결과 부위는 팔, 무릎이 가장 심했으며, 증상은 소양감의 호소가 가장 많았고, 치료함에 따라 미란, 홍반의 증상이 큰 호전도를 보였다. 6. Total IgE치를 측정한 결과 50명중 38명이 정상수치 이상으로 대체로 혈청 IgE와 연관성이 있으나, 아토피 피부염의 심한 정도와 일정하게 비례하는 것은 아니었다. Objectives : Atopic dermatitis(AD) assume an remarkable clinical aspect and it's diagnosis almost depends on clinical symptoms. Therefore, we aimed to study the clinical diagnostic standard of AD for more accurate treatment. We report as follows; Methods : For 6 months from March to August in 2000 we selected fifty outpatients who were prognosis of AD in the department of dermatology, Oriental media hospitol, Dong-eui University. Results and Conclusions : 1. We classified of the grade, the condition of AD patient was slight and severe, by the sum of total by the clinical index of AD (diagnostic features). 2. By consulting previous oriental medical theories, we divided symptom-complex (辨證) of AD into two type ; one was damp-heat type (濕熱型) and the other was deficiency of blood-wind-dryness type(血虛風燥型). 3. Male to female ratio was 17 : 33 and the third time, adolescence patients was nae than half. 4. According to the results of symptom - complex(辨證) of AD patients, on the first examination damp-heat type(濕熱型) was mere than deficiency of blood-wind-dryness type(血虛風燥型) and in progressing treatment, the condition has been change to deficiency of blood-wind-dryness type(血虛風燥型). 5. In the lesions of AD, arm and knee were most serious skin lesions and in symptoms of AD, pruritus was most complained, and in progressing treatment, erosion and erythema were greatly improved. 6. When we measured the levels of serum Total IgE, that of thirty eight patients were higher than that of normal, but elevation of serum IgE levels was not correlated with the severity of AD.