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Oral Toxicity Study and Skin Sensitization Test of a Cricket
유현열,이소민,안규섭,김혜진,이상식,고혁주,이진규,조명행,안미영,김은미,임정호,송경석 한국독성학회 2016 Toxicological Research Vol.32 No.2
Crickets have been attracting considerable interest in the field of nutrition and toxicology due to the global exhaustion of food resulting from a growing population. The cricket is normally eaten in several countries after roasting, similar to the grasshopper; however, safety evaluation data on cricket powder is limited. Here, we performed general toxicity studies of cricket powder including a single, 2-week repeated dose range evaluation test, a 13-week repeated oral dose toxicity test in Sprague-Dawley rats, a single oral dose toxicity test in Beagle dogs, and a skin sensitization test in guinea pigs following the Organization for Economic Cooperation and Development test guidelines 406 and 408 in addition to Good Laboratory Practice. To investigate the NOAEL and target organs of cricket powder, Sprague-Dawley rats were allocated to 4 groups: vehicle control, 1,250 mg/kg, 2,500 mg/kg, 5,000 mg/kg dose test groups and cricket powder was administered over 13 weeks after single dose and dose range finding studies in rats based on the results of the single oral administration toxicity study in rats and Beagle dogs. The results of the study showed that the NOAEL of cricket powder was over 5,000 mg/kg for both sexes of rats without adverse effects in a 13-week repeated oral toxicity study and there was no skin hypersensitivity reaction. Therefore, our results reveal that crickets can be widely used as a new substitute food or nutrient resource.
정은,백주열,정한희,박성일,장지혜,유현아,우기현,윤호중 대한심장학회 2014 Korean Circulation Journal Vol.44 No.4
A 66-year-old man presented with exertional dyspnea. He was found to have an unruptured aneurysm of the right sinus of Valsalva caus-ing significant right ventricular outflow obstruction. This aneurysm was diagnosed by transthoracic two-dimensional echocardiogra phy,transthoracic three-dimensional echocardiography, transesophageal echocardiography, contrast echocardiography and 64-slice multide-tector cardiac computed tomography. Because unruptured aneurysms of the sinus of Valsalva are rarely symptomatic, they can be difficultto detect. However, the unruptured aneurysm of the right sinus of Valsalva in this case caused significant right ventricular outflow tractobstruction, resulting in exertional dyspnea.
도서형 복재 신경피부 피판술을 이용한 하지 연부 조직 결손의 재건
서중배,박희곤,유현열,김종필,Seo, Joong-Bae,Park, Hee-Gon,Yoo, Hyun-Yul,Kim, Jong-Pil 대한미세수술학회 2006 Archives of reconstructive microsurgery Vol.15 No.2
Purpose: We present clinical usefulness of saphenous neurocutaneous island flap for reconstruction of soft tissue defect of the lower leg, especially anteromedial aspect, including foot and ankle. Materials and Methods: Thirteen cases of soft tissue defects in the lower leg including foot and ankle which were 6 cases of pretibial area, 2 cases of anteromedial aspect of distal two third, 2 cases of ankle, and 3 cases of foot were treated saphenous neurocutaneous island flap. They were proximally based flap 3 cases and distally based flap 10 cases. Clinically the flaps ranged in size from $4{\times}5\;cm$ to $6{\times}12\;cm$. Results: All of the flaps except 1 case survived completely. Three cases, however, had marginal necrosis. One case of flap failure was proximal tibia fracture accompanied with injury of the flap pedicle which was difficult in flap elevation, subsequently. Conclusion: The saphenous neurocutaneous island flap is a simple, reliable procedure with a versatility for soft tissue coverage of the lower leg, especially anteomedial aspect, including foot and ankle. In case of another injuries accompanied near the saphenous nerve, careful attention should be made.
자발성 척추 경막외 혈종의 수술적 치료 - 증례 보고 -
김명호,민상혁,유현열 대한척추외과학회 2008 대한척추외과학회지 Vol.15 No.4
Spontaneous spinal epidural hematomas without any risk factors, such as spinal tap, trauma, pregnancy, bleeding diathesis, vascular malformations, hypertension, etc. are relatively rare clinical entities. In addition, the clinical suspicion is quite difficult because there are various clinical symptoms according to the size and location of hematoma. However, the speed of diagnosis and initiation of the appropriate treatment are important because the outcome for patients is usually determined by the location and degree of neurological deficits and the duration of dural compression. We report the diagnosis and treatment of spontaneous spinal epidural hematoma in this case with a review of the relevant literature.
Safety evaluation of cricket(Gryllus bimaculatus) extract in Sprague-Dawley rats
이소민,안규섭,유현열,김혜진,이진규,조명행,안미영,송경석 한국잠사학회 2016 International Journal of Industrial Entomology Vol.32 No.1
Recently, research investment in the improvement of food safety as a food source and specializing of nutritional source of edible insects is being actively conducted. Cricket especially has been attracting considerable interest in entomophagy; however, research on the safety assessment of cricket is limited. This study investigated the effects of cricket ethanol extract when orally administrated in Sprague-Dawley rats. Here, we performed a 4 wk repeated oral dose toxicity test in Sprague-Dawley rats following the Organization for Economic Cooperation and Development test guidelines 407 under Good Laboratory Practice regulation. Rats were randomly allocated 4 groups: vehicle control, 250, 500, 1,000 mg/kg test groups and administrated based on body weight for 28 d. The animals were observed for mortalities and clinical signs, body weight changes, food and water consumption. At the end of treatment period, blood and urine were collected and analyzed. Subsequently, the animals were sacrificed and subjected to gross pathological examination and organ weight measurement. The organs were preserved for histopathological examination. The results showed that there were no systemic toxicological effects related with the cricket ethanol extract in the 4 wk oral repeated dose toxicity study. It is considered that NOAEL of cricket ethanol extract is greater than 1,000 mg/kg/d and there was no target organ detected.
윤남규,김병권,유현열,서보승,신창호,김관규,이한주 국제문화기술진흥원 2022 The Journal of the Convergence on Culture Technolo Vol.8 No.3
퇴행성 신경질환 치료를 위한 AChE inhibitor 관련 연구로써 생물학적 유용성을 높인 커큐민에 대한 연구를 수행하게 되었다. 본 연구의 목적은 아리큐민(강황추출물)에 대한 in vitro 신경보호 효과를 확인하는데 있다. 신경보 호효과를 확인하기 위해 아리큐민(강황추출물)에 대한 AChE inhibition을 평가하였고, HT-22 세포에 대한 세포생존 율을 분석하였으며, 산화스트레스(glutamate, H202) 유발에 따른 HT-22 세포생존을 확인하였다. 아리큐민(강황추출 물)의 AChE 저해율 변화결과 아리큐민 39.06㎍/㎖ 이상의 농도에서 약 20% 이상의 AChE 활성을 저해하는 것으로 확인하였다. 그리고 산화스트레스(glutamate 5 mM 및 H2O2 500 μM) 유발 HT-22 cell의 세포 독성을 0.01~0.1 mg/ml 농도에서부터 유의하게 억제하는 것을 확인하였다(p<0.05). 이와 같은 결과로 볼 때 아리큐민(강황추출물)은 신경보호 효과 효능이 우수한 것으로 확인되었다. This study was conducted on curcumin which had increased bioavailability as a potential AChE inhibitor for the treatment of neurodegenerative diseases. The purpose of this study is to confirm the in vitro neuroprotective effect on Aricumin (turmeric extract). To confirm the neuroprotective effect, AChE inhibition for Aricumin was evaluated, and cell viability was analyzed for HT-22cell, and oxidative stress (glutamate, H2O2)-induced HT-22 cytotoxicity was evaluated. As a result of the change in the AChE inhibition rate of Aricumin (Turmeric extract), it was confirmed that Aricumin at a concentration of 39.06㎍/㎖ or higher inhibited AChE activity by about 20% and more. And it was confirmed that the cytotoxicity of HT-22 cells induced by oxidative stress (Gluamate 5 mM and H2O2 500 μM) was significantly inhibited from 0.01 to 0.1 mg/ml concentration (p<005). These results suggest that Aricumin (turmeric extract) have potential neuroprotective effects.