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윤종형,양혜란,고재성,서정기 대한소아청소년과학회 2006 Clinical and Experimental Pediatrics (CEP) Vol.49 No.10
Chylous ascites is a rare condition caused by various diseases and conditions that interfere with the abdominal or retroperitoneal lymphatics, and uncommonly it can manifest as a post-operative complication after abdominal, retroperitoneal or mediastinal surgery. Chylous ascites can be diagnosed by a high triglyceride content in ascites. The authors experienced a 5-year-old girl with congenital hepatic fibrosis who presented with chylous ascites after a splenorenal shunt operation, who was successfully managed by fasting and total parenteral nutrition, followed by a lipid-free diet with medium chain triglyceride supplementation. Here, the authors report this case of post-operative chylous ascites after a splenorenal shunt (Warren shunt) operation with a review of the pertinent literature. 복수는 복강이나 후복강의 림프순환계에 이상이 발생하는 질환이나 각종 원인에 의해서 발생하는 드문 질환으로서, 대개 혈장 내 triglyceride보다 2-8배 이상의 높은 복수 내 triglyceride의 함량을 보이는 경우 진단이 가능하다. 유미성 복수는 여러 가지 원인에 의해서 발생할 수 있지만, 수술 후 부작용으로서 복강이나 후복강 및 종격동의 수술 후 발생하는 경우가 드물게 있다. 저자들은 선천성 간섬유화증을 가진 소아 환자에서 비-신장 단락수술(Warren 단락술) 후에 발생하여 금식 및 총정맥영양에 이어 저지방식이를 시행한 후 호전된 유미성 복수증 1례를 경험하였기에 문헌고찰과 함께 이를 보고하는 바이다.
Anemia Can Be Associated with Isovaleric Acidemia
윤종형,이홍진 대한소아혈액종양학회 2018 Clinical Pediatric Hematology-Oncology Vol.25 No.1
Organic acidemia is a form of inborn errors of metabolism. Although organic acidemia can manifest many kinds of symptoms and signs by various organ dysfunction, repeated or prolonged anemia since infantile period is uncommon. We experienced an infant with repeated anemia which was accompanied by metabolic decompensation of isovaleric acidemia and improved after management of her underlying disease, and report it with a brief review.
소아 급성림프모구백혈병 환자에서 6-mercaptopurine과 6-thioguanine 사용 후 발생한 급성 췌장염 1예
윤종형,백재숙,김은경,강형진,신희영,안효섭 대한혈액학회 2008 Blood Research Vol.43 No.1
Although pancreatitis is known as a common complication during the treatment of acute lymphoblastic leukemia, acute pancreatitis that’s induced by 6-mercaptopurine or 6-thioguanine is very uncommon. We experienced the case of an 11-year-old boy with consecutive acute pancreatitis, and this was induced by 6-mercaptopurine and 6-thioguanine during maintenance chemotherapy of childhood acute lymphoblastic leukemia. We report here on this along with a review of the pertinent literature.
윤종형,박정아,김은경,강형진,신희영,안효섭 대한의학회 2009 Journal of Korean medical science Vol.24 No.2
Relapse is the major cause of treatment failure in acute lymphoblastic leukemia (ALL), yet there is no established treatment for relapsed ALL. To improve the induction remission rate, we modified the dose of idarubicin in the original Children’s Cancer Group (CCG)-1884 protocol, and retrospectively compared the results. Twenty-eight patients diagnosed with relapsed ALL received induction chemotherapy according to the CCG-1884 protocol. Complete remission (CR) rate in all patients after induction chemotherapy was 57%. The idarubicin 10 ㎎/㎡/week group showed CR rate of 74%, compared with the 22% CR rate of the idarubicin 12.5 ㎎/㎡/week group (p=0.010). Remission failure due to treatment-related mortality (TRM) was 44% and 5.2% in the idarubicin 12.5 ㎎/㎡/week and 10 mg/m2/week groups, respectively (p=0.011). Overall survival (OS) and 4-yr event-free survival (EFS) were 12.8% and 10.3%, respectively. OS and 4-yr EFS were higher in the idarubicin 10 ㎎/㎡/week group (19.3% and 15.6%) than in the 12.5 ㎎/㎡/week group (0% and 0%). In conclusion, a modified dose of idarubicin from 12.5 ㎎/㎡/week to 10 ㎎/㎡/week resulted in an improved CR rate in the treatment of relapsed ALL, which was due to lower TRM. However, despite improved CR rate with modified dose of idarubicin, survival rates were unsatisfactory.
클라미디아 감염 의증과 연관된 소아 발작한랭혈색소뇨증 1예
윤종형,조재소,박현진,심효은,공선영,윤주영,박병규 대한소아혈액종양학회 2014 Clinical Pediatric Hematology-Oncology Vol.21 No.2
Paroxysmal cold hemoglobinuria (PCH) is a rare diagnosis of acquired hemolytic anemia in children, which is caused by a specific cold antibody named Donath-Landsteiner hemolysin. Although various bacteria or viruses were reported as triggering factor of PCH, childhood PCH related to Chlamydia pneumoniae infection is uncommon. The authors report a case of childhood PCH which is related with suspicious Chlamydia pneumoniae infection, with a review of pertinent literature.
고위험군 소아 급성림프모구백혈병에서 초기 반응에 따른 치료 변경의 효과
윤종형,김은경,박정아,강형진,신희영,안효섭 대한혈액학회 2008 Blood Research Vol.43 No.4
Background: The bone marrow (BM) findingd on day 7 of induction chemotherapy is one of major prognostic factors for patients with acute lymphoblastic leukemia (ALL). M3 marrow (blast >25% on BM examination) on day 7 is associated with lower survival rates, compared with the M1 (blast <5%) or M2 (blast 5∼25%) marrow. Herein, we analyzed the effect of augmented post-induction chemotherapy in patients who have high-risk ALL with M3 marrow on the day 7 BM examination. Methods: We analyzed the patients who were diagnosed with high-risk ALL and they received modified Children's Cancer Group (CCG)-1882 induction chemotherapy between January 1996 and October 2005 at Seoul National University Children’s Hospital. The patients with M1 or M2 marrow on day 7 were treated with modified CCG-1882A/B chemotherapy from consolidation, and the patients with M3 marrow were treated with modified CCG-1882C chemotherapy. Results: A total of 44 patients (29 with modified CCG-1882A/B and 15 with modified CCG-1882C) were analyzed. The overall survival (OS) and 5-year event-free survival (EFS) were 86.2% and 81.9%, respectively. The OS of the patients who were treated with the modified CCG-1882A/B protocol (88.9%) was not different from that of the patients who were treated with the modified CCG-1882C protocol (80.0%) (P=0.3256). Also, there was no statistical difference in the 5-year EFS of both groups (85.4% vs 72.7%, respectively, P=0.2117). Conclusions: There was no difference of survival between the patients with M1/M2 marrow on the day 7 BM examination and those with M3 marrow after augmented post-induction chemotherapy for the patient with high-risk ALL. We suggest that the poor prognosis of high-risk ALL patients with a poor initial response could be overcome by augmented post-induction chemotherapy. (Korean J Hematol 2008;43:238-246.)
윤종형,강형진,Hyery Kim,Ji Won Lee,박준동,박경덕,신희영,Hyo Seop Ahn 대한의학회 2012 Journal of Korean medical science Vol.27 No.11
Primary CNS lymphoma (PCNSL) is a very uncommon disease in children, and usually treated by chemotherapy, combined with focal or craniospinal radiotherapy (RT). However,adverse effects of RT are a concern. We evaluated the outcomes of childhood PCNSL,treated with systemic and intrathecal chemotherapy, but without RT. For fifteen years, six patients among 175 of non-Hodgkin lymphoma were diagnosed as PCNSL in Seoul National University Children’s Hospital and we analyzed their medical records retrospectively. Their male:female ratio was 5:1, and median age was 10.1 yr. The primary sites were the sellar area in three patients, parietal area in one, cerebellum in one, and multiple areas in one. Their pathologic diagnoses were diffuse large B-cell lymphoma in three patients, Burkitt lymphoma in two, and undifferentiated B-cell lymphoma in one. Five were treated with the LMB96 treatment protocol, and one was treated with the CCG-106B protocol. None had RT as a first-line treatment. One patient had a local relapse and received RT and salvage chemotherapy, without success. No patient had treatment-related mortality. Their estimated 5-yr event-free and overall survival rates were both 83.3%. In conclusion, PCNSL is a rare disease in childhood, but successfully treated by chemotherapy without RT.
기독교인의 신앙성숙도, 사회복지의식과 목회자의 서번트리더십 간의 관계에 관한 연구
곽종형 ( Kwak Jong Hyung ),윤서구 ( Yoon Seo Goo ) 한국사회복지경영학회 2018 사회복지경영연구 Vol.5 No.2
기독교인의 신앙성숙은 하나님께서 계시하신 성경말씀에 전적으로 동의하고 성경말씀대로 생활 속에서 실천하는 행위에 매우 중요한 의미를 갖는다. 이는 사회복지의식의 출발이 하나님 사랑과 이웃 사랑으로 신앙성숙을 통해 실천적이고도 구체적으로 드러나게 되기 때문이다. 본 연구는 기독교인의 신앙성숙도, 사회복지의식과 목회자의 서번트리더십 간의 관계를 확인함으로써 기독교인의 복음적 가치로써 그리스도적 사회복지 실천에 대한 사회적 합의를 이끌어 낼 수 있는 실천적 방안을 마련하는데 그 목적이 있다. Maturity of Christian faith has a very important meaning to agree with the revealed scripture and act that in the Bible's word-like life. This is because the start of social welfare consciousness is practically and concretely disclosed to the maturity of faith through God's love and neighbor's love. The purpose of this study is to provide a practical way to bring about social consensus on Christian social welfare practice as a Christian's evangelistic value by confirming the relationship between the maturity of Christian faith and social welfare consciousness and pastor's servant leadership.