전자 패키징의 플립칩 본딩 기술과 신뢰성

윤정원,김종웅,구자명,하상수,노보인,문원철,문정훈,정승부,Yoon, Jeong-Won,Kim, Jong-Woong,Koo, Ja-Myeong,Ha, Sang-Su,Noh, Bo-In,Moon, Won-Chul,Moon, Jeong-Hoon,Jung, Seung-Boo 대한용접접합학회 2007 대한용접·접합학회지 Vol.25 No.2

BALB/c 마우스에서 동종 지방유래 기질세포가 창상치유에 미치는 영향

윤정원,임진수,김정남,유결,Yoon, Jeong-Won,Lim, Jin-Soo,Kim, Jung-Nam,Yoo, Gyeol 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.4

Purpose: Adipose-derived stromal cells (ADSCs) are multipotent cells that have been found to promote wound healing through the process of angiogenesis and reepithelialization. Generally, it is well known that the antigenicity of ADSCs doesn't affect stem cell therapy. In this study, we investigated the effect of allogeneic ADSCs in the wound healing process by applying allogeneic ADSCs on the wound healing splint model of mice. Methods: Adipose tissue was harvested from the epididymal fat pads of BALB/c and C57BL/6 mice. Twenty four mice BALB/c were divided into three groups; control, isogeneic, and allogeneic groups. Two full thickness defects with 6 mm diameters were created on the back of BALB/c mice. $1{\times}10^6$ ADSCs from BALB/c mice were applied on the isogeneic group. In the allogeneic group, ADSCs from the C57BL/6 mice were applied. No cells were applied to the control group. The sizes of the wounds were evaluated in 3, 5, 7, 10, and 14 days after the wounds were applied, and tissues were harvested in 7 and 14 days for histological analysis. Results: Wound healing rates had showed significant increase in 10, and 14 days when the isogeneic group was compared to the control group, but the allogeneic group showed significantly decrease compared to the isogeneic group (p<0.05). Histological scores in the isogeneic group were significantly high, but significantly lower in the allogeneic group when compared to the isogeneic group in 2 weeks (p<0.05). In the isogeneic group, thick inflammatory cell infiltration with abundant capillaries were observed in 1 week, and thick epithelium with many large capillaries were observed in 2 weeks. Conclusion: When isogeneic ADSCs were applied to wounds, they presented a faster wound healing rate compared to controls and the allogeneic group. Unlike general stem cell therapy, these findings suggest that cell therapy targeted at enhancing wound healing may benefit from the use of ADSCs with identical antigenicity, as opposed to allogeneic or xenogenic ADSCs.

B16/F10 흑색종양세포에서 삼내자 메탄올 추출물의 멜라닌 생성에 미치는 억제효과

윤정원,한정민,윤화정,고우신,Yoon, Jung-Won,Han, Jung-Min,Yoon, Hwa-Jung,Ko, Woo-Shin 대한한방안이비인후피부과학회 2013 한방안이비인후피부과학회지 Vol.26 No.1

Objective: Recently the demands for the effective and safe depigmentative and anti-aging agents of the skin have increased due to the medical, pharmaceutical and cosmetic reasons. The purpose of this study is to investigate the MKG(Methanol Extract of Kaempferia galanga) and their dermal bioactivity properties related to cosmeceuticals such as depigmentation. Methods: We assessed inhibitory effects of MKG on melanin production in B16/F10 melanoma cells, on mushroom tyrosinase activity, effects of MKG on the expression tyrosinase, TRP-1, TRP-2, GSK-$3{\beta}$, CREB, MITF in B16/F10 melanoma cells without cytotoxicity range. Cell viability was measured by MTT assay and tyrosinase activity was assessed using by DOPA staining, western-blot analysis. We measured inhibition of melanin synthesis and tyrosinase activity by down-regulation of melanogenic enzyme expressions in ${\alpha}$-MSH induced melanogenesis B16/F10 melanoma cells. Results: MKG inhibited tyrosinase-activity, total melanin contents and dendrite out-growth. MKG inhibited melanogenesis by down-regulation of tyorsinase, TRP-1, TRP-2, CREB, and MITF in B16/F10 cells. The treatment with MKG at the 12.5, $25{\mu}g/ml$ level significantly inhibited the melanin synthesis induced ${\alpha}$-MSH in B16/F10 melanoma cells compared with untreated control. Conclusion: These results suggest that MKG inhibit melanin biosynthesis which is involved in hyper-pigmentation. So MKG is considered to be used as a whitening components reducing cytotoxicity.

전자 패키징의 요소기술

윤정원,문원철,정승부,Yoon Jeong-Won,Moon Won-Chul,Jung Seung-Boo 대한용접접합학회 2005 대한용접·접합학회지 Vol.23 No.2

전기자동차용 고신뢰성 파워모듈 패키징 기술

윤정원,방정환,고용호,유세훈,김준기,이창우,Yoon, Jeong-Won,Bang, Jung-Hwan,Ko, Yong-Ho,Yoo, Se-Hoon,Kim, Jun-Ki,Lee, Chang-Woo 한국마이크로전자및패키징학회 2014 마이크로전자 및 패키징학회지 Vol.21 No.4

The paper gives an overview of the concepts, basic requirements, and trends regarding packaging technologies of power modules in hybrid (HEV) and electric vehicles (EV). Power electronics is gaining more and more importance in the automotive sector due to the slow but steady progress of introducing partially or even fully electric powered vehicles. The demands for power electronic devices and systems are manifold, and concerns besides aspects such as energy efficiency, cooling and costs especially robustness and lifetime issues. Higher operation temperatures and the current density increase of new IGBT (Insulated Gate Bipolar Transistor) generations make it more and more complicated to meet the quality requirements for power electronic modules. Especially the increasing heat dissipation inside the silicon (Si) leads to maximum operation temperatures of nearly $200^{\circ}C$. As a result new packaging technologies are needed to face the demands of power modules in the future. Wide-band gap (WBG) semiconductors such as silicon carbide (SiC) or gallium nitride (GaN) have the potential to considerably enhance the energy efficiency and to reduce the weight of power electronic systems in EVs due to their improved electrical and thermal properties in comparison to Si based solutions. In this paper, we will introduce various package materials, advanced packaging technologies, heat dissipation and thermal management of advanced power modules with extended reliability for EV applications. In addition, SiC and GaN based WBG power modules will be introduced.

Optoelectronic 패키징을 위한 Au-Sn 플립칩 범핑 기술과 신뢰성

윤정원,김종웅,구자명,노보인,정승부,Yoon, Jeong-Won,Kim, Jong-Woong,Koo, Ja-Myeong,Noh, Bo-In,Jung, Seung-Boo 대한용접접합학회 2008 대한용접·접합학회지 Vol.26 No.1

병렬구조를 이용한 새로운 역감제시장치의 설계 및 해석

윤정원(Jung-won Yoon),류제하(Jeha Ryu) 제어로봇시스템학회 2000 제어로봇시스템학회 합동학술대회 논문집 Vol.2000 No.3

전형적인 알레르기 증상으로 내원한 6세 미만 소아 환자에서 항원 감작 패턴: 단일 기관 연구

윤정원 ( Jung Won Yoon ),이상민 ( Sang Min Lee ),김준환 ( Joon Hwan Kim ),김나연 ( Na Yeon Kim ),백지현 ( Ji Hyeon Baek ),백혜성 ( Hey Sung Baek ),지혜미 ( Hye Mi Jee ),김형윤 ( Hyeung Yoon Kim ),최선희 ( Sun Hee Choi ),김기은 ( K 대한천식알레르기학회 2014 Allergy Asthma & Respiratory Disease Vol.2 No.4

Purpose: Population studies have reported that sensitization to inhalant allergens is rare in young children; however, most subjects in those studies had little or no symptoms or signs highly suggestive of allergic diseases. The aim of the present study was to assess the prevalence of sensitization to inhalant allergens in young children with symptoms and/or signs of allergic disease. Methods: We analyzed the results of all specific IgE tests performed at our hospital laboratory in children younger than 6 years presenting with symptoms and/or signs highly suggestive of allergic diseases between 2008 and 2013. Specific IgE tests for Dermatophagoides pteronyssinus, Dermatophagoides farinae, Alternaria alternata, German cockroach, cat dander, egg white or egg yolk, milk, peanut, and soybean were performed on 295 children; a specific IgE concentration ≥0.35 or ≥0.2 IU/mL was considered positive. We also compared allergen sensitization rates using the two cutoff values. Results: One hundred eighty-one children (61.4%) were positive to at least 1 allergen tested and 53 children (18.9%) were positive to at least 1 inhalant allergen when a specific IgE concentration ≥0.35 IU/mL was considered positive. The children were more likely to have asthma or allergic rhinitis when they were sensitized to any inhalant allergen, particularly house dust mites. The prevalence of sensitization to inhalant allergens increased with age (P<0.001). There was no significant difference in the prevalence of polysensitization among different age groups, but sensitization to both inhalant and food allergens significantly increased with age. Conclusion: Our results suggest that specific IgE tests to common inhalant allergens, particularly the house dust mites, may be considered when performing blood screening tests for young children presenting with symptoms and/or signs of allergic diseases

제4섹터 주도 지역개발에 대한 연구: 강원도 화천군 관광개발 성공사례를 중심으로

윤정원 ( Jung Won Yoon ),박다현 ( Da Hyoun Park ),반장식 ( Jahng Shick Bahn ) 한국지방행정연구원 2013 地方行政硏究 Vol.27 No.3

지역개발에 있어 공공부문과 민간부문이 협력하여 합동개발사업을 추진하는 제3섹터가 각광받아 왔으나 운영에 한계점을 드러내면서 대안적인 지역개발 방식의 필요성이 대두되고 있다. 이에 본 연구는 공공부문과 지역주민의 협력방식인 제4섹터를 대안으로 제시하기 위하여 지역관광개발을 성공적으로 도모한 강원도 화천군 사례를 분석하였다. 관민합동조직으로 운영되는 화천군 나라축제조직위원회에 대한 사례 연구를 통해 제4섹터 주도 지역 개발에 영향을 미치는 성공요건과 제약요건을 도출하였다. 제4섹터 실현화가 가능했던 조건으로는 지역문제의 크기와 분포 및 사업의 타당성, 지방자치단체장의 리더십, 참여주체들과 조직목표의 적합성, 관민의 협력 분위기, 참여주민의 자율성, 개방적인 의사소통 등으로 나타났다. 반면에 운영자원 조달과 초기 자발적인 주민참여는 제4섹터가 설립되고 운영되는데 제약조건으로 나타났다. 이러한 분석결과를 통하여 본 연구는 제3섹터 주도의 개발방식에 의존했던 기존의 지역개발 패러다임을 확장함으로써 지역개발 방법론에 대한 연구 지평을 넓힌다는 의의를 갖는다. 뿐만 아니라 자생적 지역개발에 대한 정책적 시사점으로 상향식 개발전략과 지역주민 주도형 개발방식의 활성화 방안을 제시하고 있다. This paper proposes the fourth sector approach as a new alternative method of the third sector in promoting regional development. Recently, the fourth sector appears as either a non-profit organization or a public work operated in collaborations with local government and citizens. As a community-led development approach, the fourth sector becomes recognized as effective strategies for regional development. The voluntary citizen participation is essential to the establishment of the fourth sector. In order to stress the importance of citizen engagement in community development, this study analyzes the success case of the fourth sector driven local tourism development in Hwacheon County. The case analysis focuses on the foundation and management of the emerging fourth sector organization, the Hwacheon County festival organizing committee, which aims to implement a local festival project through government-citizen collaborations. The analytical results indicate that the magnitude and range of regional problems and project feasibility, local government leadership, local government-citizen cooperative atmosphere, concerted goals of organization and participants, citizen participant`s autonomy, and open communication are the main factors leading to the success of the fourth sector. However, insufficient resources and challenges of inducing initial citizen participation restrict the growth of the fourth sector.

임상 ; 분만 산모의 상급병실 선택 요인과 실제 병상 사용 현황

윤정원 ( Jung Won Yoon ),한상원 ( Sang Won Han ),이산희 ( San Hui Lee ),정연수 ( Yeon Soo Jung ),김지만 ( Ji Man Kim ),김의혁 ( Eui Hyeok Kim ) 대한주산의학회 2014 Perinatology Vol.25 No.3

목적 : 최근 저출산, 국민 소득 수준 향상 등에 따라 산모들이 분만 후 처치와 모유 수유 등을 위해 전용 공간인 상급 병실을 선호하는 경향이 있다. 한편, 국민건강보험에서는 의료기관이 상급병실을 전체 병상의 50% 미만으로 유지하도록 규정하고 있다. 본 연구는 분만 환자의 일반 병실 또는 상급 병실 선택 이유를 파악하고 실제 병상 사용 현황을 검토하여, 병상 이용의 효율성과 형평성을 높이는 정책적 방안을 모색한다. 방법 : 2011년도 기준으로 분만 건수가 10건 이상인 요양 기관 대상으로 요양 기관 종별, 병상 수, 지역을 고려, 166개 의료기관을 표본 추출한 뒤, 2012년 11월 1일부터 11월 30일 까지 설문 조사 전문 업체에 의뢰하여 802명의 산모를 대상으로 1:1 설문조사를 실시 하였다. 대상자들의 병실이용 현황과 병실 선택과 관련된 상황과 인식, 만족도를 조사하였다. 결과 : 총 802명의 산모 중 상급 병실 이용자/선호자는 각각 690명(86%)/684명(85.2%), 일반 병실은 112명(14%)/118명(14.8%) 이었다. 35세 미만의 산모에서 상급 병실을 더 많이 이용하였다(87.3% vs. 80.3%, P=0.026). 의료기관 종별 유형은 의원, 병원, 종합병원, 상급종합병원 순서로 산모들의 상급병실 이용이 많았다. 제왕절개 여부, 다태아 여부, 경산 여부는 상급 병실의 이용에 유의한 차이가 없었다. 병실의 만족도는 상급병실이 일반병실 보다 유의하게 높았고[5.9±1.0 vs. 5.4±1.2 (0-7 scale), P<0.01], 가구 총 소득 역시 상급병실 이용자에서 높았다. 상급병실 이용 이유는 분만 후 충분한 요양 (78%), 모유 수유(6.1%), 방문 가족 접객(5.4%) 등이었다. 추후 병원 이용 시 상급 병실 선호도는, 분만의 경우가 분만 외 질환 시 보다 높았다(81.8% vs. 44.9%, P<0.001). 결론 : 분만 입원의 특성상 사생활 보호, 충분한 요양의 필요, 모유 수유, 가족공간의 필요성 때문에 상급병실에 대한 선호 및 실제 이용이 높다. 반면 소득수준, 보험가입여부, 연령에 따라 상급병실 이용에 격차가 생기고 있으므로, 분만에 한해 상급병실료의 국가 지원이 필요하며 아울러서 상급병실 비율 완화와 병실료 적정화와 같은 정책적 제언이 필요할 것이다. Purpose : Demand of specialized maternity ward is increasing as national income level rises. However, the National Health Insurance limits the number of hospital’s non-standard room to less than 50% of total hospital beds. Therefore, this research was performed to investigate the utilization of non-standard room among the Korean women who recently delivered baby in medical facilities in order to examine the factors affecting their selection. Methods : One hundred sixty six medical facilities which deliver a minimum of ten cases in the year 2011 were selected and categorized by type, region, and size. A cross-sectional survey was done in November 2012 by a professional research survey company. Eight hundred and two pregnant women answered the questionnaire through a face-to-face interview. Results : Of the 802 expecting mothers, 690 (86%) occupied non-standard room and 684 (85.2%) preferred non-standard room to the standard room. Satisfaction levels were significantly higher in mothers occupying non-standard room [5.9±1.0 vs. 5.4±1.2 (0-7 scale), P<0.01] and high-income families used non-standard room more often. Reasons for using non-standard room included adequate convalescence (78%), separate place for breastfeeding (6.1%), and convenience on receiving visitors (5.4%). Preference for non-standard room on next visit was higher in case of delivery compared to other cause of hospitalization (81.8% vs. 44.9%, P<0.001). Conclusions : Preference and actual use of non-standard room after delivery was significant. In spite of concrete preference, there was certain barrier in use of non-standard room according to income and types of hospitals. Therefore, changes of policy are needed such as insurance support for room charge in case of delivery.