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이진석(Jin-Seok Lee), 서형석(Hyeong-Seok Seo), 김소정(So-Jung Kim), 김형진(Hyeong-Jin Kim), 김진(Jin Kim), 이성호(Seung-Ho Lee), 박영석(Young-Seok Park), 박병권(Byung-Kwon Park), 김병수(Byeong-Soo Kim), 김상기(Sang-Ki Kim), 정지윤(Ji-Youn Jun) 한국생명과학회 2010 생명과학회지 Vol.20 No.10
Apigenin은 과일과 야채에 들어있는 플라보노이드로 다양한 악성 세포에 항증식효과를 보여준다. 세포성장 저해효과를 확인하기 위하여 KB 구강암세포주를 96 well plate에 6×10³ cells/well로 분주하고 24시간 후에 apigenin을 24시간 동안 처치하여 MTT assay를 수행하였다. Apigenin은 배양 후 용량 의존적으로 세포사를 유도하였다. Apigenin 100 μM을 24시간 동안 처치하고 대조군과 세포성장을 비교하였을 때 유의적인 감소를 확인하였다. KB 구강암세포주에서의 apoptosis를 확인하기 위해 DAPI 염색을 수행하였다. Apigenin을 처치한 세포에서 핵의 응축이 존재함을 형광현미경으로 확인하였다. 우리는 누드마우스에 KB 구강암세포주를 이식하여 세포 성장 억제 효과를 알아보았다. Apigenin을 마우스에 25, 50 ㎎/㎏을 0.2 ml의 PBS에 녹여 경구투여 하였다. 종양 사이즈는 대조군과 25, 50 ㎎/㎏ apigenin 투여군을 비교하였을 때 유의적으로 감소하였다. Apoptosis 분석을 위해 TUNEL염색을 수행하였다. 25 ㎎/㎏ apigenin 투여군과 대조군을 비교하였을 때 apoptosis의 유의적인 증가를 확인하였다. 육안적 소견을 위한 H&E 염색은 이상이 없었다. 본 연구는 apigenin이 구강암세포주 성장 억제를 apoptosis의 유도를 통하여 확인하였다. Apigenin (4', 5, 7-trihydroxyflavone), a common dietary flavonoid abundantly present in fruits and vegetables, has shown remarkable anti-proliferative effects against various malignant cell lines. To observe the anti-proliferative effects, oral cavity cancer cell lines, 6×10³ cells/well (96 well plate) of KB oral cavity tumor cells were plated and 24 hr later treated with apigenin for one day, after which MTT assay was performed. Apigenin induced cell death in a dose-dependent manner after incubation. Cell viability was significantly decreased in the group treated with 100 μM apigenin for 24 hr (p<0.05) compared to the control group. To assess apoptosis, the nuclei of KB cells were stained with DAPI. The presence of chromatin condensation in the apigenin treated cells was detected on a fluorescent microscope (×200). We investigated the in vivo growth inhibitory effects of apigenin on oral cavity cancer KB tumor xenograft subcutaneously implanted in male nude mice. Apigenin was administered to mice by gavage at doses of 25 and 50 ㎎/㎏/day in 0.2㎖ of PBS. Tumor volume was significantly decreased in 25 and 50 ㎎/㎏ apigenin-administration groups compared to the control group. For apoptosis analysis, TUNEL staining was performed. A significant increase in TUNEL positive cells was found in the 25 ㎎/㎏ apigenin administration group compared to the non- apigenin administration group. Histopathological changes were not observed. These results indicate that apigenin inhibits oral cavity cancer cell growth through the induction of apoptosis.
The present paper deals with the continuous work of extending multi-dimensional limiting process (MLP) for higher-order discontinuous Galerkin (DG) methods to compute compressible Navier-Stokes equation. From the previous works, it was observed that the MLP shows several superior characteristics, such as efficient controlling of multi-dimensional oscillations and accurate capturing of complex flow structure. Recently, MLP has been extended into DG method for hyperbolic conservation laws. The proposed method, called hierarchical MLP, can be readily extended to convection-dominated problem, such as compressible Navier-Stokes equation. Through several test cases, it is observed that that the proposed approach yields outstanding performances in resolving non-compressive as well as compressive viscous flow features.
( Jin Woo Choo ), ( Soung Won Jeong ), ( Jae Young Jang ), ( Jin Nyoung Kim ), ( Soon Ha Kwon ), ( Sae Hwan Lee ), ( Sang Gyune Kim ), ( Sang Woo Cha ), ( Young Seok Kim ), ( Young Deok Cho ), ( Hong Soo Kim ), ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background/Aim: Transarterial chemoembolization (TACE) has been recommended as non-curative first line therapy of hepatocelluar carcinoma (HCC). There is limited information about the recurrence after TACE induced complete response (CR). The aim of this study was to investigate the predictive factors of HCC recurrence after TACE induced CR. Methods: Among 272 HCC patients treated with TACE, 39 consecutive patients who achieved CR after TACE were evaluated. Complete response was defined as the disappearance of any intratumoral arterial enhancement in all target lesions after TACE according to modified RECIST. We analyzed the factors related to recurrence including age, gender, presence of hepatitis B virus (HBV) infection, Child-Pugh score, MELD score, α-fetoprotein (AFP), tumor diameter, and tumor stage. Results: The median age was 61 years and there were 25 males (64.1%). The clinical characteristics of the 39 patients are as follows; presence of HBV infection (26/39), Child-Pugh score (6.33±1.93), MELD score (11.23±3.32), AFP (601.79±2032.10), tumor diameter (3.22±2.72), stage I/II/III (15/16/8). Age, gender, presence of HBV infection, Child-Pugh score, MELD score, AFP, and tumor diameter showed no significance for recurrence of HCC. Advanced stage (stage III) was the only independent prognostic factor for the recurrence of HCC. Median recurrence interval was 2.9 months (95% CI 1.0-7.4) for Stage III and 10.1 months (95% CI 5.1-15.0) for Stage I and II (p=0.023). Conclusion: Advanced stage (stage III) was the prognostic factor of the recurrence in HCC after TACE induced CR.
To clarify whether inhibitory effect of estrogen on liver tumor is associated with cell proliferation, we investigated its role in diethylnitrosamine (DEN)-induced rat preneoplastic lesions, with time sequenced manners. F344 male rats (n = 90) were divided into three groups at 5 weeks of age. The mini-osmotic pumps providing a continuous infusion of DEN was implanted into the abdominal cavity of each animal in group 1, 2 and 3 at 6 weeks of age. To see the effect of estrogen, pellet containing 1 or 10μg of estradiol-3-benzoate (EB) was implanted subcutaneously in the animals of groups 2 or 3, respectively, one week prior to DEN treatment. Ten animals of each group were euthanized at 10, 14 and 18 weeks after DEN treatment. Liver tissues at each time point were fixed in 10% phosphate-buffered formalin and were processed and embedded in paraffin and 5μm sections mounted on a silanized slide. Glutathione S-transferase placental form (GST-P) positive foci and 5-bromo-2-deoxyuridine (BrdU) labeling cells were detected at each time point. Area of GST-P positive foci in DEN+EB 1 or 10μg group was significantly decreased compared to DEN alone at 14 weeks (p < 0.01 or p < 0.05, respectively) an at 18 weeks (p< 0.05 or p< 0.01, respectively). BrdU index in DEN+EB 1 or 10μg groups was significantly decreased compared to DEN alone at 14 weeks and at 18 weeks (p < 0.01). Taken together, we conclude that EB treatment decrease the DEN-induced liver preneoplastic lesions and this may be associated with decrease of cellular proliferation.
Energy acquisition due to the increase of oil price is one of the most important issues and policy for most countries. Various tankers have been built in the world and sent to the trade market. It is necessary to build the port infrastructure and facilities to give them proper services such as mooring, packing, storing, and transshipment, etc. However, the domestic guidelines or standards for design and construction for the dolphin berth among these facilities are out of date and do not meet the recent trend of tanker types. Therefore, it requires amendment on the guidelines or standards. In this study, a detailed analysis of the tanker fleet, covering 8,000 ships under operation and order to build, is made to estimate the proper PBL(Parallel Body Length) of each tanker class. After discussion and comparison on the dolphin berth design and construction codes of various countries, those are the leading countries of tanker operation and management, suggestion was made to amend on the design code. The referred codes are of Korea, Japan, UK, USA, and Canada. The analysis of tanker fleet shows the PBL as 0.45L under the normal ballast condition. In order to verify the deduced amendment on the domestic design code for dolphin berth, it was selected one of the domestic dolphin berth, located at the Yeosu oil terminal, which is almost completed to construct. The design criteria and expected tankers to moor in that terminal were analyzed and the appropriateness and countermeasure for deficiency were summarized.
Dermoid cysts are rare congenital tumors that occur primarily at the midline at a characteristic intradural location. However, dermoid cysts located at extradural and lateral regions have been rarely reported until now. In the present study, the authors demonstrate the unusual instance of an intracranial extradural dermoid cyst at the lateral sphenoid ridge. A 53-year-old woman admitted because of progressive headache and dizziness. The patient had no neurologic deficits, and magnetic resonance imaging with no contrast enhancement revealed a mass at the right sphenoid ridge. The mass was accompanied with sphenoid bone erosion visible on computed tomography. The patient underwent right pterional craniotomy, and the tumor including the capsule was totally resected. Presence of a dermoid cyst was confirmed with histopathological examination. The patient had no complications during the postoperative period. This study suggests that dermoid cyst should be considered for differential diagnosis of extradural and lateral intracranial masses.