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만성활동성 (慢性活動性) 간질환자에서 (肝疾患者) Glycyrrhizin preparation ( Stronger Neo - minophagen C ) 의 투여효과
윤종만(Chong Mann Yoon),박종춘(Jong Chun Park),박광숙(Kwang Sook Park),범희승(Hee Seung Bom),유종선(chong Sung Rheu),박세원(Seh Won Park),국돈표(don Pio Kook),김성열(Seong Rhyull Kim) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.2
N/A Glycyrrhizin, one of the active component of licorice root, has been known to have various therapeutic effects in chronic hepatitis. For the assessment of therapeutic effect of glycyrrhizin preparation, we administered 40 ml of glycyrrhizin preparation intravenously in 566 ml of dextrose solution for 8 to 12 weeks, who had no symptomatic and biochemical improvement (more than 5 fold increase compared to normal value) during recent 3months in 17 patients with chronic active hepatitis. Also, laboratory follow-up of serum transaminase, HBsAg, and serum electrolyte were repeated at intervals of 7 days. The results were as follows. 1) In 16 out of 17 patients with chronic active hepatitis, serum transaminase level decreased to half value after glycyrrhizin preparation for 8 to 12 weeks duration. 2) In 14 out of 17 patients (82%), serum transaminase dropped to 2 fold level compared to normal value after 2 to 10 weeks treatment (mean SGOT: 4.5 weeks. SGPT: 5 weeks). 3) Serum transaminase were normalized in 7 out of 17 patients(42%) after 3 to 12 weeks treatment (mean SGOT: 6. 5 weeks, SGPT: 8 weeks). 4) There was no seroconversion of HBsAg during treatment. 5) There were no signs of pseudoaldosteronism including changes of serum sodium and potassium, presence of edema or hypertension during treatment.
윤종만(Chong Mann Yoon),유종선(Jong Sun Rew),최성규(Sung Kyu Choi),양대현(Dae Hyun Yang),이숭(Soong Lee),구철(Chull Koo) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.4
N/A Bile duct carcinoma is relatively rare malignancy with an extremely grave prognosis. The case records of 49 patients with primary carcinoma of the bile ducts seen at the Chonnam University Hospital from 1981 to 1988 were reviewed and analyzed. The results were as fo]lows 1) The peak age distribution was in seventh decade and the average age being 61.4 years. The sex ratio of male to female was 1.9:l. 2) In 43 of the 49 patients, anatomic location was extrahepatic bile duct. The most frequently involved site among the extrahepatic bile ducts was common bile duct (38.8%). 3) The most common symptom and sign were RUQ abdominal pain (75.5%), jaundice (89.7%), respectively. 4) Serum alkaline phosphatase and r-GTP were more increased in extrahepatic bile duct carcinoma than intrahepatic bile duct carcinoma. 5) Associated disease were clonorchiasis (12.2%), choledocholithiasis (10.2%), and gall stone (4.0%). 6) The most useful diagnostic modality was percutaneous transhepatic cholangiography and focal stenotic lesions (66.6%) were rnost common. 7) Operability and resectability were 26.5%, 16.3%, respectively. 8) Tubular adenocarcinoma was the most frequent histo]ogic type.
최확도법을 (最確度法) 이용한 무증상 (無症狀) 정상간기능 (正常肝機能) HBsAg 양성자 간스캔의 감별진단 (鑑別診斷)
윤종만(Chong Mann Yoon),범희승(Hee Seung Bom),류종선(Jong Sun Rew),이성(Sung Lee),윤경환(Kyung Hwan Yoon),김지열(Ji Yeoul Kim) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.2
N/A For the differential diagnosis of asymptomatic HBsAg carrier with normal liver function by the liver scan, authors applied the maximum likelihood method as follows: 1) Ninety-six cases who underwent both peritoneoscopic liver biopsy and liver scan were divided randomly into two groups. In one group scoring table was made and in the other group diagnostic accuracy of the data was evaluated. The diagnostic accuracy in general was 53.2% and those in normal, liver cirrhosis, nonspecific reactive hepatitis, and chronic active hepatitis were 85.7%, 75%, 62.5%, and 12.5%, respectively. 2) Twenty-eight liver scans of aymptomatic HBsAg carrier with normal liver function were revealed to be normal in 23 cases (82.2%) and liver cirrhosis in 5 cases (17.8%). In conclusion the maximum likelihood method was considered to be useful in the differential diagnosis of liver scans. And we recommend a careful evaluation of asymptomatic HBsAg carrier with normal liver function in view of the fact that 17.8% of them was diagnosed as liver cirrhosis in this study.