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윤종만(Chong Mann Yoon),유종선(Jong Sun Rew),박일종(Il Jong park),서순팔(Soon Pal Suh),유주용(Joo Yong Yoo) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.3
N/A The biological characteristics and the genesis of gastric carcinoma, the most common malignancy in Korean adult male, have not been established so far. Estrogen receptors (ER) have been idnetified in many hormone-dependent cancer such as breast cancer, prostate cancer and ovarian cancer and utilized clinically to provide hormonal therapeutic manipulation. In order to find any hormonal relation in gastric cancer, the presence of ER was examined in 38 patients with primary gastric carcinoma, six with benign stomach lesions and 17 normal gastric tissues, using monoclonal antibody by enzyme immunoassay in cystosol. The results obtained were as follows; 1) ER concetration (Mean+SD) in cytosol from noraml gastric tissue, benign gastric lesion and gastric cancer tissue were 5.6+4.6, 14.617.7 and 20.1+41.7 fmol/mg protein, respectively. Positivities of ER in normal gastric tissue, benign gastric lesion and gastric cancer tissue were 0, 16.7 and 21.1%, respectively. Concentration and positivity of ER were higher in gastric cancer tissue, especially in female gastric cancer tissue, than noraml gastric tissue and benign gastric lesion. 2) Highest value of ER concentration and ER posiitvity according to the macroscopic classification of the gastric carcinoma was observed in Borrmann type II. There was an increasing tendency in ER positivity as the size of the cancer increase. 3) ER concentration and positivity according to the histologic pattern were higher in poorly and well differentiated tubular adenocarcinoma than mucinous adenocarcinomas, signet ring cell carcinoma and moderately differentiated tubular adenocarcinomas. 4) Concentration and postitivity of ER from cancerous tissue of the postmenopausal patients were more higher than that of the premenopausal patients. These results suggested that there was close reation between the presence of ER and the evolution of gastric carcinoma, but not with the degree of histologic malignancy.