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윤장욱,박상훈,김은정,홍지현,이형석,오길찬,박철희,한태호,이동근,김종혁,박혜림,박충기 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.3
Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disease of unknown cause associated with circulating autoantibodies and high serum globulin level. Systemic lupus erythematosus (SLE) is a disease of unknown etiology in which tissues and cells are damaged by pathogenic autoantibodies and immune complex, affecting multiple organs including the liver, kidney, and CNS. The difference between the hepatic involvement of SLE and autoimmune hepatitis has not been clearly defined in the past due to similarities in clinical and biochemical features. A scoring system for the diagnosis of AIH has been established, and AIH and SLE associated hepatitis have been defined as two different entities, although both have the same autoimmune features such as polyarthralgia, hypergammaglobulinemia and circulating autoantibodies. AIH has been considered to occur infrequently in SLE. We report two cases of AIH which simultaneously satisfied the criteria of SLE.(Korean J Hepatol 2003;9:231-235)
윤장욱,정영옥 대한내과학회 2003 대한내과학회지 Vol.64 No.2
폐암이 소장으로 전이된 경우 임상 증상이 뚜렷하지 않기 때문에 조기에 발견하기가 어려우며, 또한 복통, 오심, 구토 등의 증상이 있을 때는 장중첩증이나 장폐쇄로 인한 복막염이 함께 있는 경우가 많기 때문에 예후가 극히 불량하다. 소장 전이로 외과적 처치를 한 후 평균 생존율은 12주 이하였으며, 16주 이상 생존한 경우는 한 예를 제외하고는 없었다. 본 저자들은 47세 남자 환자에서 비소세포폐암의 공장 전이로 인한 장중첩증이 진단되어, 공장 부분 절개술 및 문합술 후 보존적 항암요법을 시행하여 폐암의 소장 전이로 진단된 후 30주 생존한 예를 경험하여 보고하는 바이다. Metastasis to small bowel from non-small cell lung cancer is known to be very rare. Here we report a case of intussusception induced by jejunal metastasis of non-small cell lung cancer. A 47-year old man was admitted to hospital complaining cough and sputum for 3 months. He was diagnosed as squamous cell lung cancer by percutaneous needle biopsy of lung mass detected by chest X-ray and CT. Multiple brain metastatic lesions were detected by brain CT on admission. systemic chemotherapy with whole brain irradiation was performed. After three cycles of chemotherapy, he was admitted with sudden-onset abdominal pain, nausea and vomiting. Jejunal intussusception was the diagnosis by abdominal CT and histologic examination of resected jejunum showed it was induced by metastatic mass from the primary lung cancer. (Korean J Med 64:235-239, 2003)
윤장욱,박상훈,김은정,홍지현,이형석,오길찬,박철희,한태호,이동근,김종혁,박혜림,박충기 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.3
Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disease of unknown cause associated with circulating autoantibodies and high serum globulin level. Systemic lupus erythematosus (SLE) is a disease of unknown etiology in which tissues and cells are damaged by pathogenic autoantibodies and immune complex, affecting multiple organs including the liver, kidney, and CNS. The difference between the hepatic involvement of SLE and autoimmune hepatitis has not been clearly defined in the past due to similarities in clinical and biochemical features. A scoring system for the diagnosis of AIH has been established, and AIH and SLE- associated hepatitis have been defined as two different entities, although both have the same autoimmune features such as polyarthralgia, hypergammaglobulinemia and circulating autoantibodies. AIH has been considered to occur infrequently in SLE. We report two cases of AIH which simultaneously satisfied the criteria of SLE.(Korean J Hepatol 2003;9:231-235) 자가면역성 간염은 고감마글로불린혈증과 혈액내 자가항체를 가진 원인 불명의 만성 염증성 간 질환으로 15-25세의 젊은 여성, 45-60세의 폐경 전후 여성에서 흔하며, 동양인에게서는 HLA-DR4유전인자와 관련있는 것으로 알려져 있다.1 1950년대에 처음 기술되어, 그 후로 자가면역성 만성 활동성 간염으로 불려왔다.2 최근까지 간을 침범한 루푸스를 루푸스 간염(lupus hepatitis)으로, 루푸스와 비슷한 임상 증상을 보이는 만성 활동성 간염을 자가면역성 간염이라 불렀으나 사실상 구분하기 어려웠다. 자가면역성 간염과 루푸스의 진단 기준이 제시되면서 구분하기 어려웠던 루푸스 간염과 자가면역성 간염은 각각 독립된 질환으로 분류되기 시작했다. 루푸스 환자에서 루푸스 간염이 아닌 자가면역성 간염이 동반되는 경우는 매우 드문 것으로 알려져 있다.3-5 저자들은 루푸스와 동반된 자가면역성 간염 2예를 경험하였기에 보고하는 바이다.
대한간학회지 제8차 춘계학술대회 초록집 : 포스터 전시 ; 전신성 홍반성 루푸스와 동반된 자가면역성 간염 2예
윤장욱 ( Yun Jang Ug ),박상훈 ( Park Sang Hun ),이형석 ( Lee Hyeong Seog ),임해성 ( Im Hae Seong ),박철희 ( Park Cheol Hui ),송진영 ( Song Jin Yeong ),한태호 ( Han Tae Ho ),박현주 ( Park Hyeon Ju ),김종혁 ( Kim Jong Hyeog ),박충기 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
피부근염에서 동시에 발생된 거대세포바이러스 폐렴과 망막염
윤장욱 ( Jang Uk Yoon ),윤호성 ( Ho Sung Yoon ),곽승기 ( Seung Ki Kwok ),고혁재 ( Hyek Jae Koh ),김호연 ( Ho Youn Kim ),박성환 ( Sung Hwan Park ) 대한류마티스학회 2009 대한류마티스학회지 Vol.16 No.3
Cytomegalovirus (CMV) infection commonly affects patients who are in an immunocompromised state, such as acquired immune deficiency syndrome (AIDS) and during organ transplantation. Although cytomegalovirus infection does not occur frequently, it is a major cause of morbidity and mortality in patients suffering with connective tissue diseases, including dermatomyositis. Cytomegalovirus pneumonitis and retinitis has been rarely reported in patients with dermatomyositis. We report here on an usual case involving the simultaneous occurrence of cytomegalovirus pneumonitis and retinitis in a 39-year-old female with dermatomyositis, and this woman had been treated with steroids and immunosuppressive agents for the previous 5 months.
Emphysematous Cystitis with Bladder Rupture by Candida albicans
Kim, Ki-Seong,Moon, Sun You,Yoon, Jang Uk,Lee, Seung Soon,Cho, Jin Seon,Chung, Doo Ryeon 대한감염학회 2005 감염과 화학요법 Vol.37 No.2
공기증방광염(emphysematous cystitis)은 주로 당뇨병이나 신경탓방광 환자에서 발생하는 드문 감염질환으로서 치명률이 매우 높다. 이의 원인 미생물은 Escherichia coli, Klebsiella와 같은 세균이 가장 흔하며 칸디다에 의한 증례는 아주 드물어 현재까지 몇 증례만 보고되어 있을 뿐치다. 이 중에서도 방광 파열이 동반된 증례는 non-albicans Candida 종에 의한 증례가 2예 보고되었을 뿐이다. 저자 등은 Candida albicans에 의한 공기증방광염이면서 자발적 방광 파열로 초기 발현된 증례를 경험하여 이를 문헌 고찰과 함께 최초로 보고하는 바이다. Emphysematous cystitis is an uncommon life-threatening disease, which often occurs in patients with diabetes mellitus or neurogenic bladder. Bacterial etiologies are common, while cases by Candida species have been very rarely reported. To date, only six cases of Candida albicans related emphysematous cystitis have been reported; two cases resulted in bladder repture and the causative organisms were non-albicans Candida species. We report the first case of emphysematous cystitis caused by Candida albicans accompanying a spontaneous bladder rupture with the review of literatures.
녹색발광 β-SiAlON:Eu 세라믹 플레이트 형광체의 치밀화 소결
박영조,이성훈,장욱경,윤창번,윤철수,Park, Young-Jo,Lee, Sung-Hoon,Jang, Wook-Kyung,Yoon, Chang-Bun,Yoon, Chul-Soo 한국세라믹학회 2010 한국세라믹학회지 Vol.47 No.6
$Eu^{2+}$-doped $\beta$-SiAlONs ($Si_{6-z}Al_zO_zN_{8-z}:Eu_y$) are recognized as promising phosphor materials to build an white LED for lighting application due to its excellent absorption/emission efficiency in the long wave length region. In this research, the fabrication of $\beta$-SiAlON:Eu plate phosphor by sintering was investigated with fixed Eu content(y) and varied composition of the host lattice(z). The addition of the activator $Eu_2O_3$ lead to enhanced densification by forming the transient liquid phase. The refinement of a composition by the calculated lattice parameter indicated that the measured composition of the fabricated specimens is nearly same to that of designed one. The single phase $\beta$-SiAlON:Eu plate with relative density of 96.4% was achieved by addition of 2 wt% CaO, which implies the possibility of full densification by adjusting the processing variables.
방광 파열이 동반된 Candida albicans에 의한 공기증방광염 1예
김기성,문선유,윤장욱,이승순,조진선,정두련 대한감염학회 2005 Infection and Chemotherapy Vol.37 No.2
Emphysematous cystitis is an uncommon life-threatening disease, which often occurs in patients with diabetes mellitus or neurogenic bladder. Bacterial etiologies are common, while cases by Candida species have been very rarely reported. To date, only six cases of Candida albicans related emphysematous cystitis have been reported; two cases resulted in bladder repture and the causative organisms were non-albicans Candida species. We report the first case of emphysematous cystitis caused by Candida albicans accompanying a spontaneous bladder rupture with the review of literatures. 공기증방광염(emphysematous cystitis)은 주로 당뇨병이나 신경탓방광 환자에서 발생하는 드문 감염질환으로서 치명률이 매우 높다. 이의 원인 미생물은 Escherichia coli, Klebsiella와 같은 세균이 가장 흔하며 칸디다에 의한 증례는 아주 드물어 현재까지 몇 증례만 보고되어 있을 뿐이다. 이 중에서도 방광 파열이 동반된 증례는 non-albicans Candida 종에 의한 증례가 2예 보고되었을 뿐이다. 저자 등은 Candida albicans에 의한 공기증방광염이면서 자발적 방광 파열로 초기 발현된 증례를 경험하여 이를 문헌 고찰과 함께 최초로 보고하는 바이다.