PMMA 나노 입자를 이용한 생분해성 필름 제조 및 물리적 특성

윤순도 ( Soon Do Yoon ),강웅일 ( Ung Il Kang ),윤연흠 ( Yeon Hum Yun ) 조선대학교 공학기술연구원 2009 공학기술논문지 Vol.2 No.4

In this study, biodegradable films are prepared by using com starch, polyvinyl alcohol (PVA), nanosized polymer particles (polymethyl methacrylate (PMMA)), and additives. Glycerol (GL), xylitol (XL) tartaric acid (TA), and citric acid (CA) were used as additives. Nano-sized PMMA particles synthesized by the method of emulsion polymerization. The morphology and the physical properties such as tensile strength (TS), elongation (%E), degree of swelling (DS), and solubility (S) of biodegradable films were investigated. The results verified that with the increase in PMMA contents, the TS and DS values of films were increased, whereas %E and S values were decreased. Also, the biodegradation of films was carried out using the soil burial test.

초임계유체 공정과 분리기술의 응용

윤순도(Soon-Do Yoon),변헌수(Hun-Soo Byun) 한국청정기술학회 2012 청정기술 Vol.18 No.2

초임계유체기술은 최근 다양한 화학 산업 분야에서 새로운 관심을 모으고 있는 신기술의 하나라 할 수 있다. 초임계유체기술은 높은 용해성, 빠른 침투성, 빠른 물질 이동 등의 초임계유체 장점을 이용한 기술로써 친환경, 에너지 절감, 고효율성을 가진 현재로서 가장 효과적이고 실용적인 기술이라 하겠다. 이러한 특징을 가진 초임계유체기술을 이용한 응용 기술의 잠재력을 분석 및 평가하고 개발하는 것은 필수적이다. 따라서 본 총설에서는 초임계유체기술의 응용 측면에서 초임계유체내에서 고분자 중합 공정의 최적화를 위한 기초자료인 모노머/고분자의 고온·고압에서 초임계유체 내에서의 상거동 현상을 설명하고, 이러한 자료를 통해 초임계유체 내에서 특정물질을 분리 할 수 있는 분자인식고분자의 제조와 성능 평가에 대해 소개하였다. Supercritical fluid technology (SFT) is recently one of the most new techniques, which has been interested various fields of related chemical industries. SFT is the most effective and practical technology with eco-friendly, energy-savings, and high efficiency as the technique using the advantages of supercritical fluid such as high solvation power, solubility, mass transfer rate, and diffusion rate. Especially, it is necessary to analyze, evaluate, and develop the potential of application techniques using SFT with these characterizations. Therefore in this review, the phase behavior in supercritical fluid at high temperature and pressure of monomers/polymers for the optimization of polymerization process are briefly described, and the preparation of molecularly imprinted polymers (MIPs) in supercritical fluid using supercritical polymerization and the performance evaluation of MIPs are introduced.

Starch와 PVA를 이용한 생분해성 필름의 제조와 물리적 특성

윤연흠 ( Yeon Hum Yun ),윤순도 ( Soon Do Yoon ) 조선대학교 공학기술연구원 2008 공학기술논문지 Vol.1 No.1

We report on the preparation and physical properties of films using corn starch and poly(vinyl alcohol) (PVA). Starch/PVA biodegradable films were synthesized with a mixing process and casting method. Glycerol (GL), sorbitol (SO), malic acid (MA), tartaric acid (TA) and citric acid (CA) were used as additives. Gelatin (GE) was used as filler for increasing of physical properties of starch/PVA biodegradable films. The additives and the influence of filler in films on the physical properties of the films were investigated. The mechanical properties, tensile strength (TS), elongation al break (% E), degree of swelling (DS), and solubility (S) of starch/PVA blend film were examined adding GL, SO, MA, TA and CA as additives and GE as filler. The results of the measurements indicated that the GE-added films were better than the other films.

나프록센이 각인된 생분해성 고분자 기반 다층 바이오소재의 제조 및 약물 방출 특성

조은비,김한성,황민진,윤순도,Eun-Bi Cho,Han-Seong Kim,Min‑Jin Hwang,Soon-Do Yoon 한국공업화학회 2023 공업화학 Vol.34 No.2

본 연구는 allbanggae starch (ABS), polyvinyl alcohol (PVA), alginic acid (SA)를 이용하여 naproxen (NP) 각인 starch 기반 다층 바이오소재를 제조하고, 물리화학적 특성과 약물 방출 제어 효과를 조사하였다. 또한, FE-SEM과 FT-IR 분석에 의해 제조한 다층 바이오소재의 특성을 조사하였다. 약물 방출 제어 효과와 경피 약물 전달 시스템의 적용 가능성을 확인하기 위해 NP 각인 다층 바이오소재로부터 NP 방출 특성을 사람의 체온인 36.5 ℃에서 다양한 pH buffer solution과 인공 피부를 이용하여 확인하였다. NP는 낮은 pH보다 높은 pH에서 1.3배 더 빠른 방출을 나타냈고, single-layer 바이오소재에서보다 multi-layer 바이오소재에서 약 4.0배 느린 방출이 일어남을 확인하였다. 인공 피부 방출에서도 동일하게 single-layer 바이오소재보다 multi-layer 바이오소재에서 약 4.0배 더 느린 약물 방출 결과를 나타내었다. 또한, double-layer와 triple-layer 바이오소재 모두 12시간 동안 지속적으로 NP가 방출되었음을 확인 하였다. NP 방출 mechanism을 규명하기 위해 수학적 모델링에 적용하여 비교했을 때, pH buffer solution에서의 방출은 Fickian diffusion mechanism, 인공 피부 방출은 empirical mechanism에 적합한 것을 확인하였다.

키토산 기반 분자 각인 고분자 필름의 슐린닥 흡착 및 방출 특성

윤연흠 ( Yeon-hum Yoon ),윤순도 ( Soon-do Yoon ),나재운 ( Jae Woon Nah ),심왕근 ( Wang Geun Shim ) 한국공업화학회 2019 공업화학 Vol.30 No.2

분자인식기술은 특정 분자를 고분자 매트릭스에 각인시켜 특정 분자의 선택성을 높이는 기술로 관심을 받아왔다. 이 연구에서는 Sulindac (SLD)을 각인시킨 키토산 기반 약물 전달용 필름의 흡착 및 방출 특성을 가소제, 온도, pH를 변화시켜 실험하고 그 결과를 관련 모델식으로 해석하였다. SLD 각인 고분자 필름의 약물 흡착은 Freundlich와 Sips식이 Langmuir식보다 더 잘 설명되었고 binding site 에너지 분포 함수는 SLD와 고분자 필름 간의 흡착 특성관계를 이해하는데 유용하였다. 그리고 SLD 각인 고분자 필름의 약물 방출은 Fickian 확산 거동을 보인 반면, 인공피부조건에서는 non-Fickian 확산 거동을 따랐다. Molecular recognition technology has attracted considerable attention for improving the selectivity of a specific molecule by imprinting it on a polymer matrix. In this study, adsorption and release characteristics of chitosan based drug delivery films imprinted with sulindac (SLD) were investigated in terms of the plasticizer, temperature and pH and the results were also interpreted by the related mathematical models. The adsorption characteristics of target molecules on SLD-imprinted polymer films were better explained by the Freundlich and Sips equation than that of the Langmuir equation. The binding site energy distribution function was also useful for understanding the adsorption relationship between target molecules and polymer films. The drug release of SLD-imprinted polymer films followed the Fickian diffusion mechanism, whereas the drug release using artificial skin followed the non-Fickian diffusion behavior.

폐플라스틱과 키토산을 활용한 입상형 활성탄의 염료 흡착특성 평가

김은식 ( Eun-sik Kim ),윤순도 ( Soon-do Yoon ),김지윤 ( Ji-yoon Kim ),황민진 ( Min-jin Hwang ) 한국키틴키토산학회 2020 한국키틴키토산학회지 Vol.25 No.4

염색 폐수 처리를 위한 흡착제를 개발하기 위하여, 폐 PET 수지로부터 활성탄을 개발하였으며, 이를 활용한 입상형 키토산 비드를 제조하였다. 활성제의 함량에 따른 활성탄의 세공특성과 methylene blue (MB) 흡착 제거효율을 평가하였다. MB 수용액에 대한 ACPRs의 최대흡착량은 ACPR-15에서 694.1 mg/g으로 나타났으며, Langmuir 흡착등온식으로 설명할 수 있었다. 폐 PET 수지를 활용한 활성탄의 흡착제거 공정 효율을 극대화하기 위해, 키토산을 활용하여 입상형 비드 CB-ACPR-15를 제조하였다. 흡착반응 온도 증가에 따라 염료의 제거 효율은 저하되었으며 Sips 흡착등온식과 Gibbs 자유에너지를 통해 설명하였다. 또한, MB 수용액의 초기농도에 따라 흡착속도가 증가되는 현상을 세공확산모델을 통해 분석하였다. The activated carbons (ACPRs) derived from Polyethylene terephthalate (PET) residues was prepared using wet impregnation of potassium hydroxide. The influence of the impregnation ratio on textural properties were evaluated. The overall porosity was improved with increasing impregnation ratio. For applying adsorption-based wastewater treatment system, the chitosan granules (CB-ACPR) combined with the ACPRs were prepared. In order to estimate the methylene blue (MB) adsorption capability of the CB-ACPR, the adsorption equilibrium isotherm and kinetic studies were evaluated. The adsorption equilibrium isotherm of MB on the CB-ACPR was represented by Sips isotherm model. The pore diffusion model was employed to determine the internal diffusion coefficient and the results was in good agreement with experimental kinetic data. Adsorption equilibrium capacities and diffusion coefficients of the MB increased with initial concentration.

지황 추출물 첨가 chitosan 기반 기능성 바이오 소재 제조 및 응용

이시연,김경중,김윤섭,윤순도,Lee, Si-Yeon,Kim, Kyeong-Jung,Kim, Youn-Sop,Yoon, Soon-Do 한국공업화학회 2022 공업화학 Vol.33 No.2

The main objective of this work is to prepare Rehmannia glutinosa extract (RE) incorporated functional chitosan (CH) based biomaterials and evaluate their physical properties, RE release properties, inhibitory effect of melanogenesis, and antioxidant and elastase inhibitory activities. RE incorporated CH based biomaterials were synthesized by a casting method and UV curing process. The surface and cross sections of prepared biomaterials were characterized by a field emission scanning electron microscope (FE-SEM). The physical properties such as tensile strength and elongation at break were also investigated. To apply the transdermal drug delivery system, RE release properties were examined with pH 4.5, 5.5, and 6.5 buffer solutions and artificial skin test at 36.5 ℃. Results indicated that RE release of RE incorporated biomaterials with/without the addition of plasticizers [glycerol (GL) and citric acid (CA)] at pH 6.5 was about 1.10 times higher than that of at pH 4.5. In addition, results of the artificial skin test verified that RE was released constantly for 6 h. To verify the applicability of the prepared biomaterials, tyrosinase, 2,2-diphenyl-1-picrylhydrazyl (DPPH), and elastase assays were investigated. Results indicated that RE incorporated biomaterials added CA exhibited tyrosinase activation, DPPH radical scavenging activity rate, and elastase activation of 45.12, 89.40, and 59.94%, respectively.

정수슬러지를 활용한 입상형 키토산비드의 인산염 흡착특성평가

김은식 ( Eun-sik Kim ),윤순도 ( Soon-do Yoon ),심왕근 ( Wang-geun Shim ),황민진 ( Min-jin Hwang ) 한국키틴키토산학회 2018 한국키틴키토산학회지 Vol.23 No.3

수계에 잔류하는 인산염 제거 및 회수용 흡착여재를 개발하기 위하여, 정수처리과정에서 발생하는 폐슬러지 기반의 입상형 키토산 비드를 제조하였다. 정수슬러지가 함유된 PDWTSGCB는 단일성분의 키토산 비드의 인산염 흡착량의 약 2.8배 향상된 96.9mg/g으로 조사되었다. 흡착평형량과 흡착속도는 각각 Freundlich 흡착등온식과 세공확산모델로 설명할 수 있었으며, 반응온도 증가에 따라 인산염에 대한 세공확산계수와 최대흡착량이 증가함을 확인하였다. Drinking water treatment sludge based adsorptive granular chitosan bead (GCB) was prepared for removal or recovery of phosphate in aqueous solution. The phosphate adsorption capacity of the chitosan granules combined with pyrolyzed drinking water treatment residuals (PDWTS-GCB) was about 2.8 times higher than that of control (GCB without PDWTS addition). In order to assess the phosphate adsorption capability of PDWTS-GCB, the adsorption equilibrium isotherm, kinetics, and regeneration performance were rigorously evaluated. The adsorption equilibrium isotherm of phosphate on the PDWTS-GCB could be represented by Fruendlich isotherm model. The pore diffusion model was employed to determine the internal diffusion coefficient and the results was in good agreement with experimental kinetic data. Adsorption equilibrium capacities and diffusion coefficients of the phosphate increased with increasing system temperature.

슐린닥 각인 키토산 기반 기능성 바이오 소재 제조 및 평가

탁혜영 ( Hye-yeong Tak ),이창문 ( Chang-moon Lee ),심왕근 ( Wang-geun Shim ),윤순도 ( Soon-do Yoon ) 한국키틴키토산학회 2017 한국키틴키토산학회지 Vol.22 No.3

In this work, biodegradable functional biomaterial for sulindac (SLD) recognition are prepared by using chitosan (CHS), polyvinyl alcohol (PVA), SLD as the target molecule, sulfosuccinic acid (SSA) as a crosslinker, and glycerol (GL) and citric acid (CA) as plasticizers. CHS-based functional biomaterials were synthesized by using UV curing process and evaluated their physical properties such as tensile strength (TS), elongation at break (%E), swelling behavior (SB) and solubility (S) with UV curing time. The results indicate that the physical properties was improved about 1.2-1.5 times by UV curing. The optimal UV curing time for the preparation of CHS-based functional biomaterials is about 20 min. We investigated the physical properties of the prepared CHS-based functional biomaterial with/without the addition of SLD. In addition, their surface morphology was observed by the scanning electron microscope (SEM). To evaluate the binding characteristics of CHS-based functional biomaterial with/without the addition of SLD, the adsorption-desorption properties of the prepared biomaterials was investigated by equilibrium binding experiment. The results of the evaluation analysis indicate that the prepared high functional biomaterials have the binding site for SLD as the target molecule. The drug release of SLD for the transdermal drug deliverly systems was examined with pH and temperature. In addition, the release of SLD was carried out by using artificial skin. From the results of the artificial skin test, it could be confirmed that the SLD as the target drug was released constantly during 20 days. The results can be applied in medical patches and various fields.

페놀류인 4-isopropylphenol의 선택적 분리를 위한 키토산 기반 바이오 소재 제조와 흡력 성능 평가

윤현기 ( Hyun-gi Youn ),김은식 ( Eun-sik Kim ),윤순도 ( Soon-do Yoon ) 한국키틴키토산학회 2018 한국키틴키토산학회지 Vol.23 No.2

The main objectives of this work are to prepare the chitosan(CH)/PVA biomaterials for the selective separation of 4- isopropylphenol (4IPP) as a phenolic. In order to improve the selective separation, CH/PVA biomaterials was also synthesized using benzoic acid (BA) or p-toluic acid (pTA) which have a similar structure with 4IPP as the target material. The CH/PVA biomaterials were prepared by casting method and UV irradiation process. Physical properties such as tensile strength (TS), elongation at break (%E), swelling behavior (SB), and solubility (S) for prepared biomaterials were investigated. The adsorption properties were evaluated by the adsorption kinetics, binding isotherm, Scatchard plot analysis, adsorption of materials with structures similar to target molecules, and selectivity factor (α). The results of the evaluation indicate that the prepared CH/PVA biomaterials have high separation abilities and selectivity.