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The incidence of venous thromboembolism is not lowin Korean patients with advanced pancreatic cancer
윤석윤,이민영,윤진아,김한조,김경하,김세형,이상철,배상병,김찬규,이남수,이규택,박성규,홍대식,원종호 대한혈액학회 2018 Blood Research Vol.53 No.3
Background Pancreatic cancer is among the most common malignancies associated with venous thromboembolism (VTE). Asian patients are known to have a lower incidence of VTE com-pared to Caucasian patients. However, few studies have investigated the incidence of VTE in Asian patients with pancreatic cancer. Methods This retrospective review of medical records was performed on 505 patients with histo-pathologically proven advanced stage pancreatic cancer, from January 2006 to December 2012, at Soonchunhyang University Hospitals. Results Ninety-four patients (18.6%) had at least one pulmonary embolism (PE), deep vein throm-bosis (DVT), or splanchnic vein thrombosis (SVT); 38 patients had isolated SVT; and 56 patients (11.1%) had at least one classic VTE (PE and/or DVT of lower extremities). Patients with more advanced stages of pancreatic cancer (distant metastatic stage, recurrence) or who had received chemotherapy had a higher incidence of classic VTE. Patients who were simultaneously diagnosed with pancreatic cancer and classic VTE had a poorer prog-nosis than patients with subsequent VTEs. There was a significant difference in overall survival (OS) between the presence and absence of a concurrent classic VTE diagnosis (median: OS, 2.1 mo vs. 10.7 mo; P<0.001). Even when VTE included SVT, the result was similar (P<0.001). ConclusionIn In Korean patients with advanced pancreatic cancer, the incidence of VTEs is comparable to that of Caucasian patients. We also found that pancreatic cancer patients with con-current VTEs had a poor prognosis compared to patients who developed VTEs later.
전이성 신세포암에서 수술 후 우연히 발견된 상악동 전이
윤석윤,박정완,권성순,김소라,김경하,원종호,이남수,최인호 순천향대학교 순천향의학연구소 2014 Journal of Soonchunhyang Medical Science Vol.20 No.1
The classic presentation of renal cell carcinoma (pain, hematuria, and flank mass) occurs in a minority of patients and often is indicative of advanced disease. Common sites of metastatic renal cell carcinoma are lung, soft tissues, bone, and liver. Paranasal sinus is an unusual site for metastasis of renal cell carcinoma. One 73-year-old male presented to Soonchunhyang University Seoul Hospital with melena. Renal cell carcinoma with metastasis to duodenum was diagnosed by computed tomography (CT). He underwent right radical nephrectomy and Whipple’s operation. Positron emission tomography/CT was performed postoperatively, and then metastasis to maxillary sinus was found by accident. He was treated with molecular targeted therapy (pazopanib hydrochloride 800 mg).
Philadelphia+ Chronic Myeloid Leukemia with CALR Mutation: A Case Report and Literature Review
윤석윤,정선영,김창곤,이민영,김지은,김경하,이남수,원종호 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3
Myeloproliferative neoplasms (MPNs) are classified as chronic myeloid leukemia (CML) and Philadelphia chromosome-negative MPN. In MPN cases, the presence of a BCR-ABL1 translocation with a coexisting mutation is exceptionally rare. Herein, we report the first documented patient with CML harboring CALR mutation in Korea. A 33-year-old woman was referred to our hospital in February 2015 with splenomegaly, leukocytosis, and thrombocytosis. She was diagnosed with CML and started receiving nilotinib. In October 2015, a major molecular response was observed, but thrombocytosis persisted. A repeat bone marrow (BM) examination revealed no specific findings. However, as thrombocytosis worsened, we changed nilotinib to dasatinib. In May 2019, owing to persistent thrombocytosis, we repeated the BM examination and found CALR mutation (15.97%) on the MPN–next generation sequencing (NGS) test. We then retrospectively performed repeat MPN-NGS testing using the BM aspirate sample obtained in 2015 and found CALR mutation (10.64%).
The clinical role of interferon alpha in Philadelphia-negative myeloproliferative neoplasms
윤석윤,원종호 대한혈액학회 2021 Blood Research Vol.56 No.-
Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell malignancies. Chronic inflammation and a dysregulated immune system are central to the pathogenesis and progression of MPNs. Interferon alpha (IFN) was first used for the treatment of MPNs approximately 40 years ago. It has significant antiviral effects and plays a role in anti-proliferative, pro-apoptotic, and immunomodulatory responses. IFN is an effective drug that can simultaneously induce significant rates of clinical, hematological, molecular, and histopathological responses, suggesting that the disease may be cured in some patients. However, its frequent dosage and toxicity profile are major barriers to its widespread use. Pegylated IFN (peg-IFN), and more recently, ropeginterferon alpha-2b (ropeg-IFN-2b), are expected to overcome these drawbacks. The objective of this article is to discuss the clinical role of IFN in Philadelphia-negative MPNs through a review of recent studies. In particular, it is expected that new IFNs, such as peg-IFN and ropeg- IFN-2b, with lower rates of discontinuation due to fewer adverse effects, will play important clinical roles.
The incidence of venous thromboembolism is not lowin Korean patients with advanced pancreatic cancer
윤석윤,이민영,윤진아,김한조,김경하,김세형,이상철,배상병,김찬규,이남수,이규택,박성규,홍대식,원종호 대한혈액학회 2018 Blood Research Vol.53 No.3
Background Pancreatic cancer is among the most common malignancies associated with venous thromboembolism (VTE). Asian patients are known to have a lower incidence of VTE com-pared to Caucasian patients. However, few studies have investigated the incidence of VTE in Asian patients with pancreatic cancer. Methods This retrospective review of medical records was performed on 505 patients with histo-pathologically proven advanced stage pancreatic cancer, from January 2006 to December 2012, at Soonchunhyang University Hospitals. Results Ninety-four patients (18.6%) had at least one pulmonary embolism (PE), deep vein throm-bosis (DVT), or splanchnic vein thrombosis (SVT); 38 patients had isolated SVT; and 56 patients (11.1%) had at least one classic VTE (PE and/or DVT of lower extremities). Patients with more advanced stages of pancreatic cancer (distant metastatic stage, recurrence) or who had received chemotherapy had a higher incidence of classic VTE. Patients who were simultaneously diagnosed with pancreatic cancer and classic VTE had a poorer prog-nosis than patients with subsequent VTEs. There was a significant difference in overall survival (OS) between the presence and absence of a concurrent classic VTE diagnosis (median: OS, 2.1 mo vs. 10.7 mo; P<0.001). Even when VTE included SVT, the result was similar (P<0.001). ConclusionIn In Korean patients with advanced pancreatic cancer, the incidence of VTEs is comparable to that of Caucasian patients. We also found that pancreatic cancer patients with con-current VTEs had a poor prognosis compared to patients who developed VTEs later.
윤석윤(Yun, Seok-Yun) 한국주거환경학회 2015 주거환경(한국주거환경학회논문집) Vol.13 No.1
In this research, revolving around the urban general plan, we carefully reviewed and analyzed the overall process and contents of cities" residential land use in order to conduct causal analysis of the problems of current land development plan: excessive development and accompanying difficulties. An urban general plan, in principle, ought to suggest a future blueprint of a city and lead a balanced local development from a long-term perspective. During the process of development-oriented operation, however, recent urban plans that primarily focus on new town construction while disregarding the problems caused by such excessive development, and the current city regeneration matter eventually brought about the distortion of balanced city development. Throughout the analysis of land use plan, we henceforth indicated problems as follows: unrealistic population forecast, lacking accuracy and effectiveness of current development sites which is the foundation of land use status report, absence of objectivity in land use demanding forecasting process, immoderate demanding forecast, establishment of land use plan irrelevant to demanding forecast.
윤석윤(Yun, Seok-Yun) 한국주거환경학회 2015 주거환경(한국주거환경학회논문집) Vol.13 No.3
In this research, revolving around the urban general plan, we carefully reviewed and analyzed the overall process and contents of cities’ industrial land use in order to conduct causal analysis of the problems of current land development plan: excessive development and accompanying difficulties. The needs of industrial land totaled 1,464㎢ in 2020, compared the results with those from other previous studies. Throughout the analysis of industrial land use plan, we henceforth indicated problems as follows: unrealistic industrial land demanding forecast, lacking accuracy and effectiveness of current development sites, absence of objectivity in land use demanding forecasting process, immoderate demanding forecast, neglecting unregistered factory, uncontrolled development out of manufacturing area, oversupply and unused industrial land in provincial cities.