진단검사의학과 외래진료전 검사 TAT 모니터링

유화종,유광현,김종원 한국의료QA학회 2008 가을학술대회 Vol.2008 No.3

이명 클리닉을 내원한 환자의 진단적 분류에 따른 빈도와 임상적 특성

유화종,박시내,김동기,박경호,김민지,김지은,김애리,여상원 대한이비인후과학회 2011 대한이비인후과학회지 두경부외과학 Vol.54 No.6

Background and Objectives Knowledge about the incidence and clinical characteristics of tinnitus can be useful for diagnostic approach and treatment plan. We analyzed the incidence and clinical characteristics of each case of tinnitus according to the classification of tinnitus. Subjects and Method The study recruited 211 tinnitus patients who visited tinnitus clinic from March 2009 to August 2009. First, patients were diagnosed and classified as sensorineural tinnitus and somatosounds. Somatosounds were subdivided to vascular tinnitus, muscle origin tinnitus and patulous Eustachian tube. Patients were evaluated by history taking by means of having them fill out tinnitus questionnaires and psychoacoustic questionnaires. Audiologic findings of each type of tinnitus have also been analyzed. Results Incidences of sensorineural tinnitus and somatosounds were 82.9% and 17.1% respectively. Among somatosounds, vascular tinnitus occupied 7.6%, muscle origin tinnitus, 4.3% and patulous Eustachian tube, 5.2%. The mean age of the patients with sensorineural tinnitus was older than somatosounds. Patients with muscle origin tinnitus had higher scores of tinnitus loudness, effect on life, tinnitus handicap inventory, stress and depression than those with other types of tinnitus. Overall compliance of the treatment was 66.7% and their tinnitus had been significantly improved after treatment. Conclusion With the knowledge of incidence, clinical characteristics and treatment approach for each tinnitus, clinicians can be more confident in providing proper diagnosis and management of patients with tinnitus. Somatosounds, which showed relatively high incidence in this study, should not be neglected but properly treated with early diagnosis.

비출혈을 동반한 감염성 내경 동맥류의 파열 1예

유화종,이범준,박재원,조진희 대한비과학회 2010 Journal of rhinology Vol.17 No.2

Cavernous carotid aneurysms represent fewer than 2% of all intracranial aneurysms and are a rare cause of epistaxis, but rupture of an aneurysm into the sphenoid sinus may result in a massive hemorrhage. Infectious intracranial aneurysms are rare, but can develop as a result of direct extension from bacterial endocarditis or local infection of the head, neck, face, and paranasal sinus. The incidence of infectious intracavernous aneurysm is much lower. Because the sphenoid sinus is located adjacent to the cavernous sinus, sphenoid sinusitis may cause an infectious carotid aneurysm. We have experienced a case of ruptured infectious carotid aneurysm following sphenoid sinusitis presenting with epistaxis. We describe several aspects of the diagnosis and management of this rare case with a review of the literature.

진단검사의학과 응급검사 TAT 모니터링

유화종,유광현,김종원 한국의료QA학회 2008 가을학술대회 Vol.2008 No.3

구연 4 : Daratumumab 투여 다발성 골수종 환자 비예기항체 동정검사시 panagglutinin 소견

김은영,유화종,서지영,김은지 대한임상병리사협회 2015 임상수혈검사학회 발표자료집 Vol.2015 No.-

배경(Background): 다발성 골수종 환자의 비예기항체동정검사에서 panagglutinin을 보여 고빈도항원에 대한 항체로 추정하였으나 다발성 골수종 환자 치료제인 Daratumumab(anti-CD38)과 적혈구에 발현하는 CD38이 반응하여 나타난 결과로 확인되어 단클론성항체치료가 보편화되고 있는 최근 상황에서 수혈검사에 주의가 필요하게 되었다. 이에 저자들은 본원에서 Daratumumab (anti-CD38)을 투여하고 있는 다발성 골수종 환자들의 수혈전검사결과를 알아보고자 한다. 방법(Methods): 2014년 1월부터 현재까지 본원에서 Daratumumab(anti-CD38)을 투여한4명의 다발성 골수종 환자의 비예기항체 선별 및 동정검사를 시행 한 후 분석하였다. 결과(Results): 증례 1에서는 65세, 남자, 항체동정검사에서 panagglutinin, 자가 항체 양성,직접 항 글로불린 양성을 보였다. 이때 고빈도항원에 대한 항체로 추정하였다. 증례 2~4에서는 56~71세, 여(3), 항체동정검사에서 panagglutinin, 자가 항체 음성, 직접 항글로불린 음성을 보였다. 4명의 환자 모두 Daratumumab(anti-CD38) 투여전 항체선별검사 음성이었다. 사망으로 검사를 못한 증례 1을 제외하고, 3예는 DTT(Dithiothreitol)로 처리한 항체 동정용 적혈구와 반응 시 모두 음성을 보였다. 고찰(Discussion): 최근 발표된 논문에 따르면 Daratumumab(anti-CD38)로 치료 받은 다발성 골수종환자에서 항체 동정 검사 시 panagglutinin을 보이고, Daratumumab(anti-CD38)과 반응을 막기 위해 DTT(Dithiothreitol) 처리한 적혈구로 항체 동정 검사 시 음성을 보인 보고가 있다. 본원에서도 같은 사례가 있어 2014년부터 Daratumumab(anti-CD38) 투여 환자를 조사하였다. 결과 4명의 다발성 골수종 환자가 있었고 항체 동정 검사에서 모두 panagglutinin을 보이며 DTT(Dithiothreitol)로 처리한 항체 선별용 적혈구 검사 시 음성을 보였다. 환자의 혈액 요청 시 DTT(Dithiothreitol)로 처리된 적혈구와 교차시험 후 불출해야 한다. 따라서 다발성 골수종환자의 항체동정검사에서 panagglutinin을 보이면 고빈도 항원에 의한 항체를 추정하는 것이 아니라 Daratumumab(anti-CD38)치료 유무를 확인하고 치료 전에 항체 선별검사와 환자의 적혈구 phenotype을 권고해야 할 것으로 사료된다.

境界要素法을 이용한 평판 크랙의 應力擴大係數 解析

양인수,유화종,박철희,오환섭 慶熙大學校 大學院 院友會 1996 高凰論集 Vol.19 No.-

It is necessary to analyze the effect of the cracks which are expected to exist in structures and machines at the initial design phase by calculating the stress intensity factor(SIF). In this paper, therefore, the stress intensity factor analysis was performed using boundary element method(BEM) of 2-dimensional elastic problem. A simple analytical method is also presented for the determination of the elastic stress intensity factor at the crack tip of edge stiffened two dimensional crack. In this study, the crack models considered are as follows: 1) Edge crack located on the hole. 2) Center thorough crack on interface of length 2a subjected to uniform tension. In each case, stress intensity factors are determined by using BEM. The results of this study are summarized bellows: 1) When the ratio of crack tip element length and crack length is 1/10, the best results are obtained. 2) Calculated SIF in case of edge crack located on the hole, and center thorough cack on interface of cohesion was compared with Kitagawa's solutions and Rice's. The mean errors were 0.627% and 0.452%, respectively.

갑상선내 부갑상선선종의 자연출혈 1예

최지영,유화종,박영학,조승호 대한이비인후과학회 2010 대한이비인후과학회지 두경부외과학 Vol.53 No.4

Intrathyroidal parathyroid adenoma is an infrequent lesion which can be explained by abnormalities during embryonic migration of the parathyroid glands. Extracapsular hemorrhage from a intrathyroidal parathyroid adenoma is extremely rare, however, due to its location near upper airway, it might cause a life-threatening situation. Therefore, if patients presented with anterior neck painful swelling, skin ecchymosis associated with dysphagia and/or hoarseness, extracapsular hemorrhage from parathyroid adenoma should be considered as a possible diagnosis. Estimation of serum calcium level is essential as the presence of hypercalcemia can help to make the diagnosis pre-operatively. As rupture of a parathyroid adenoma and cyst may lead to local dissemination of tumor cells and an increased risk of recurrent hyperparathyroidism, careful longterm follow-up is required. We report an unusual case of spontaneous rupture of intrathyroidal parathyroid adenoma with a review of literature. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:245-7

疲勞限度에서의 停留크랙거동에 관한 실험적 연구

吳煥燮,劉和鍾,金政泰 慶熙大學校 材料科學技術硏究所 1993 材料科學技術硏究論集 Vol.6 No.-

In this study the behaviour of micro crack subjected to rotary bending stress in the vicinity of fatigue endurance limit in order to make a firm definition of endurance limit in case of notched and unnoitched specimen. The behaviour of micro crack was investigated around artifial micro defect and noticeable conclusion was resulted that, in the vicinity of micro defect which have no effect on fatigue endurance limit, initial crack(stage Ⅰ) was found in the derection of principal stress and propagating crack(stage Ⅱ) was investigated as non-propagating crak where micro defect have no effect.

원발성 접형동 점액종에 의한 단독 외향 신경 마비 1예

전은주,박재영,유화종,김동현 대한이비인후과학회 2010 대한이비인후과학회지 두경부외과학 Vol.53 No.12

Mucoceles of the sphenoid sinus are relatively rare and can lead to visual impairment, diplopia and external ophthalmoplegia. The ophthalmic symptoms seem to be caused mainly by compression or inflammatory changes. It is difficult to diagnose mucocele of the sphenoid sinus just on the basis of patient history or physical examination alone. CT scans and MRI help in the correct assessment of this lesion. We experienced one patient with a sphenoid sinus mucocele who presented simply with diplopia. The mucocele was managed successfully by endoscopic marsupialization. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:781-3

Clinical Outcome of Squamous Cell Carcinoma of the Tongue in Young Patients: A Stage-Matched Comparative Analysis

박준욱,선동일,조광재,조영훈,유화종,김민식 대한이비인후과학회 2010 Clinical and Experimental Otorhinolaryngology Vol.3 No.3

Objectives. The reported incidence of tongue cancer in young patients has recently increased. The aim of this study was to analyze the clinical characteristics of tongue cancer in a young group of patients, and to compare them with those of an older group of tongue cancer patients. Methods. We retrospectively reviewed the records of 85 patients who were diagnosed with squamous cell carcinoma of the tongue. They were divided into two age groups: over 45 years of age and under 45 years. To compare the prognosis of similarly staged patients in the group, each age group was divided into the early (stage I, II) and advanced stage groups (stage III, IV), and then they were compared. The young group consisted of 23 patients and the older group had 62 patients. Results. At the early stage, the clinical prognosis of the patients in both age groups was good, and no significant difference was observed. However, at the advanced stage, the overall and regional recurrence rates were significantly higher in the younger age group as compared to that in the old age group (P=0.007, P=0.001, respectively). The diseasespecific survival rate of the patients in the young group was significantly lower than that in the old age group (P=0.025). Conclusion. Tongue cancer in young subjects has significantly different clinical outcomes according to the stage. The clinical outcome of the advanced-stage tongue cancer in young subjects was poorer than that in the older subjects. Regional recurrence seemed to be the main cause of the poor prognosis.